Potato protease inhibitors inhibit food intake and increase circulating cholecystokinin levels by a trypsin-dependent mechanism

International Journal of Obesity

Volumn 35, Issue 2, 2011, Pages 236-243

  Komarnytsky, S ^a   Cook, A ^a   Raskin, I ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

body weight; cholecystokinin; potato; protease inhibitors; satiety

Indexed keywords

CHOLECYSTOKININ; ENZYME INHIBITOR; GLUCOSE; INSULIN; PROTEASE INHIBITOR CONCERATE DERIVED FROM POTATO; TRYPSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG INHIBITION; ENZYME METABOLISM; FOOD INTAKE; GENETIC TRANSCRIPTION; GLUCOSE BLOOD LEVEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SATIETY; STOMACH EMPTYING; WEIGHT GAIN;

ANIMALS; CELLS, CULTURED; CHOLECYSTOKININ; DUODENUM; ENERGY INTAKE; GASTRIC EMPTYING; MALE; PHYTOTHERAPY; PLANT PREPARATIONS; PROTEASE INHIBITORS; PROTEINS; RATS; RATS, WISTAR; SATIATION; SOLANUM TUBEROSUM; TRYPSIN INHIBITORS;

RATTUS; SOLANUM TUBEROSUM;

EID: 79951682968     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2010.192     Document Type: Article

References (44)

1. Imming P, Sinning C, Meyer A. Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov 2006; 5: 821-834. (Pubitemid 44480536)
2. Padwal R, Kezouh A, Levine M, Etminan M. Long-term persis-tence with orlistat and sibutramine in a population-based cohort. Int J Obes (Lond) 2007; 31: 1567-1570. (Pubitemid 47482652)
3. Liener IE. The nutritional significance of plant protease inhibi-tors. Proc Nutr Soc 1979; 38: 109-113.
4. Shewry PR. Tuber storage proteins. Ann Bot 2003; 91: 755-769. (Pubitemid 41308837)
5. Schnebeli HP, Braun NJ. Proteinase inhibitors as drugs. In: Barrett AJ, Salvesen G (eds). Proteinase Inhibitors. Elsevier: Amsterdam, 1986, pp 613-627.
6. Hill AJ, Peikin SR, Ryan CA, Blundell JE. Oral administration of proteinase inhibitor II from potatoes reduces energy intake in man. Physiol Behav 1990; 48: 241-246. (Pubitemid 20270234)
7. Schwartz JG, Guan D, Green GM, Phillips WT. Treatment with an oral proteinase inhibitor slows gastric emptying and acutely reduces glucose and insulin levels after a liquid meal in type II diabetic patients. Diabetes Care 1994; 17: 255-262. (Pubitemid 24123404)
8. Levitt J. The isolation and preliminary fractionation of proteins from dormant and growing potato tubers. Plant Physiol 1951; 26: 59-65.
9. Bryant J, Green TR, Gurusaddaiah T, Ryan CA. Proteinase inhibitor II from potatoes: isolation and characterization of its protomer components. Biochemistry 1976; 15: 3418-3424.
10. Kim MH, Park SC, Kim JY, Lee SY, Lim HT, Cheong H et al. Purification and characterization of a heat-stable inhibitor from the tubers of new potato variety 'Golden Valley". Biochem Biophys Res Commun 2006; 346: 681-686. (Pubitemid 43949253)
11. Pouvreau L, Gruppen H, Piersma SR, van den Broek LA, van Koningsveld GA, Voragen AG. Relative abundance and inhibitory distribution of protease inhibitors in potato juice from cv. Elkana. J Agric Food Chem 2001; 49: 2864-2874. (Pubitemid 32826082)
12. Van Kaningsveld GA. Physico-chemical and functional properties of potato proteins. PhD thesis, University of Wageningen 2001.
13. Liddle RA, Goldfine ID, Williams JA. Bioassay of plasma cholecystokinin in rats: effects of food, trypsin inhibitor, and alcohol. Gastroenterology 1984; 87: 542-549. (Pubitemid 14061405)
14. Louie DS, May D, Miller P, Owyang C. Cholecystokinin mediates feedback regulation of pancreatic enzyme secretion in rats. Am J Physiol 1986; 250: G252-G259.
15. Fried M, Erlacher U, Schwizer W, Lochner C, Koerfer J, Beglinger C et al. Role of cholecystokinin in the regulation of gastric emptying and pancreatic enzyme secretion in humans. Studies with the cholecystokinin-receptor antagonist loxiglumide. Gastroenterology 1991; 101: 503-511.
16. Schafmayer A, Becker HD, Werner M, Folsch UR, Creutzfeldt W. Plasma cholecystokinin levels in patients with chronic pancrea-titis. Digestion 1985; 32: 136-139. (Pubitemid 15046228)
17. Schneeman BO, Lyman RL. Distribution of cholecystokinin activity in the rat small intestine. Digestion 1977; 15: 28-33. (Pubitemid 8014537)
18. Miyasaka K, Guan DF, Liddle RA, Green GM. Feedback regulation by trypsin: evidence for intraluminal CCK-releasing peptide. Am J Physiol 1989; 257: G175-G181.
19. Spannagel AW, Green GM, Guan D, Liddle RA, Faull K, Reeve Jr JR. Purification and characterization of a luminal cholecystokinin-releasing factor from rat intestinal secretion. Proc Natl Acad Sci USA 1996; 93: 4415-4420. (Pubitemid 26144301)
20. Chavan JK, Hejgaard J. Detection and partial characterisation of subtilisin inhibitors in legume seeds by isoelectric focusing. J Sci Food Agric 1981; 32: 857-862.
21. Yakoby N, Raskin I. A simple method to determine trypsin and chymotrypsin inhibitory activity. JBiochem Biophys Methods 2004; 59: 241-251. (Pubitemid 38681047)
22. Rolls BJ, Hetherington M, Burley VJ. The specificity of satiety: the influence of foods of different macronutrient content on the development of satiety. Physiol Behav 1988; 43: 145-153.
23. Shi G, Leray V, Scarpignato C, Bentouimou N, Bruley des Varannes S, Cherbut C et al. Specific adaptation of gastric emptying to diets with differing protein content in the rat: is endogenous cholecystokinin implicated? Gut 1997; 41: 612-618. (Pubitemid 27496138)
24. Rindi G, Grant SG, Yiangou Y, Ghatei MA, Bloom SR, Bautch VL et al. Development of neuroendocrine tumors in the gastrointestinal tract of transgenic mice. Heterogeneity of hormone expression. Am J Pathol 1990; 136: 1349-1363. (Pubitemid 20210334)
25. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63. (Pubitemid 14203433)
26. Komarnytsky S, Borisjuk N, Yakoby N, Garvey A, Raskin I. Cosecretion of protease inhibitor stabilizes antibodies produced by plant roots. Plant Physiol 2006; 141: 1185-1193. (Pubitemid 44223271)
27. Kizelsztein P, Govorko D, Komarnytsky S, Evans A, Wang Z, Cefalu WT et al. 20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model. Am J Physiol Endocrinol Metab 2009; 296: E433-E439.
28. Winer J, Jung CK, Shackel I, Williams PM. Development and validation of real-time quantitative reverse transcriptase-poly-merase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal Biochem 1999; 270: 41-49. (Pubitemid 29230718)
29. Ausich R, Sheabar FZ, Stomp R, Ryan CA, Davidson B. Method for the elimination of Kunitz and Bowman-Birk trypsin inhibitors and carboxypeptidase inhibitor from potato proteins. US patent no 6686456 2004; 1-12.
30. Cleveland TE, Thornburg RW, Ryan CA. Molecular characteriza-tion of a wound-inducible inhibitor I gene from potato and the processing of its mRNA and protein. Plant Mol Biol 1987; 8: 199-207.
31. Birk Y Plant Protease Inhibitors. Springer-Verlag New York, 2003.
32. Pouvreau L, Gruppen H, van Koningsveld GA, van den Broek LAM, Voragen AGJ. The most abundant protease inhibitor in potato tuber (Cv. Elkana) is a serine protease inhibitor from the Kunitz family. Journal of Agricultural and Food Chemistry 2003; 51: 5001-5005.
33. Cohn C, Joseph D. Changes in body composition attendant on force feeding. Am J Physiol 1959; 196: 965-968.
34. Cunningham KM, Daly J, Horowitz M, Read NW. Gastrointestinal adaptation to diets of differing fat composition in human volunteers. Gut 1991; 32: 483-486.
35. Liddle RA, Carter JD, McDonald AR. Dietary regulation of rat intestinal cholecystokinin gene expression. J Clin Invest 1988; 81: 2015-2019.
36. Cordier-Bussat M, Bernard C, Haouche S, Roche C, Abello J, Chayvialle JA et al. Peptones stimulate cholecystokinin secretion and gene transcription in the intestinal cell line STC-1. Endocrinology 1997; 138: 1137-1144. (Pubitemid 27089771)
37. Westerterp-Plantenga MS, Nieuwenhuizen A, Tome D, Soenen S, Westerterp KR. Dietary protein, weight loss, and weight main-tenance. Annu Rev Nutr 2009; 29: 21-41.
38. Park MI, Camilleri M. Gastric motor and sensory functions in obesity. Obes Res 2005; 13: 491-500.
39. Peters JH, Simasko SM, Ritter RC. Modulation of vagal afferent excitation and reduction of food intake by leptin and cholecys-tokinin. Physiol Behav 2006; 89: 477-485. (Pubitemid 44634574)
40. Rolls BJ, Fedoroff IC, Guthrie JF. Gender differences in eating behavior and body weight regulation. Health Psychol 1991; 10: 133-142.
41. Smeets PA, de Graaf C, Stafleu A, van Osch MJ, Nievelstein RA, van der Grond J. Effect of satiety on brain activation during chocolate tasting in men and women. Am J Clin Nutr 2006; 83: 1297-1305. (Pubitemid 44713059)
42. Goetzman ES, Tian L, Nagy TR, Gower BA, Schoeb TR, Elgavish A et al. HIV protease inhibitor ritonavir induces lipoatrophy in male mice. AIDS Res Hum Retroviruses 2003; 19: 1141-1150. (Pubitemid 38037384)
43. Burton-Freeman B. Sex and cognitive dietary restraint influence cholecystokinin release and satiety in response to preloads varying in fatty acid composition and content. J Nutr 2005; 135: 1407-1414. (Pubitemid 40799603)
44. Niederau C, Meereis-Schwanke K, Klonowski-Stumpe H, Herberg L. CCK-resistance in Zucker obese versus lean rats. Regul Pept 1997; 70: 97-104. (Pubitemid 27362300)