Pregnane glycosides interfere with steroidogenic enzymes to down-regulate corticosteroid production in human adrenocortical H295R cells

Journal of Cellular Physiology

Volumn 228, Issue 5, 2013, Pages 1120-1126

  Komarnytsky, Slavko ^a,b   Esposito, Debora ^a,b   Poulev, Alexander ^a   Raskin, Ilya ^a  

^a RUTGERS UNIVERSITY   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMFEBUTAMONE; ANDROSTENEDIONE; CHLORZOXAZONE; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CORTICOSTEROID; CORTICOSTERONE; CORTISONE; COUMARIN; CYTOCHROME P450; CYTOCHROME P450 11B1; CYTOCHROME P450 21A1; DICLOFENAC; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; MIDAZOLAM; OMEPRAZOLE; PACLITAXEL; PHENACETIN; PREGNANE DERIVATIVE; PROGESTERONE; STEROID 11BETA MONOOXYGENASE; STEROID 17ALPHA MONOOXYGENASE; STEROID 21 MONOOXYGENASE; TESTOSTERONE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; GENE EXPRESSION; HORMONE RELEASE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR BINDING; STEROID METABOLISM; STEROIDOGENESIS; STRUCTURE ACTIVITY RELATION;

3-HYDROXYSTEROID DEHYDROGENASES; ADRENAL CORTEX HORMONES; ANDROSTENEDIONE; ANIMALS; CELL LINE, TUMOR; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CORTICOSTERONE; CORTISONE; GLYCOSIDES; HUMANS; PREGNANES; PROGESTERONE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873858511     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24262     Document Type: Article

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