Runx2 protein represses axin2 expression in osteoblasts and is required for craniosynostosis in axin2-deficient mice

Journal of Biological Chemistry

Volumn 288, Issue 8, 2013, Pages 5291-5302

  McGee Lawrence, Meghan E ^a   Li, Xiaodong ^a   Bledsoe, Krista L ^a   Wu, Hai ^b   Hawse, John R ^a   Subramaniam, Malayannan ^a   Razidlo, David F ^a   Stensgard, Bridget A ^a   Stein, Gary S ^b   Van Wijnen, Andre J ^a   Lian, Jane B ^b   Hsu, Wei ^c   Westendorf, Jennifer J ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF VERMONT   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALVARIAL BONES; CRANIAL SUTURES; CRANIOSYNOSTOSIS; REGULATORY MECHANISM; SKELETAL DEVELOPMENT;

BIOCHEMISTRY; BIOLOGY;

MAMMALS;

AXIN; AXIN2; BETA CATENIN; HISTONE DEACETYLASE 3; MESSENGER RNA; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; BONE DEVELOPMENT; BONE MASS; CALVARIA; CHROMATIN IMMUNOPRECIPITATION; CONSENSUS SEQUENCE; CONTROLLED STUDY; CRANIAL SUTURE; CRANIOFACIAL SYNOSTOSIS; EMBRYO; ENZYME REPRESSION; GENE EXPRESSION; HAPLOINSUFFICIENCY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

3T3 CELLS; ANIMALS; AXIN PROTEIN; BONE AND BONES; BONE MARROW CELLS; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CRANIOSYNOSTOSES; GENE EXPRESSION; GENE EXPRESSION REGULATION; HISTONE DEACETYLASES; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; OSTEOBLASTS; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; SKULL; TIME FACTORS; WNT PROTEINS;

EID: 84874325204     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.414995     Document Type: Article

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