MicroRNA-126 regulates the induction and function of CD4+ Foxp3+ regulatory T cells through PI3K/AKT pathway

Journal of Cellular and Molecular Medicine

Volumn 17, Issue 2, 2013, Pages 252-264

  Qin, Andong ^a   Wen, Zhenke ^b   Zhou, Ya ^a   Li, Ying ^a   Li, Yongju ^a   Luo, Junmin ^a   Ren, Tao ^c   Xu, Lin ^a  

^a ZUNYI MEDICAL UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Adoptive cell transfer; AKT; CD4+ regulatory T cell; MiR 126

Indexed keywords

FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; MESSENGER RNA; MICRORNA; MIRN126 MICRORNA, HUMAN; MIRN126 MICRORNA, MOUSE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ADENOCARCINOMA; ADULT; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; DRUG ANTAGONISM; EXPERIMENTAL MAMMARY NEOPLASM; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; METASTASIS; MOUSE; NUDE MOUSE; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; YOUNG ADULT;

ADENOCARCINOMA; ADULT; ANIMALS; BLOTTING, WESTERN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, INBRED BALB C; MICE, NUDE; MICRORNAS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY; YOUNG ADULT;

EID: 84874361847     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12003     Document Type: Article

References (39)

1. + human thymocytes. J Exp Med. 2002; 196: 379-87.
2. Zou W. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol. 2006; 6: 295-307.
3. Ono MH, Yaguchi N, Ohkura I, et al. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature. 2007; 446: 685-9.
4. Coffer PJ, Burgering BM. Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol. 2004; 4: 889.
5. Lee HM, Bautista JL, Hsieh CS. Thymic and peripheral differentiation of regulatory T cells. Adv Immunol. 2011; 112: 25-71.
6. Geiger TL, Tauro S. Nature and nurture in Foxp3(+) regulatory T cell development, stability, and function. Hum Immunol. 2011; 73: 232-9.
7. Bilate AM, Lafaille JJ. Induced CD4(+)Foxp3(+) Regulatory T Cells in Immune Tolerance. Annu Rev Immunol. 2012; 30: 733-58.
8. Josefowicz SZ, Lu LF, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol. 2012; 30: 531-64.
9. Sauer S, Bruno L, Hertweck A, et al. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci USA. 2008; 105: 7797-802.
10. Merkenschlager M. Boehmer Hvon. PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors. J Exp Med. 2010; 207: 1347-50.
11. Crellin NK, Garcia RV, Levings MK. Altered activation of AKT is required for the suppressive function of human CD4 + CD25 + T regulatory cells. Blood. 2007; 109: 2014-22.
12. + regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR. J Leukoc Biol. 2008; 83: 1230-9.
13. + cells. J Exp Med. 2008; 205: 565-74.
14. Harris TA, Yamakuchi M, Ferlito M, et al. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci USA. 2008; 105: 1516-21.
15. Landgraf P, Rusu M, Sheridan R, et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell. 2007; 129: 1401-14.
16. Wang S, Aurora AB, Johnson BA, et al. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell. 2008; 15: 261-71.
17. Chen JJ, Zhou SH. Mesenchymal stem cells overexpressing MiR-126 enhance ischemic angiogenesis via the AKT/ERK-related pathway. Cardiol J. 2011; 18: 675-81.
18. Guo C, Sah JF, Beard L, et al. The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosom Cancer. 2008; 47: 939-46.
19. Meister J, Schmidt MH. miR-126 and miR-126*: new players in cancer. Sci World J. 2010; 10: 2090-100.
20. Zhao S, Wang Y, Liang Y, et al. MicroRNA-126 regulates DNA methylation in CD4 + T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1. Arthritis Rheum. 2011; 63: 1376-86.
21. Mattes J, Collison A, Plank M, et al. Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease. Proc Natl Acad Sci USA. 2009; 106: 18704-9.
22. Xu L, Xu W, Wen Z, et al. In situ prior proliferation of CD4 + CCR6 + regulatory T cells facilitated by TGF-β secreting DCs is crucial for their enrichment and suppression in tumor immunity. PLoS ONE. 2011; 6: e20282.
23. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116: 281-97.
24. Liston A, Lu LF, O'Carroll D, et al. Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med. 2008; 205: 1993-2004.
25. Zhou X, Jeker LT, Fife BT, et al. Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med. 2008; 205: 1983-91.
26. Kohlhaas S, Garden OA, Scudamore C, et al. Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells. J Immunol. 2009; 182: 2578-82.
27. Rouas R, Fayyad-Kazan H, El N, et al. Human natural Treg microRNA signature: role of microRNA-31 and microRNA-21 in FOXP3 expression. Eur J Immunol. 2009; 39: 1608-18.
28. Lu LF, Thai TH, Calado DP, et al. Foxp3-dependent miR-155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity. 2009; 30: 80-91.
29. Lu LF, Boldin MP, Chaudhry A, et al. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell. 2010; 142: 914-29.
30. Jiang S, Li C, Olive VE, et al. Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation. Blood. 2011; 118: 5487-97.
31. Josefowicz SZ, Wilson CB, Rudensky AY. Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1. J Immunol. 2009; 182: 6648-52.
32. Gordanpour A, Nam RK, Sugar L, et al. MicroRNAs in prostate cancer: from biomarkers to molecularly-based therapeutics. Prostate Cancer Prostatic Dis. 2012; 15: 314-9.
33. Rooij VE, Purcell AL, Levin AA. Developing microRNA therapeutics. Circ Res. 2012; 110: 496-507.
34. Majumder S, Jacob ST. Emerging role of microRNAs in drug-resistant breast cancer. Gene Expr. 2011; 15: 141-51.
35. Murugaiyan G, Beynon V, Mittal A, et al. Silencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis. J Immunol. 2011; 187: 2213-21.
36. Hullinger TG, Montgomery RL, Seto AG, et al. Inhibition of miR-15 protects against cardiac ischemic injury. Circ Res. 2012; 110: 71-81.
37. high regulatory T cells from tumor infiltrating lymphocytes predominantly induces Th1 type immune response in vivo which inhibits tumor growth in adoptive immunotherapy. Cancer Biol Ther. 2009; 4: 293-8.
38. + cells unmasks tumour immunogenicity leading to the rejection of late-stage tumours. J Exp Med. 2005; 201: 779-91.
39. + CTLs and anti-CD25 mAb provide improved immunotherapy. Oncol Rep. 2008; 19: 1265-70.