Trypanosoma brucei S-adenosylmethionine decarboxylase N terminus is essential for allosteric activation by the regulatory subunit prozyme

Journal of Biological Chemistry

Volumn 288, Issue 7, 2013, Pages 5232-5240

  Velez, Nahir ^a   Brautigam, Chad A ^a   Phillips, Margaret A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOMETDC; ALLOSTERIC ACTIVATION; CONFORMATIONAL CHANGE; HETERODIMERIZATION; N TERMINUS; N-TERMINALS; PARALOGS; REGULATORY SUBUNITS; S-ADENOSYLMETHIONINE DECARBOXYLASE; TRYPANOSOMA BRUCEI;

BIOCHEMISTRY;

BIOLOGY;

ADENOSYLMETHIONINE DECARBOXYLASE; ALANINE; ENZYME; HETERODIMER; LEUCINE; METHIONINE; POLYAMINE; PROZYME; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BIOSYNTHESIS; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DELETION MUTANT; DIMERIZATION; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME MODIFICATION; ENZYME STRUCTURE; HETERODIMERIZATION; HUMAN; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; SEDIMENTATION RATE; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STEADY STATE; STRUCTURE ANALYSIS; TRYPANOSOMA BRUCEI;

ADENOSYLMETHIONINE DECARBOXYLASE; ALANINE; ALLOSTERIC SITE; AMINO ACID SEQUENCE; CATALYSIS; DIMERIZATION; ESCHERICHIA COLI; HUMANS; KINETICS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PEPTIDES; POLYAMINES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

EID: 84874054287     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.442475     Document Type: Article

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