메뉴 건너뛰기




Volumn 158, Issue 3, 2012, Pages 386-392

Hyaluronic acid-based hydrogel for regional delivery of paclitaxel to intraperitoneal tumors

Author keywords

Drug delivery; Hydrogel; Intraperitoneal; Paclitaxel; Particles

Indexed keywords

ANTITUMOR EFFECT; CROSS-LINKABLE; DRUG CONCENTRATION; HYALURONIC ACIDS; IN-SITU; IN-VITRO; INTRAPERITONEAL; NUDE MICE; OVARIAN CANCERS; PACLITAXEL; PERITONEAL CAVITY; RELEASE KINETICS; TEMPORAL AVAILABILITY; THERAPEUTIC EFFECTS;

EID: 84862777576     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.12.001     Document Type: Article
Times cited : (122)

References (56)
  • 4
    • 77953289893 scopus 로고    scopus 로고
    • Drug delivery systems for intraperitoneal therapy
    • G. Bajaj, and Y. Yeo Drug delivery systems for intraperitoneal therapy Pharm. Res. 27 5 2010 735 738
    • (2010) Pharm. Res. , vol.27 , Issue.5 , pp. 735-738
    • Bajaj, G.1    Yeo, Y.2
  • 7
    • 79959774261 scopus 로고    scopus 로고
    • Recent progress in the diagnosis and treatment of ovarian cancer
    • D. Jelovac, and D.K. Armstrong Recent progress in the diagnosis and treatment of ovarian cancer CA Cancer J. Clin. 61 3 2011 183 203
    • (2011) CA Cancer J. Clin. , vol.61 , Issue.3 , pp. 183-203
    • Jelovac, D.1    Armstrong, D.K.2
  • 8
    • 0017853566 scopus 로고
    • Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer
    • R.L. Dedrick, C.E. Myers, P.M. Bungay, and V.T. DeVita Jr. Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer Cancer Treat. Rep. 62 1 1978 1 11 (Pubitemid 8278518)
    • (1978) Cancer Treatment Reports , vol.62 , Issue.1 , pp. 1-11
    • Dedrick, R.L.1    Myers, C.E.2    Bungay, P.M.3    Devita Jr, V.T.4
  • 9
    • 0034916275 scopus 로고    scopus 로고
    • Intraperitoneal drug delivery of antineoplastics
    • M. Markman Intraperitoneal drug delivery of antineoplastics Drugs 61 8 2001 1057 1065 (Pubitemid 32663868)
    • (2001) Drugs , vol.61 , Issue.8 , pp. 1057-1065
    • Markman, M.1
  • 10
    • 69749097864 scopus 로고    scopus 로고
    • Evidence-based medicine in the treatment of peritoneal carcinomatosis: Past, present, and future
    • N. Aviram, S. Alexander, G. Alfredo, E. Jesus, and P. Pompiliu Evidence-based medicine in the treatment of peritoneal carcinomatosis: Past, present, and future J. Surg. Oncol. 100 4 2009 335 344
    • (2009) J. Surg. Oncol. , vol.100 , Issue.4 , pp. 335-344
    • Aviram, N.1    Alexander, S.2    Alfredo, G.3    Jesus, E.4    Pompiliu, P.5
  • 12
    • 33846512864 scopus 로고    scopus 로고
    • Impact of intraperitoneal, sustained delivery of paclitaxel on the expression of P-glycoprotein in ovarian tumors
    • DOI 10.1016/j.jconrel.2006.10.007, PII S0168365906005451
    • E.A. Ho, P.L. Soo, C. Allen, and M. Piquette-Miller Impact of intraperitoneal, sustained delivery of paclitaxel on the expression of P-glycoprotein in ovarian tumors J. Control. Release 117 1 2007 20 27 (Pubitemid 46161865)
    • (2007) Journal of Controlled Release , vol.117 , Issue.1 , pp. 20-27
    • Ho, E.A.1    Soo, P.L.2    Allen, C.3    Piquette-Miller, M.4
  • 13
    • 79952980483 scopus 로고    scopus 로고
    • Combination drug delivery strategy for the treatment of multidrug resistant ovarian cancer
    • P. Zahedi, R. De Souza, L. Huynh, M. Piquette-Miller, and C. Allen Combination drug delivery strategy for the treatment of multidrug resistant ovarian cancer Mol. Pharmaceutics 8 1 2011 260 269
    • (2011) Mol. Pharmaceutics , vol.8 , Issue.1 , pp. 260-269
    • Zahedi, P.1    De Souza, R.2    Huynh, L.3    Piquette-Miller, M.4    Allen, C.5
  • 14
    • 0242298095 scopus 로고    scopus 로고
    • Pharmacokinetics and tissue distribution of intraperitoneal paclitaxel with different carrier solutions
    • DOI 10.1007/s00280-003-0680-2
    • F. Mohamed, P. Marchettini, O.A. Stuart, and P.H. Sugarbaker Pharmacokinetics and tissue distribution of intraperitoneal paclitaxel with different carrier solutions Cancer Chemother. Pharmacol. 52 5 2003 405 410 (Pubitemid 37363614)
    • (2003) Cancer Chemotherapy and Pharmacology , vol.52 , Issue.5 , pp. 405-410
    • Mohamed, F.1    Marchettini, P.2    Stuart, O.A.3    Sugarbaker, P.H.4
  • 15
    • 0042855665 scopus 로고    scopus 로고
    • Pharmacokinetics and tissue distribution of intraperitoneal docetaxel with different carrier solutions
    • DOI 10.1016/S0022-4804(03)00162-8
    • F. Mohamed, O.A. Stuart, and P.H. Sugarbaker Pharmacokinetics and tissue distribution of intraperitoneal docetaxel with different carrier solutions J. Surg. Res. 113 1 2003 114 120 (Pubitemid 36999800)
    • (2003) Journal of Surgical Research , vol.113 , Issue.1 , pp. 114-120
    • Mohamed, F.1    Stuart, O.A.2    Sugarbaker, P.H.3
  • 16
    • 34547639533 scopus 로고    scopus 로고
    • Effects of carrier on disposition and antitumor activity of intraperitoneal paclitaxel
    • DOI 10.1007/s11095-007-9298-0
    • M. Tsai, Z. Lu, J. Wang, T.-K. Yeh, M. Wientjes, and J. Au Effects of carrier on disposition and antitumor activity of intraperitoneal paclitaxel Pharm. Res. 24 9 2007 1691 1701 (Pubitemid 47206619)
    • (2007) Pharmaceutical Research , vol.24 , Issue.9 , pp. 1691-1701
    • Tsai, M.1    Lu, Z.2    Wang, J.3    Yeh, T.-K.4    Wientjes, M.G.5    Au, J.L.-S.6
  • 17
    • 33745728898 scopus 로고    scopus 로고
    • Challenges for chemotherapy in ovarian cancer
    • R.F. Ozols Challenges for chemotherapy in ovarian cancer Ann. Oncol. 17 Suppl. 5 2006 v181 v187
    • (2006) Ann. Oncol. , vol.17 , Issue.SUPPL. 5
    • Ozols, R.F.1
  • 18
    • 33644908789 scopus 로고    scopus 로고
    • Intraperitoneal chemotherapy of ovarian cancer: A review, with a focus on practical aspects of treatment
    • DOI 10.1200/JCO.2005.05.2456
    • M. Markman, and J.L. Walker Intraperitoneal chemotherapy of ovarian cancer: a review, with a focus on practical aspects of treatment J. Clin. Oncol. 24 6 2006 988 994 (Pubitemid 46638854)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.6 , pp. 988-994
    • Markman, M.1    Walker, J.L.2
  • 19
    • 33845350357 scopus 로고    scopus 로고
    • Paclitaxel nanoparticle inhibits growth of ovarian cancer xenografts and enhances lymphatic targeting
    • DOI 10.1007/s00280-006-0256-z
    • H. Lu, B. Li, Y. Kang, W. Jiang, Q. Huang, Q. Chen, L. Li, and C. Xu Paclitaxel nanoparticle inhibits growth of ovarian cancer xenografts and enhances lymphatic targeting Cancer Chemother. Pharmacol. 59 2 2007 175 181 (Pubitemid 44885147)
    • (2007) Cancer Chemotherapy and Pharmacology , vol.59 , Issue.2 , pp. 175-181
    • Lu, H.1    Li, B.2    Kang, Y.3    Jiang, W.4    Huang, Q.5    Chen, Q.6    Li, L.7    Xu, C.8
  • 20
    • 34247561766 scopus 로고    scopus 로고
    • In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing postsurgical adhesions
    • DOI 10.1097/01.sla.0000251519.49405.55, PII 0000065820070500000022
    • Y. Yeo, T. Ito, E. Bellas, C.B. Highley, R. Marini, and D.S. Kohane In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing postsurgical adhesions Ann. Surg. 245 5 2007 819 824 (Pubitemid 46684114)
    • (2007) Annals of Surgery , vol.245 , Issue.5 , pp. 819-824
    • Yeo, Y.1    Ito, T.2    Bellas, E.3    Highley, C.B.4    Marini, R.5    Kohane, D.S.6
  • 23
    • 57349141530 scopus 로고    scopus 로고
    • Tumor-penetrating microparticles for intraperitoneal therapy of ovarian cancer
    • Z. Lu, M. Tsai, D. Lu, J. Wang, M.G. Wientjes, and J.L.S. Au Tumor-penetrating microparticles for intraperitoneal therapy of ovarian cancer J. Pharmacol. Exp. Ther. 327 3 2008 673 682
    • (2008) J. Pharmacol. Exp. Ther. , vol.327 , Issue.3 , pp. 673-682
    • Lu, Z.1    Tsai, M.2    Lu, D.3    Wang, J.4    Wientjes, M.G.5    Au, J.L.S.6
  • 25
    • 78649318605 scopus 로고    scopus 로고
    • Peritoneal retention of liposomes: Effects of lipid composition, PEG coating and liposome charge
    • S. Dadashzadeh, N. Mirahmadi, M.H. Babaei, and A.M. Vali Peritoneal retention of liposomes: effects of lipid composition, PEG coating and liposome charge J. Control. Release 148 2010 177 186
    • (2010) J. Control. Release , vol.148 , pp. 177-186
    • Dadashzadeh, S.1    Mirahmadi, N.2    Babaei, M.H.3    Vali, A.M.4
  • 26
    • 36549085538 scopus 로고    scopus 로고
    • Polymers in the prevention of peritoneal adhesions
    • DOI 10.1016/j.ejpb.2007.03.027, PII S0939641107002457, Interactive Polymers for Pharmaceutical and Biomedical Applications
    • Y. Yeo, and D.S. Kohane Polymers in the prevention of peritoneal adhesions Eur. J. Pharm. Biopharm. 68 1 2008 57 66 (Pubitemid 350186238)
    • (2008) European Journal of Pharmaceutics and Biopharmaceutics , vol.68 , Issue.1 , pp. 57-66
    • Yeo, Y.1    Kohane, D.S.2
  • 27
    • 18144413904 scopus 로고    scopus 로고
    • In vitro and in vivo characterization of a novel biocompatible polymer-lipid implant system for the sustained delivery of paclitaxel
    • DOI 10.1016/j.jconrel.2005.02.008
    • E.A. Ho, V. Vassileva, C. Allen, and M. Piquette-Miller In vitro and in vivo characterization of a novel biocompatible polymer-lipid implant system for the sustained delivery of paclitaxel J. Control. Release 104 1 2005 181 191 (Pubitemid 40615245)
    • (2005) Journal of Controlled Release , vol.104 , Issue.1 , pp. 181-191
    • Ho, E.A.1    Vassileva, V.2    Allen, C.3    Piquette-Miller, M.4
  • 28
    • 41549145733 scopus 로고    scopus 로고
    • Drug release mechanism of paclitaxel from a chitosan-lipid implant system: Effect of swelling, degradation and morphology
    • P.L. Soo, J. Cho, J. Grant, E. Ho, M. Piquette-Miller, and C. Allen Drug release mechanism of paclitaxel from a chitosan-lipid implant system: effect of swelling, degradation and morphology Eur. J. Pharm. Biopharm. 69 1 2008 149 157
    • (2008) Eur. J. Pharm. Biopharm. , vol.69 , Issue.1 , pp. 149-157
    • Soo, P.L.1    Cho, J.2    Grant, J.3    Ho, E.4    Piquette-Miller, M.5    Allen, C.6
  • 29
    • 34548563731 scopus 로고    scopus 로고
    • Novel biocompatible intraperitoneal drug delivery system increases tolerability and therapeutic efficacy of paclitaxel in a human ovarian cancer xenograft model
    • DOI 10.1007/s00280-007-0449-0
    • V. Vassileva, J. Grant, R. De Souza, C. Allen, and M. Piquette-Miller Novel biocompatible intraperitoneal drug delivery system increases tolerability and therapeutic efficacy of paclitaxel in a human ovarian cancer xenograft model Cancer Chemother. Pharmacol. 60 6 2007 907 914 (Pubitemid 47389398)
    • (2007) Cancer Chemotherapy and Pharmacology , vol.60 , Issue.6 , pp. 907-914
    • Vassileva, V.1    Grant, J.2    De Souza, R.3    Allen, C.4    Piquette-Miller, M.5
  • 31
    • 67349093532 scopus 로고    scopus 로고
    • Biocompatibility of injectable chitosan-phospholipid implant systems
    • R. De Souza, P. Zahedi, C.J. Allen, and M. Piquette-Miller Biocompatibility of injectable chitosan-phospholipid implant systems Biomaterials 30 23-24 2009 3818 3824
    • (2009) Biomaterials , vol.30 , Issue.2324 , pp. 3818-3824
    • De Souza, R.1    Zahedi, P.2    Allen, C.J.3    Piquette-Miller, M.4
  • 32
    • 67649664258 scopus 로고    scopus 로고
    • Chitosan-phospholipid blend for sustained and localized delivery of docetaxel to the peritoneal cavity
    • P. Zahedi, R. De Souza, M. Piquette-Miller, and C. Allen Chitosan-phospholipid blend for sustained and localized delivery of docetaxel to the peritoneal cavity Int. J. Pharm. 377 1-2 2009 76 84
    • (2009) Int. J. Pharm. , vol.377 , Issue.12 , pp. 76-84
    • Zahedi, P.1    De Souza, R.2    Piquette-Miller, M.3    Allen, C.4
  • 33
    • 84856513525 scopus 로고    scopus 로고
    • The antitumor effect of a thermosensitive polymeric hydrogel containing paclitaxel in a peritoneal carcinomatosis model
    • doi:10.1007/s10637-010-9499-y in press
    • J. Yu, H.J. Lee, K. Hur, M.K. Kwak, T.S. Han, W.H. Kim, S.C. Song, K. Yanagihara, H.K. Yang, The antitumor effect of a thermosensitive polymeric hydrogel containing paclitaxel in a peritoneal carcinomatosis model, Invest. New Drugs (in press), doi: 10.1007/s10637-010-9499-y.
    • Invest. New Drugs
    • Yu, J.1    Lee, H.J.2    Hur, K.3    Kwak, M.K.4    Han, T.S.5    Kim, W.H.6    Song, S.C.7    Yanagihara, K.8    Yang, H.K.9
  • 34
    • 77955072472 scopus 로고    scopus 로고
    • 5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice
    • Y. Wang, C. Gong, L. Yang, Q. Wu, S. Shi, H. Shi, Z. Qian, and Y. Wei 5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice BMC Cancer 10 2010 402
    • (2010) BMC Cancer , vol.10 , pp. 402
    • Wang, Y.1    Gong, C.2    Yang, L.3    Wu, Q.4    Shi, S.5    Shi, H.6    Qian, Z.7    Wei, Y.8
  • 35
    • 34447503641 scopus 로고    scopus 로고
    • Prevention of peritoneal adhesions with an in situ cross-linkable hyaluronan hydrogel delivering budesonide
    • DOI 10.1016/j.jconrel.2007.04.016, PII S0168365907001927
    • Y. Yeo, M. Adil, E. Bellas, A. Astashkina, N. Chaudhary, and D.S. Kohane Prevention of peritoneal adhesions with an in situ cross-linkable hyaluronan hydrogel delivering budesonide J. Control. Release 120 3 2007 178 185 (Pubitemid 47064479)
    • (2007) Journal of Controlled Release , vol.120 , Issue.3 , pp. 178-185
    • Yeo, Y.1    Adil, M.2    Bellas, E.3    Astashkina, A.4    Chaudhary, N.5    Kohane, D.S.6
  • 37
    • 0032819928 scopus 로고    scopus 로고
    • New strategy for chemical modification of hyaluronic acid: Preparation of functionalized derivatives and their use in the formation of novel biocompatible hydrogels
    • DOI 10.1002/(SICI)1097-4636(199911)47:2<152::AID-JBM5>3.0.CO;2-I
    • P. Bulpitt, and D. Aeschlimann New strategy for chemical modification of hyaluronic acid: preparation of functionalized derivatives and their use in the formation of novel biocompatible hydrogels J. Biomed. Mater. Res. 47 2 1999 152 169 (Pubitemid 29409734)
    • (1999) Journal of Biomedical Materials Research , vol.47 , Issue.2 , pp. 152-169
    • Bulpitt, P.1    Aeschlimann, D.2
  • 38
    • 34547639164 scopus 로고    scopus 로고
    • Enhanced peritoneal ovarian tumor dissemination by tissue transglutaminase
    • DOI 10.1158/0008-5472.CAN-07-0307
    • M. Satpathy, L. Cao, R. Pincheira, R. Emerson, R. Bigsby, H. Nakshatri, and D. Matei Enhanced peritoneal ovarian tumor dissemination by tissue transglutaminase Cancer Res. 67 15 2007 7194 7202 (Pubitemid 47206547)
    • (2007) Cancer Research , vol.67 , Issue.15 , pp. 7194-7202
    • Satpathy, M.1    Cao, L.2    Pincheira, R.3    Emerson, R.4    Bigsby, R.5    Nakshatri, H.6    Matei, D.7
  • 39
    • 0022474231 scopus 로고
    • Patterns of changes in proteins in the peritoneal fluid of women during the periovulatory phase of the menstrual cycle
    • P.X. Bouckaert, J.L. Evers, W.H. Doesburg, L.A. Schellekens, P.H. Brombacher, and R. Rolland Patterns of changes in proteins in the peritoneal fluid of women during the periovulatory phase of the menstrual cycle J. Reprod. Fertil. 77 2 1986 329 336 (Pubitemid 16075388)
    • (1986) Journal of Reproduction and Fertility , vol.77 , Issue.2 , pp. 329-336
    • Bouckaert, P.X.J.M.1    Evers, J.L.H.2    Doesburg, W.H.3
  • 40
    • 34249901034 scopus 로고    scopus 로고
    • Peritoneal adhesion prevention with an in situ cross-linkable hyaluronan gel containing tissue-type plasminogen activator in a rabbit repeated-injury model
    • DOI 10.1016/j.biomaterials.2007.04.033, PII S0142961207003547
    • Y. Yeo, E. Bellas, C.B. Highley, R. Langer, and D.S. Kohane Peritoneal adhesion prevention with an in situ cross-linkable hyaluronan gel containing tissue-type plasminogen activator in a rabbit repeated injury model Biomaterials 28 25 2007 3704 3713 (Pubitemid 46863374)
    • (2007) Biomaterials , vol.28 , Issue.25 , pp. 3704-3713
    • Yeo, Y.1    Bellas, E.2    Highley, C.B.3    Langer, R.4    Kohane, D.S.5
  • 41
    • 0014012174 scopus 로고
    • Peritoneal fluid volume and the oestrus cycle in mice
    • F. Hartveit, and S. Thunold Peritoneal fluid volume and the oestrus cycle in mice Nature 210 5041 1966 1123 1125
    • (1966) Nature , vol.210 , Issue.5041 , pp. 1123-1125
    • Hartveit, F.1    Thunold, S.2
  • 43
    • 0031961779 scopus 로고    scopus 로고
    • The pathobiology of peritonitis
    • DOI 10.1016/S0016-5085(98)70646-8
    • J.C. Hall, K.A. Heel, J.M. Papadimitriou, and C. Platell The pathobiology of peritonitis Gastroenterology 114 1 1998 185 196 (Pubitemid 28020968)
    • (1998) Gastroenterology , vol.114 , Issue.1 , pp. 185-196
    • Hall, J.C.1    Heel, K.A.2    Papadimitriou, J.M.3    Platell, C.4
  • 44
    • 33644755543 scopus 로고    scopus 로고
    • The influence of implantation site on the biocompatibility and survival of alginate encapsulated pig islets in rats
    • DOI 10.1016/j.biomaterials.2006.01.028, PII S0142961206000871
    • D. Dufrane, M.v. Steenberghe, R.-M. Goebbels, A. Saliez, Y. Guiot, and P. Gianello The influence of implantation site on the biocompatibility and survival of alginate encapsulated pig islets in rats Biomaterials 27 17 2006 3201 3208 (Pubitemid 43344334)
    • (2006) Biomaterials , vol.27 , Issue.17 , pp. 3201-3208
    • Dufrane, D.1    Steenberghe, M.V.2    Goebbels, R.-M.3    Saliez, A.4    Guiot, Y.5    Gianello, P.6
  • 46
    • 33745031294 scopus 로고    scopus 로고
    • In situ cross-linkable hyaluronic acid hydrogels prevent post-operative abdominal adhesions in a rabbit model
    • DOI 10.1016/j.biomaterials.2006.04.043, PII S0142961206004376
    • Y. Yeo, C.B. Highley, E. Bellas, T. Ito, R. Marini, R. Langer, and D.S. Kohane In situ cross-linkable hyaluronic acid hydrogels prevent post-operative abdominal adhesions in a rabbit model Biomaterials 27 27 2006 4698 4705 (Pubitemid 43870121)
    • (2006) Biomaterials , vol.27 , Issue.27 , pp. 4698-4705
    • Yeo, Y.1    Highley, C.B.2    Bellas, E.3    Ito, T.4    Marini, R.5    Langer, R.6    Kohane, D.S.7
  • 47
    • 0023199652 scopus 로고
    • Taxol is converted to 7-epitaxol, a biologically active isomer, in cell culture medium
    • I. Ringel, and S.B. Horwitz Taxol is converted to 7-epitaxol, a biologically active isomer, in cell culture medium J. Pharmacol. Exp. Ther. 242 2 1987 692 698 (Pubitemid 17143505)
    • (1987) Journal of Pharmacology and Experimental Therapeutics , vol.242 , Issue.2 , pp. 692-698
    • Ringel, I.1    Horwitz, S.B.2
  • 48
    • 0027332063 scopus 로고
    • High-performance liquid chromatographic procedure for the quantitative determination of paclitaxel (Taxol) in human plasma
    • T.A. Willey, E.J. Bekos, R.C. Gaver, G.F. Duncan, L.K. Tay, J.H. Beijnen, and R.H. Farmen High-performance liquid chromatographic procedure for the quantitative determination of paclitaxel (Taxol) in human plasma J. Chromatogr. 621 2 1993 231 238
    • (1993) J. Chromatogr. , vol.621 , Issue.2 , pp. 231-238
    • Willey, T.A.1    Bekos, E.J.2    Gaver, R.C.3    Duncan, G.F.4    Tay, L.K.5    Beijnen, J.H.6    Farmen, R.H.7
  • 49
    • 0015122797 scopus 로고
    • The route of absorption of intraperitoneally administered compounds
    • G. Lukas, S.D. Brindle, and P. Greengard The route of absorption of intraperitoneally administered compounds J. Pharmacol. Exp. Ther. 178 3 1971 562 566
    • (1971) J. Pharmacol. Exp. Ther. , vol.178 , Issue.3 , pp. 562-566
    • Lukas, G.1    Brindle, S.D.2    Greengard, P.3
  • 50
    • 0021810511 scopus 로고
    • Lymphatic transport of liposome-encapsulated agents: Effects of liposome size following intraperitoneal administration
    • DOI 10.1002/jps.2600740902
    • K. Hirano, and C.A. Hunt Lymphatic transport of liposome-encapsulated agents: effects of liposome size following intraperitoneal administration J. Pharm. Sci. 74 9 1985 915 921 (Pubitemid 15014130)
    • (1985) Journal of Pharmaceutical Sciences , vol.74 , Issue.9 , pp. 915-921
    • Hirano, K.1    Hunt, C.A.2
  • 51
    • 5344234787 scopus 로고    scopus 로고
    • The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs
    • DOI 10.1016/j.ijpharm.2004.07.019, PII S0378517304004582
    • J.E. Kipp The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs Int. J. Pharm. 284 1-2 2004 109 122 (Pubitemid 39349144)
    • (2004) International Journal of Pharmaceutics , vol.284 , Issue.1-2 , pp. 109-122
    • Kipp, J.E.1
  • 52
    • 0029080002 scopus 로고
    • Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs
    • G.G. Liversidge, and K.C. Cundy Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs Int. J. Pharm. 125 1 1995 91 97
    • (1995) Int. J. Pharm. , vol.125 , Issue.1 , pp. 91-97
    • Liversidge, G.G.1    Cundy, K.C.2
  • 53
  • 55
    • 0034880214 scopus 로고    scopus 로고
    • Cremophor EL: The drawbacks and advantages of vehicle selection for drug formulation
    • DOI 10.1016/S0959-8049(01)00171-X, PII S095980490100171X
    • H. Gelderblom, J. Verweij, K. Nooter, and A. Sparreboom Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation Eur. J. Cancer 37 13 2001 1590 1598 (Pubitemid 32778603)
    • (2001) European Journal of Cancer , vol.37 , Issue.13 , pp. 1590-1598
    • Gelderblom, H.1    Verweij, J.2    Nooter, K.3    Sparreboom, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.