CD40 ligand (CD154) incorporated into HIV virions induces activation-induced cytidine deaminase (AID) expression in human B lymphocytes

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Epeldegui, Marta ^a   Thapa, Dharma R ^a   de la Cruz, Justin ^a   Kitchen, Scott ^a,b   Zack, Jerome A ^a,b   Martínez Maza, Otoniel ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CD40 LIGAND; CYTIDINE DEAMINASE;

ANTIGEN FUNCTION; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; NONHODGKIN LYMPHOMA; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; VIRION; VIRUS CELL INTERACTION; CELL CULTURE; ENZYMOLOGY; GENETICS; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIROLOGY;

HEPATITIS C VIRUS; HUMAN PAPILLOMAVIRUS;

B-LYMPHOCYTES; CD40 LIGAND; CELLS, CULTURED; CYTIDINE DEAMINASE; FLOW CYTOMETRY; HIV; HUMANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VIRION;

EID: 77955362036     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011448     Document Type: Article

References (39)

1. Schroff RW, Gottlieb MS, Prince HE, Chai LL, Fahey JL (1983) Immunological studies of homosexual men with immunodeficiency and Kaposi's sarcoma. Clin Immunol Immunopathol 27: 300-314.
2. Pahwa SG, Quilop MT, Lange M, Pahwa RN, Grieco MH (1984) Defective Blymphocyte function in homosexual men in relation to the acquired immunodeficiency syndrome. Ann Intern Med 101: 757-763.
3. Martinez-Maza O, Crabb E, Mitsuyasu RT, Fahey JL, Giorgi JV (1987) Infection with the human immunodeficiency virus (HIV) is associated with an in vivo increase in B lymphocyte activation and immaturity. J Immunol 138: 3720-3724.
4. Mizuma H, Litwin S, Zolla-Pazner S (1988) B-cell activation in HIV infection: relationship of spontaneous immunoglobulin secretion to various immunological parameters. Clin Exp Immunol 71: 410-416.
5. Pluda JM, Venzon DJ, Tosato G, Lietzau J, Wyvill K, et al. (1993) Parameters affecting the development of non-Hodgkin's lymphoma in patients with severe human immunodeficiency virus infection receiving antiretroviral therapy. J Clin Oncol 11: 1099-1107.
6. Yawetz S, Cumberland WG, van der Meyden M, Martinez-Maza O (1995) Elevated serum levels of soluble CD23 (sCD23) precede the appearance of acquired immunodeficiency syndrome-associated non-Hodgkin's lymphoma. Blood 85: 1843-1849.
7. Martinez-Maza O, Breen EC (2002) B-cell activation and lymphoma in patients with HIV. Curr Opin Oncol 14: 528-532.
8. Breen EC, Boscardin WJ, Detels R, Jacobson LP, Smith MW, et al. (2003) Non-Hodgkin's B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the IL10 promoter -592 C/C genotype. Clin Immunol 109: 119-129.
9. Breen EC, Epeldegui M, Boscardin WJ, Widney DP, Detels R, et al. (2005) Elevated levels of soluble CD44 precede the development of AIDS-associated non-Hodgkin's B-cell lymphoma. Aids 19: 1711-1712.
10. Breen EC, Fatahi S, Epeldegui M, Boscardin WJ, Detels R, et al. (2006) Elevatedserum soluble CD30 precedes the development of AIDS-associated non-Hodgkin's B cell lymphoma. Tumour Biol 27: 187-194.
11. Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, et al. (2000) Class switch recombination and hypermutation require activation-induced cytitine deaminase (AID), a potential RNA editing enzyme. Cell 102: 553-563.
12. Pasqualucci L, Bhagat G, Jankovic M, Compagno M, Smith P, et al. (2008) AID is required for germinal center-derived lymphomagenesis. Nat Genet 40: 108-112.
13. Boshoff C, Weiss R (2002) AIDS-related malignancies. Nat Rev Cancer 2: 373-382.
14. Bonnet F, Lewden C, May T, Heripret L, Jougla E, et al. (2004) Malignancy related causes of death in human immunodeficiency virus-infected patients in the era of highly active antiretroviral therapy. Cancer 101: 317-324.
15. Bonnet F, Balestre E, Thiebaut R, Morlat P, Pellegrin JL, et al. (2006) Factors associated with the occurrence of AIDS-related non-Hodgkin lymphoma in the era of highly active antiretroviral therapy: Aquitaine Cohort, France. Clin Infect Dis 42: 411-417.
16. Epeldegui M, Widney DP, Martinez-Maza O (2006) Pathogenesis of AIDS lymphoma: role of oncogenic viruses and B cell activation-associated molecular lesions. Curr Opin Oncol 18: 444-448.
17. Epeldegui M, Breen EC, Hung YP, Boscardin WJ, Detels R, et al. (2007) Elevated expression of activation induced cytidine deaminase in peripheral blood mononuclear cells precedes AIDS-NHL diagnosis. Aids 21: 2265-2270.
18. Machida K, Cheng KT, Sung VM, Shimodaira S, Lindsay KL, et al. (2004)Hepatatis C virus induced a mutator phenotype: enhanced mutations of immunoglobulin and proto-oncoges. PNAS (USA) 101: 4262-4267.
19. He B, Raab-Traub N, Casali P, Cerutti A (2003) EBV-encoded latent membrane protein 1 cooperates with BAFF/BLyS and APRIL to induce T cell-independent Ig heavy chain class switching. Journal of Immunology 171:5215-5224.
20. Epeldegui M, Hung YP, McQuay A, Ambinder RF, Martinez-Maza O (2007) Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations. Mol Immunol 44: 934-942.
21. Swingler S, Zhou J, Swingler C, Dauphin A, Greenough T, et al. (2008) Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS. Cell Host Microbe 4: 63-76.
22. Schnittman SM, Lane HC, Higgins SE, Folks T, Fauci AS (1986) Directpolyclonal activation of human B lymphocytes by the acquired immune deficiency syndrome virus. Science 233: 1084-1086.
23. He B, Qiao X, Klasse PJ, Chiu A, Chadburn A, et al. (2006) HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors. J Immunol 176: 3931-3941.
24. Martin G, Roy J, Barat C, Ouellet M, Gilbert C, et al. (2007) Human immunodeficiency virus type 1-associated CD40 ligand transactivates B lymphocytes and promotes infection of CD4+ T cells. J Virol 81: 5872-5881.
25. Baenziger S, Heikenwalder M, Johansen P, Schlaepfer E, Hofer U, et al. (2009) Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology. Blood 113: 377-388.
26. Martin G, Tremblay MJ (2004) HLA-DR, ICAM-1, CD40, CD40L, and CD86are incorporated to a similar degree into clinical human immunodeficiency virus type 1 variants expanded in natural reservoirs such as peripheral blood mononuclear cells and human lymphoid tissue cultured ex vivo. Clin Immunol 111: 275-285.
27. Rosina J, Kvasnak E, Suta D, Kolarova H, Malek J, et al. (2007) Temperature dependence of blood surface tension. Physiol Res 56 Suppl 1: S93-98.
28. Malaspina A, Moir S, Ho J, Wang W, Howell ML, et al. (2006) Appearance of immature/transitional B cells in HIV-infected individuals with advanced disease: correlation with increased IL-7. Proc Natl Acad Sci U S A 103: 2262-2267.
29. Amadori A, Chieco-Bianchi L (1990) B-cell activation and HIV-1 infection: deeds and misdeeds. Immunol Today 11: 374-379.
30. Berberian L, Goodglick L, Kipps TJ, Braun J (1993) Immunoglobulin VH3 gene products: natural ligands for HIV gp120. Science 261: 1588-1591.
31. Amadori A, Zamarchi R, Veronese ML, Panozzo M, Mazza MR, et al. (1991) B-cell activation during HIV-1 infection. III. Down-regulating effect of mitogens. Aids 5: 821-828.
32. Breen EC, Rezai AR, Nakajima K, Beall GN, Mitsuyasu RT, et al. (1990) Infection with HIV is associated with elevated IL-6 levels and production. J Immunol 144: 480-484.
33. Birx DL, Redfield RR, Tencer K, Fowler A, Burke DS, et al. (1990) Induction of interleukin-6 during human immunodeficiency virus infection. Blood 76: 2303-2310.
34. Martinez-Maza O (1992) IL6 and AIDS. Res Immunol 143: 764-769.
35. Dorsett Y, Robbiani DF, Jankovic M, Reina-San-Martin B, Eisenreich TR, et al. (2007) A role for AID in chromosome translocations between c-myc and the IgH variable region. J Exp Med 204: 2225-2232.
36. Ramiro AR, Jankovic M, Eisenreich T, Difilippantonio S, Chen-Kiang S, et al. (2004) AID is required for c-myc/IgH chromosome translocations in vivo. Cell 118: 431-438.
37. Matsumoto Y, Marusawa H, Kinoshita K, Endo Y, Kou T, et al. (2007) Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat Med 13: 470-476.
38. Reiser J, Harmison G, Kluepfel-Stahl S, Brady RO, Karlsson S, et al. (1996) Transduction of nondividing cells using pseudotyped defective high-titer HIV type 1 particles. Proc Natl Acad Sci U S A 93: 15266-15271.
39. Vatakis DN, Bristol G, Wilkinson TA, Chow SA, Zack JA (2007) Immediate activation fails to rescue efficient human immunodeficiency virus replication in quiescent CD4+ T cells. J Virol 81: 3574-3582.