Human urotensin-II is a potent vasoactive peptide: Pharmacological characterization in the rat, mouse, dog and primate

Journal of Cardiovascular Pharmacology

Volumn 36, Issue 5 SUPPL. 1, 2000, Pages

  Douglas, S A ^a   Ashton, D J ^a   Sauermelch, C F ^a   Coatney, R W ^a   Ohlstein, D H ^a   Ruffolo, M R ^a   Ohlstein, E H ^a   Aiyar, N V ^a   Willette, R N ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Coronary artery; Endothelin 1; G protein coupled receptor; GPR14; Hemodynamics; Orphan receptor; Urotensin II; Vasoconstriction

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GPR 14; UNCLASSIFIED DRUG; UROTENSIN II;

ARTICLE; BLOOD VESSEL REACTIVITY; CORONARY ARTERY; DOG; HEART FUNCTION; HEMOSTASIS; MONKEY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE FIBER; SPECIES DIFFERENCE; VASOCONSTRICTION;

ANIMALS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMODYNAMIC PROCESSES; HUMANS; MACACA FASCICULARIS; MALE; MICE; MICE, INBRED C57BL; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; UROTENSINS; VASOCONSTRICTION;

EID: 0033766157     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200000006-00001     Document Type: Article

References (17)

1. A novel putative neuropeptide receptor expressed in neural tissue, including sensory epithelia
2. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors
3. Human U-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
4. Orphan G protein-coupled receptors: A neglected opportunity for pioneer drug discovery
5. Identification of the natural ligand of an orphan GPCR involved in the regulation of vasoconstriction
6. Distribution and molecular forms of urotensin II and its role in cardiovascular regulation in vertebrates
7. Cloning and sequence analysis of cDNAs encoding precursors of urotensin II-α and -γ
8. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord
9. Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors
10. Pharmacological evidence for the presence of three distinct functional endothelin receptor subtypes in the rabbit lateral saphenous vein
11. Complex effects of Gillichthys U-II on rat aortic strips
12. Contraction of major artery segments of rat by fish neuropeptide urotensin II
13. Functional receptors for fish neuropeptide urotensin II in major rat arteries
14. Pharmacological effects of urotensins: Regional vascular effects of urotensins I and II in the rat
15. Cardiovascular effects of urotensin II in anaesthetized and pithed rats
16. Vasodepressor effects of urotensin II in rats
17. Effect of endothelin on systemic and regional hemodynamics in rats