메뉴 건너뛰기




Volumn 3, Issue JAN, 2013, Pages

Update on the urotensinergic system: New trends in receptor localization, activation, and drug design

Author keywords

Allosteric modulation; Biased agonist; Nuclear receptors; Urotensin II; Urotensin II related peptide

Indexed keywords


EID: 84874269735     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2012.00174     Document Type: Review
Times cited : (26)

References (98)
  • 1
    • 0033575930 scopus 로고    scopus 로고
    • Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
    • Ames, R. S., Sarau, H. M., Chambers, J. K., Willette, R. N., Aiyar, N. V., Romanic, A. M., et al. (1999). Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature 401, 282-286.
    • (1999) Nature , vol.401 , pp. 282-286
    • Ames, R.S.1    Sarau, H.M.2    Chambers, J.K.3    Willette, R.N.4    Aiyar, N.V.5    Romanic, A.M.6
  • 3
    • 84865560018 scopus 로고    scopus 로고
    • Nuclear inositol 1 4 5-trisphosphate is a necessary and conserved signal for the induction of both pathological and physiological cardiomyocyte hypertrophy
    • Arantes, L. A., Aguiar, C. J., Amaya, M. J., Figueiro, N. C., Andrade, L. M., Rocha-Resende, C., et al. (2012). Nuclear inositol 1, 4, 5-trisphosphate is a necessary and conserved signal for the induction of both pathological and physiological cardiomyocyte hypertrophy. J. Mol. Cell. Cardiol. 53, 475-486.
    • (2012) J. Mol. Cell. Cardiol. , vol.53 , pp. 475-486
    • Arantes, L.A.1    Aguiar, C.J.2    Amaya, M.J.3    Figueiro, N.C.4    Andrade, L.M.5    Rocha-Resende, C.6
  • 4
    • 77955823424 scopus 로고    scopus 로고
    • GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharma-codynamic activity ex vivo
    • Behm, D. J., Aiyar, N. V., Olzinski, A. R., McAtee, J. J., Hilfiker, M. A., Dodson, J. W., et al. (2010). GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharma-codynamic activity ex vivo. Br. J. Pharmacol. 161, 207-228.
    • (2010) Br. J. Pharmacol. , vol.161 , pp. 207-228
    • Behm, D.J.1    Aiyar, N.V.2    Olzinski, A.R.3    McAtee, J.J.4    Hilfiker, M.A.5    Dodson, J.W.6
  • 5
    • 52949145624 scopus 로고    scopus 로고
    • Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues
    • Behm, D. J., McAtee, J. J., Dodson, J. W., Neeb, M. J., Fries, H. E., Evans, C. A., et al. (2008). Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues. Br. J. Pharmacol. 155, 374-386.
    • (2008) Br. J. Pharmacol. , vol.155 , pp. 374-386
    • Behm, D.J.1    McAtee, J.J.2    Dodson, J.W.3    Neeb, M.J.4    Fries, H.E.5    Evans, C.A.6
  • 6
    • 0025833977 scopus 로고
    • Brain extracellular matrix and nerve regeneration
    • Bignami, A., Asher, R., and Perides, G. (1991). Brain extracellular matrix and nerve regeneration. Adv. Exp. Med. Biol. 296, 197-206.
    • (1991) Adv. Exp. Med. Biol. , vol.296 , pp. 197-206
    • Bignami, A.1    Asher, R.2    Perides, G.3
  • 7
    • 0041706091 scopus 로고    scopus 로고
    • Functional endothelin receptors are present on nuclei in cardiac ventricular myocytes
    • Boivin, B., Chevalier, D., Villeneuve, L. R., Rousseau, E., and Allen, B. G. (2003). Functional endothelin receptors are present on nuclei in cardiac ventricular myocytes. J. Biol. Chem. 278, 29153-29163.
    • (2003) J. Biol. Chem. , vol.278 , pp. 29153-29163
    • Boivin, B.1    Chevalier, D.2    Villeneuve, L.R.3    Rousseau, E.4    Allen, B.G.5
  • 8
    • 33744909351 scopus 로고    scopus 로고
    • Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular car-diomyocytes
    • Boivin, B., Lavoie, C., Vaniotis, G., Baragli, A., Villeneuve, L. R., Ethier, N., et al. (2006). Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular car-diomyocytes. Cardiovasc. Res. 71, 69-78.
    • (2006) Cardiovasc. Res. , vol.71 , pp. 69-78
    • Boivin, B.1    Lavoie, C.2    Vaniotis, G.3    Baragli, A.4    Villeneuve, L.R.5    Ethier, N.6
  • 9
    • 42549102347 scopus 로고    scopus 로고
    • G protein-coupled receptors in and on the cell nucleus: a new signaling paradigm? J
    • Boivin, B., Vaniotis, G., Allen, B. G., and Hebert, T. E. (2008). G protein-coupled receptors in and on the cell nucleus: a new signaling paradigm? J. Recept. Signal Transduct. Res. 28, 15-28.
    • (2008) Recept. Signal Transduct. Res. , vol.28 , pp. 15-28
    • Boivin, B.1    Vaniotis, G.2    Allen, B.G.3    Hebert, T.E.4
  • 11
    • 0041430625 scopus 로고    scopus 로고
    • Functional and binding characterizations of urotensin II-related peptides in human and rat urotensin II-receptor assay
    • Brkovic, A., Hattenberger, A., Kostenis, E., Klabunde, T., Flohr, S., Kurz, M., et al. (2003). Functional and binding characterizations of urotensin II-related peptides in human and rat urotensin II-receptor assay. J. Pharmacol. Exp. Ther. 306, 1200-1209.
    • (2003) J. Pharmacol. Exp. Ther. , vol.306 , pp. 1200-1209
    • Brkovic, A.1    Hattenberger, A.2    Kostenis, E.3    Klabunde, T.4    Flohr, S.5    Kurz, M.6
  • 13
    • 33749165925 scopus 로고    scopus 로고
    • Biochemical and functional characterization of high-affinity urotensin II receptors in rat cortical astrocytes
    • Castel, H., Diallo, M., Chatenet, D., Leprince, J., Desrues, L., Schouft, M. T., et al. (2006). Biochemical and functional characterization of high-affinity urotensin II receptors in rat cortical astrocytes.J. Neurochem. 99, 582-595.
    • (2006) J. Neurochem. , vol.99 , pp. 582-595
    • Castel, H.1    Diallo, M.2    Chatenet, D.3    Leprince, J.4    Desrues, L.5    Schouft, M.T.6
  • 14
    • 5144231980 scopus 로고    scopus 로고
    • Structure-activity relationships and structural conformation of a novel urotensin II-related peptide
    • Chatenet, D., Dubessy, C., Leprince, J., Boularan, C., Carlier, L., Segalas-Milazzo, I., et al. (2004). Structure-activity relationships and structural conformation of a novel urotensin II-related peptide. Peptides25, 1819-1830.
    • (2004) Peptides , vol.25 , pp. 1819-1830
    • Chatenet, D.1    Dubessy, C.2    Leprince, J.3    Boularan, C.4    Carlier, L.5    Segalas-Milazzo, I.6
  • 15
    • 84872941025 scopus 로고    scopus 로고
    • Discovery of new antagonists aimed at discriminating UII and URP-mediated biological activities: insight into UII and URP receptor activation
    • doi: 10.111 1/j.1476-5381.2012.02217.x. [Epub ahead of print]
    • Chatenet, D., Nguyen, Q. T., Letourneau, M., Doan, N. D., Dupuis, J., and Fournier, A. (2012a). Discovery of new antagonists aimed at discriminating UII and URP-mediated biological activities: insight into UII and URP receptor activation. Br. J. Pharmacol. doi: 10.111 1/j.1476-5381.2012.02217.x. [Epub ahead of print].
    • (2012) Br. J. Pharmacol.
    • Chatenet, D.1    Nguyen, Q.T.2    Letourneau, M.3    Doan, N.D.4    Dupuis, J.5    Fournier, A.6
  • 16
    • 84856110521 scopus 로고    scopus 로고
    • Urocontrin, a novel UT receptor ligand with a unique pharmacological profile
    • Chatenet, D., Nguyen, Q. T., Letourneau, M., Dupuis, J., and Fournier, A. (2012b). Urocontrin, a novel UT receptor ligand with a unique pharmacological profile. Biochem. Pharmacol. 83, 608-615.
    • (2012) Biochem. Pharmacol. , vol.83 , pp. 608-615
    • Chatenet, D.1    Nguyen, Q.T.2    Letourneau, M.3    Dupuis, J.4    Fournier, A.5
  • 17
    • 0036258990 scopus 로고    scopus 로고
    • G protein-coupled receptor allosterism and complexing
    • Christopoulos, A., and Kenakin, T. (2002). G protein-coupled receptor allosterism and complexing. Pharmacol. Rev. 54, 323-374.
    • (2002) Pharmacol. Rev. , vol.54 , pp. 323-374
    • Christopoulos, A.1    Kenakin, T.2
  • 18
    • 4644332005 scopus 로고    scopus 로고
    • Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System
    • Clozel, M., Binkert, C., Birker-Robaczewska, M., Boukhadra, C., Ding, S. S., Fischli, W., et al. (2004). Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System. J. Pharmacol. Exp. Ther. 311,204-212.
    • (2004) J. Pharmacol. Exp. Ther. , vol.311 , pp. 204-212
    • Clozel, M.1    Binkert, C.2    Birker-Robaczewska, M.3    Boukhadra, C.4    Ding, S.S.5    Fischli, W.6
  • 19
    • 33644754588 scopus 로고    scopus 로고
    • The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats
    • Clozel, M., Hess, P., Qiu, C., Ding, S. S., and Rey, M. (2006). The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats. J. Pharmacol. Exp. Ther. 316, 1115-1121.
    • (2006) J. Pharmacol. Exp. Ther. , vol.316 , pp. 1115-1121
    • Clozel, M.1    Hess, P.2    Qiu, C.3    Ding, S.S.4    Rey, M.5
  • 20
    • 0026438883 scopus 로고
    • Isolation and primary structure of urotensin II from the brain of a tetrapod, the frog Rana ridibunda
    • Conlon, J. M., O'Harte, F., Smith, D. D., Tonon, M. C., and Vaudry, H. (1992). Isolation and primary structure of urotensin II from the brain of a tetrapod, the frog Rana ridibunda. Biochem. Biophys. Res. Commun. 188, 578-583.
    • (1992) Biochem. Biophys. Res. Commun. , vol.188 , pp. 578-583
    • Conlon, J.M.1    O'Harte, F.2    Smith, D.D.3    Tonon, M.C.4    Vaudry, H.5
  • 21
    • 0032428160 scopus 로고    scopus 로고
    • Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneu-rons of the spinal cord
    • Coulouarn, Y., Lihrmann, I., Jegou, S., Anouar, Y., Tostivint, H., Beauvillain, J. C., et al. (1998). Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneu-rons of the spinal cord. Proc. Natl. Acad. Sci. U.S.A. 95, 15803-15808.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 15803-15808
    • Coulouarn, Y.1    Lihrmann, I.2    Jegou, S.3    Anouar, Y.4    Tostivint, H.5    Beauvillain, J.C.6
  • 22
    • 33847309050 scopus 로고    scopus 로고
    • The involvement of transforming growth factor-beta1 secretion in urotensin II-induced collagen synthesis in neonatal cardiac fibroblasts
    • Dai, H. Y., Kang, W. Q., Wang, X., Yu, X. J., Li, Z. H., Tang, M. X., et al. (2007). The involvement of transforming growth factor-beta1 secretion in urotensin II-induced collagen synthesis in neonatal cardiac fibroblasts. Regul Pept. 140, 88-93.
    • (2007) Regul Pept , vol.140 , pp. 88-93
    • Dai, H.Y.1    Kang, W.Q.2    Wang, X.3    Yu, X.J.4    Li, Z.H.5    Tang, M.X.6
  • 23
    • 47349128297 scopus 로고    scopus 로고
    • Intracellular and extracellular renin have opposite effects on the regulation of heart cell volume Implications for myocardial ischaemia
    • De Mello, W. C. (2008). Intracellular and extracellular renin have opposite effects on the regulation of heart cell volume. Implications for myocardial ischaemia. J. Renin Angiotensin Aldosterone Syst. 9, 112-118.
    • (2008) J. Renin Angiotensin Aldosterone Syst. , vol.9 , pp. 112-118
    • De Mello, W.C.1
  • 24
    • 84892564187 scopus 로고    scopus 로고
    • Urotensin II and urotensin II-related peptide regulate normal astrocyte activity Potential involvement in glioma proliferation
    • Diallo, M., Castel, H., Jarry, M., Desrues, L., Lefebvre, T., Leprince, J., et al. (2007). Urotensin II and urotensin II-related peptide regulate normal astrocyte activity. Potential involvement in glioma proliferation. Neuron Glia Biol. 3, S161.
    • (2007) Neuron Glia Biol , vol.3
    • Diallo, M.1    Castel, H.2    Jarry, M.3    Desrues, L.4    Lefebvre, T.5    Leprince, J.6
  • 25
    • 84856091972 scopus 로고    scopus 로고
    • Biochemical and pharmacological characterization of nuclear urotensin-II binding sites in rat heart
    • Doan, N. D., Nguyen, T. T., Letourneau, M., Turcotte, K., Fournier, A., and Chatenet, D. (2012). Biochemical and pharmacological characterization of nuclear urotensin-II binding sites in rat heart. Br. J. Pharmacol. 166, 243-257.
    • (2012) Br. J. Pharmacol. , vol.166 , pp. 243-257
    • Doan, N.D.1    Nguyen, T.T.2    Letourneau, M.3    Turcotte, K.4    Fournier, A.5    Chatenet, D.6
  • 26
    • 0033766157 scopus 로고    scopus 로고
    • Human urotensin-II is a potent vasoactive peptide: pharmacological characterization in the rat, mouse, dog and primate
    • Douglas, S. A., Ashton, D. J., Sauermelch, C. F., Coatney, R. W., Ohlstein, D. H., Ruffolo, M. R., et al. (2000). Human urotensin-II is a potent vasoactive peptide: pharmacological characterization in the rat, mouse, dog and primate. J. Cardiovasc. Pharmacol. 36, S163-S166.
    • (2000) J. Cardiovasc. Pharmacol. , vol.36
    • Douglas, S.A.1    Ashton, D.J.2    Sauermelch, C.F.3    Coatney, R.W.4    Ohlstein, D.H.5    Ruffolo, M.R.6
  • 27
    • 0034466374 scopus 로고    scopus 로고
    • Human urotensin-II, the most potent mammalian vasoconstrictor identified to date, as a therapeutic target for the management of cardiovascular disease
    • Douglas, S. A., and Ohlstein, E. H. (2000). Human urotensin-II, the most potent mammalian vasoconstrictor identified to date, as a therapeutic target for the management of cardiovascular disease. Trends Cardiovasc. Med. 10, 229-237.
    • (2000) Trends Cardiovasc. Med. , vol.10 , pp. 229-237
    • Douglas, S.A.1    Ohlstein, E.H.2
  • 28
    • 53149138960 scopus 로고    scopus 로고
    • Characterization of urotensin II, distribution of urotensin II, urotensin II-related peptide and UT receptor mRNAs in mouse: evidence of urotensin II at the neuromuscular junction
    • Dubessy, C., Cartier, D., Lectez, B., Bucharles, C., Chartrel, N., Montero-Hadjadje, M., et al. (2008). Characterization of urotensin II, distribution of urotensin II, urotensin II-related peptide and UT receptor mRNAs in mouse: evidence of urotensin II at the neuromuscular junction. J. Neurochem. 107, 361-374.
    • (2008) J. Neurochem. , vol.107 , pp. 361-374
    • Dubessy, C.1    Cartier, D.2    Lectez, B.3    Bucharles, C.4    Chartrel, N.5    Montero-Hadjadje, M.6
  • 29
    • 0028940657 scopus 로고
    • Nuclear import of glycoconjugates is distinct from the classical NLS pathway
    • Duverger, E., Pellerin-Mendes, C., Mayer, R., Roche, A. C., and Monsigny, M. (1995). Nuclear import of glycoconjugates is distinct from the classical NLS pathway. J. Cell Sci. 108(Pt 4), 1325-1332.
    • (1995) J. Cell Sci. , vol.108 , Issue.PART 4 , pp. 1325-1332
    • Duverger, E.1    Pellerin-Mendes, C.2    Mayer, R.3    Roche, A.C.4    Monsigny, M.5
  • 30
    • 0027432809 scopus 로고
    • Nuclear angiotensin receptors induce transcription of renin and angiotensinogen mRNA
    • Eggena, P., Zhu, J. H., Clegg, K., and Barrett, J. D. (1993). Nuclear angiotensin receptors induce transcription of renin and angiotensinogen mRNA. Hypertension 22, 496-501.
    • (1993) Hypertension , vol.22 , pp. 496-501
    • Eggena, P.1    Zhu, J.H.2    Clegg, K.3    Barrett, J.D.4
  • 31
    • 0036261206 scopus 로고    scopus 로고
    • Molecular and pharmacological characterization of genes encoding urotensin-II peptides and their cognate G-protein-coupled receptors from the mouse and monkey
    • Elshourbagy, N. A., Douglas, S. A., Shabon, U., Harrison, S., Duddy, G., Sechler, J. L., et al. (2002). Molecular and pharmacological characterization of genes encoding urotensin-II peptides and their cognate G-protein-coupled receptors from the mouse and monkey. Br. J. Pharmacol. 136, 9-22.
    • (2002) Br. J. Pharmacol. , vol.136 , pp. 9-22
    • Elshourbagy, N.A.1    Douglas, S.A.2    Shabon, U.3    Harrison, S.4    Duddy, G.5    Sechler, J.L.6
  • 32
    • 72649084930 scopus 로고    scopus 로고
    • Urotensin II-induced increase in myocardial distensibility is modulated by angiotensin II and endothelin-1
    • Fontes-Sousa, A. P., Pires, A. L., Monteiro-Cardoso, V. F., and Leite-Moreira, A. E (2009). Urotensin II-induced increase in myocardial distensibility is modulated by angiotensin II and endothelin-1. Physiol. Res. 58, 653-660.
    • (2009) Physiol. Res. , vol.58 , pp. 653-660
    • Fontes-Sousa, A.P.1    Pires, A.L.2    Monteiro-Cardoso, V.F.3    Leite-Moreira, A.E.4
  • 33
    • 0023226879 scopus 로고
    • Complex effects of Gillichthys urotensin II on rat aortic strips
    • Gibson, A. (1987). Complex effects of Gillichthys urotensin II on rat aortic strips. Br. J. Pharmacol. 91,205-212.
    • (1987) Br. J. Pharmacol. , vol.91 , pp. 205-212
    • Gibson, A.1
  • 34
    • 0021352955 scopus 로고
    • Neuropeptide-induced contraction and relaxation of the mouse anococ-cygeus muscle
    • Gibson, A., Bern, H. A., Ginsburg, M., and Botting, J. H. (1984). Neuropeptide-induced contraction and relaxation of the mouse anococ-cygeus muscle. Proc. Natl. Acad. Sci. U.S.A. 81,625-629.
    • (1984) Proc. Natl. Acad. Sci. U. S. A. , vol.81 , pp. 625-629
    • Gibson, A.1    Bern, H.A.2    Ginsburg, M.3    Botting, J.H.4
  • 35
    • 26244465123 scopus 로고    scopus 로고
    • Arrestin-independent internal-ization and recycling of the urotensin receptor contribute to long-lasting urotensin II-mediated vasoconstriction
    • Giebing, G., Tolle, M., Jurgensen, J., Eichhorst, J., Furkert, J., Beyermann, M., et al. (2005). Arrestin-independent internal-ization and recycling of the urotensin receptor contribute to long-lasting urotensin II-mediated vasoconstriction. Circ. Res. 97, 707-715.
    • (2005) Circ. Res. , vol.97 , pp. 707-715
    • Giebing, G.1    Tolle, M.2    Jurgensen, J.3    Eichhorst, J.4    Furkert, J.5    Beyermann, M.6
  • 37
    • 77952546031 scopus 로고    scopus 로고
    • Urotensin II induction of adult car-diomyocytes hypertrophy involves the Akt/GSK-3beta signaling pathway
    • Gruson, D., Ginion, A., Decroly, N., Lause, P., Vanoverschelde, J. L., Ketelslegers, J. M., et al. (2010). Urotensin II induction of adult car-diomyocytes hypertrophy involves the Akt/GSK-3beta signaling pathway. Peptides 31, 1326-1333.
    • (2010) Peptides , vol.31 , pp. 1326-1333
    • Gruson, D.1    Ginion, A.2    Decroly, N.3    Lause, P.4    Vanoverschelde, J.L.5    Ketelslegers, J.M.6
  • 38
    • 77952110710 scopus 로고    scopus 로고
    • Urotensin-II as an angio-genic factor
    • Guidolin, D., Albertin, G., and Ribatti, D. (2010). Urotensin-II as an angio-genic factor.Peptides31, 1219-1224.
    • (2010) Peptides , vol.31 , pp. 1219-1224
    • Guidolin, D.1    Albertin, G.2    Ribatti, D.3
  • 39
    • 41149090339 scopus 로고    scopus 로고
    • Regulation of GPCRs by endocytic membrane trafficking and its potential implications
    • Hanyaloglu, A. C., and von Zastrow, M. (2008). Regulation of GPCRs by endocytic membrane trafficking and its potential implications. Annu. Rev. Pharmacol. Toxicol. 48, 537-568.
    • (2008) Annu. Rev. Pharmacol. Toxicol. , vol.48 , pp. 537-568
    • Hanyaloglu, A.C.1    von Zastrow, M.2
  • 40
    • 0038606902 scopus 로고    scopus 로고
    • The neuromedin B receptor antagonist, BIM-23127, is a potent antagonist at human and rat urotensin-II receptors
    • Herold, C. L., Behm, D. J., Buckley, P. T., Foley, J. J., Wixted, W. E., Sarau, H. M., et al. (2003). The neuromedin B receptor antagonist, BIM-23127, is a potent antagonist at human and rat urotensin-II receptors. Br. J. Pharmacol. 139, 203-207.
    • (2003) Br. J. Pharmacol. , vol.139 , pp. 203-207
    • Herold, C.L.1    Behm, D.J.2    Buckley, P.T.3    Foley, J.J.4    Wixted, W.E.5    Sarau, H.M.6
  • 41
    • 0035853051 scopus 로고    scopus 로고
    • Effects of urotensin II in human arteries and veins of varying caliber
    • Hillier, C., Berry, C., Petrie, M. C., O'Dwyer, P. J., Hamilton, C., Brown, A., et al. (2001). Effects of urotensin II in human arteries and veins of varying caliber. Circulation 103, 1378-1381.
    • (2001) Circulation , vol.103 , pp. 1378-1381
    • Hillier, C.1    Berry, C.2    Petrie, M.C.3    O'Dwyer, P.J.4    Hamilton, C.5    Brown, A.6
  • 42
    • 65549161827 scopus 로고    scopus 로고
    • Increased expression of urotensin II, urotensin II-related peptide and urotensin II receptor mRNAs in the cardiovascular organs of hypertensive rats: comparison with endothelin-1
    • Hirose, T., Takahashi, K., Mori, N., Nakayama, T., Kikuya, M., Ohkubo, T., et al. (2009). Increased expression of urotensin II, urotensin II-related peptide and urotensin II receptor mRNAs in the cardiovascular organs of hypertensive rats: comparison with endothelin-1. Peptides 30, 1124-1129.
    • (2009) Peptides , vol.30 , pp. 1124-1129
    • Hirose, T.1    Takahashi, K.2    Mori, N.3    Nakayama, T.4    Kikuya, M.5    Ohkubo, T.6
  • 43
    • 20444408409 scopus 로고    scopus 로고
    • Cardiac actions of central but not peripheral urotensin II are prevented by beta-adrenoceptor blockade
    • Hood, S. G., Watson, A. M., and May, C. N. (2005). Cardiac actions of central but not peripheral urotensin II are prevented by beta-adrenoceptor blockade. Peptides 26, 1248-1256.
    • (2005) Peptides , vol.26 , pp. 1248-1256
    • Hood, S.G.1    Watson, A.M.2    May, C.N.3
  • 44
    • 77953393621 scopus 로고    scopus 로고
    • The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation
    • Jarry, M., Diallo, M., Lecointre, C., Desrues, L., Tokay, T., Chatenet, D., et al. (2010). The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation. Biochem. J. 428, 113-124.
    • (2010) Biochem. J. , vol.428 , pp. 113-124
    • Jarry, M.1    Diallo, M.2    Lecointre, C.3    Desrues, L.4    Tokay, T.5    Chatenet, D.6
  • 45
    • 34547781132 scopus 로고    scopus 로고
    • Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A
    • Jiang, X., Benovic, J. L., and Wedegaertner, P. B. (2007). Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A. Mol. Biol. Cell 18, 2960-2969.
    • (2007) Mol. Biol. Cell , vol.18 , pp. 2960-2969
    • Jiang, X.1    Benovic, J.L.2    Wedegaertner, P.B.3
  • 46
    • 24044447233 scopus 로고    scopus 로고
    • Functional metabotropic glutamate receptors on nuclei from brain and primary cultured stri-atal neurons Role of transporters in delivering ligand
    • Jong, Y. J., Kumar, V., Kingston, A. E., Romano, C., and O'Malley, K. L. (2005). Functional metabotropic glutamate receptors on nuclei from brain and primary cultured stri-atal neurons. Role of transporters in delivering ligand. J. Biol. Chem. 280, 30469-30480.
    • (2005) J. Biol. Chem. , vol.280 , pp. 30469-30480
    • Jong, Y.J.1    Kumar, V.2    Kingston, A.E.3    Romano, C.4    O'Malley, K.L.5
  • 47
    • 72149133087 scopus 로고    scopus 로고
    • Intracellular metabotropic glutamate receptor 5 (mGluR5) activates signaling cascades distinct from cell surface counterparts
    • Jong, Y. J., Kumar, V., and O'Malley, K. L. (2009). Intracellular metabotropic glutamate receptor 5 (mGluR5) activates signaling cascades distinct from cell surface counterparts. J. Biol. Chem. 284, 35827-35838.
    • (2009) J. Biol. Chem. , vol.284 , pp. 35827-35838
    • Jong, Y.J.1    Kumar, V.2    O'Malley, K.L.3
  • 48
    • 27844519281 scopus 로고    scopus 로고
    • New concepts in drug discovery: collateral efficacy and permissive antagonism
    • Kenakin, T. (2005). New concepts in drug discovery: collateral efficacy and permissive antagonism. Nat. Rev. DrugDiscov. 4, 919-927.
    • (2005) Nat. Rev. DrugDiscov. , vol.4 , pp. 919-927
    • Kenakin, T.1
  • 49
    • 45149129202 scopus 로고    scopus 로고
    • Functional selectivity in GPCR modulator screening
    • Kenakin, T. (2008). Functional selectivity in GPCR modulator screening. Comb. Chem. High Throughput Screen. 11,337-343.
    • (2008) Comb. Chem. High Throughput Screen. , vol.11 , pp. 337-343
    • Kenakin, T.1
  • 50
    • 78751498756 scopus 로고    scopus 로고
    • Functional selectivity and biased receptor signaling
    • Kenakin, T. (2011). Functional selectivity and biased receptor signaling. J. Pharmacol. Exp. Ther. 336, 296-302.
    • (2011) J. Pharmacol. Exp. Ther. , vol.336 , pp. 296-302
    • Kenakin, T.1
  • 51
    • 77952354490 scopus 로고    scopus 로고
    • Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery
    • Kenakin, T., and Miller, L. J. (2010). Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery. Pharmacol. Rev. 62, 265-304.
    • (2010) Pharmacol. Rev. , vol.62 , pp. 265-304
    • Kenakin, T.1    Miller, L.J.2
  • 52
    • 78149496159 scopus 로고    scopus 로고
    • Allosteric modulation of G protein-coupled receptors: a pharmacological perspective
    • Keov, P., Sexton, P. M., and Christopoulos, A. (2011). Allosteric modulation of G protein-coupled receptors: a pharmacological perspective. Neuropharmacology 60, 24-35.
    • (2011) Neuropharmacology , vol.60 , pp. 24-35
    • Keov, P.1    Sexton, P.M.2    Christopoulos, A.3
  • 53
    • 0028017489 scopus 로고
    • Competition between nuclear localization and secretory signals determines the subcellular fate of a single CUG-initiated form of FGF3
    • Kiefer, P., Acland, P., Pappin, D., Peters, G., and Dickson, C. (1994). Competition between nuclear localization and secretory signals determines the subcellular fate of a single CUG-initiated form of FGF3. EMBO J. 13, 4126-4136.
    • (1994) EMBO J , vol.13 , pp. 4126-4136
    • Kiefer, P.1    Acland, P.2    Pappin, D.3    Peters, G.4    Dickson, C.5
  • 54
    • 2542423686 scopus 로고    scopus 로고
    • Differential desensitization, receptor phospho-rylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7
    • Kohout, T. A., Nicholas, S. L., Perry, S. J., Reinhart, G., Junger, S., and Struthers, R. S. (2004). Differential desensitization, receptor phospho-rylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7. J. Biol. Chem. 279,23214-23222.
    • (2004) J. Biol. Chem. , vol.279 , pp. 23214-23222
    • Kohout, T.A.1    Nicholas, S.L.2    Perry, S.J.3    Reinhart, G.4    Junger, S.5    Struthers, R.S.6
  • 55
    • 34047250447 scopus 로고    scopus 로고
    • Therapeutic potential of blockade of the urotensin II system in systemic hypertension
    • Krum, H., and Kemp, W. (2007). Therapeutic potential of blockade of the urotensin II system in systemic hypertension. Curr. Hypertens. Rep. 9, 53-58.
    • (2007) Curr. Hypertens. Rep. , vol.9 , pp. 53-58
    • Krum, H.1    Kemp, W.2
  • 56
    • 34447632041 scopus 로고    scopus 로고
    • Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology
    • Leach, K., Sexton, P. M., and Christopoulos, A. (2007). Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology. Trends Pharmacol. Sci. 28, 382-389.
    • (2007) Trends Pharmacol. Sci. , vol.28 , pp. 382-389
    • Leach, K.1    Sexton, P.M.2    Christopoulos, A.3
  • 57
    • 1542289804 scopus 로고    scopus 로고
    • Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors
    • Lee, D. K., Lanca, A. J., Cheng, R., Nguyen, T., Ji, X. D., Gobeil, E Jr., et al. (2004). Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors. J. Biol. Chem. 279, 7901-7908.
    • (2004) J. Biol. Chem. , vol.279 , pp. 7901-7908
    • Lee, D.K.1    Lanca, A.J.2    Cheng, R.3    Nguyen, T.4    Ji, X.D.5    Gobeil Jr, E.6
  • 58
    • 0033524747 scopus 로고    scopus 로고
    • Distinct renin isoforms generated by tissue-specific transcription initiation and alternative splicing
    • Lee-Kirsch, M. A., Gaudet, F., Cardoso, M. C., and Lindpaintner, K. (1999). Distinct renin isoforms generated by tissue-specific transcription initiation and alternative splicing. Circ. Res. 84, 240-246.
    • (1999) Circ. Res. , vol.84 , pp. 240-246
    • Lee-Kirsch, M.A.1    Gaudet, F.2    Cardoso, M.C.3    Lindpaintner, K.4
  • 59
    • 50849111783 scopus 로고    scopus 로고
    • Three-dimensional model of the human urotensin-II receptor: docking of human urotensin-II and non-peptide antagonists in the binding site and comparison with an antagonist pharmacophore model
    • Lescot, E., Sopkova-De Oliveira Santos, J., Colloc'h, N., Rodrigo, J., Milazzo-Segalas, I., Bureau, R., et al. (2008). Three-dimensional model of the human urotensin-II receptor: docking of human urotensin-II and non-peptide antagonists in the binding site and comparison with an antagonist pharmacophore model. Proteins 73, 173-184.
    • (2008) Proteins , vol.73 , pp. 173-184
    • Lescot, E.1    Sopkova-De Oliveira Santos, J.2    Colloc'h, N.3    Rodrigo, J.4    Milazzo-Segalas, I.5    Bureau, R.6
  • 60
    • 0033539884 scopus 로고    scopus 로고
    • Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14
    • Liu, Q., Pong, S. S., Zeng, Z., Zhang, Q., Howard, A. D., Williams, D. L. Jr., et al. (1999). Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14. Biochem. Biophys. Res. Commun. 266, 174-178.
    • (1999) Biochem. Biophys. Res. Commun. , vol.266 , pp. 174-178
    • Liu, Q.1    Pong, S.S.2    Zeng, Z.3    Zhang, Q.4    Howard, A.D.5    Williams Jr, D.L.6
  • 61
    • 0036848062 scopus 로고    scopus 로고
    • Is urotensin-II the new endothelin? Br
    • Maguire, J. J., and Davenport, A. P. (2002). Is urotensin-II the new endothelin? Br. J. Pharmacol. 137, 579-588.
    • (2002) J. Pharmacol. , vol.137 , pp. 579-588
    • Maguire, J.J.1    Davenport, A.P.2
  • 62
    • 0033776533 scopus 로고    scopus 로고
    • Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1
    • Maguire, J. J., Kuc, R. E., and Davenport, A. P. (2000). Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1. Br. J. Pharmacol. 131, 441-446.
    • (2000) Br. J. Pharmacol. , vol.131 , pp. 441-446
    • Maguire, J.J.1    Kuc, R.E.2    Davenport, A.P.3
  • 63
    • 42049091846 scopus 로고    scopus 로고
    • Immunocytochemical localization of the urotensin-II receptor, UT, to rat and human tissues: relevance to function
    • Maguire, J. J., Kuc, R. E., Kleinz, M. J., and Davenport, A. P. (2008). Immunocytochemical localization of the urotensin-II receptor, UT, to rat and human tissues: relevance to function. Peptides 29, 735-742.
    • (2008) Peptides , vol.29 , pp. 735-742
    • Maguire, J.J.1    Kuc, R.E.2    Kleinz, M.J.3    Davenport, A.P.4
  • 64
    • 0029102720 scopus 로고
    • Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors
    • Marchese, A., Heiber, M., Nguyen, T., Heng, H. H., Saldivia, V. R., Cheng, R., et al. (1995). Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. Genomics 29, 335-344.
    • (1995) Genomics , vol.29 , pp. 335-344
    • Marchese, A.1    Heiber, M.2    Nguyen, T.3    Heng, H.H.4    Saldivia, V.R.5    Cheng, R.6
  • 65
    • 77950552273 scopus 로고    scopus 로고
    • Urotensin-II receptor modulators as potential drugs
    • Maryanoff, B. E., and Kinney, W. A. (2010). Urotensin-II receptor modulators as potential drugs. J. Med. Chem. 53, 2695-2708.
    • (2010) J. Med. Chem. , vol.53 , pp. 2695-2708
    • Maryanoff, B.E.1    Kinney, W.A.2
  • 67
    • 0033547450 scopus 로고    scopus 로고
    • Urotensin II is the endogenous ligand of a G-protein-coupled orphan receptor SENR (GPR14)
    • Mori, M., Sugo, T., Abe, M., Shimomura, Y., Kurihara, M., Kitada, C., et al. (1999). Urotensin II is the endogenous ligand of a G-protein-coupled orphan receptor, SENR (GPR14). Biochem. Biophys. Res. Commun. 265, 123-129.
    • (1999) Biochem. Biophys. Res. Commun. , vol.265 , pp. 123-129
    • Mori, M.1    Sugo, T.2    Abe, M.3    Shimomura, Y.4    Kurihara, M.5    Kitada, C.6
  • 68
    • 84857923121 scopus 로고    scopus 로고
    • Presence of urotensin-II receptors at the cell nucleus: specific tissue distribution and hypoxia-induced modulation
    • Nguyen, T. T., Letourneau, M., Chatenet, D., and Fournier, A. (2012). Presence of urotensin-II receptors at the cell nucleus: specific tissue distribution and hypoxia-induced modulation. Int. J. Biochem. CellBiol. 44, 639-647.
    • (2012) Int. J. Biochem. CellBiol. , vol.44 , pp. 639-647
    • Nguyen, T.T.1    Letourneau, M.2    Chatenet, D.3    Fournier, A.4
  • 69
    • 0033202995 scopus 로고    scopus 로고
    • Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction
    • Nothacker, H. P., Wang, Z., McNeill, A. M., Saito, Y., Merten, S., O'Dowd, B., et al. (1999). Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction. Nat. Cell Biol. 1, 383-385.
    • (1999) Nat. Cell Biol. , vol.1 , pp. 383-385
    • Nothacker, H.P.1    Wang, Z.2    McNeill, A.M.3    Saito, Y.4    Merten, S.5    O'Dowd, B.6
  • 70
    • 45849086109 scopus 로고    scopus 로고
    • Urotensin II evokes neurotransmitter release from rat cerebrocortical slices
    • Ono, T., Kawaguchi, Y., Kudo, M., Kushikata, T., Hashiba, E., Yoshida, H., et al. (2008). Urotensin II evokes neurotransmitter release from rat cerebrocortical slices. Neurosci. Lett. 440, 275-279.
    • (2008) Neurosci. Lett. , vol.440 , pp. 275-279
    • Ono, T.1    Kawaguchi, Y.2    Kudo, M.3    Kushikata, T.4    Hashiba, E.5    Yoshida, H.6
  • 71
    • 42049112735 scopus 로고    scopus 로고
    • Urotensin-II and cardiovascular remodeling
    • Papadopoulos, P., Bousette, N., and Giaid, A. (2008). Urotensin-II and cardiovascular remodeling. Peptides 29, 764-769.
    • (2008) Peptides , vol.29 , pp. 764-769
    • Papadopoulos, P.1    Bousette, N.2    Giaid, A.3
  • 72
    • 78649918839 scopus 로고    scopus 로고
    • Functional selectivity in adrenergic and angiotensin signaling systems
    • Patel, C. B., Noor, N., and Rockman, H. A. (2010). Functional selectivity in adrenergic and angiotensin signaling systems. Mol. Pharmacol. 78, 983-992.
    • (2010) Mol. Pharmacol. , vol.78 , pp. 983-992
    • Patel, C.B.1    Noor, N.2    Rockman, H.A.3
  • 74
    • 33745684385 scopus 로고    scopus 로고
    • Angiotensin II infusion restores stimulated angiogenesis in the skeletal muscle of rats on a high-salt diet
    • Petersen, M. C., Munzenmaier, D. H., and Greene, A. S. (2006). Angiotensin II infusion restores stimulated angiogenesis in the skeletal muscle of rats on a high-salt diet. Am. J. Physiol. Heart Circ. Physiol. 291,H114-H120.
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.291
    • Petersen, M.C.1    Munzenmaier, D.H.2    Greene, A.S.3
  • 75
    • 42049101979 scopus 로고    scopus 로고
    • Urotensin II and urotensin II-related peptide (URP) in cardiac ischemia-reperfusion injury
    • Prosser, H. C., Forster, M. E., Richards, A. M., and Pemberton, C. J. (2008). Urotensin II and urotensin II-related peptide (URP) in cardiac ischemia-reperfusion injury. Peptides 29, 770-777.
    • (2008) Peptides , vol.29 , pp. 770-777
    • Prosser, H.C.1    Forster, M.E.2    Richards, A.M.3    Pemberton, C.J.4
  • 76
    • 42049109932 scopus 로고    scopus 로고
    • Biological properties and functional determinants of the urotensin II receptor
    • Proulx, C. D., Holleran, B. J., Lavigne, P., Escher, E., Guillemette, G., and Leduc, R. (2008). Biological properties and functional determinants of the urotensin II receptor. Peptides 29,691-699.
    • (2008) Peptides , vol.29 , pp. 691-699
    • Proulx, C.D.1    Holleran, B.J.2    Lavigne, P.3    Escher, E.4    Guillemette, G.5    Leduc, R.6
  • 77
    • 0032743442 scopus 로고    scopus 로고
    • The nature of intracrine peptide hormone action
    • Re, R. (1999). The nature of intracrine peptide hormone action. Hypertension 34, 534-538.
    • (1999) Hypertension , vol.34 , pp. 534-538
    • Re, R.1
  • 78
    • 5644297177 scopus 로고    scopus 로고
    • A proposal regarding the biology of memory: participation of intracrine peptide networks
    • Re, R. N. (2004). A proposal regarding the biology of memory: participation of intracrine peptide networks. Med. Hypotheses 63, 887-894.
    • (2004) Med. Hypotheses , vol.63 , pp. 887-894
    • Re, R.N.1
  • 79
    • 0030993594 scopus 로고    scopus 로고
    • Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor
    • Roettger, B. F., Ghanekar, D., Rao, R., Toledo, C., Yingling, J., Pinon, D., et al. (1997). Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor. Mol. Pharmacol. 51, 357-362.
    • (1997) Mol. Pharmacol. , vol.51 , pp. 357-362
    • Roettger, B.F.1    Ghanekar, D.2    Rao, R.3    Toledo, C.4    Yingling, J.5    Pinon, D.6
  • 80
    • 0038495795 scopus 로고    scopus 로고
    • Sugar-dependent nuclear import of glycosylated proteins in living cells
    • Rondanino, C., Bousser, M. T., Monsigny, M., and Roche, A. C. (2003). Sugar-dependent nuclear import of glycosylated proteins in living cells. Glycobiology 13, 509-519.
    • (2003) Glycobiology , vol.13 , pp. 509-519
    • Rondanino, C.1    Bousser, M.T.2    Monsigny, M.3    Roche, A.C.4
  • 81
    • 84862294189 scopus 로고    scopus 로고
    • ERK1/2 MAP kinases: structure, function, and regulation
    • Roskoski, R. Jr. (2012). ERK1/2 MAP kinases: structure, function, and regulation. Pharmacol. Res. 66, 105-143.
    • (2012) Pharmacol. Res. , vol.66 , pp. 105-143
    • Roskoski Jr, R.1
  • 83
    • 58149127425 scopus 로고    scopus 로고
    • Chronic urotensin II infusion enhances macrophage foam cell formation and atherosclerosis in apolipoprotein E-knockout mice
    • Shiraishi, Y., Watanabe, T., Suguro, T., Nagashima, M., Kato, R., Hongo, S., et al. (2008). Chronic urotensin II infusion enhances macrophage foam cell formation and atherosclerosis in apolipoprotein E-knockout mice.J. Hypertens. 26, 1955-1965.
    • (2008) J. Hypertens. , vol.26 , pp. 1955-1965
    • Shiraishi, Y.1    Watanabe, T.2    Suguro, T.3    Nagashima, M.4    Kato, R.5    Hongo, S.6
  • 84
    • 11844271454 scopus 로고    scopus 로고
    • Urotensin-II is present in pancreatic extracts and inhibits insulin release in the perfused rat pancreas
    • Silvestre, R. A., Egido, E. M., Hernandez, R., Leprince, J., Chatenet, D., Tollemer, H., et al. (2004). Urotensin-II is present in pancreatic extracts and inhibits insulin release in the perfused rat pancreas. Eur. J. Endocrinol. 151, 803-809.
    • (2004) Eur. J. Endocrinol. , vol.151 , pp. 803-809
    • Silvestre, R.A.1    Egido, E.M.2    Hernandez, R.3    Leprince, J.4    Chatenet, D.5    Tollemer, H.6
  • 86
    • 69249137477 scopus 로고    scopus 로고
    • Endocytosis and signalling: intertwining molecular networks
    • Sorkin, A., and von Zastrow, M. (2009). Endocytosis and signalling: intertwining molecular networks. Nat. Rev. Mol. CellBiol. 10, 609-622.
    • (2009) Nat. Rev. Mol. CellBiol. , vol.10 , pp. 609-622
    • Sorkin, A.1    von Zastrow, M.2
  • 87
    • 34249799747 scopus 로고    scopus 로고
    • Urotensin-II and its receptor (UT-R) are expressed in rat brain endothelial cells, and urotensin-II via UT-R stimulates angiogenesis in vivo and in vitro
    • Spinazzi, R., Albertin, G., Nico, B., Guidolin, D., Di Liddo, R., Rossi, G. P., et al. (2006). Urotensin-II and its receptor (UT-R) are expressed in rat brain endothelial cells, and urotensin-II via UT-R stimulates angiogenesis in vivo and in vitro. Int. J. Mol. Med. 18, 1107-1112.
    • (2006) Int. J. Mol. Med. , vol.18 , pp. 1107-1112
    • Spinazzi, R.1    Albertin, G.2    Nico, B.3    Guidolin, D.4    Di Liddo, R.5    Rossi, G.P.6
  • 89
    • 0141534246 scopus 로고    scopus 로고
    • Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain
    • Sugo, T., Murakami, Y., Shimomura, Y., Harada, M., Abe, M., Ishibashi, Y., et al. (2003). Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain. Biochem. Biophys. Res. Commun. 310, 860-868.
    • (2003) Biochem. Biophys. Res. Commun. , vol.310 , pp. 860-868
    • Sugo, T.1    Murakami, Y.2    Shimomura, Y.3    Harada, M.4    Abe, M.5    Ishibashi, Y.6
  • 90
    • 84858228729 scopus 로고    scopus 로고
    • G protein-coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and patho-physiological function
    • Tadevosyan, A., Vaniotis, G., Allen, B. G., Hebert, T. E., and Nattel, S. (2012). G protein-coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and patho-physiological function. J. Physiol. 590, 1313-1330.
    • (2012) J. Physiol. , vol.590 , pp. 1313-1330
    • Tadevosyan, A.1    Vaniotis, G.2    Allen, B.G.3    Hebert, T.E.4    Nattel, S.5
  • 92
    • 8144222927 scopus 로고    scopus 로고
    • Receptor activity-independent recruitment of betaarrestin2 reveals specific signalling modes
    • Terrillon, S., and Bouvier, M. (2004). Receptor activity-independent recruitment of betaarrestin2 reveals specific signalling modes. EMBO J. 23,3950-3961.
    • (2004) EMBO J , vol.23 , pp. 3950-3961
    • Terrillon, S.1    Bouvier, M.2
  • 95
    • 0041331762 scopus 로고    scopus 로고
    • Urotensin II acts centrally to increase epinephrine and ACTH release and cause potent inotropic and chronotropic actions
    • Watson, A. M., Lambert, G. W., Smith, K. J., and May, C. N. (2003). Urotensin II acts centrally to increase epinephrine and ACTH release and cause potent inotropic and chronotropic actions. Hypertension 42, 373-379.
    • (2003) Hypertension , vol.42 , pp. 373-379
    • Watson, A.M.1    Lambert, G.W.2    Smith, K.J.3    May, C.N.4
  • 96
    • 73349119699 scopus 로고    scopus 로고
    • Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin
    • Xu, D., Borges, G. R., Grobe, J. L., Pelham, C. J., Yang, B., and Sigmund, C. D. (2009). Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension 54, 1240-1247.
    • (2009) Hypertension , vol.54 , pp. 1240-1247
    • Xu, D.1    Borges, G.R.2    Grobe, J.L.3    Pelham, C.J.4    Yang, B.5    Sigmund, C.D.6
  • 97
    • 5144222594 scopus 로고    scopus 로고
    • Role of urotensin II in peripheral tissue as an autocrine/paracrine growth factor
    • Yoshimoto, T., Matsushita, M., and Hirata, Y (2004). Role of urotensin II in peripheral tissue as an autocrine/paracrine growth factor. Peptides25, 1775-1781.
    • (2004) Peptides , vol.25 , pp. 1775-1781
    • Yoshimoto, T.1    Matsushita, M.2    Hirata, Y.3
  • 98
    • 43449112074 scopus 로고    scopus 로고
    • Urotensin II induces phenotypic differentiation, migration, and collagen synthesis of adventitial fibroblasts from rat aorta
    • Zhang, Y G., Li, J., Li, Y G., and Wei, R. H. (2008). Urotensin II induces phenotypic differentiation, migration, and collagen synthesis of adventitial fibroblasts from rat aorta. J. Hypertens. 26, 1119-1126.
    • (2008) J. Hypertens. , vol.26 , pp. 1119-1126
    • Zhang, Y.G.1    Li, J.2    Li, Y.G.3    Wei, R.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.