Ocular drug delivery using 20-kHz ultrasound

Ultrasound in Medicine and Biology

Volumn 28, Issue 6, 2002, Pages 823-829

  Zderic, Vesna ^a,c   Vaezy, Shahram ^a,b   Martin, Roy W ^a,b   Clark, John I ^b  

^a University of Washington   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Center for Industrial and Medical Ultrasound   (United States)

Author keywords

Drug delivery; Eye; Phonophoresis; Sonophoresis; Ultrasound

Indexed keywords

DRUG THERAPY; EYE PROTECTION; ULTRASONICS;

CORNEAL PERMEABILITY;

MEDICINE;

ATENOLOL; BETAXOLOL; CARTEOLOL; TIMOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; CORNEA PERMEABILITY; CORNEA STROMA; DRUG DELIVERY SYSTEM; DRUG PENETRATION; GLAUCOMA; IN VITRO STUDY; LIPOPHILICITY; NONHUMAN; PRIORITY JOURNAL; RABBIT; ULTRASOUND; ANIMAL; ANIMAL MODEL; CORNEA; DRUG EFFECT; EPITHELIUM; METABOLISM; METHODOLOGY; PERMEABILITY;

ADRENERGIC BETA-ANTAGONISTS; ANIMAL; ATENOLOL; BETAXOLOL; CARTEOLOL; CORNEA; DRUG DELIVERY SYSTEMS; EPITHELIUM; MODELS, ANIMAL; PERMEABILITY; RABBITS; SUPPORT, NON-U.S. GOV'T; TIMOLOL; ULTRASONICS; ANIMALS;

EID: 0036019870     PISSN: 03015629     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-5629(02)00515-X     Document Type: Article

References (33)

1. Physicochemical determinants of drug diffusion across the conjunctiva, sclera, and cornea
2. Formulation influence on conjunctival penetration of four beta blockers in the pigmented rabbit: A comparison with corneal penetration
3. Current status of research on biophysical effects of ultrasound
4. 2O as a tracer molecule
5. Phonophoresis of hypotensive agents in the treatment of simple glaucoma
6. Penetration routes of topically applied eye medications
7. On diffusion
8. The treatment of eye diseases using the Gamma-G ultrasonic apparatus
9. Ultrasound-induced cavitation damage to external epithelia of fish skin
10. Ultrasound-mediated disruption of cell membranes. I. Quantification of molecular uptake and cell viability
11. Effect of superphonoelectrophoresis on chorioretinal dystrophy
12. Age-related permeability changes in rabbit corneas
13. Standardization of ultrasonic power for sonochemical reaction
14. Non-invasive assessment and control of ultrasound-mediated membrane permeabilization
15. Practical sonochemistry
16. Transdermal drug delivery using low-frequency sonophoresis
17. A mechanistic study of ultrasonically-enhanced transdermal drug delivery
18. Determination of threshold energy dose for ultrasound-induced transdermal drug transport
19. Phonophoresis and cavitation
20. The structural basis of the blood-ocular barriers
21. Penetration of beta-blockers through ocular membranes in albino rabbits
22. Different effects of absorption promoters on corneal and conjunctival penetration of ophthalmic beta-blockers
23. Enhancement of ocular drug penetration
24. Ocular drug delivery. Pharmacokinetic considerations
25. Safety levels for exposure of cornea and lens to very high-frequency ultrasound
26. The use of ultrasound for drug delivery
27. Theoretical description of transdermal transport of hydrophilic permeants: Application to low-frequency sonophoresis
28. Reconstruction of an in vitro cornea and its use for drug permeation studies from different formulations containing pilocarpine hydrochloride
29. The effect of ultrasonic oscillations of different frequencies on radionuclide accumulation in the eye tissues
30. Corneal thickness and endothelial density before and after cataract surgery
31. Lipophilicity influence on conjunctival drug penetration in the pigmented rabbit: A comparison with corneal penetration