Cisplatin-Induced Apoptosis Inhibits Autophagy, Which Acts as a Pro-Survival Mechanism in Human Melanoma Cells

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Del Bello, Barbara ^a   Toscano, Marzia ^a   Moretti, Daniele ^a   Maellaro, Emilia ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; [1 [(1 FORMYL 2 PHENYLETHYL)CARBAMOYL] 2 METHYLPROPYL]CARBAMIC ACID BENZYL ESTER; AUTOPHAGY PROTEIN 5; BECLIN 1; CALPAIN; CALPEPTIN; CASPASE 3; CASPASE 7; CELL PROTEIN; CISPLATIN; PROTEIN ATG14; PROTEIN LC3 II; TREHALOSE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; ATG5 GENE; AUTOPHAGY; CELL PROTECTION; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; ENZYME ACTIVATION; FEEDBACK SYSTEM; GENE SILENCING; HUMAN; HUMAN CELL; MELANOMA CELL;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ADENINE; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MELANOMA; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; SIGNAL TRANSDUCTION; TREHALOSE;

EID: 84874238503     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057236     Document Type: Article

References (46)

1. Levine B, Klionsky DJ, (2004) Development of self-digestion: molecular mechanismsand biological functions of autophagy. Dev Cell 6: 463-467.
2. Eskelinen EL, Saftig P, (2009) Autophagy: a lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta 1793: 664-673.
3. Cuervo AM, (2004) Autophagy: in sickness and in health. Trends Cell Biol 14: 70-77.
4. Eisenberg-Lerner A, Kimchi A, (2009) The paradox of autophagy and ist implication in cancer etiology and therapy. Apoptosis 14: 376-391.
5. Levy JM, Thorburn A, (2011) Targeting autophagy during cancer therapy to improve clinical outcomes. Pharmacol Ther 131: 130-141.
6. Chen S, Rehman SK, Zhang W, Wen A, Yao L, et al. (2010) Autophagy is a therapeutic target in anticancer drug resistance. Biochim Biophys Acta 1806: 220-229.
7. Choi KS, (2012) Autophagy and cancer. Exp Mol Med 44: 109-120.
8. Goll DE, Thompson VF, Li H, Wei W, Cong J, (2003) The calpain system. Physiol Rev 83: 731-801.
9. Suzuki K, Hata S, Kawabata Y, Sorimachi H, (2004) Structure, activation and biology of calpain. Diabetes 53: S12-S18.
10. Ono Y, Sorimachi H, (2012) Calpains: an elaborate proteolytic system. Biochim Biophys Acta 1824: 224-236.
11. Moretti D, Del Bello B, Cosci E, Biagioli M, Miracco C, et al. (2009) Novel variants of muscle calpain 3 identified in human melanoma cells: cisplatin-induced changes in vitro and differential expression in melanocytic lesions. Carcinogenesis 30: 960-967.
12. Demarchi F, Schneider C, (2007) The calpain system as a modulator of stress/damage response. Cell Cycle 6: 136-138.
13. Madden DT, Egger L, Bredesen DE, (2007) A calpain-like protease inhibits autophagic cell death. Autophagy 3: 519-522.
14. Xia HG, Zhang L, Chen G, Zhang T, Liu J, et al. (2010) Control of basal autophagy by calpain1 mediated cleavage of ATG5. Autophagy 6: 61-66.
15. Yoo BH, Wu X, Li Y, Haniff M, Sasazuki T, et al. (2010) Oncogenic ras-induced down-regulation of autophagy mediator Beclin-1 is required for malignant transformation of intestinal epithelial cells. J Biol Chem 285: 5438-5449.
16. Del Bello B, Moretti D, Gamberucci A, Maellaro E, (2007) Cross-talk between calpain and caspase-3/-7 in cisplatin-induced apoptosis of melanoma cells: a major role of calpain inhibition in cell death protection and p53 status. Oncogene 26: 2717-2726.
17. Supino R, Mapelli E, Sanfilippo O, Silvestro L, (1992) Biological and enzymatic features of human melanoma clones with different invasive potential. Melanoma Res 2: 377-384.
18. Del Bello B, Valentini MA, Mangiavacchi P, Comporti M, Maellaro E, (2004) Role of caspases-3 and-7 in Apaf-1 proteolytic cleavage and degradation events during cisplatin-induced apoptosis in melanoma cells. Exp Cell Res 293: 302-310.
19. Mallya SK, Meyer S, Bozyczko-Coyne D, Siman R, Ator MA, (1998) A sensitive, continuously recording fluorogenic assay for calpain. Biochem Biophys Res Commun 248: 293-296.
20. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, et al. (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4: 151-175.
21. Romero-Calvo I, Ocòn B, Martìnez-Moya P, Suàrez MD, Zarzuelo A, et al. (2010) Reversible Ponceau staining as a loading control alternative to actin in Western blots. Anal Biochem 401: 318-320.
22. Biederbick A, Kern HF, Elsässer HP, (1995) Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles. Eur J Cell Biol 66: 3-14.
23. Mizushima N, Yoshimori T, (2007) How to interpret LC3 immunoblotting. Autophagy 3: 542-545.
24. Petiot A, Ogier-Denis E, Blommaart EF, Meijer AJ, Codogno P, (2000) Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem 275: 992-998.
25. Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC, (2007) Trehalose, a novel mTORindependent autophagy enhancer, accelerates the clearance of mutant huntingtin and alphasynuclein. J Biol Chem 282: 5641-5652.
26. Ciuffreda L, Di Sanza C, Incani UC, Milella M, (2010) The mTOR pathway: a new target in cancer therapy. Curr Cancer Drug Targets 10: 484-495.
27. Harhaji-Trajkovic L, Vilimanovich U, Kravic-Stevovic T, Bumbasirevic V, Trajkovic V, (2009) AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells. J.
28. Liu D, Yang Y, Liu Q, Wang J, (2011) Inhibition of autophagy by 3-MA potentiates cisplatin induced apoptosis in esophageal squamous cell carcinoma cells. Med Oncol 28: 105-111.
29. Jang C, Kaushal V, Shah SV, Kaushal GP, (2008) Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells. Am J Physiol Renal Physiol 294: F777-F787.
30. Guo XL, Li D, Hu F, Song JR, Zhang SS, et al. (2012) Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells. Cancer Lett 320: 171-179.
31. Dadakhujaev S, Jung EJ, Noh HS, Hah YS, Kim CJ, et al. (2009) Interplay between autophagy and apoptosis in TrkA-induced cell death. Autophagy 5: 103-105.
32. Wirawan E, Vande Walle L, Kersse K, Cornelis S, Claerhout S, et al. (2010) Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria. Cell Death Dis 1: e18.
33. Luo S, Rubinsztein DC, (2010) Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death Differ 17: 268-277.
34. Norman JM, Cohen GM, Bampton ET, (2010) The in vitro cleavage of the hAtg proteins by cell death proteases. Autophagy 6: 1042-1056.
35. Lazova R, Pawelek JM, (2009) Why do melanomas get so dark? Exp Dermatol 18: 934-938.
36. Lazova R, Klump V, Pawelek J, (2010) Autophagy in cutaneous malignant melanoma. J Cutan Pathol 37: 256-268.
37. Han C, Sun B, Wang W, Cai W, Lou D, et al. (2011) Overexpression of microtubule-associated protein-1 light chain 3 is associated with melanoma metastasis and vasculogenic mimicry. Tohoku J Exp Med 223: 243-251.
38. Armstrong JL, Corazzari M, Martin S, Pagliarini V, Falasca L, et al. (2011) Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition. Clin Cancer Res 17: 2216-2226.
39. Marino ML, Fais S, Djavaheri-Mergny M, Villa A, Meschini S, et al. (2010) Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells. Cell Death Dis 1: e87.
40. Yang Z, Lei Z, Li B, Zhou Y, Zhang GM, et al. (2010) Rapamycin inhibits lung metastasis of B16 melanoma cells through down-regulating alphav integrin expression and up-regulating apoptosis signalling. Cancer Sci 101: 494-500.
41. Wangpaichitr M, Wu C, You M, Kuo MT, Feun L, et al. (2008) Inhibition of mTor restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins. Eur J Pharmacol 591: 124-127.
42. Williams A, Sarkar S, Cuddon P, Ttofi EK, Saiki S, et al. (2008) Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat Chem Biol 4: 295-305.
43. Yousefi S, Perozzo R, Schmid I, Ziemiecki A, Schaffner T, et al. (2006) Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol 8: 1124-1132.
44. Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, et al. (2008) Regulation of autophagy by cytoplasmic p53. Nat Cell Biol 10: 676-687.
45. Zhang JY, Peng C, Shi H, Wang S, Wang Q, et al. (2009) Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain. J Alzheimer Dis 16: 39-47.
46. Levine B, Yuan J, (2005) Autophagy in cell death: an innocent convict? J Clin Invest 115: 2679-2688.