-
1
-
-
77950263954
-
China National Diabetes and Metabolic Disorders Study Group: Prevalence of diabetes among men and women in China
-
Yang W, Lu J, Weng J, Jia W, Ji L, et al. (2010) China National Diabetes and Metabolic Disorders Study Group: Prevalence of diabetes among men and women in China. N Engl J Med 362: 1090-1101.
-
(2010)
N Engl J Med
, vol.362
, pp. 1090-1101
-
-
Yang, W.1
Lu, J.2
Weng, J.3
Jia, W.4
Ji, L.5
-
2
-
-
0242383401
-
Obesity-is it a genetic disorder
-
Loos RJ, Bouchard C, (2003) Obesity-is it a genetic disorder? J Intern Med 254: 401-425.
-
(2003)
J Intern Med
, vol.254
, pp. 401-425
-
-
Loos, R.J.1
Bouchard, C.2
-
3
-
-
31544453288
-
Phenotypic and genetic clustering of diabetes and metabolic syndrome in Chinese families with type 2 diabetes mellitus
-
Li JK, Ng MC, So WY, Chiu CK, Ozaki R, et al. (2006) Phenotypic and genetic clustering of diabetes and metabolic syndrome in Chinese families with type 2 diabetes mellitus. Diabetes Metab Res Rev 22: 46-52.
-
(2006)
Diabetes Metab Res Rev
, vol.22
, pp. 46-52
-
-
Li, J.K.1
Ng, M.C.2
So, W.Y.3
Chiu, C.K.4
Ozaki, R.5
-
4
-
-
34249777814
-
Variation in FTO contributes to childhood obesity and severe adult obesity
-
Dina C, Meyre D, Gallina S, Durand E, Korner A, et al. (2007) Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 39: 724-726.
-
(2007)
Nat Genet
, vol.39
, pp. 724-726
-
-
Dina, C.1
Meyre, D.2
Gallina, S.3
Durand, E.4
Korner, A.5
-
5
-
-
34248594090
-
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
-
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894.
-
(2007)
Science
, vol.316
, pp. 889-894
-
-
Frayling, T.M.1
Timpson, N.J.2
Weedon, M.N.3
Zeggini, E.4
Freathy, R.M.5
-
6
-
-
41749090524
-
Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants
-
Hinney A, Nguyen TT, Scherag A, Friedel S, Brönner G, et al. (2007) Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS ONE 2: e1361.
-
(2007)
PLoS ONE
, vol.2
-
-
Hinney, A.1
Nguyen, T.T.2
Scherag, A.3
Friedel, S.4
Brönner, G.5
-
7
-
-
34547625955
-
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
-
Scuteri A, Sanna S, Chen WM, Uda M, Albai G, et al. (2007) Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 3: e115.
-
(2007)
PLoS Genet
, vol.3
-
-
Scuteri, A.1
Sanna, S.2
Chen, W.M.3
Uda, M.4
Albai, G.5
-
8
-
-
44349142294
-
Common variants near MC4R are associated with fat mass, weight and risk of obesity
-
Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40: 768-775.
-
(2008)
Nat Genet
, vol.40
, pp. 768-775
-
-
Loos, R.J.1
Lindgren, C.M.2
Li, S.3
Wheeler, E.4
Zhao, J.H.5
-
9
-
-
58149163141
-
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
-
Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, et al. (2009) Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41: 18-24.
-
(2009)
Nat Genet
, vol.41
, pp. 18-24
-
-
Thorleifsson, G.1
Walters, G.B.2
Gudbjartsson, D.F.3
Steinthorsdottir, V.4
Sulem, P.5
-
10
-
-
58149163142
-
Genetic Investigation of Anthropometric Traits Consortium. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
-
Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, et al. (2009) Genetic Investigation of Anthropometric Traits Consortium. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41: 25-34.
-
(2009)
Nat Genet
, vol.41
, pp. 25-34
-
-
Willer, C.J.1
Speliotes, E.K.2
Loos, R.J.3
Li, S.4
Lindgren, C.M.5
-
11
-
-
78049337953
-
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
-
Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, et al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42: 937-948.
-
(2010)
Nat Genet
, vol.42
, pp. 937-948
-
-
Speliotes, E.K.1
Willer, C.J.2
Berndt, S.I.3
Monda, K.L.4
Thorleifsson, G.5
-
12
-
-
34249885875
-
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
-
Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, et al. (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316: 1341-1345.
-
(2007)
Science
, vol.316
, pp. 1341-1345
-
-
Scott, L.J.1
Mohlke, K.L.2
Bonnycastle, L.L.3
Willer, C.J.4
Li, Y.5
-
13
-
-
84880255967
-
Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population
-
doi:10.1038/ijo.2012.175
-
Robiou-du-Pont S, Bonnefond A, Yengo L, Vaillant E, Lobbens S, et al. (2012) Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population. Int J Obes doi:10.1038/ijo.2012.175.
-
(2012)
Int J Obes
-
-
Robiou-du-Pont, S.1
Bonnefond, A.2
Yengo, L.3
Vaillant, E.4
Lobbens, S.5
-
14
-
-
50449104632
-
Implication of genetic variants near TCF7L2,SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
-
Ng MC, Park KS, Oh B, Tam CH, Cho YM, et al. (2008) Implication of genetic variants near TCF7L2,SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes 57: 2226-2233.
-
(2008)
Diabetes
, vol.57
, pp. 2226-2233
-
-
Ng, M.C.1
Park, K.S.2
Oh, B.3
Tam, C.H.4
Cho, Y.M.5
-
15
-
-
77952701364
-
Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1,and WFS1 in type 2 diabetes in a Chinese population
-
Han X, Luo Y, Ren Q, Zhang X, Wang F, et al. (2010) Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1,and WFS1 in type 2 diabetes in a Chinese population. BMC Med Genet 11: 81.
-
(2010)
BMC Med Genet
, vol.11
, pp. 81
-
-
Han, X.1
Luo, Y.2
Ren, Q.3
Zhang, X.4
Wang, F.5
-
16
-
-
49249104932
-
Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan
-
Horikawa Y, Miyake K, Yasuda K, Enya M, Hirota Y, et al. (2008) Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. J Clin Endocrinol Metab 93: 3136-3141.
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 3136-3141
-
-
Horikawa, Y.1
Miyake, K.2
Yasuda, K.3
Enya, M.4
Hirota, Y.5
-
17
-
-
84862564504
-
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians
-
Li H, Kilpeläinen TO, Liu C, Zhu J, Liu Y, et al. (2012) Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia 55: 981-995.
-
(2012)
Diabetologia
, vol.55
, pp. 981-995
-
-
Li, H.1
Kilpeläinen, T.O.2
Liu, C.3
Zhu, J.4
Liu, Y.5
-
18
-
-
0021813187
-
Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
-
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419.
-
(1985)
Diabetologia
, vol.28
, pp. 412-419
-
-
Matthews, D.R.1
Hosker, J.P.2
Rudenski, A.S.3
Naylor, B.A.4
Treacher, D.F.5
-
19
-
-
0036516860
-
Predictive value of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults-study on optimal cut-off points of body mass index and waist circumference in Chinese adults
-
Cooperartive Meta-analysis Group of the Working Group on Obesity in China
-
Cooperartive Meta-analysis Group of the Working Group on Obesity in China (2002) Predictive value of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults-study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci 15: 83-95.
-
(2002)
Biomed Environ Sci
, vol.15
, pp. 83-95
-
-
-
20
-
-
77952746932
-
Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2,LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese
-
Ng MC, Tam CH, So WY, Ho JS, Chan AW, et al. (2010) Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2,LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. J Clin Endocrinol Metab 95: 2418-2425.
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 2418-2425
-
-
Ng, M.C.1
Tam, C.H.2
So, W.Y.3
Ho, J.S.4
Chan, A.W.5
-
21
-
-
80052540977
-
Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals
-
Takeuchi F, Yamamoto K, Katsuya T, Nabika T, Sugiyama T, et al. (2011) Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals. Diabetologia 54: 1350-1359.
-
(2011)
Diabetologia
, vol.54
, pp. 1350-1359
-
-
Takeuchi, F.1
Yamamoto, K.2
Katsuya, T.3
Nabika, T.4
Sugiyama, T.5
-
22
-
-
33845984333
-
Epidemic obesity and type 2 diabetes in Asia
-
Yoon KH, Lee JH, Kim JW, Cho JH, Choi YH, et al. (2006) Epidemic obesity and type 2 diabetes in Asia. Lancet 368: 1681-1688.
-
(2006)
Lancet
, vol.368
, pp. 1681-1688
-
-
Yoon, K.H.1
Lee, J.H.2
Kim, J.W.3
Cho, J.H.4
Choi, Y.H.5
-
23
-
-
0842268349
-
Ethnic differences in insulin sensitivity and β-cell function in premenopausal or early perimenopausal women without diabetes: the Study of Women's Health Across the Nation (SWAN)
-
Torrens JI, Skurnick J, Davidow AL, Korenman SG, Santoro N, et al. (2004) Ethnic differences in insulin sensitivity and β-cell function in premenopausal or early perimenopausal women without diabetes: the Study of Women's Health Across the Nation (SWAN). Diabetes Care 27: 354-361.
-
(2004)
Diabetes Care
, vol.27
, pp. 354-361
-
-
Torrens, J.I.1
Skurnick, J.2
Davidow, A.L.3
Korenman, S.G.4
Santoro, N.5
-
24
-
-
84863670156
-
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases
-
Perry JR, Voight BF, Yengo L, Amin N, Dupuis J, et al. (2012) Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet 8: e1002741.
-
(2012)
PLoS Genet
, vol.8
-
-
Perry, J.R.1
Voight, B.F.2
Yengo, L.3
Amin, N.4
Dupuis, J.5
-
25
-
-
80052397686
-
Studies of metabolic phenotypic correlates of 15 obesity associated gene variants
-
Sandholt CH, Vestmar MA, Bille DS, Borglykke A, Almind K, et al. (2011) Studies of metabolic phenotypic correlates of 15 obesity associated gene variants. PLoS One 6: e23531.
-
(2011)
PLoS One
, vol.6
-
-
Sandholt, C.H.1
Vestmar, M.A.2
Bille, D.S.3
Borglykke, A.4
Almind, K.5
-
26
-
-
84868337361
-
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
-
Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, et al. (2012) Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 44: 981-990.
-
(2012)
Nat Genet
, vol.44
, pp. 981-990
-
-
Morris, A.P.1
Voight, B.F.2
Teslovich, T.M.3
Ferreira, T.4
Segrè, A.V.5
-
27
-
-
0024451643
-
Molecular cloning and expression of brain-derived neurotrophic factor
-
Leibrock J, Lottspeich F, Hohn A, Hofer M, Hengerer B, et al. (1989) Molecular cloning and expression of brain-derived neurotrophic factor. Nature 341: 149-152.
-
(1989)
Nature
, vol.341
, pp. 149-152
-
-
Leibrock, J.1
Lottspeich, F.2
Hohn, A.3
Hofer, M.4
Hengerer, B.5
-
28
-
-
0025873435
-
The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
-
Klein R, Nanduri V, Jing SA, Lamballe F, Tapley P, et al. (1991) The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell 66: 395-403.
-
(1991)
Cell
, vol.66
, pp. 395-403
-
-
Klein, R.1
Nanduri, V.2
Jing, S.A.3
Lamballe, F.4
Tapley, P.5
-
29
-
-
0035200716
-
Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors
-
Cassiman D, Denef C, Desmet VJ, Roskams T, (2001) Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors. Hepatology 33: 148-158.
-
(2001)
Hepatology
, vol.33
, pp. 148-158
-
-
Cassiman, D.1
Denef, C.2
Desmet, V.J.3
Roskams, T.4
-
30
-
-
33745009522
-
BDNF is expressed in skeletal muscle satellite cells and inhibits myogenic differentiation
-
Mousavi K, Jasmin BJ, (2006) BDNF is expressed in skeletal muscle satellite cells and inhibits myogenic differentiation. J Neurosci 26: 5739-5749.
-
(2006)
J Neurosci
, vol.26
, pp. 5739-5749
-
-
Mousavi, K.1
Jasmin, B.J.2
-
31
-
-
0032848721
-
Abundant production of brain-derived neurotrophic factor by adult visceral epithelia. Implications for paracrine and target-derived neurotrophic functions
-
Lommatzsch M, Braun A, Mannsfeldt A, Botchkarev VA, Botchkareva NV, et al. (1999) Abundant production of brain-derived neurotrophic factor by adult visceral epithelia. Implications for paracrine and target-derived neurotrophic functions. Am J Pathol 155: 1183-1193.
-
(1999)
Am J Pathol
, vol.155
, pp. 1183-1193
-
-
Lommatzsch, M.1
Braun, A.2
Mannsfeldt, A.3
Botchkarev, V.A.4
Botchkareva, N.V.5
-
32
-
-
57649136525
-
Adipose tissue and skeletal muscle plasticity modulates metabolic health
-
Ukropec J, Ukropcova B, Kurdiova T, Gasperikova D, Klimes I, (2008) Adipose tissue and skeletal muscle plasticity modulates metabolic health. Arch Physiol Biochem 114: 357-368.
-
(2008)
Arch Physiol Biochem
, vol.114
, pp. 357-368
-
-
Ukropec, J.1
Ukropcova, B.2
Kurdiova, T.3
Gasperikova, D.4
Klimes, I.5
-
33
-
-
0034653422
-
BDNF regulates eating behavior and locomotor activity in mice
-
Kernie SG, Liebl DJ, Parada LF, (2000) BDNF regulates eating behavior and locomotor activity in mice. EMBO J 19: 1290-1300.
-
(2000)
EMBO J
, vol.19
, pp. 1290-1300
-
-
Kernie, S.G.1
Liebl, D.J.2
Parada, L.F.3
-
34
-
-
0034792085
-
Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity
-
Rios M, Fan G, Fekete C, Kelly J, Bates B, et al. (2001) Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol 15: 1748-1757.
-
(2001)
Mol Endocrinol
, vol.15
, pp. 1748-1757
-
-
Rios, M.1
Fan, G.2
Fekete, C.3
Kelly, J.4
Bates, B.5
-
35
-
-
0035200051
-
Brain-derived neurotrophic factor regulates energy expenditure through the central nervous system in obese diabetic mice
-
Nonomura T, Tsuchida A, Ono-Kishino M, Nakagawa T, Taiji M, et al. (2001) Brain-derived neurotrophic factor regulates energy expenditure through the central nervous system in obese diabetic mice. Int J Exp Diabetes Res 2: 201-209.
-
(2001)
Int J Exp Diabetes Res
, vol.2
, pp. 201-209
-
-
Nonomura, T.1
Tsuchida, A.2
Ono-Kishino, M.3
Nakagawa, T.4
Taiji, M.5
-
36
-
-
50449091665
-
Brain-derived neurotrophic factor and obesity in the WAGR syndrome
-
Han JC, Liu QR, Jones M, Levinn RL, Menzie CM, et al. (2008) Brain-derived neurotrophic factor and obesity in the WAGR syndrome. N Engl J Med 359: 918-927.
-
(2008)
N Engl J Med
, vol.359
, pp. 918-927
-
-
Han, J.C.1
Liu, Q.R.2
Jones, M.3
Levinn, R.L.4
Menzie, C.M.5
-
37
-
-
33845530762
-
Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene
-
Gray J, Yeo GS, Cox JJ, Morton J, Adlam AL, et al. (2006) Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. Diabetes 55: 3366-3371.
-
(2006)
Diabetes
, vol.55
, pp. 3366-3371
-
-
Gray, J.1
Yeo, G.S.2
Cox, J.J.3
Morton, J.4
Adlam, A.L.5
-
38
-
-
79955774117
-
Associations of single nucleotide polymorphisms (SNPs) in brain-derived neurotrophic factor (BDNF) with BDNF expression in human ventromedial hypothalamus (VMH) and with body mass index
-
Ong C, Han JC, Hyde TM, Lipska BK, Mou Z, et al. (2010) Associations of single nucleotide polymorphisms (SNPs) in brain-derived neurotrophic factor (BDNF) with BDNF expression in human ventromedial hypothalamus (VMH) and with body mass index. Obesity 18: S61-S62.
-
(2010)
Obesity
, vol.18
-
-
Ong, C.1
Han, J.C.2
Hyde, T.M.3
Lipska, B.K.4
Mou, Z.5
-
39
-
-
34447127251
-
Brain-derived neurotrophic factor (BDNF) and type 2diabetes
-
Krabbe KS, Nielsen AR, Krogh-Madsen R, Plomgaard P, Rasmussen P, et al. (2007) Brain-derived neurotrophic factor (BDNF) and type 2diabetes. Diabetologia 50: 431-438.
-
(2007)
Diabetologia
, vol.50
, pp. 431-438
-
-
Krabbe, K.S.1
Nielsen, A.R.2
Krogh-Madsen, R.3
Plomgaard, P.4
Rasmussen, P.5
-
40
-
-
84859560308
-
Dendritically targeted BDNF mRNA is essential for energy balance and response to leptin
-
Liao GY, An JJ, Gharami K, Waterhouse EG, Vanevski F, et al. (2012) Dendritically targeted BDNF mRNA is essential for energy balance and response to leptin. Nat Med 18: 564-571.
-
(2012)
Nat Med
, vol.18
, pp. 564-571
-
-
Liao, G.Y.1
An, J.J.2
Gharami, K.3
Waterhouse, E.G.4
Vanevski, F.5
-
41
-
-
84862777036
-
Meta-analysis identifies common variants associated with body mass index in east Asians
-
Wen W, Cho YS, Zheng W, Dorajoo R, Kato N, et al. (2012) Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet 44: 307-311.
-
(2012)
Nat Genet
, vol.44
, pp. 307-311
-
-
Wen, W.1
Cho, Y.S.2
Zheng, W.3
Dorajoo, R.4
Kato, N.5
|