Microwave synthesis and in vitro stability of diclofenac-β- cyclodextrin conjugate for colon delivery

Carbohydrate Polymers

Volumn 93, Issue 2, 2013, Pages 512-517

  Vieira, Amélia C F ^a,b,d   Serra, Arménio C ^b   Carvalho, Rui A ^c   Gonsalves, Alexandra ^b   Figueiras, Ana ^a   Veiga, Francisco J ^a   Basit, Abdul W ^d   Rocha Gonsalves, António M D'A ^b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Colonic targeting; Fermentation; Large intestine; Microbiota; Oligosaccharides; Prodrugs

Indexed keywords

COLONIC TARGETING; LARGE INTESTINE; MATRIX ASSISTED LASER DESORPTION; MICROBIOTAS; NUCLEAR OVERHAUSER EFFECTS; NUCLEOPHILIC SUBSTITUTIONS; PRODRUGS; PROTON NUCLEAR MAGNETIC RESONANCE;

ESTERIFICATION; ESTERS; FERMENTATION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOSACCHARIDES; PURIFICATION;

NUCLEAR MAGNETIC RESONANCE;

BETA CYCLODEXTRIN DERIVATIVE; DICLOFENAC; DRUG CARRIER; PRODRUG;

ANAEROBIC GROWTH; ARTICLE; BODY FLUID; CHEMISTRY; COLON; DRUG DELIVERY SYSTEM; DRUG STABILITY; FECES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; MASS SPECTROMETRY; METHODOLOGY; MICROWAVE RADIATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TIME;

ANAEROBIOSIS; BETA-CYCLODEXTRINS; BODY FLUIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLON; DICLOFENAC; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; FECES; HUMANS; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MICROWAVES; PRODRUGS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS;

EID: 84874151691     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carbpol.2012.12.053     Document Type: Article

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