Novel therapy for hearing loss: Delivery of insulin-like growth factor 1 to the cochlea using gelatin hydrogel

Otology and Neurotology

Volumn 28, Issue 7, 2007, Pages 976-981

  Lee, Kyu Yup ^a,c   Nakagawa, Takayuki ^a   Okano, Takayuki ^a   Hori, Ryusuke ^a   Ono, Kazuya ^a   Tabata, Yasuhiko ^b   Lee, Sang Heun ^c   Ito, Juichi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c Kyungpook National University Hospital   (South Korea)

Author keywords

Biomaterial; Drug delivery; Growth factor; Noise trauma; Round window

Indexed keywords

GELATIN; SODIUM CHLORIDE; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDITORY THRESHOLD; BRAIN STEM RESPONSE; COCHLEA; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GUINEA PIG; HAIR CELL; HEARING LOSS; HISTOLOGY; HYDROGEL; NOISE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; AUDITORY THRESHOLD; CHEMISTRY, PHARMACEUTICAL; COCHLEA; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; FEMALE; GELATIN; GUINEA PIGS; HEARING LOSS, NOISE-INDUCED; HYDROGELS; IMMUNOHISTOCHEMISTRY; INJECTIONS; INSULIN-LIKE GROWTH FACTOR I; NOISE; RECOMBINANT PROTEINS;

EID: 34848903929     PISSN: 15317129     EISSN: 15374505     Source Type: Journal    
DOI: 10.1097/MAO.0b013e31811f40db     Document Type: Article

References (17)

1. Juhn SK, Rybak LP. Labyrinthine barriers and cochlear homeostasis. Acta Otolaryngol 1981;91:529-34.
2. Angelborg C, Hillerdal M, Hultcrantz E, Larsen HC. The microsphere method for studies of inner ear blood flow. ORL J Otorhinolaryngol Relat Spec 1998;50:355-62.
3. Salt AN, Plontke S. Local inner-ear drug delivery and pharmacokinetics. Drug Discov Today 2005;10:1299-306.
4. Takemura K, Komeda M, Yagi M, et al. Direct inner ear infusion of dexamethasone attenuates noise-induced trauma in guinea pig. Hear Res 2004;196:58-68.
5. Lefebvre PP, Staecker H. Steroid perfusion of the inner ear for sudden sensorineural hearing loss after failure of conventional therapy: a pilot study. Acta Otolaryngol 2002;122:698-702.
6. Plontke S, Lowenheim H, Preyer S, et al. Outcomes research analysis of continuous intratympanic glucocorticoid delivery in patients with acute severe to profound hearing loss: basis for planning randomized controlled trials. Acta Otolaryngol 2005;125:830-9.
7. Nakagawa T, Ito J. Drug delivery systems for the treatment of sensorineural hearing loss. Acta Otolaryngol 2007;557:30-5.
8. Endo T, Nakagawa T, Kita T, et al. A novel strategy for treatment of inner ears using a biodegradable gel. Laryngoscope 2005;115:2000-5.
9. Iwai K, Nakagawa T, Endo T, et al. Cochlear protection by local IGF-1 application using biodegradable hydrogel. Laryngoscope 2006;116:526-33.
10. Young S, Wong M, Tabata Y, et al. Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J Control Release 2005;109:256-74.
11. Holland TA, Tabata Y, Mikos AG. Dual growth factor delivery from degradable oligo(poly[ethylene glycol] fumarate) hydrogel scaffolds for cartilage engineering. J Control Release 2005;101:111-25.
12. Antonelli PJ, Schultz GS, Kim KM, et al. Alpha 1-antitrypsin and ilomastat inhibit inflammatory proteases present in human middle ear effusions. Laryngoscope 2003;113:1347-51.
13. Jang CH, Shin SH, Cho HH, et al. Expression of matrix metalloproteinase-9 and -2 in pediatric chronic otitis media with effusion. Int J Pediatr Otorhinolaryngol 2006;70:1155-8.
14. Wang J, Ruel J, Ladrech S, et al. Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals. Mol Pharmacol 2007;71:654-66.
15. Tanaka K, Takemoto T, Sugahara K, et al. Post-exposure administration of edaravone attenuates noise-induced hearing loss. Eur J Pharmacol 2005;522:116-21.
16. Tamura T, Kita T, Nakagawa T, et al. Drug delivery to the cochlea using PLGA nanoparticles. Laryngoscope 2005;115:2000-5.
17. Arai Y, Marui A, Komeda M. Regenerative medicine with the sustained release system of basic fibroblast growth factor. Nippon Rinsho 2006;64:2142-7.