Direct phenotypical and functional dysregulation of primary human b cells by human immunodeficiency virus (HIV) type 1 in vitro

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Perisé Barrios, Ana Judith ^a   Muñoz Fernandez, María Ángeles ^a,b   Pion, Marjorie ^a  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MESSENGER RNA;

ACTIVATION INDUCED CYTIDINE DEAMINASE GENE; ARTICLE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; CELL CONTACT; CELL SURFACE; CELL SURVIVAL; CONTROLLED STUDY; GENE; GENE EXPRESSION REGULATION; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE DYSREGULATION; IMMUNOGLOBULIN PRODUCTION; IMMUNOREACTIVITY; INTRACELLULAR SIGNALING; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MEMORY CELL; NONHUMAN; PHENOTYPIC VARIATION; PRIMARY CELL CULTURE; SOMATIC HYPERMUTATION; SURVIVAL RATE; VIRUS CELL INTERACTION; VIRUS PARTICLE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84874287754     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039472     Document Type: Article

References (44)

1. Agematsu K, (2000) Memory B cells and CD27. Histol Histopathol 15: 573-576.
2. Bernasconi NL, Traggiai E, Lanzavecchia A, (2002) Maintenance of serological memory by polyclonal activation of human memory B cells. Science 298: 2199-2202.
3. Lane HC, Masur H, Edgar LC, Whalen G, Rook AH, et al. (1983) Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N Engl J Med 309: 453-458.
4. Moir S, Fauci AS, (2009) B cells in HIV infection and disease. Nat Rev Immunol 9: 235-245.
5. Titanji K, De Milito A, Cagigi A, Thorstensson R, Grutzmeier S, et al. (2006) Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection. Blood 108: 1580-1587.
6. De Milito A, Nilsson A, Titanji K, Thorstensson R, Reizenstein E, et al. (2004) Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection. Blood 103: 2180-2186.
7. Hart M, Steel A, Clark SA, Moyle G, Nelson M, et al. (2007) Loss of discrete memory B cell subsets is associated with impaired immunization responses in HIV-1 infection and may be a risk factor for invasive pneumococcal disease. J Immunol 178: 8212-8220.
8. Wright DN, Nelson RP Jr, Ledford DK, Fernandez-Caldas E, Trudeau WL, et al. (1990) Serum IgE and human immunodeficiency virus (HIV) infection. J Allergy Clin Immunol 85: 445-452.
9. Malaspina A, Moir S, Orsega SM, Vasquez J, Miller NJ, et al. (2005) Compromised B cell responses to influenza vaccination in HIV-infected individuals. J Infect Dis 191: 1442-1450.
10. Moir S, Ho J, Malaspina A, Wang W, DiPoto AC, et al. (2008) Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals. J Exp Med 205: 1797-1805.
11. Martinez-Maza O, Breen EC, (2002) B-cell activation and lymphoma in patients with HIV. Curr Opin Oncol 14: 528-532.
12. Epeldegui M, Vendrame E, Martinez-Maza O, (2010) HIV-associated immune dysfunction and viral infection: role in the pathogenesis of AIDS-related lymphoma. Immunol Res.
13. De Milito A, (2004) B lymphocyte dysfunctions in HIV infection. Curr HIV Res 2: 11-21.
14. Chong Y, Ikematsu H, Kikuchi K, Yamamoto M, Murata M, et al. (2004) Selective CD27+ (memory) B cell reduction and characteristic B cell alteration in drug-naive and HAART-treated HIV type 1-infected patients. AIDS Res Hum Retroviruses 20: 219-226.
15. Jacobson MA, Khayam-Bashi H, Martin JN, Black D, Ng V, (2002) Effect of long-term highly active antiretroviral therapy in restoring HIV-induced abnormal B-lymphocyte function. J Acquir Immune Defic Syndr 31: 472-477.
16. French M, Keane N, EJ McKinnon EJ, Phung S, Price P, (2007) Susceptibility to opportunistic infections in HIV-infected patients with increased CD4 T-cell counts on antiretroviral therapy may be predicted by markers of dysfunctional effector memory CD4 T cells and B cells. HIV Medecine 8: 148-155.
17. Redgrave BE, Stone SF, French MA, Krueger R, James IR, et al. (2005) The effect of combination antiretroviral therapy on CD5 B- cells, B-cell activation and hypergammaglobulinaemia in HIV-1-infected patients. HIV Med 6: 307-312.
18. Swingler S, Zhou J, Swingler C, Dauphin A, Greenough T, et al. (2008) Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS. Cell Host Microbe 4: 63-76.
19. Schnittman SM, Lane HC, Higgins SE, Folks T, Fauci AS, (1986) Direct polyclonal activation of human B lymphocytes by the acquired immune deficiency syndrome virus. Science 233: 1084-1086.
20. Baenziger S, Heikenwalder M, Johansen P, Schlaepfer E, Hofer U, et al. (2009) Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology. Blood 113: 377-388.
21. He B, Qiao X, Klasse PJ, Chiu A, Chadburn A, et al. (2006) HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors. J Immunol 176: 3931-3941.
22. Moir S, Malaspina A, Li Y, Chun TW, Lowe T, et al. (2000) B cells of HIV-1-infected patients bind virions through CD21-complement interactions and transmit infectious virus to activated T cells. J Exp Med 192: 637-646.
23. Shen X, Tomaras GD, (2011) Alterations of the B-cell response by HIV-1 replication. Curr HIV/AIDS Rep 8: 23-30.
24. Jakubik JJ, Saifuddin M, Takefman DM, Spear GT, (2000) Immune complexes containing human immunodeficiency virus type 1 primary isolates bind to lymphoid tissue B lymphocytes and are infectious for T lymphocytes. J Virol 74: 552-555.
25. Malaspina A, Moir S, Nickle DC, Donoghue ET, Ogwaro KM, et al. (2002) Human immunodeficiency virus type 1 bound to B cells: relationship to virus replicating in CD4+ T cells and circulating in plasma. J Virol 76: 8855-8863.
26. Epeldegui M, Thapa DR, De la Cruz J, Kitchen S, Zack JA, et al. (2010) CD40 ligand (CD154) incorporated into HIV virions induces activation-induced cytidine deaminase (AID) expression in human B lymphocytes. PLoS One 5: e11448.
27. Martin G, Roy J, Barat C, Ouellet M, Gilbert C, et al. (2007) Human immunodeficiency virus type 1-associated CD40 ligand transactivates B lymphocytes and promotes infection of CD4+ T cells. J Virol 81: 5872-5881.
28. Imbeault M, Ouellet M, Giguere K, Bertin J, Belanger D, et al. (2011) Acquisition of host-derived CD40L by HIV-1 in vivo and its functional consequences in the B-cell compartment. J Virol 85: 2189-2200.
29. Schmid I, Uittenbogaart CH, Giorgi JV, (1994) Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry. Cytometry 15: 12-20.
30. Cerutti A, Zan H, Schaffer A, Bergsagel L, Harindranath N, et al. (1998) CD40 ligand and appropriate cytokines induce switching to IgG, IgA, and IgE and coordinated germinal center and plasmacytoid phenotypic differentiation in a human monoclonal IgM+IgD+ B cell line. J Immunol 160: 2145-2157.
31. Seidl T, Whittall T, Babaahmady K, Lehner T, (2011) B cell agonists upregulate AID and APOBEC3G deaminases, which induce IgA and IgG class antibodies and anti-viral function. Immunology.
32. Strong DM, Ahmed AA, Scher I, Knudsen RC, Sell KW, (1974) Specificity of in vitro murine B cell activation by protein and polysaccharide polymers. J Immunol 113: 1429-1437.
33. Stevenson PG, Doherty PC, (1999) Non-antigen-specific B-cell activation following murine gammaherpesvirus infection is CD4 independent in vitro but CD4 dependent in vivo. J Virol 73: 1075-1079.
34. Maddaly R, Pai G, Balaji S, Sivaramakrishnan P, Srinivasan L, et al. (2010) Receptors and signaling mechanisms for B-lymphocyte activation, proliferation and differentiation-insights from both in vivo and in vitro approaches. FEBS Lett 584: 4883-4894.
35. De Milito A, Morch C, Sonnerborg A, Chiodi F, (2001) Loss of memory (CD27) B lymphocytes in HIV-1 infection. AIDS 15: 957-964.
36. Chong Y, Ikematsu H, Yamamoto M, Murata M, Yamaji K, et al. (2004) Increased frequency of CD27- (naive) B cells and their phenotypic alteration in HIV type 1-infected patients. AIDS Res Hum Retroviruses 20: 621-629.
37. Racanelli V, Frassanito MA, Leone P, Galiano M, De Re V, et al. (2006) Antibody production and in vitro behavior of CD27-defined B-cell subsets: persistent hepatitis C virus infection changes the rules. J Virol 80: 3923-3934.
38. Cagigi A, Du L, Dang LV, Grutzmeier S, Atlas A, et al. (2009) CD27(-) B-cells produce class switched and somatically hyper-mutated antibodies during chronic HIV-1 infection. PLoS One 4: e5427.
39. Moir S, Malaspina A, Ogwaro KM, Donoghue ET, Hallahan CW, et al. (2001) HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals. Proc Natl Acad Sci U S A 98: 10362-10367.
40. Garcia-Merino I, de Las Cuevas N, Jimenez JL, Gallego J, Gomez C, et al. (2009) The Spanish HIV BioBank: a model of cooperative HIV research. Retrovirology 6: 27.
41. Haertle T, Carrera CJ, Wasson DB, Sowers LC, Richman DD, et al. (1988) Metabolism and anti-human immunodeficiency virus-1 activity of 2-halo-2′, 3′-dideoxyadenosine derivatives. J BilChem 263: 5870-5875.
42. Pear WS, Nolan GP, Scott ML, Baltimore D, (1993) Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci U S A 90: 8392-8396.
43. Adachi A, Gendelman HE, Koenig S, Folks T, Willey R, et al. (1986) Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J Virol 59: 284-291.
44. Vujcic LK, Quinnan GV Jr, (1995) Preparation and characterization of human HIV type 1 neutralizing reference sera. AIDS Res Hum Retroviruses 11: 783-787.