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Volumn 18, Issue 2, 2013, Pages 221-231

The potential role of aerobic exercise to modulate cardiotoxicity of molecularly targeted cancer therapeutics

Author keywords

Cardiotoxicity; Exercise; Molecular therapeutics; Solid malignancies

Indexed keywords

AXITINIB; BEVACIZUMAB; CEDIRANIB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; INTERLEUKIN 6; LAPATINIB; MITOGEN ACTIVATED PROTEIN KINASE; MOTESANIB; NEU DIFFERENTIATION FACTOR; PAZOPANIB; PERTUZUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; RAMUCIRUMAB; SORAFENIB; STAT3 PROTEIN; SUNITINIB; TRANSFORMING GROWTH FACTOR BETA; TRASTUZUMAB; VANDETANIB; VASCULOTROPIN;

EID: 84874349671     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2012-0226     Document Type: Review
Times cited : (35)

References (141)
  • 1
    • 50949132320 scopus 로고    scopus 로고
    • Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics
    • Chen MH, Kerkela R, Force T. Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics. Circulation 2008; 118:84-95.
    • (2008) Circulation , vol.118 , pp. 84-95
    • Chen, M.H.1    Kerkela, R.2    Force, T.3
  • 2
    • 34247480545 scopus 로고    scopus 로고
    • Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition
    • Force T, Krause DS, Van Etten RA. Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition. Nat Rev Cancer 2007;7:332-344.
    • (2007) Nat Rev Cancer , vol.7 , pp. 332-344
    • Force, T.1    Krause, D.S.2    van Etten, R.A.3
  • 3
    • 67649958842 scopus 로고    scopus 로고
    • Cardiovascular complications of cancer therapy: Incidence, pathogenesis, diagnosis, and management
    • Yeh ET, Bickford CL. Cardiovascular complications of cancer therapy: Incidence, pathogenesis, diagnosis, and management. J Am Coll Cardiol 2009; 53:2231-2247.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 2231-2247
    • Yeh, E.T.1    Bickford, C.L.2
  • 4
    • 51249084565 scopus 로고    scopus 로고
    • Cardiotoxicity of the new cancer therapeutics: Mechanisms of, and approaches to, the problem
    • Force T, Kerkela R. Cardiotoxicity of the new cancer therapeutics: Mechanisms of, and approaches to, the problem. Drug Discov Today 2008; 13:778-784.
    • (2008) Drug Discov Today , vol.13 , pp. 778-784
    • Force, T.1    Kerkela, R.2
  • 5
    • 34848877728 scopus 로고    scopus 로고
    • Early breast cancer therapy and cardiovascular injury
    • Jones LW, Haykowsky MJ, Swartz JJ et al. Early breast cancer therapy and cardiovascular injury. J Am Coll Cardiol 2007;50:1435-1441.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1435-1441
    • Jones, L.W.1    Haykowsky, M.J.2    Swartz, J.J.3
  • 7
    • 77955907895 scopus 로고    scopus 로고
    • Role of biomarkers in chemotherapy-induced cardiotoxicity
    • Cardinale D, Sandri MT. Role of biomarkers in chemotherapy-induced cardiotoxicity. Prog Cardiovasc Dis 2010;53:121-129.
    • (2010) Prog Cardiovasc Dis , vol.53 , pp. 121-129
    • Cardinale, D.1    Sandri, M.T.2
  • 8
    • 84870613644 scopus 로고    scopus 로고
    • Cancer therapy-induced cardiac toxicity in early breast cancer: Addressing the unresolved issues
    • in press
    • Khouri M, Douglas P, Mackey J et al. Cancer therapy-induced cardiac toxicity in early breast cancer: Addressing the unresolved issues. Circulation 2012 (in press).
    • (2012) Circulation
    • Khouri, M.1    Douglas, P.2    Mackey, J.3
  • 9
    • 0030072570 scopus 로고    scopus 로고
    • Vertebrate non-receptor protein-tyrosine kinase families
    • Neet K, Hunter T. Vertebrate non-receptor protein-tyrosine kinase families. Genes Cells 1996;1: 147-169.
    • (1996) Genes Cells , vol.1 , pp. 147-169
    • Neet, K.1    Hunter, T.2
  • 10
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000;103:211-225.
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 12
    • 33747855481 scopus 로고    scopus 로고
    • Comparing antibody and small-molecule therapies for cancer
    • Imai K, Takaoka A. Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer 2006;6:714-727.
    • (2006) Nat Rev Cancer , vol.6 , pp. 714-727
    • Imai, K.1    Takaoka, A.2
  • 13
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG et al. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987;235:177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 14
    • 4944232647 scopus 로고    scopus 로고
    • Lung cancer: Intragenic ERBB2 kinase mutations in tumours
    • Stephens P, Hunter C, Bignell G et al. Lung cancer: Intragenic ERBB2 kinase mutations in tumours. Nature 2004;431:525-526.
    • (2004) Nature , vol.431 , pp. 525-526
    • Stephens, P.1    Hunter, C.2    Bignell, G.3
  • 15
    • 31544449750 scopus 로고    scopus 로고
    • Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas
    • Lee JW, Soung YH, Seo SH et al. Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas. Clin Cancer Res 2006;12: 57-61.
    • (2006) Clin Cancer Res , vol.12 , pp. 57-61
    • Lee, J.W.1    Soung, Y.H.2    Seo, S.H.3
  • 16
    • 26844503270 scopus 로고    scopus 로고
    • Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
    • Piccart-Gebhart MJ, Procter M, Leyland-Jones B et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005; 353:1659-1672.
    • (2005) N Engl J Med , vol.353 , pp. 1659-1672
    • Piccart-Gebhart, M.J.1    Procter, M.2    Leyland-Jones, B.3
  • 17
    • 80053539103 scopus 로고    scopus 로고
    • Adjuvant trastuzumab in HER2-positive breast cancer
    • Slamon D, Eiermann W, Robert N et al. Adjuvant trastuzumab in HER2-positive breast cancer. N Engl J Med 2011;365:1273-1283.
    • (2011) N Engl J Med , vol.365 , pp. 1273-1283
    • Slamon, D.1    Eiermann, W.2    Robert, N.3
  • 18
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006;355:2733-2743.
    • (2006) N Engl J Med , vol.355 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 19
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • Hynes NE, Lane HA. ERBB receptors and cancer: The complexity of targeted inhibitors. Nat Rev Cancer 2005;5:341-354.
    • (2005) Nat Rev Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 21
    • 34248591612 scopus 로고    scopus 로고
    • Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
    • Roberts PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 2007;26:3291-3310.
    • (2007) Oncogene , vol.26 , pp. 3291-3310
    • Roberts, P.J.1    Der, C.J.2
  • 22
    • 78649938024 scopus 로고    scopus 로고
    • HER2 silences tumor suppression in breast cancer cells by switching expression of C/EBPss isoforms
    • Arnal-Estape A, Tarragona M, Morales M et al. HER2 silences tumor suppression in breast cancer cells by switching expression of C/EBPss isoforms. Cancer Res 2010;70:9927-9936.
    • (2010) Cancer Res , vol.70 , pp. 9927-9936
    • Arnal-Estape, A.1    Tarragona, M.2    Morales, M.3
  • 23
    • 20244378529 scopus 로고    scopus 로고
    • Neoadjuvant trastuzumab induces apoptosis in primary breast cancers
    • Mohsin SK, Weiss HL, Gutierrez MC et al. Neoadjuvant trastuzumab induces apoptosis in primary breast cancers. J Clin Oncol 2005;23:2460-2468.
    • (2005) J Clin Oncol , vol.23 , pp. 2460-2468
    • Mohsin, S.K.1    Weiss, H.L.2    Gutierrez, M.C.3
  • 24
    • 79951997890 scopus 로고    scopus 로고
    • Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers
    • Dave B, Migliaccio I, Gutierrez MC et al. Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers. J Clin Oncol 2011;29:166-173.
    • (2011) J Clin Oncol , vol.29 , pp. 166-173
    • Dave, B.1    Migliaccio, I.2    Gutierrez, M.C.3
  • 25
    • 0036099675 scopus 로고    scopus 로고
    • ErbB2 is essential in the prevention of dilated cardiomyopathy
    • Crone SA, Zhao YY, Fan L et al. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med 2002;8:459-465.
    • (2002) Nat Med , vol.8 , pp. 459-465
    • Crone, S.A.1    Zhao, Y.Y.2    Fan, L.3
  • 26
    • 68249087127 scopus 로고    scopus 로고
    • Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure
    • Ky B, Kimmel SE, Safa RN et al. Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure. Circulation 2009; 120:310-317.
    • (2009) Circulation , vol.120 , pp. 310-317
    • Ky, B.1    Kimmel, S.E.2    Safa, R.N.3
  • 27
    • 59049093631 scopus 로고    scopus 로고
    • Blockade of the erbB2 receptor induces cardiomyocyte death through mitochondrial and reactive oxygen species-dependent pathways
    • Gordon LI, Burke MA, Singh AT et al. Blockade of the erbB2 receptor induces cardiomyocyte death through mitochondrial and reactive oxygen species-dependent pathways. J Biol Chem 2009;284: 2080-2087.
    • (2009) J Biol Chem , vol.284 , pp. 2080-2087
    • Gordon, L.I.1    Burke, M.A.2    Singh, A.T.3
  • 28
    • 78149338262 scopus 로고    scopus 로고
    • Neuregulin1beta1 rapidly modulates nitric oxide synthesis and calcium handling in rat cardiomyocytes
    • Brero A, Ramella R, Fitou A et al. Neuregulin1beta1 rapidly modulates nitric oxide synthesis and calcium handling in rat cardiomyocytes. Cardiovasc Res 88:443-452.
    • Cardiovasc Res , vol.88 , pp. 443-452
    • Brero, A.1    Ramella, R.2    Fitou, A.3
  • 29
    • 62649116580 scopus 로고    scopus 로고
    • The role of Neuregulin-1beta/ErbB signaling in the heart
    • Pentassuglia L, Sawyer DB. The role of Neuregulin-1beta/ErbB signaling in the heart. Exp Cell Res 2009;315:627-637.
    • (2009) Exp Cell Res , vol.315 , pp. 627-637
    • Pentassuglia, L.1    Sawyer, D.B.2
  • 30
    • 33746048823 scopus 로고    scopus 로고
    • Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes
    • Kuramochi Y, Guo X, Sawyer DB. Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes. J Mol Cell Cardiol 2006;41:228-235.
    • (2006) J Mol Cell Cardiol , vol.41 , pp. 228-235
    • Kuramochi, Y.1    Guo, X.2    Sawyer, D.B.3
  • 31
    • 33748929841 scopus 로고    scopus 로고
    • Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy
    • Liu X, Gu X, Li Z et al. Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy. J Am Coll Cardiol 2006;48:1438-1447.
    • (2006) J Am Coll Cardiol , vol.48 , pp. 1438-1447
    • Liu, X.1    Gu, X.2    Li, Z.3
  • 32
    • 0034785348 scopus 로고    scopus 로고
    • TGF-beta signaling in tumor suppression and cancer progression
    • Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 2001;29:117-129.
    • (2001) Nat Genet , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 33
    • 74049114704 scopus 로고    scopus 로고
    • Intramyocardial fibroblast myocyte communication
    • Kakkar R, Lee RT. Intramyocardial fibroblast myocyte communication. Circ Res 2010;106:47-57.
    • (2010) Circ Res , vol.106 , pp. 47-57
    • Kakkar, R.1    Lee, R.T.2
  • 34
    • 78650472007 scopus 로고    scopus 로고
    • C/EBPbeta controls exercise-induced cardiac growth and protects against pathological cardiac remodeling
    • Bostrom P, Mann N, Wu J et al. C/EBPbeta controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell 2010; 143:1072-1083.
    • (2010) Cell , vol.143 , pp. 1072-1083
    • Bostrom, P.1    Mann, N.2    Wu, J.3
  • 35
    • 67650569135 scopus 로고    scopus 로고
    • Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury
    • Bersell K, Arab S, Haring B, Kuhn B. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 2009;138: 257-270.
    • (2009) Cell , vol.138 , pp. 257-270
    • Bersell, K.1    Arab, S.2    Haring, B.3    Kuhn, B.4
  • 36
    • 34548132413 scopus 로고    scopus 로고
    • Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: Implications for therapy of heart failure
    • Lemmens K, Doggen K, De Keulenaer GW. Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: Implications for therapy of heart failure. Circulation 2007;116:954-960.
    • (2007) Circulation , vol.116 , pp. 954-960
    • Lemmens, K.1    Doggen, K.2    de Keulenaer, G.W.3
  • 37
    • 33745805840 scopus 로고    scopus 로고
    • Role of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-talk
    • Lemmens K, Segers VF, Demolder M, De Keulenaer GW. Role of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-talk. J Biol Chem 2006;281:19469-19477.
    • (2006) J Biol Chem , vol.281 , pp. 19469-19477
    • Lemmens, K.1    Segers, V.F.2    Demolder, M.3    de Keulenaer, G.W.4
  • 38
    • 65749110372 scopus 로고    scopus 로고
    • Left ventricular torsion and untwisting during exercise in heart transplant recipients
    • Esch BT, Scott JM, Warburton DE et al. Left ventricular torsion and untwisting during exercise in heart transplant recipients. J Physiol 2009;587: 2375-2386.
    • (2009) J Physiol , vol.587 , pp. 2375-2386
    • Esch, B.T.1    Scott, J.M.2    Warburton, D.E.3
  • 39
    • 80051473367 scopus 로고    scopus 로고
    • Aerobic exercise training-induced left ventricular hypertrophy involves regulatory MicroRNAs, decreased angiotensin-converting enzyme-angiotensin ii, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin (1-7)
    • Fernandes T, Hashimoto NY, Magalhaes FC et al. Aerobic exercise training-induced left ventricular hypertrophy involves regulatory MicroRNAs, decreased angiotensin-converting enzyme-angiotensin ii, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin (1-7). Hypertension 2011;58: 182-189.
    • (2011) Hypertension , vol.58 , pp. 182-189
    • Fernandes, T.1    Hashimoto, N.Y.2    Magalhaes, F.C.3
  • 40
    • 0037405153 scopus 로고    scopus 로고
    • Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle
    • Lebrasseur NK, Cote GM, Miller TA et al. Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle. Am J Physiol Cell Physiol 2003;284:C1149-1155.
    • (2003) Am J Physiol Cell Physiol , vol.284 , pp. 1149-1155
    • Lebrasseur, N.K.1    Cote, G.M.2    Miller, T.A.3
  • 41
    • 0142027759 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy
    • McMullen JR, Shioi T, Zhang L et al. Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy. Proc Natl Acad Sci U S A 2003;100:12355-12360.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12355-12360
    • McMullen, J.R.1    Shioi, T.2    Zhang, L.3
  • 42
    • 33846966331 scopus 로고    scopus 로고
    • Differences between pathological and physiological cardiac hypertrophy: Novel therapeutic strategies to treat heart failure
    • McMullen JR, Jennings GL. Differences between pathological and physiological cardiac hypertrophy: Novel therapeutic strategies to treat heart failure. Clin Exp Pharmacol Physiol 2007;34: 255-262.
    • (2007) Clin Exp Pharmacol Physiol , vol.34 , pp. 255-262
    • McMullen, J.R.1    Jennings, G.L.2
  • 43
    • 20244378531 scopus 로고    scopus 로고
    • Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: Restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor
    • Yoon YS, Uchida S, Masuo O et al. Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: Restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor. Circulation 2005;111:2073-2085.
    • (2005) Circulation , vol.111 , pp. 2073-2085
    • Yoon, Y.S.1    Uchida, S.2    Masuo, O.3
  • 44
    • 34547121683 scopus 로고    scopus 로고
    • Long-term aerobic exercise protects the heart against ischemia/reperfusion injury via PI3 kinase-dependent and Akt-mediated mechanism
    • Zhang KR, Liu HT, Zhang HF et al. Long-term aerobic exercise protects the heart against ischemia/reperfusion injury via PI3 kinase-dependent and Akt-mediated mechanism. Apoptosis 2007;12: 1579-1588.
    • (2007) Apoptosis , vol.12 , pp. 1579-1588
    • Zhang, K.R.1    Liu, H.T.2    Zhang, H.F.3
  • 45
    • 33846318098 scopus 로고    scopus 로고
    • Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy
    • McMullen JR, Amirahmadi F, Woodcock EA et al. Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy. Proc Natl Acad Sci USA2007;104:612-617.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 612-617
    • McMullen, J.R.1    Amirahmadi, F.2    Woodcock, E.A.3
  • 46
    • 77950201708 scopus 로고    scopus 로고
    • Primary contribution to zebrafish heart regeneration by gata4() cardiomyocytes
    • Kikuchi K, Holdway JE, Werdich AA et al. Primary contribution to zebrafish heart regeneration by gata4() cardiomyocytes. Nature 2010;464: 601-605.
    • (2010) Nature , vol.464 , pp. 601-605
    • Kikuchi, K.1    Holdway, J.E.2    Werdich, A.A.3
  • 47
    • 68049139569 scopus 로고    scopus 로고
    • Adjuvant trastuzumab induces ventricular remodeling despite aerobic exercise training
    • Haykowsky MJ, Mackey JR, Thompson RB et al. Adjuvant trastuzumab induces ventricular remodeling despite aerobic exercise training. Clin Cancer Res 2009;15:4963-4967.
    • (2009) Clin Cancer Res , vol.15 , pp. 4963-4967
    • Haykowsky, M.J.1    Mackey, J.R.2    Thompson, R.B.3
  • 48
    • 34249981756 scopus 로고    scopus 로고
    • A meta-analysis of the effect of exercise training on left ventricular remodeling in heart failure patients: The benefit depends on the type of training performed
    • Haykowsky MJ, Liang Y, Pechter D et al. A meta-analysis of the effect of exercise training on left ventricular remodeling in heart failure patients: The benefit depends on the type of training performed. J Am Coll Cardiol 2007;49:2329-2336.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 2329-2336
    • Haykowsky, M.J.1    Liang, Y.2    Pechter, D.3
  • 49
    • 34250750734 scopus 로고    scopus 로고
    • Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: A randomized study
    • Wisloff U, Stoylen A, Loennechen JP et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: A randomized study. Circulation 2007;115:3086-3094.
    • (2007) Circulation , vol.115 , pp. 3086-3094
    • Wisloff, U.1    Stoylen, A.2    Loennechen, J.P.3
  • 50
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy. Science 2005;307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 51
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS. Tumor angiogenesis. N Engl J Med 2008;358:2039-2049.
    • (2008) N Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 52
    • 4644356480 scopus 로고    scopus 로고
    • Angiogenesis and signal transduction in endothelial cells
    • Munoz-Chapuli R, Quesada AR, Angel Medina M. Angiogenesis and signal transduction in endothelial cells. Cell Mol Life Sci 2004;61:2224-2243.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 2224-2243
    • Munoz-Chapuli, R.1    Quesada, A.R.2    Angel, M.M.3
  • 53
    • 27244450145 scopus 로고    scopus 로고
    • Phase II study of doxorubicin and bevacizumab for patients with metastatic soft-tissue sarcomas
    • D'Adamo DR, Anderson SE, Albritton K et al. Phase II study of doxorubicin and bevacizumab for patients with metastatic soft-tissue sarcomas. J Clin Oncol 2005;23:7135-7142.
    • (2005) J Clin Oncol , vol.23 , pp. 7135-7142
    • D'Adamo, D.R.1    Anderson, S.E.2    Albritton, K.3
  • 54
    • 79952083872 scopus 로고    scopus 로고
    • Congestive heart failure risk in patients with breast cancer treated with bevacizumab
    • Choueiri TK, Mayer EL, Je Y et al. Congestive heart failure risk in patients with breast cancer treated with bevacizumab. J Clin Oncol 29: 632-638.
    • J Clin Oncol , vol.29 , pp. 632-638
    • Choueiri, T.K.1    Mayer, E.L.2    Je, Y.3
  • 55
    • 0032931234 scopus 로고    scopus 로고
    • VEGF is required for growth and survival in neonatal mice
    • Gerber HP, Hillan KJ, Ryan AM et al. VEGF is required for growth and survival in neonatal mice. Development 1999;126:1149-1159.
    • (1999) Development , vol.126 , pp. 1149-1159
    • Gerber, H.P.1    Hillan, K.J.2    Ryan, A.M.3
  • 56
    • 65249181467 scopus 로고    scopus 로고
    • Musclespecific VEGF deficiency greatly reduces exercise endurance in mice
    • Olfert IM, Howlett RA, Tang K et al. Musclespecific VEGF deficiency greatly reduces exercise endurance in mice. J Physiol 2009;587:1755-1767.
    • (2009) J Physiol , vol.587 , pp. 1755-1767
    • Olfert, I.M.1    Howlett, R.A.2    Tang, K.3
  • 57
    • 14344279280 scopus 로고    scopus 로고
    • A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function
    • Giordano FJ, Gerber HP, Williams SP et al. A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proc Natl Acad Sci U S A 2001;98:5780-5785.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 5780-5785
    • Giordano, F.J.1    Gerber, H.P.2    Williams, S.P.3
  • 58
    • 16644372195 scopus 로고    scopus 로고
    • Genetics in zebrafish, mice, and humans to dissect congenital heart disease: Insights in the role of VEGF
    • Lambrechts D, Carmeliet P. Genetics in zebrafish, mice, and humans to dissect congenital heart disease: Insights in the role of VEGF. Curr Top Dev Biol 2004;62:189-224.
    • (2004) Curr Top Dev Biol , vol.62 , pp. 189-224
    • Lambrechts, D.1    Carmeliet, P.2
  • 59
    • 77957131569 scopus 로고    scopus 로고
    • Endothelial cells regulate cardiomyocyte development from embryonic stem cells
    • Chen K, Bai H, Arzigian M et al. Endothelial cells regulate cardiomyocyte development from embryonic stem cells. J Cell Biochem 2010;111:29-39.
    • (2010) J Cell Biochem , vol.111 , pp. 29-39
    • Chen, K.1    Bai, H.2    Arzigian, M.3
  • 60
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • Dimmeler S, Fleming I, Fisslthaler B et al. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999;399: 601-605.
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3
  • 61
    • 33749342733 scopus 로고    scopus 로고
    • Vascular endothelial growth factor promotes cardiomyocyte differentiation of embryonic stem cells
    • Chen Y, Amende I, Hampton TG et al. Vascular endothelial growth factor promotes cardiomyocyte differentiation of embryonic stem cells. Am J Physiol Heart Circ Physiol 2006;291:H1653-1658.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291 , pp. 1653-1658
    • Chen, Y.1    Amende, I.2    Hampton, T.G.3
  • 62
    • 36849023013 scopus 로고    scopus 로고
    • Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
    • Chu TF, Rupnick MA, Kerkela R et al. Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet 2007;370:2011-2019.
    • (2007) Lancet , vol.370 , pp. 2011-2019
    • Chu, T.F.1    Rupnick, M.A.2    Kerkela, R.3
  • 63
    • 70349249625 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression
    • Facemire CS, Nixon AB, Griffiths R et al. Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression. Hypertension 2009;54:652-658.
    • (2009) Hypertension , vol.54 , pp. 652-658
    • Facemire, C.S.1    Nixon, A.B.2    Griffiths, R.3
  • 64
    • 33646149385 scopus 로고    scopus 로고
    • Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload
    • Izumiya Y, Shiojima I, Sato K et al. Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload. Hypertension 2006;47:887-893.
    • (2006) Hypertension , vol.47 , pp. 887-893
    • Izumiya, Y.1    Shiojima, I.2    Sato, K.3
  • 65
    • 34548480949 scopus 로고    scopus 로고
    • Chemotherapy agents and hypertension: A focus on angiogenesis blockade
    • Jain M, Townsend RR. Chemotherapy agents and hypertension: A focus on angiogenesis blockade. Curr Hypertens Rep 2007;9:320-328.
    • (2007) Curr Hypertens Rep , vol.9 , pp. 320-328
    • Jain, M.1    Townsend, R.R.2
  • 66
    • 0024221113 scopus 로고
    • Left ventricular hypertrophy. Epidemiological insights from the Framingham Heart Study
    • Levy D. Left ventricular hypertrophy. Epidemiological insights from the Framingham Heart Study. Drugs 1988;35(suppl 5):1-5.
    • (1988) Drugs , vol.35 , Issue.5 SUPPL. , pp. 1-5
    • Levy, D.1
  • 67
    • 13844255115 scopus 로고    scopus 로고
    • Contribution of left ventricular diastolic dysfunction to heart failure regardless of ejection fraction
    • Brucks S, Little WC, Chao T et al. Contribution of left ventricular diastolic dysfunction to heart failure regardless of ejection fraction. Am J Cardiol 2005;95:603-606.
    • (2005) Am J Cardiol , vol.95 , pp. 603-606
    • Brucks, S.1    Little, W.C.2    Chao, T.3
  • 68
    • 33748436537 scopus 로고    scopus 로고
    • Exercise training improves aging-induced downregulation of VEGF angiogenic signaling cascade in hearts
    • Iemitsu M, Maeda S, Jesmin S et al. Exercise training improves aging-induced downregulation of VEGF angiogenic signaling cascade in hearts. Am J Physiol Heart Circ Physiol 2006;291:H1290-1298.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291 , pp. 1290-1298
    • Iemitsu, M.1    Maeda, S.2    Jesmin, S.3
  • 69
    • 61949475135 scopus 로고    scopus 로고
    • Exerciseinduced expression of VEGF and salvation of myocardium in the early stage of myocardial infarction
    • Wu G, Rana JS, Wykrzykowska J et al. Exerciseinduced expression of VEGF and salvation of myocardium in the early stage of myocardial infarction. Am J Physiol Heart Circ Physiol 2009;296:H389-395.
    • (2009) Am J Physiol Heart Circ Physiol , vol.296 , pp. 389-395
    • Wu, G.1    Rana, J.S.2    Wykrzykowska, J.3
  • 70
    • 39749140405 scopus 로고    scopus 로고
    • HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha
    • Arany Z, Foo SY, Ma Y et al. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature 2008; 451:1008-1012.
    • (2008) Nature , vol.451 , pp. 1008-1012
    • Arany, Z.1    Foo, S.Y.2    Ma, Y.3
  • 71
    • 0037102256 scopus 로고    scopus 로고
    • Transcriptional coactivator PGC-1 alpha drives the formation of slowtwitch muscle fibres
    • Lin J, Wu H, Tarr PT et al. Transcriptional coactivator PGC-1 alpha drives the formation of slowtwitch muscle fibres. Nature 2002;418:797-801.
    • (2002) Nature , vol.418 , pp. 797-801
    • Lin, J.1    Wu, H.2    Tarr, P.T.3
  • 72
    • 1642576175 scopus 로고    scopus 로고
    • Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis
    • Laufs U, Werner N, Link A et al. Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation 2004;109:220-226.
    • (2004) Circulation , vol.109 , pp. 220-226
    • Laufs, U.1    Werner, N.2    Link, A.3
  • 73
    • 73449120374 scopus 로고    scopus 로고
    • Time-dependent mobilization of circulating progenitor cells during strenuous exercise in healthy individuals
    • Mobius-Winkler S, Hilberg T, Menzel K et al. Time-dependent mobilization of circulating progenitor cells during strenuous exercise in healthy individuals. J Appl Physiol 2009;107:1943-1950.
    • (2009) J Appl Physiol , vol.107 , pp. 1943-1950
    • Mobius-Winkler, S.1    Hilberg, T.2    Menzel, K.3
  • 74
    • 0034093782 scopus 로고    scopus 로고
    • Increase in immune activation, vascular endothelial growth factor and erythropoietin after an ultramarathon run at moderate altitude
    • Schobersberger W, Hobisch-Hagen P, Fries D et al. Increase in immune activation, vascular endothelial growth factor and erythropoietin after an ultramarathon run at moderate altitude. Immunobiology 2000;201:611-620.
    • (2000) Immunobiology , vol.201 , pp. 611-620
    • Schobersberger, W.1    Hobisch-Hagen, P.2    Fries, D.3
  • 75
    • 0032945433 scopus 로고    scopus 로고
    • Ischemia-and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
    • Takahashi T, Kalka C, Masuda H et al. Ischemia-and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 1999;5:434-438.
    • (1999) Nat Med , vol.5 , pp. 434-438
    • Takahashi, T.1    Kalka, C.2    Masuda, H.3
  • 76
    • 0034908652 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway
    • Dimmeler S, Aicher A, Vasa M et al. HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. J Clin Invest 2001;108:391-397.
    • (2001) J Clin Invest , vol.108 , pp. 391-397
    • Dimmeler, S.1    Aicher, A.2    Vasa, M.3
  • 77
    • 20044373820 scopus 로고    scopus 로고
    • Cathepsin L is required for endothelial progenitor cell-induced neovascularization
    • Urbich C, Heeschen C, Aicher A et al. Cathepsin L is required for endothelial progenitor cell-induced neovascularization. Nat Med 2005;11:206-213.
    • (2005) Nat Med , vol.11 , pp. 206-213
    • Urbich, C.1    Heeschen, C.2    Aicher, A.3
  • 78
    • 0031019745 scopus 로고    scopus 로고
    • Isolation of putative progenitor endothelial cells for angiogenesis
    • Asahara T, Murohara T, Sullivan A et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:964-967.
    • (1997) Science , vol.275 , pp. 964-967
    • Asahara, T.1    Murohara, T.2    Sullivan, A.3
  • 79
    • 37549051776 scopus 로고    scopus 로고
    • Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro
    • Fan Y, Ye J, Shen F et al. Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro. J Cereb Blood Flow Metab 2008;28:90-98.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 90-98
    • Fan, Y.1    Ye, J.2    Shen, F.3
  • 80
    • 54049134432 scopus 로고    scopus 로고
    • Voluntary wheel running and pacing-induced dysfunction in hypertension
    • Kolwicz SC, MacDonnell SM, Kendrick ZV et al. Voluntary wheel running and pacing-induced dysfunction in hypertension. Clin Exp Hypertens 2008; 30:565-573.
    • (2008) Clin Exp Hypertens , vol.30 , pp. 565-573
    • Kolwicz, S.C.1    Macdonnell, S.M.2    Kendrick, Z.V.3
  • 81
    • 0030046481 scopus 로고    scopus 로고
    • Interleukin 6 induces the expression of vascular endothelial growth factor
    • Cohen T, Nahari D, Cerem LW et al. Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem 1996;271:736-741.
    • (1996) J Biol Chem , vol.271 , pp. 736-741
    • Cohen, T.1    Nahari, D.2    Cerem, L.W.3
  • 82
    • 0029843527 scopus 로고    scopus 로고
    • Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes
    • Kunisada K, Hirota H, Fujio Y et al. Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes. Circulation 1996;94:2626-2632.
    • (1996) Circulation , vol.94 , pp. 2626-2632
    • Kunisada, K.1    Hirota, H.2    Fujio, Y.3
  • 83
    • 3342889421 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury
    • Hilfiker-Kleiner D, Hilfiker A, Fuchs M et al. Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury. Circ Res 2004;95:187-195.
    • (2004) Circ Res , vol.95 , pp. 187-195
    • Hilfiker-Kleiner, D.1    Hilfiker, A.2    Fuchs, M.3
  • 84
    • 0034602781 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy
    • Kunisada K, Negoro S, Tone E et al. Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy. Proc Natl Acad Sci U S A 2000;97:315-319.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 315-319
    • Kunisada, K.1    Negoro, S.2    Tone, E.3
  • 85
    • 34147191715 scopus 로고    scopus 로고
    • STAT3 signaling is activated in human skeletal muscle following acute resistance exercise
    • Trenerry MK, Carey KA, Ward AC, Cameron-Smith D. STAT3 signaling is activated in human skeletal muscle following acute resistance exercise. J Appl Physiol 2007;102:1483-1489.
    • (2007) J Appl Physiol , vol.102 , pp. 1483-1489
    • Trenerry, M.K.1    Carey, K.A.2    Ward, A.C.3    Cameron-Smith, D.4
  • 86
    • 79952428226 scopus 로고    scopus 로고
    • IL-6 induced STAT3 signalling is associated with the proliferation of human muscle satellite cells following acute muscle damage
    • Toth KG, McKay BR, De Lisio M et al. IL-6 induced STAT3 signalling is associated with the proliferation of human muscle satellite cells following acute muscle damage. PLoS One 2011;6:e17392.
    • (2011) PLoS One , vol.6
    • Toth, K.G.1    McKay, B.R.2    de Lisio, M.3
  • 87
    • 79961150780 scopus 로고    scopus 로고
    • Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies
    • Hoch M, Fischer P, Stapel B et al. Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies. Cell Stem Cell 2011;9:131-143.
    • (2011) Cell Stem Cell , vol.9 , pp. 131-143
    • Hoch, M.1    Fischer, P.2    Stapel, B.3
  • 88
    • 77955136355 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is crucial for erythropoietin-induced improvement of cardiac function in heart failure
    • Westenbrink BD, Ruifrok WP, Voors AA et al. Vascular endothelial growth factor is crucial for erythropoietin-induced improvement of cardiac function in heart failure. Cardiovasc Res 2010;87: 30-39.
    • (2010) Cardiovasc Res , vol.87 , pp. 30-39
    • Westenbrink, B.D.1    Ruifrok, W.P.2    Voors, A.A.3
  • 89
    • 29744442709 scopus 로고    scopus 로고
    • Assessment of cardiac dysfunction in a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel, with or without trastuzumab as adjuvant therapy in node-positive, human epidermal growth factor receptor 2-overexpressing breast cancer: NSABP B-31
    • Tan-Chiu E, Yothers G, Romond E et al. Assessment of cardiac dysfunction in a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel, with or without trastuzumab as adjuvant therapy in node-positive, human epidermal growth factor receptor 2-overexpressing breast cancer: NSABP B-31. J Clin Oncol 2005;23: 7811-7819.
    • (2005) J Clin Oncol , vol.23 , pp. 7811-7819
    • Tan-Chiu, E.1    Yothers, G.2    Romond, E.3
  • 90
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial
    • Bang YJ, Van Cutsem E, Feyereislova A et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial. Lancet 2010;376:687-697.
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.J.1    van Cutsem, E.2    Feyereislova, A.3
  • 91
    • 84862914692 scopus 로고    scopus 로고
    • Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
    • Baselga J, Cortés J, Kim S, et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med 2012;366:109-119.
    • (2012) N Engl J Med , vol.366 , pp. 109-119
    • Baselga, J.1    Cortés, J.2    Kim, S.3
  • 92
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783-792.
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 93
    • 0032850677 scopus 로고    scopus 로고
    • Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
    • Cobleigh MA, Vogel CL, Tripathy D et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 1999;17:2639-2648.
    • (1999) J Clin Oncol , vol.17 , pp. 2639-2648
    • Cobleigh, M.A.1    Vogel, C.L.2    Tripathy, D.3
  • 94
    • 0036467826 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
    • Vogel CL, Cobleigh MA, Tripathy D et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002;20:719-726.
    • (2002) J Clin Oncol , vol.20 , pp. 719-726
    • Vogel, C.L.1    Cobleigh, M.A.2    Tripathy, D.3
  • 96
    • 17144371333 scopus 로고    scopus 로고
    • Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule
    • Baselga J, Carbonell X, Castaneda-Soto NJ et al. Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule. J Clin Oncol 2005;23:2162-2171.
    • (2005) J Clin Oncol , vol.23 , pp. 2162-2171
    • Baselga, J.1    Carbonell, X.2    Castaneda-Soto, N.J.3
  • 97
    • 44949253343 scopus 로고    scopus 로고
    • Cardiac safety of lapatinib: Pooled analysis of 3689 patients enrolled in clinical trials
    • Perez EA, Koehler M, Byrne J et al. Cardiac safety of lapatinib: Pooled analysis of 3689 patients enrolled in clinical trials. Mayo Clin Proc 2008;83: 679-686.
    • (2008) Mayo Clin Proc , vol.83 , pp. 679-686
    • Perez, E.A.1    Koehler, M.2    Byrne, J.3
  • 98
    • 77949694139 scopus 로고    scopus 로고
    • Randomized phase II multicenter trial of two schedules of lapatinib as firstor second-line monotherapy in patients with advanced or metastatic non-small cell lung cancer
    • Ross HJ, Blumenschein GR, Jr. Aisner J et al. Randomized phase II multicenter trial of two schedules of lapatinib as firstor second-line monotherapy in patients with advanced or metastatic non-small cell lung cancer. Clin Cancer Res 2010;16: 1938-1949.
    • (2010) Clin Cancer Res , vol.16 , pp. 1938-1949
    • Ross, H.J.1    Blumenschein Jr., G.R.2    Aisner, J.3
  • 99
    • 55249101007 scopus 로고    scopus 로고
    • Randomized study of pazopanib lapatinib vs. lapatinib alone in patients with HER2-positive advanced or metastatic breast cancer
    • Slamon D, Gomez HL, Kabbinavar FF et al. Randomized study of pazopanib lapatinib vs. lapatinib alone in patients with HER2-positive advanced or metastatic breast cancer. J Clin Oncol 2008; 26(15 suppl):1016.
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL. , pp. 1016
    • Slamon, D.1    Gomez, H.L.2    Kabbinavar, F.F.3
  • 100
    • 52049088286 scopus 로고    scopus 로고
    • Cardiac toxicity and efficacy of trastuzumab combined with pertuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer
    • Portera CC, Walshe JM, Rosing DR et al. Cardiac toxicity and efficacy of trastuzumab combined with pertuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. Clin Cancer Res 2008;14:2710-2716.
    • (2008) Clin Cancer Res , vol.14 , pp. 2710-2716
    • Portera, C.C.1    Walshe, J.M.2    Rosing, D.R.3
  • 101
    • 77949903478 scopus 로고    scopus 로고
    • Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
    • Baselga J, Gelmon KA, Verma S et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol 2010;28:1138-1144.
    • (2010) J Clin Oncol , vol.28 , pp. 1138-1144
    • Baselga, J.1    Gelmon, K.A.2    Verma, S.3
  • 102
    • 84857601768 scopus 로고    scopus 로고
    • Pooled analysis of cardiac safety in patients with cancer treated with pertuzumab
    • Lenihan D, Suter T, Brammer M et al. Pooled analysis of cardiac safety in patients with cancer treated with pertuzumab. Ann Oncol 2012;23:791-800.
    • (2012) Ann Oncol , vol.23 , pp. 791-800
    • Lenihan, D.1    Suter, T.2    Brammer, M.3
  • 103
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007;357:2666-2676.
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 104
    • 20044364346 scopus 로고    scopus 로고
    • Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
    • Miller KD, Chap LI, Holmes FA et al. Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol 2005;23:792-799.
    • (2005) J Clin Oncol , vol.23 , pp. 792-799
    • Miller, K.D.1    Chap, L.I.2    Holmes, F.A.3
  • 105
    • 84856325150 scopus 로고    scopus 로고
    • Phase II feasibility trial incorporating bevacizumab into dose-dense doxorubicin and cyclophosphamide followed by paclitaxel in patients with lymph node-positive breast cancer: A trial of the Eastern Cooperative Oncology Group (E2104)
    • Miller K, O'Neill A, Perez E et al. Phase II feasibility trial incorporating bevacizumab into dose-dense doxorubicin and cyclophosphamide followed by paclitaxel in patients with lymph node-positive breast cancer: a trial of the Eastern Cooperative Oncology Group (E2104). Ann Oncol 2012;23:331-337.
    • (2012) Ann Oncol , vol.23 , pp. 331-337
    • Miller, K.1    O'Neill, A.2    Perez, E.3
  • 106
    • 80052882569 scopus 로고    scopus 로고
    • The effect on pCR of bevacizumab and/or antimetabolites added to standard neoadjuvant chemotherapy: NSABP protocol B-40
    • Bear HD, Tang G, Rastogi P et al. The effect on pCR of bevacizumab and/or antimetabolites added to standard neoadjuvant chemotherapy: NSABP protocol B-40. J Clin Oncol 2011;29(15 suppl):1005.
    • (2011) J Clin Oncol , vol.29 , Issue.15 SUPPL. , pp. 1005
    • Bear, H.D.1    Tang, G.2    Rastogi, P.3
  • 107
    • 69949086180 scopus 로고    scopus 로고
    • Preliminary safety results: Addition of bevacizumab to 3 docetaxel regimens as adjuvant therapy for early stage breast cancer
    • Abstract 4107
    • Yardley DA, Hart L, Waterhouse DM et al. Preliminary safety results: Addition of bevacizumab to 3 docetaxel regimens as adjuvant therapy for early stage breast cancer. Cancer Res 2009;69(suppl 2): Abstract 4107.
    • (2009) Cancer Res , vol.69 , Issue.2 SUPPL.
    • Yardley, D.A.1    Hart, L.2    Waterhouse, D.M.3
  • 108
    • 79953874259 scopus 로고    scopus 로고
    • RIBBON-1: Randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer
    • Robert NJ, Dieras V, Glaspy J et al. RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer. J Clin Oncol 2011;29:1252-1260.
    • (2011) J Clin Oncol , vol.29 , pp. 1252-1260
    • Robert, N.J.1    Dieras, V.2    Glaspy, J.3
  • 109
    • 66149147757 scopus 로고    scopus 로고
    • Initial safety report of NSABP C-08: A randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer
    • Allegra CJ, Yothers G, O'Connell MJ et al. Initial safety report of NSABP C-08: A randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer. J Clin Oncol 2009;27:3385-3390.
    • (2009) J Clin Oncol , vol.27 , pp. 3385-3390
    • Allegra, C.J.1    Yothers, G.2    O'Connell, M.J.3
  • 110
    • 35348984015 scopus 로고    scopus 로고
    • Hypertension secondary to anti-angiogenic therapy: Experience with bevacizumab
    • Pande A, Lombardo J, Spangenthal E, Javle M. Hypertension secondary to anti-angiogenic therapy: Experience with bevacizumab. Anticancer Res 2007;27:3465-3470.
    • (2007) Anticancer Res , vol.27 , pp. 3465-3470
    • Pande, A.1    Lombardo, J.2    Spangenthal, E.3    Javle, M.4
  • 111
    • 77649213706 scopus 로고    scopus 로고
    • Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2
    • Spratlin JL, Cohen RB, Eadens M et al. Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2. J Clin Oncol 2010; 28:780-787.
    • (2010) J Clin Oncol , vol.28 , pp. 780-787
    • Spratlin, J.L.1    Cohen, R.B.2    Eadens, M.3
  • 112
    • 44649165869 scopus 로고    scopus 로고
    • Heart failure associated with sunitinib malate: A multitargeted receptor tyrosine kinase inhibitor
    • Khakoo AY, Kassiotis CM, Tannir N et al. Heart failure associated with sunitinib malate: A multitargeted receptor tyrosine kinase inhibitor. Cancer 2008;112:2500-2508.
    • (2008) Cancer , vol.112 , pp. 2500-2508
    • Khakoo, A.Y.1    Kassiotis, C.M.2    Tannir, N.3
  • 113
    • 77951296573 scopus 로고    scopus 로고
    • Phase III randomized trial of sunitinib versus capecitabine in patients with previously treated HER2-negative advanced breast cancer
    • Barrios CH, Liu MC, Lee SC et al. Phase III randomized trial of sunitinib versus capecitabine in patients with previously treated HER2-negative advanced breast cancer. Breast Cancer Res Treat 2010;121:121-131.
    • (2010) Breast Cancer Res Treat , vol.121 , pp. 121-131
    • Barrios, C.H.1    Liu, M.C.2    Lee, S.C.3
  • 114
    • 77955911251 scopus 로고    scopus 로고
    • Sunitinib (SU) in combination with docetaxel (D) versus D alone for the first-line treatment of advanced breast cancer (ABC)
    • Bergh J, Greil R, Voytko N et al. Sunitinib (SU) in combination with docetaxel (D) versus D alone for the first-line treatment of advanced breast cancer (ABC). J Clin Oncol 2010;28(18 suppl):1010.
    • (2010) J Clin Oncol , vol.28 , Issue.18 SUPPL. , pp. 1010
    • Bergh, J.1    Greil, R.2    Voytko, N.3
  • 115
    • 55949123335 scopus 로고    scopus 로고
    • Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma
    • Schmidinger M, Zielinski CC, Vogl UM et al. Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol 2008;26:5204-5212.
    • (2008) J Clin Oncol , vol.26 , pp. 5204-5212
    • Schmidinger, M.1    Zielinski, C.C.2    Vogl, U.M.3
  • 116
    • 77649168107 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor therapies and cardiovascular toxicity: What are the important clinical markers to target?
    • Vaklavas C, Lenihan D, Kurzrock R, Tsimberidou AM. Anti-vascular endothelial growth factor therapies and cardiovascular toxicity: What are the important clinical markers to target? The Oncologist 2010;15:130-141.
    • (2010) The Oncologist , vol.15 , pp. 130-141
    • Vaklavas, C.1    Lenihan, D.2    Kurzrock, R.3    Tsimberidou, A.M.4
  • 117
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B, Eisen T, Stadler WM et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007;356:125-134.
    • (2007) N Engl J Med , vol.356 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 118
    • 33744984843 scopus 로고    scopus 로고
    • Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
    • Ratain MJ, Eisen T, Stadler WM et al. Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol 2006;24:2505-2512.
    • (2006) J Clin Oncol , vol.24 , pp. 2505-2512
    • Ratain, M.J.1    Eisen, T.2    Stadler, W.M.3
  • 119
    • 38549085315 scopus 로고    scopus 로고
    • Incidence and risk of hypertension with sorafenib in patients with cancer: A systematic review and meta-analysis
    • Wu S, Chen JJ, Kudelka A et al. Incidence and risk of hypertension with sorafenib in patients with cancer: A systematic review and meta-analysis. Lancet Oncol 2008;9:117-123.
    • (2008) Lancet Oncol , vol.9 , pp. 117-123
    • Wu, S.1    Chen, J.J.2    Kudelka, A.3
  • 120
    • 77956842743 scopus 로고    scopus 로고
    • A phase II study of pazopanib in patients with recurrent or metastatic invasive breast carcinoma: A trial of the Princess Margaret Hospital phase II consortium
    • Taylor SK, Chia S, Dent S et al. A phase II study of pazopanib in patients with recurrent or metastatic invasive breast carcinoma: A trial of the Princess Margaret Hospital phase II consortium. The Oncologist2010;15: 810-818.
    • (2010) The Oncologist , vol.15 , pp. 810-818
    • Taylor, S.K.1    Chia, S.2    Dent, S.3
  • 121
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
    • Sternberg CN, Davis ID, Mardiak J et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial. J Clin Oncol 2010;28:1061-1068.
    • (2010) J Clin Oncol , vol.28 , pp. 1061-1068
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3
  • 122
    • 84864348077 scopus 로고    scopus 로고
    • Cediranib (AZD2171) in patients with advanced hepatocellular carcinoma: A phase II North Central Cancer Treatment Group Clinical Trial
    • Alberts SR, Fitch TR, Kim GP et al. Cediranib (AZD2171) in patients with advanced hepatocellular carcinoma: A phase II North Central Cancer Treatment Group Clinical Trial. Am J Clin Oncol 2012;35:329-333.
    • (2012) Am J Clin Oncol , vol.35 , pp. 329-333
    • Alberts, S.R.1    Fitch, T.R.2    Kim, G.P.3
  • 123
    • 77954720781 scopus 로고    scopus 로고
    • Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma
    • Batchelor TT, Duda DG, di Tomaso E et al. Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol 2010;28:2817-2823.
    • (2010) J Clin Oncol , vol.28 , pp. 2817-2823
    • Batchelor, T.T.1    Duda, D.G.2    Di Tomaso, E.3
  • 124
    • 84861678476 scopus 로고    scopus 로고
    • Cediranib in combination with fulvestrant in hormonesensitive metastatic breast cancer: A phase II randomized study
    • Abstract 204
    • Hyams DM, de Oliveira C, Snyder R et al. Cediranib in combination with fulvestrant in hormonesensitive metastatic breast cancer: A phase II randomized study. Cancer Res 2009;69(suppl 24): Abstract 204.
    • (2009) Cancer Res , vol.69 , Issue.24 SUPPL.
    • Hyams, D.M.1    de Oliveira, C.2    Snyder, R.3
  • 125
    • 79952748468 scopus 로고    scopus 로고
    • Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-smallcell lung cancer
    • Natale RB, Thongprasert S, Greco FA et al. Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-smallcell lung cancer. J Clin Oncol 2011;29:1059-1066.
    • (2011) J Clin Oncol , vol.29 , pp. 1059-1066
    • Natale, R.B.1    Thongprasert, S.2    Greco, F.A.3
  • 126
    • 66249113517 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled phase II study of vandetanib plus docetaxel/prednisolone in patients with hormone-refractory prostate cancer
    • Horti J, Widmark A, Stenzl A et al. A randomized, double-blind, placebo-controlled phase II study of vandetanib plus docetaxel/prednisolone in patients with hormone-refractory prostate cancer. Cancer Biother Radiopharm 2009;24:175-180.
    • (2009) Cancer Biother Radiopharm , vol.24 , pp. 175-180
    • Horti, J.1    Widmark, A.2    Stenzl, A.3
  • 127
    • 79952742483 scopus 로고    scopus 로고
    • Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: A randomized, double-blind phase III trial
    • de Boer RH, Arrieta O, Yang CH et al. Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: A randomized, double-blind phase III trial. J Clin Oncol 2011;29:1067-1074.
    • (2011) J Clin Oncol , vol.29 , pp. 1067-1074
    • de Boer, R.H.1    Arrieta, O.2    Yang, C.H.3
  • 128
    • 79953196070 scopus 로고    scopus 로고
    • Motesanib, or open-label bevacizumab, in combination with paclitaxel, as first-line treatment for HER2-negative locally recurrent or metastatic breast cancer: A phase 2, randomised, double-blind, placebo-controlled study
    • Martin M, Roche H, Pinter T et al. Motesanib, or open-label bevacizumab, in combination with paclitaxel, as first-line treatment for HER2-negative locally recurrent or metastatic breast cancer: A phase 2, randomised, double-blind, placebo-controlled study. Lancet Oncol 2011;12:369-376.
    • (2011) Lancet Oncol , vol.12 , pp. 369-376
    • Martin, M.1    Roche, H.2    Pinter, T.3
  • 129
    • 79959286206 scopus 로고    scopus 로고
    • Randomized, placebo-controlled, double-blind, phase II study of axitinib plus docetaxel versus docetaxel plus placebo in patients with metastatic breast cancer
    • Rugo HS, Stopeck AT, Joy AA et al. Randomized, placebo-controlled, double-blind, phase II study of axitinib plus docetaxel versus docetaxel plus placebo in patients with metastatic breast cancer. J Clin Oncol 2011;29:2459-2465.
    • (2011) J Clin Oncol , vol.29 , pp. 2459-2465
    • Rugo, H.S.1    Stopeck, A.T.2    Joy, A.A.3
  • 130
    • 79952036599 scopus 로고    scopus 로고
    • Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: A double-blind randomised phase 3 study
    • Kindler HL, Ioka T, Richel DJ et al. Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: A double-blind randomised phase 3 study. Lancet Oncol 2011;12:256-262.
    • (2011) Lancet Oncol , vol.12 , pp. 256-262
    • Kindler, H.L.1    Ioka, T.2    Richel, D.J.3
  • 131
    • 0033620976 scopus 로고    scopus 로고
    • Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity
    • Koch LG, Britton SL, Barbato JC et al. Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity. Physiol Genomics 1999;1:63-69.
    • (1999) Physiol Genomics , vol.1 , pp. 63-69
    • Koch, L.G.1    Britton, S.L.2    Barbato, J.C.3
  • 132
    • 0031905376 scopus 로고    scopus 로고
    • Spectrum of aerobic endurance running performance in eleven inbred strains of rats
    • Barbato JC, Koch LG, Darvish A et al. Spectrum of aerobic endurance running performance in eleven inbred strains of rats. J Appl Physiol 1998;85:530-536.
    • (1998) J Appl Physiol , vol.85 , pp. 530-536
    • Barbato, J.C.1    Koch, L.G.2    Darvish, A.3
  • 134
    • 0036785954 scopus 로고    scopus 로고
    • Intensity-controlled treadmill running in mice: Cardiac and skeletal muscle hypertrophy
    • Kemi OJ, Loennechen JP, Wisloff U, Ellingsen O. Intensity-controlled treadmill running in mice: Cardiac and skeletal muscle hypertrophy. J Appl Physiol 2002;93:1301-1309.
    • (2002) J Appl Physiol , vol.93 , pp. 1301-1309
    • Kemi, O.J.1    Loennechen, J.P.2    Wisloff, U.3    Ellingsen, O.4
  • 135
    • 0034971980 scopus 로고    scopus 로고
    • Intensity-controlled treadmill running in rats: VO(2 max) and cardiac hypertrophy
    • Wisloff U, Helgerud J, Kemi OJ, Ellingsen O. Intensity-controlled treadmill running in rats: VO(2 max) and cardiac hypertrophy. Am J Physiol Heart Circ Physiol 2001;280:H1301-1310.
    • (2001) Am J Physiol Heart Circ Physiol , vol.280 , pp. 1301-1310
    • Wisloff, U.1    Helgerud, J.2    Kemi, O.J.3    Ellingsen, O.4
  • 136
    • 33947730242 scopus 로고    scopus 로고
    • Longtermriskofcardiovasculardiseasein10-yearsurvivors of breast cancer
    • Hooning MJ, Botma A, Aleman BM et al. Longtermriskofcardiovasculardiseasein10-yearsurvivors of breast cancer. J Natl Cancer Inst 2007;99:365-375.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 365-375
    • Hooning, M.J.1    Botma, A.2    Aleman, B.M.3
  • 137
    • 78649721950 scopus 로고    scopus 로고
    • Animal models in the study of exercise-induced cardiac hypertrophy
    • Wang Y, Wisloff U, Kemi OJ. Animal models in the study of exercise-induced cardiac hypertrophy. Physiol Res 2010;59:633-644.
    • (2010) Physiol Res , vol.59 , pp. 633-644
    • Wang, Y.1    Wisloff, U.2    Kemi, O.J.3
  • 138
    • 80051494089 scopus 로고    scopus 로고
    • Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: Current evidence and underlying mechanisms
    • Scott JM, Khakoo A, Mackey JR et al. Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: Current evidence and underlying mechanisms. Circulation 2011;124: 642-650.
    • (2011) Circulation , vol.124 , pp. 642-650
    • Scott, J.M.1    Khakoo, A.2    Mackey, J.R.3
  • 139
    • 58049198447 scopus 로고    scopus 로고
    • Chemotherapy and targeted agents for elderly women with advanced breast cancer
    • Brunello A, Roma A, Falci C, Basso U. Chemotherapy and targeted agents for elderly women with advanced breast cancer. Recent Pat Anticancer Drug Discov 2008;3:187-201.
    • (2008) Recent Pat Anticancer Drug Discov , vol.3 , pp. 187-201
    • Brunello, A.1    Roma, A.2    Falci, C.3    Basso, U.4
  • 140
    • 79952589266 scopus 로고    scopus 로고
    • Effect of exercise training on peak oxygen consumption in patients with cancer: A meta-analysis
    • Jones LW, Liang Y, Pituskin EN et al. Effect of exercise training on peak oxygen consumption in patients with cancer: A meta-analysis. The Oncologist 2011;16:112-120.
    • (2011) The Oncologist , vol.16 , pp. 112-120
    • Jones, L.W.1    Liang, Y.2    Pituskin, E.N.3
  • 141
    • 84875370950 scopus 로고    scopus 로고
    • Effects and potential mechanisms of exercise training on cancer progression: A translational perspective
    • [Epub ahead of print]
    • Betof AS, Dewhirst MW, Jones LW. Effects and potential mechanisms of exercise training on cancer progression: A translational perspective. Brain Behav Immun 2012 [Epub ahead of print].
    • (2012) Brain Behav Immun
    • Betof, A.S.1    Dewhirst, M.W.2    Jones, L.W.3


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