-
1
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783-92.
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
2
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005;353:1673-84.
-
(2005)
N Engl J Med
, vol.353
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
-
3
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005; 353:1659-72.
-
(2005)
N Engl J Med
, vol.353
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
Procter, M.2
Leyland-Jones, B.3
-
4
-
-
0032850677
-
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
-
Cobleigh MA, Vogel CL,Tripathy D, et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 1999;17:2639-48.
-
(1999)
J Clin Oncol
, vol.17
, pp. 2639-2648
-
-
Cobleigh, M.A.1
Vogel, C.L.2
Tripathy, D.3
-
5
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
Vogel CL, Cobleigh MA,Tripathy D, et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002;20:719-26.
-
(2002)
J Clin Oncol
, vol.20
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
-
6
-
-
17144371333
-
Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule
-
Baselga J, Carbonell X, Castaneda-Soto NJ, et al. Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule. J Clin Oncol 2005;23:2162-71.
-
(2005)
J Clin Oncol
, vol.23
, pp. 2162-2171
-
-
Baselga, J.1
Carbonell, X.2
Castaneda-Soto, N.J.3
-
7
-
-
32244435355
-
Mechanisms of trastuzumab resistance and their clinical implications
-
Lan KH, Lu CH, Yu D. Mechanisms of trastuzumab resistance and their clinical implications. Ann N Y Acad Sci 2005;1059:70-5.
-
(2005)
Ann N Y Acad Sci
, vol.1059
, pp. 70-75
-
-
Lan, K.H.1
Lu, C.H.2
Yu, D.3
-
8
-
-
0037291226
-
The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors
-
Garrett TP, McKern NM, Lou M, et al. The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors. Mol Cell 2003;11:495-505.
-
(2003)
Mol Cell
, vol.11
, pp. 495-505
-
-
Garrett, T.P.1
McKern, N.M.2
Lou, M.3
-
9
-
-
0037434791
-
-
Cho HS, Mason K, Ramyar KX, et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 2003;421:756-60.
-
Cho HS, Mason K, Ramyar KX, et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 2003;421:756-60.
-
-
-
-
10
-
-
19044380618
-
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
-
Agus DB, Akita RW, Fox WD, et al. Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer Cell 2002;2:127-37.
-
(2002)
Cancer Cell
, vol.2
, pp. 127-137
-
-
Agus, D.B.1
Akita, R.W.2
Fox, W.D.3
-
11
-
-
0036606779
-
The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides
-
Motoyama AB, Hynes NE, Lane HA. The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides. Cancer Res 2002:62:3151-8
-
(2002)
Cancer Res
, vol.62
, pp. 3151-3158
-
-
Motoyama, A.B.1
Hynes, N.E.2
Lane, H.A.3
-
12
-
-
0026685034
-
Therapy of an animal model of human gastric cancer using a combination of anti-erbB-2 monoclonal antibodies
-
Kasprzyk PG, Song SU, Di Fiore PP. King CR. Therapy of an animal model of human gastric cancer using a combination of anti-erbB-2 monoclonal antibodies. Cancer Res 1992;52:2771-6.
-
(1992)
Cancer Res
, vol.52
, pp. 2771-2776
-
-
Kasprzyk, P.G.1
Song, S.U.2
Di Fiore, P.P.3
King, C.R.4
-
13
-
-
0036284422
-
Targeting multiple Her-2 epitopes with monoclonal antibodies results in improved antigrowth activity of a human breast cancer cell line in vitro and in vivo
-
Spiridon Cl, Ghetie MA, Uhr J, et al.Targeting multiple Her-2 epitopes with monoclonal antibodies results in improved antigrowth activity of a human breast cancer cell line in vitro and in vivo. Clin Cancer Res 2002;8:1720-30.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1720-1730
-
-
Spiridon, C.1
Ghetie, M.A.2
Uhr, J.3
-
14
-
-
13844306484
-
Synergistic down-regulation of receptor tyrosine kinases by combinations of mAbs: Implications for cancer immunotherapy
-
Friedman LM, Rinon A, Schechter B, et al. Synergistic down-regulation of receptor tyrosine kinases by combinations of mAbs: implications for cancer immunotherapy. Proc Natl Acad Sci U S A 2005:102: 1915-20.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 1915-1920
-
-
Friedman, L.M.1
Rinon, A.2
Schechter, B.3
-
15
-
-
0023836818
-
Monoclonal antibodies reactive with distinct domains of the neu oncogene-encoded p185 molecule exert synergistic anti-tumor effects in vivo
-
Drebin JA, Link VC, Greene Ml. Monoclonal antibodies reactive with distinct domains of the neu oncogene-encoded p185 molecule exert synergistic anti-tumor effects in vivo. Oncogene 1988;2:273-7.
-
(1988)
Oncogene
, vol.2
, pp. 273-277
-
-
Drebin, J.A.1
Link, V.C.2
Greene, M.3
-
16
-
-
1942441770
-
Blockade of epidermal growth factor-or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects
-
Jackson JG, St Clair P, Sliwkowski MX, Brattain MG. Blockade of epidermal growth factor-or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects. Cancer Res 2004;64: 2601-9.
-
(2004)
Cancer Res
, vol.64
, pp. 2601-2609
-
-
Jackson, J.G.1
St Clair, P.2
Sliwkowski, M.X.3
Brattain, M.G.4
-
17
-
-
1842605531
-
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
-
Franklin MC, Carey KD,Vajdos FF, Leahy DJ, de Vos AM, Sliwkowski MX. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell 2004;5:317-28.
-
(2004)
Cancer Cell
, vol.5
, pp. 317-328
-
-
Franklin, M.C.1
Carey, K.D.2
Vajdos, F.F.3
Leahy, D.J.4
de Vos, A.M.5
Sliwkowski, M.X.6
-
18
-
-
1942474587
-
The HER-2-targeting antibodies trastuzumab and pertuzumab synergisti-cally inhibit the survival of breast cancer cells
-
Nahta R, Hung MC, Esteva FJ. The HER-2-targeting antibodies trastuzumab and pertuzumab synergisti-cally inhibit the survival of breast cancer cells. Cancer Res 2004;64:2343-6.
-
(2004)
Cancer Res
, vol.64
, pp. 2343-2346
-
-
Nahta, R.1
Hung, M.C.2
Esteva, F.J.3
-
19
-
-
20244378677
-
Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer
-
Agus DB, Gordon MS, Taylor C, et al. Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer. J Clin Oncol 2005;23:2534-43.
-
(2005)
J Clin Oncol
, vol.23
, pp. 2534-2543
-
-
Agus, D.B.1
Gordon, M.S.2
Taylor, C.3
-
20
-
-
0028884413
-
Requirement for neuregulin receptor erbB2 in neural and cardiac development
-
Lee KF, Simon H, Chen H, Bates B, Hung MC, Hauser C. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 1995;378: 394-8.
-
(1995)
Nature
, vol.378
, pp. 394-398
-
-
Lee, K.F.1
Simon, H.2
Chen, H.3
Bates, B.4
Hung, M.C.5
Hauser, C.6
-
21
-
-
0028785406
-
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
-
Gassmann M, Casagranda F, Orioli D, et al. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 1995;378:390-4.
-
(1995)
Nature
, vol.378
, pp. 390-394
-
-
Gassmann, M.1
Casagranda, F.2
Orioli, D.3
-
22
-
-
0036099675
-
ErbB2 is essential in the prevention of dilated cardiomyopathy
-
Crone SA, Zhao YY, Fan L, et al. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med 2002;8:459-65.
-
(2002)
Nat Med
, vol.8
, pp. 459-465
-
-
Crone, S.A.1
Zhao, Y.Y.2
Fan, L.3
-
23
-
-
0037172982
-
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyo-cytes leads to dilated cardiomyopathy
-
Ozcelik C, Erdmann B, Pilz B, et al. Conditional mutation of the ErbB2 (HER2) receptor in cardiomyo-cytes leads to dilated cardiomyopathy. Proc Natl Acad Sci USA2002;99:8880-5.
-
Proc Natl Acad Sci
, vol.USA2002
, Issue.99
, pp. 8880-8885
-
-
Ozcelik, C.1
Erdmann, B.2
Pilz, B.3
-
24
-
-
0032562770
-
Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes
-
Zhao YY, Sawyer DR, Baliga RR, et al. Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes. J Biol Chem 1998; 273:10261-9.
-
(1998)
J Biol Chem
, vol.273
, pp. 10261-10269
-
-
Zhao, Y.Y.1
Sawyer, D.R.2
Baliga, R.R.3
-
25
-
-
0034594628
-
European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. New guidelines to evaluate the response to treatment in solid tumors
-
Therasse P, Arbuck SG, Eisenhauer EA, et al. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 2000;92:205-16.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 205-216
-
-
Therasse, P.1
Arbuck, S.G.2
Eisenhauer, E.A.3
-
26
-
-
0028156927
-
Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: A mechanism of interreceptor kinase activation and transphosphorylation
-
Qian X, LeVea CM, Freeman JK, Dougall WC, Greene Ml. Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation. Proc Natl Acad Sci U S A 1994;91:1500-4.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 1500-1504
-
-
Qian, X.1
LeVea, C.M.2
Freeman, J.K.3
Dougall, W.C.4
Greene, M.5
-
27
-
-
0032860819
-
Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo-and heterodimers
-
Muthuswamy SK, Gilman M, Brugge JS. Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo-and heterodimers. Mol Cell Biol 1999;19:6845-57.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 6845-6857
-
-
Muthuswamy, S.K.1
Gilman, M.2
Brugge, J.S.3
-
28
-
-
16944363368
-
Activation of ErbB2 during wallerian degeneration of sciatic nerve
-
Kwon YK, Bhattacharyya A, Alberta JA, et al. Activation of ErbB2 during wallerian degeneration of sciatic nerve. J Neurosci 1997;17:8293-9.
-
(1997)
J Neurosci
, vol.17
, pp. 8293-8299
-
-
Kwon, Y.K.1
Bhattacharyya, A.2
Alberta, J.A.3
-
29
-
-
4143149763
-
Evaluation of biologic end points and pharmacokinetics in patients with metastatic breast cancer after treatment with erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor
-
Tan AR, Yang X, Hewitt SM, et al. Evaluation of biologic end points and pharmacokinetics in patients with metastatic breast cancer after treatment with erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor. J Clin Oncol 2004;22:3080-90.
-
(2004)
J Clin Oncol
, vol.22
, pp. 3080-3090
-
-
Tan, A.R.1
Yang, X.2
Hewitt, S.M.3
-
30
-
-
33644863001
-
Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer
-
Wedam SB, Low JA, Yang SX, et al. Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer. J Clin Oncol 2006;24:769-77.
-
(2006)
J Clin Oncol
, vol.24
, pp. 769-777
-
-
Wedam, S.B.1
Low, J.A.2
Yang, S.X.3
-
31
-
-
0024536437
-
Optimal two-stage designs for phase II clinical trials
-
Simon R. Optimal two-stage designs for phase II clinical trials. Control Clin Trials 1989;10:1-10.
-
(1989)
Control Clin Trials
, vol.10
, pp. 1-10
-
-
Simon, R.1
-
32
-
-
58349104376
-
-
Baselga J, Cameron D, Miles D, et al. Objective response rate in a phase II multicenter trial of pertuzumab (P), a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuzumab (T) in patients with HER2-positive metastatic breast cancer (MBC) which has progressed during treatment with T. 2007 ASCO Annual Meeting Proceedings Part I. 25. No. 18S (June 20 Supplement). Abstract #1004.
-
Baselga J, Cameron D, Miles D, et al. Objective response rate in a phase II multicenter trial of pertuzumab (P), a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuzumab (T) in patients with HER2-positive metastatic breast cancer (MBC) which has progressed during treatment with T. 2007 ASCO Annual Meeting Proceedings Part I. Vol. 25. No. 18S (June 20 Supplement). Abstract #1004.
-
-
-
-
34
-
-
34548533485
-
Congestive heart failure in older women treated with adjuvant anthracycline chemotherapy for breast cancer
-
Pinder MC, Duan Z, Goodwin JS, Hortobagyi GN, Giordano SH. Congestive heart failure in older women treated with adjuvant anthracycline chemotherapy for breast cancer. J Clin Oncol 2007;25:3808-15.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3808-3815
-
-
Pinder, M.C.1
Duan, Z.2
Goodwin, J.S.3
Hortobagyi, G.N.4
Giordano, S.H.5
-
36
-
-
33749003463
-
Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: Potential predictive relationship with tumor HER2 activation status
-
Gordon MS, Matei D, Aghajanian C, et al. Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: potential predictive relationship with tumor HER2 activation status. J Clin Oncol 2006;24:4324-32.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4324-4332
-
-
Gordon, M.S.1
Matei, D.2
Aghajanian, C.3
-
37
-
-
33846927744
-
Open-label phase II study evaluating the efficacy and safety of two doses of pertuzumab in castrate chemotherapy-naive patients with hormone-refractory prostate cancer
-
de Bono JS, Bellmunt J, Attard G, et al. Open-label phase II study evaluating the efficacy and safety of two doses of pertuzumab in castrate chemotherapy-naive patients with hormone-refractory prostate cancer. J Clin Oncol 2007;25:257-62.
-
(2007)
J Clin Oncol
, vol.25
, pp. 257-262
-
-
de Bono, J.S.1
Bellmunt, J.2
Attard, G.3
-
38
-
-
33947594043
-
Efficacy and safety of single-agent pertuzumab (rhuMAb 2C4), a human epidermal growth factor receptor dimerization inhibitor, in castration-resistant prostate cancer after progression from taxane-based therapy
-
Agus DB, Sweeney CJ, Morris MJ, et al. Efficacy and safety of single-agent pertuzumab (rhuMAb 2C4), a human epidermal growth factor receptor dimerization inhibitor, in castration-resistant prostate cancer after progression from taxane-based therapy. J Clin Oncol 2007;25:675-81.
-
(2007)
J Clin Oncol
, vol.25
, pp. 675-681
-
-
Agus, D.B.1
Sweeney, C.J.2
Morris, M.J.3
-
39
-
-
32144448027
-
Reversibility of trastuzumab-related cardiotoxicity: New insights based on clinical course and response to medical treatment
-
Ewer MS, Vooletich MT, Durand JB, et al. Reversibility of trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatment. J Clin Oncol 2005;23:7820-6.
-
(2005)
J Clin Oncol
, vol.23
, pp. 7820-7826
-
-
Ewer, M.S.1
Vooletich, M.T.2
Durand, J.B.3
-
40
-
-
0035914308
-
Multiple ErbB-2/Neu phosphorylation sites mediate transformation through distinct effector proteins
-
Dankort D, Jeyabalan N, Jones N, Dumont DJ, MullerWJ. Multiple ErbB-2/Neu phosphorylation sites mediate transformation through distinct effector proteins. J Biol Chem 2001;276:38921-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 38921-38928
-
-
Dankort, D.1
Jeyabalan, N.2
Jones, N.3
Dumont, D.J.4
MullerWJ5
-
41
-
-
33745585792
-
Phosphopro-teomic analysis of Her2/neu signaling and inhibition
-
Bose R, Molina H, Patterson AS, et al. Phosphopro-teomic analysis of Her2/neu signaling and inhibition. Proc Natl Acad Sci U S A 2006;103:9773-8.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 9773-9778
-
-
Bose, R.1
Molina, H.2
Patterson, A.S.3
-
42
-
-
0028912598
-
Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake
-
Hurwitz E, Stancovski I, Sela M,YardenY. Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake. Proc Natl Acad Sci U S A 1995;92: 3353-7.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 3353-3357
-
-
Hurwitz, E.1
Stancovski, I.2
Sela, M.3
Yarden, Y.4
-
43
-
-
0035915421
-
Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
-
Lu Y, Zi X, Zhao Y, Mascarenhas D, Pollak M. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst 2001;93:1852-7.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1852-1857
-
-
Lu, Y.1
Zi, X.2
Zhao, Y.3
Mascarenhas, D.4
Pollak, M.5
-
44
-
-
28244432561
-
Insulin-like growth factor-l receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
-
Nahta R,Yuan LX, Zhang B, Kobayashi R, Esteva FJ. Insulin-like growth factor-l receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res 2005;65:11118-28.
-
(2005)
Cancer Res
, vol.65
, pp. 11118-11128
-
-
Nahta, R.1
Yuan, L.X.2
Zhang, B.3
Kobayashi, R.4
Esteva, F.J.5
-
45
-
-
30544450275
-
Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells
-
Xia W, Gerard CM, Liu L, Baudson NM, Ory TL, Spector NL. Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene 2005;24:6213-21.
-
(2005)
Oncogene
, vol.24
, pp. 6213-6221
-
-
Xia, W.1
Gerard, C.M.2
Liu, L.3
Baudson, N.M.4
Ory, T.L.5
Spector, N.L.6
-
46
-
-
34249739172
-
Treatment of human epidermal growth factor receptor 2-overex-pressing breast cancer xenografts with multiagent HER-targeted therapy
-
Arpino G, Gutierrez C, Weiss H, et al. Treatment of human epidermal growth factor receptor 2-overex-pressing breast cancer xenografts with multiagent HER-targeted therapy. J Natl Cancer Inst 2007;99: 694-705
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 694-705
-
-
Arpino, G.1
Gutierrez, C.2
Weiss, H.3
-
47
-
-
23944439945
-
Phase II study of temsirolimus (CCl-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
-
Chan S, Scheulen ME, Johnston S, et al. Phase II study of temsirolimus (CCl-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer. J Clin Oncol 2005;23:5314-22.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5314-5322
-
-
Chan, S.1
Scheulen, M.E.2
Johnston, S.3
|