Voluntary wheel running and pacing-induced dysfunction in hypertension

Clinical and Experimental Hypertension

Volumn 30, Issue 7, 2008, Pages 565-573

  Kolwicz, Stephen C ^a   MacDonnell, Scott M ^b   Kendrick, Zebulon V ^a   Houser, Steven R ^a,b   Libonati, Joseph R ^c  

^a TEMPLE UNIVERSITY   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Beta adrenergic pathway; Cardiac function; Chronic exercise; Hypertrophy

Indexed keywords

ADENYLATE CYCLASE; FORSKOLIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOMEGALY; DEVICE; EXERCISE TOLERANCE; FEMALE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART PACING; HEART PERFORMANCE; HEART PROTECTION; HEART RATE; HEART STRESS; HYPERTENSION; INOTROPISM; NONHUMAN; RAT; RUNNING; SYSTOLIC BLOOD PRESSURE; VOLUNTARY MOVEMENT;

ADENYLATE CYCLASE; ANIMALS; BLOOD PRESSURE; CARDIAC PACING, ARTIFICIAL; FEMALE; FORSKOLIN; HEART RATE; HYPERTENSION; PHYSICAL EXERTION; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTORS, ADRENERGIC, BETA; VENTRICULAR DYSFUNCTION, LEFT;

EID: 54049134432     PISSN: 10641963     EISSN: 15256006     Source Type: Journal    
DOI: 10.1080/10641960802251891     Document Type: Article

References (35)

1. Choi DJ, Koch WJ, Hunter JJ, Rockman HA. Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase. The Journal of Biological Chemistry. 1997;272:17223-17229.
2. MacDonnell SM, Kubo H, Crabbe DL, Renna BF, Reger PO, Mohara J, Smithwick LA, Koch WJ, Houser SR, Libonati JR. Improved myocardial beta-adrenergic responsiveness and signaling with exercise training in hypertension. Circulation. 2005;111:3420-3428.
3. Lim PO, MacFadyen RJ, Clarkson PB, MacDonald TM. Impaired exercise tolerance in hypertensive patients. Annals of Internal Medicine. 1996;124:41-55.
4. Kolwicz SC, Kubo H, MacDonnell SM, Houser SR, Libonati JR. Effects of forskolin on inotropic performance and phospholamban phosphorylation in exercise-trained hypertensive myocardium. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 2007;102:628-633.
5. 2+ pump of sarcoplasmic reticulum. Nature. 1989;342:90-92.
6. Reger PO, Barbe MF, Amin M, Renna BF, Hewston LA, MacDonnell SM, Houser SR, Libonati JR. Myocardial hypoperfusion/reperfusion tolerance with exercise training in hypertension. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 2006;100:541-547.
7. Renna BF, Kubo H, MacDonnell SM, Crabbe DL, Reger PO, Houser SR, Libonati JR. Enhanced acidotic myocardial Ca2+ responsiveness with training in hypertension. Medicine and Science in Sports and Exercise. 2006;38:847-855.
8. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42:1206-1252.
9. Pescatello LS, Franklin BA, Fagard R, Farquhar WB, Kelley GA, Ray CA. American College of Sports Medicine position stand. Exercise and hypertension. Medicine and Science in Sports and Exercise. 2004;36:533-553.
10. Collins HL, Loka AM, Dicarlo SE. Daily exercise-induced cardioprotection is associated with changes in calcium regulatory proteins in hypertensive rats. American Journal of Physiology: Heart and Circulatory Physiology. 2005;288:H532-H540.
11. Collins HL, Rodenbaugh DW, DiCarlo SE. Daily exercise attenuates the development of arterial blood pressure related cardiovascular risk factors in hypertensive rats. Clin Exp Hypertens. 2000;22:193-202.
12. DiCarlo SE, Collins HL, Rodenbaugh DW, Smitha MR, Berger RD, Yeragani VK. Daily exercise reduces measures of heart rate and blood pressure variability in hypertensive rats. Clin Exp Hypertens. 2002;24:221-234.
13. DiCarlo SE, Zheng H, Collins HL, Rodenbaugh DW, Patel KP. Daily exercise normalizes the number of diaphorase (NOS) positive neurons in the hypothalamus of hypertensive rats. Brain Research. 2002;955:153-160.
14. Hoffmann P, Friberg P, Ely D, Thoren P. Effect of spontaneous running on blood pressure, heart rate and cardiac dimensions in developing and established spontaneous hypertension in rats. Acta Physiol Scand. 1987;129:535-542.
15. LaPier TL, Swislocki AL, Clark RJ, Rodnick KJ. Voluntary running improves glucose tolerance and insulin resistance in female spontaneously hypertensive rats. American Journal of Hypertension. 2001;14:708-715.
16. Overton JM, Tipton CM, Matthes RD, Leininger JR. Voluntary exercise and its effects on young SHR and stroke-prone hypertensive rats. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 1986;61:318-324.
17. Palmer BM, Mokelke EA, Thayer AM, Moore RL. Mild renal hypertension alters run training effects on the frequency response of rat cardiomyocyte mechanics. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 2003;95:1799-1807.
18. Ziada AM, Hassan MO, Tahlilkar KI, Inuwa IM. Long-term exercise training and angiotensinconverting enzyme inhibition differentially enhance myocardial capillarization in the spontaneously hypertensive rat. Journal of Hypertension. 2005;23:1233-1240.
19. Libonati JR, Gaughan JP. Low-intensity exercise training improves survival in Dahl salt hypertension. Medicine and Science in Sports and Exercise. 2006;38:856-858.
20. Eikelboom R. Human parallel to voluntary wheel running: Exercise. Animal Behavior. 1999;57:F11-F12.
21. Eikelboom R, Mills R. A microanalysis of wheel running in male and female rats. Physiol Behav. 1988;43:625-630.
22. APS Committee. Exercise protocols using rats and mice. Resource Book for the Design of Animal Exercise Protocols. Bethesda, Md.: American Physiological Society; 2006:23-30.
23. Bhat S, Bajwa B, Dornauer H, De Souza N, Fehlhaber H. Structures and stereochemistry of new Labdane diterpenoids from Coleus forskolii. Tetrahedron Letters. 1997;19:1669-1672.
24. Brooks WW, Apstein CS. Effect of treppe on isovolumic function in the isolated blood-perfused mouse heart. Journal of Molecular and Cellular Cardiology. 1996;28:1817-1822.
25. Brooks WW, Bing OH, Litwin SE, Conrad CH, Morgan JP. Effects of treppe and calcium on intracellular calcium and function in the failing heart from the spontaneously hypertensive rat. Hypertension. 1994;24:347-356.
26. 2+ signalling and gene expression. The Journal of Physiology. 2004;554:309-320.
27. 2+ handling in isolated rat myocardium. The American Journal of Physiology. 1998;274:H1361-H1370.
28. Pieske B, Trost S, Schutt K, Minami K, Just H, Hasenfuss G. Influence of forskolin on the force-frequency behavior in nonfailing and end-stage failing human myocardium. Basic Res Cardiol. 1998;93 (Suppl. 1):66-75.
29. 2+ cycling contributes to improved contractile performance in SERCA2a- overexpressing transgenic rats. Cardiovasc Res. 2005;67:636-646.
30. 2+)-exchanger on the force-frequency relation. Basic Research in Cardiology. 1998;93 (Suppl. 1):38-45.
31. Shorofsky SR, Aggarwal R, Corretti M, Baffa JM, Strum JM, Al-Seikhan BA, Kobayashi YM, Jones LR, Wier WG, Balke CW. Cellular mechanisms of altered contractility in the hypertrophied heart: Big hearts, big sparks. Circulation Research. 1999;84:424-434.
32. Rupp H. Differential effect of physical exercise routines on ventricular myosin and peripheral catecholamine stores in normotensive and spontaneously hypertensive rats. Circulation Research. 1989;65:370-377.
33. Schultz RL, Swallow JG, Waters RP, Kuzman JA, Redetzke RA, Said S, de Escobar GM, Gerdes AM. Effects of excessive long-term exercise on cardiac function and myocyte remodeling in hypertensive heart failure rats. Hypertens. 2007;50:410-416.
34. Boluyt MO, O'Neill L, Meredith AL, Bing OH, Brooks WW, Conrad CH, Crow MT, Lakatta EG. Alterations in cardiac gene expression during the transition from stable hypertrophy to heart failure. Marked upregulation of genes encoding extracellular matrix components. Circulation Research. 1994;75:23-32.
35. Doggrell SA, Brown L. Rat models of hypertension, cardiac hypertrophy and failure. Cardiovascular Research. 1998;39:89-105.