Does branched-chain amino acids supplementation modulate skeletal muscle remodeling through inflammation modulation? Possible mechanisms of action

Journal of Nutrition and Metabolism

Volumn 2012, Issue , 2012, Pages

  Nicastro, Humberto ^a   Da Luz, Claudia Ribeiro ^a   Chaves, Daniela Fojo Seixas ^a   Bechara, Luiz Roberto Grassmann ^a   Voltarelli, Vanessa Azevedo ^a   Rogero, Marcelo MacEdo ^a   Lancha, Antonio Herbert ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84873802152     PISSN: 20900724     EISSN: 20900732     Source Type: Journal    
DOI: 10.1155/2012/136937     Document Type: Review

References (118)

1. Spiering B. A., Kraemer W. J., Anderson J. M., Armstrong L. E., Nindl B. C., Volek J. S., Maresh C. M., Resistance exercise biology: manipulation of resistance exercise programme variables determines the responses of cellular and molecular signalling pathways. Sports Medicine 2008 38 7 527 540 2-s2.0-45549108831 10.2165/00007256-200838070-00001 (Pubitemid 351861942)
2. Glover E. I., Phillips S. M., Resistance exercise and appropriate nutrition to counteract muscle wasting and promote muscle hypertrophy. Current Opinion in Clinical Nutrition and Metabolic Care 2010 13 6 630 634 2-s2.0-78149280203 10.1097/MCO.0b013e32833f1ae5
3. Little J. P., Phillips S. M., Resistance exercise and nutrition to counteract muscle wasting. Applied Physiology, Nutrition and Metabolism 2009 34 5 817 829 2-s2.0-73649133312 10.1139/H09-093
4. Burd N. A., Tang J. E., Moore D. R., Phillips S. M., Exercise training and protein metabolism: influences of contraction, protein intake, and sex-based differences. Journal of Applied Physiology 2009 106 5 1692 1701 2-s2.0-66349103681 10.1152/japplphysiol.91351.2008
5. Fry A. C., The role of resistance exercise intensity on muscle fibre adaptations. Sports Medicine 2004 34 10 663 679 2-s2.0-4644353080 10.2165/00007256-200434100-00004 (Pubitemid 39280352)
6. Walker S., Taipale R. S., Nyman K., Kraemer W. J., Häkkinen K., Neuromuscular and hormonal responses to constant and variable resistance loadings. Medicine & Science in Sports & Exercise 2011 3 1 26 33
7. Izquierdo M., mikel.izquierdo@gmail.com González-Izal M., Navarro-Amezqueta I., Calbet J. A., Ibañez J., Malanda A., Mallor F., Häkkinen K., Kraemer W. J., Gorostiaga E. M., Effects of strength training on muscle fatigue mapping from surface EMG and blood metabolites. Medicine and Science in Sports and Exercise 2011 43 2 303 311 10.1249/MSS.0b013e3181edfa96
8. Zanchi N. E., Nicastro H., Lancha A. H. Jr., Potential antiproteolytic effects of L-leucine: observations of in vitro and in vivo studies. Nutrition and Metabolism 2008 5 1, article 20 2-s2.0-48349086611 10.1186/1743-7075-5-20
9. Nicastro H., Artioli G. G., dos Santos Costa A., Solis M. Y., da Luz C. R., Blachier F., Lancha A. H., An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions. Amino Acids 2011 40 2 287 300 2-s2.0-77952731055 10.1007/s00726-010-0636-x
10. Layman D. K., The role of leucine in weight loss diets and glucose homeostasis. Journal of Nutrition 2003 133 1 261S 267S 2-s2.0-0037224768 (Pubitemid 36070614)
11. Dreyer H. C., Drummond M. J., Pennings B., Fujita S., Glynn E. L., Chinkes D. L., Dhanani S., Volpi E., Rasmussen B. B., blrasmus@utmb.edu Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle. American Journal of Physiology 2008 294 2 E392 E400 10.1152/ajpendo. 00582.2007 (Pubitemid 351231467)
12. Nicastro H., Gualano B., de Moraes W. M. A. M., Effects of creatine supplementation on muscle wasting and glucose homeostasis in rats treated with high dose of dexamethasone. Amino Acids. In press 10.1007/s00726-011-0871-9
13. Zanchi N. E., Lancha A. H., Mechanical stimuli of skeletal muscle: implications on mTOR/p70s6k and protein synthesis. European Journal of Applied Physiology 2008 102 3 253 263 2-s2.0-37148998533 10.1007/s00421-007-0588-3 (Pubitemid 350252848)
14. Nobukuni T., Joaquin M., Roccio M., Dann S. G., Kim S. Y., Gulati P., Byfield M. P., Backer J. M., Natt F., Bos J. L., Zwartkruis F. J. T., Thomas G., Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proceedings of the National Academy of Sciences of the United States of America 2005 102 40 14238 14243 2-s2.0-26444575415 10.1073/pnas.0506925102 (Pubitemid 41429682)
15. Yoshizawa F., Hirayama S., Sekizawa H., Nagasawa T., Sugahara K., Oral administration of leucine stimulates phosphorylation of 4E-BP1 and S6K1 in skeletal muscle but not in liver of diabetic rats. Journal of Nutritional Science and Vitaminology 2002 48 1 59 64 2-s2.0-0036212848 (Pubitemid 34288925)
16. Crozier S. J., Kimball S. R., Emmert S. W., Anthony J. C., Jefferson L. S., Oral leucine administration stimulates protein synthesis in rat skeletal muscle. Journal of Nutrition 2005 135 3 376 382 2-s2.0-14944341734 (Pubitemid 40365191)
17. Busquets S., Alvarez B., Llovera M., Agell N., López-Soriano F. J., Argilés J. M., argiles@porthos.bio.ub.es Branched-chain amino acids inhibit proteolysis in rat skeletal muscle: mechanisms involved. Journal of Cellular Physiology 2000 184 3 380 384 10.1002/1097-4652(200009)184:3380::AID- JCP13>3.0.CO;2-F (Pubitemid 30625502)
18. Sandri M., Signaling in muscle atrophy and hypertrophy. Physiology 2008 23 3 160 170 2-s2.0-49049083353 10.1152/physiol.00041.2007
19. Glass D. J., Skeletal muscle hypertrophy and atrophy signaling pathways. International Journal of Biochemistry and Cell Biology 2005 37 10 1974 1984 2-s2.0-23944456384 10.1016/j.biocel.2005.04.018 (Pubitemid 41206815)
20. Wang Q., Somwar R., Bilan P. J., Liu Z., Jin J., Woodgett J. R., Klip A., Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Molecular and Cellular Biology 1999 19 6 4008 4018 2-s2.0-0033049422 (Pubitemid 29241975)
21. Bohé J., Low A., Wolfe R. R., Rennie M. J., Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response study. Journal of Physiology 2003 552 1 315 324 2-s2.0-0142062041 10.1113/jphysiol.2003.050674 (Pubitemid 37265489)
22. Rennie M. J., Anabolic resistance in critically ill patients. Critical Care Medicine 2009 37 10, supplement S398 S399 2-s2.0-70350520654 10.1097/CCM.0b013e3181b6ec1f
23. Huard J., Li Y., Fu F. H., Muscle injuries and repair: current trends in research. Journal of Bone and Joint Surgery A 2002 84 5 822 832 2-s2.0-0036563345 (Pubitemid 34925047)
24. Beaton L. J., Tarnopolsky M. A., Phillips S. M., Contraction-induced muscle damage in humans following calcium channel blocker administration. Journal of Physiology 2002 544 3 849 859 2-s2.0-0036848746 10.1113/jphysiol. 2002.022350 (Pubitemid 35355963)
25. Raastad T., truls.raastad@nih.no Risoy B. A., Benestad H. B., Fjeld J. G., Hallén J., Temporal relation between leukocyte accumulation in muscles and halted recovery 10-20 h after strength exercise. Journal of Applied Physiology 2003 95 6 2503 2509 (Pubitemid 37444996)
26. Hamada K., Vannier E., Sacheck J. M., Witsell A. L., Roubenoff R., Senescence of human skeletal muscle impairs the local inflammatory cytokine response to acute eccentric exercise. The FASEB Journal 2005 19 2 264 266 2-s2.0-13244281764 10.1096/fj.03-1286fje (Pubitemid 40189276)
27. Peterson J. M., Feeback K. D., Baas J. H., Pizza F. X., Tumor necrosis factor- α promotes the accumulation of neutrophils and macrophages in skeletal muscle. Journal of Applied Physiology 2006 101 5 1394 1399 2-s2.0-33751194420 10.1152/japplphysiol.01453.2005
28. Pedersen B. K., Steensberg A., Schjerling P., Muscle-derived interleukin-6: possible biological effects. Journal of Physiology 2001 536 2 329 337 2-s2.0-0035886973 10.1111/j.1469-7793.2001.0329c.xd (Pubitemid 32976115)
29. Tomiya A., Aizawa T., Nagatomi R., Sensui H., Kokubun S., Myofibers Express IL-6 after Eccentric Exercise. American Journal of Sports Medicine 2004 32 2 503 508 2-s2.0-1242316229 10.1177/0095399703258788 (Pubitemid 38235524)
30. Tidball J. G., Inflammatory processes in muscle injury and repair. American Journal of Physiology 2005 288 2 R345 R353 2-s2.0-12344259549 10.1152/ajpregu.00454.2004 (Pubitemid 40129595)
31. Li Y. P., Reid M. B., NF- κ B mediates the protein loss induced by TNF- α in differentiated skeletal muscle myotubes. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2000 279 4 R1165 R1170 2-s2.0-0033696398
32. Lang C. H., Frost R. A., Sepsis-induced suppression of skeletal muscle translation initiation mediated by tumor necrosis factor α Metabolism 2007 56 1 49 57 2-s2.0-33845222306 10.1016/j.metabol.2006.08.025 (Pubitemid 44855012)
33. 12 myotubes through a MEK1-sensitive mechanism. American Journal of Physiology 2005 289 1 52-1 E95 E104 10.1152/ajpendo.00397.2004 (Pubitemid 40874940)
34. Langen R. C. J., Van Der Velden J. L. J., Schols A. M. W. J., Kelders M. C. J. M., Wouters E. F. M., Janssen-Heininger Y. M. W., Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization. The FASEB Journal 2004 18 2 227 237 2-s2.0-0442324933 10.1096/fj.03-0251com (Pubitemid 38186242)
35. Coletti D., Moresi V., Adamo S., Molinaro M., Sassoon D., Tumor necrosis factor- α gene transfer induces cachexia and inhibits muscle regeneration. Genesis 2005 43 3 120 128 2-s2.0-28844451913 10.1002/gene.20160 (Pubitemid 41780911)
36. Tan Y., Peng X., Wang F., You Z., Dong Y., Wang S., Effects of tumor necrosis factor-alpha on the 26S proteasome and 19S regulator in skeletal muscle of severely scalded mice. Journal of Burn Care and Research 2006 27 2 226 233 2-s2.0-33745346649 (Pubitemid 43970330)
37. Saini A., Al-Shanti N., Faulkner S. H., Stewart C. E., Pro- and anti-apoptotic roles for IGF-I in TNF- α -induced apoptosis: a MAP kinase mediated mechanism. Growth Factors 2008 26 5 239 253 2-s2.0-52649129311 10.1080/08977190802291634
38. Li Y. P., Chen Y., Li A. S., Reid M. B., Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubes. American Journal of Physiology 2003 285 4 C806 C812 2-s2.0-0141791457 (Pubitemid 37158805)
39. Stupka N., Tarnopolsky M. A., Yardley N. J., Phillips S. M., Cellular adaptation to repeated eccentric exercise-induced muscle damage. Journal of Applied Physiology 2001 91 4 1669 1678 2-s2.0-0034802263 (Pubitemid 32900358)
40. Foulstone E. J., Huser C., Crown A. L., Holly J. M. P., Stewart C. E. H., Differential signalling mechanisms predisposing primary human skeletal muscle cells to altered proliferation and differentiation: roles of IGF-I and TNF α Experimental Cell Research 2004 294 1 223 235 2-s2.0-1242339602 10.1016/j.yexcr.2003.10.034 (Pubitemid 38229793)
41. Langen R. C., Schols A. M., Kelders M. C., Van der Velden J. L., Wouters E. F., Janssen-Heininger Y. M., Muscle wasting and impaired muscle regeneration in a murine model of chronic pulmonary inflammation. American Journal of Respiratory Cell and Molecular Biology 2006 35 6 689 696 2-s2.0-33845455679 10.1165/rcmb.2006-0103OC (Pubitemid 44901858)
42. Chen S. E., Jin B., Li Y. P., TNF- α regulates myogenesis and muscle regeneration by activating p38 MAPK. American Journal of Physiology 2007 292 5 C1660 C1671 2-s2.0-34250669605 10.1152/ajpcell.00486.2006 (Pubitemid 47080547)
43. 12 and primary myotubes by enhancing protein translation via the TNF-R1, PI3K, and MEK. American Journal of Physiology 2008 294 2 E241 E250 10.1152/ajpendo.00129.2007 (Pubitemid 351231450)
44. Dehoux M., Gobier C., Lause P., Bertrand L., Ketelslegers J. M., Thissen J. P., IGF-I does not prevent myotube atrophy caused by proinflammatory cytokines despite activation of Akt/Foxo and GSK-3beta pathways and inhibition of atrogin-1 mRNA. American Journal of Physiology 2007 292 1 145 150
45. Waters D. L., Baumgartner R. N., Garry P. J., Sarcopenia: current perspectives. Journal of Nutrition, Health and Aging 2000 4 3 133 139 2-s2.0-0033811865
46. Metter E. J., Talbot L. A., Schrager M., Conwit R., Skeletal muscle strength as a predictor of all-cause mortality in healthy men. Journals of Gerontology A 2002 57 10 B359 B365 2-s2.0-0036786911
47. Rantanen T., Harris T., Leveille S. G., Visser M., Foley D., Masaki K., Guralnik J. M., Muscle strength and body mass index as long-term predictors of mortality in initially healthy men. Journals of Gerontology A 2000 55 3 M168 M173 2-s2.0-0034096374 (Pubitemid 30243739)
48. Giresi P. G., Stevenson E. J., Theilhaber J., Koncarevic A., Parkington J., Fielding R. A., Kandarian S. C., Identification of a molecular signature of sarcopenia. Physiological Genomics 2005 21 253 263 2-s2.0-21244483460 10.1152/physiolgenomics.00249.2004 (Pubitemid 40898485)
49. Schaap L. A., Pluijm S. M., Deeg D. J., Visser M., Inflammatory markers and loss of muscle mass (Sarcopenia) and strength. American Journal of Medicine 2006 119 6 526.e9 526.e17 2-s2.0-33646902419 10.1016/j.amjmed.2005.10.049 (Pubitemid 43795180)
50. Schrager M. A., Metter E. J., Simonsick E., Ble A., Bandinelli S., Lauretani F., Ferrucci L., Sarcopenic obesity and inflammation in the InCHIANTI study. Journal of Applied Physiology 2007 102 3 919 925 2-s2.0-33847767040 10.1152/japplphysiol.00627.2006 (Pubitemid 46377013)
51. Carbó N., Ribas V., Busquets S., Alvarez B., López-Soriano F. J., Argilés J. M., Short-term effects of leptin on skeletal muscle protein metabolism in the rat. Journal of Nutritional Biochemistry 2000 11 9 431 435 2-s2.0-0033696629 10.1016/S0955-2863(00)00101-7
52. Greiwe J. S., Holloszy J. O., Semenkovich C. F., Exercise induces lipoprotein lipase and GLUT-4 protein in muscle independent of adrenergic-receptor signaling. Journal of Applied Physiology 2000 89 1 176 181 2-s2.0-0033928070 (Pubitemid 30482578)
53. Nystrom G., Pruznak A., Huber D., Frost R. A., Lang C. H., Local insulin-like growth factor I prevents sepsis-induced muscle atrophy. Metabolism 2009 58 6 787 797 2-s2.0-65549162587 10.1016/j.metabol.2009.01.015
54. Svanberg E., Frost R. A., Lang C. H., Isgaard J., Jefferson L. S., Kimball S. R., Vary T. C., tvary@psu.edu IGF-I/IGFBP-3 binary complex modulates sepsis-induced inhibition of protein synthesis in skeletal muscle. American Journal of Physiology 2000 279 5 42-5 E1145 E1158
55. Frost R. A., Nystrom G. J., Lang C. H., Endotoxin and interferon- γ inhibit translation in skeletal muscle cells by stimulating nitric oxide synthase activity. Shock 2009 32 4 416 426 2-s2.0-70349664576 10.1097/SHK.0b013e3181a034d2
56. Haddad F., Zaldivar F., Cooper D. M., Adams G. R., IL-6-induced skeletal muscle atrophy. Journal of Applied Physiology 2005 98 3 911 917 2-s2.0-14144252542 10.1152/japplphysiol.01026.2004 (Pubitemid 40283672)
57. Baeza-Raja B., Muñoz-Cánoves P., p38 MAPK-induced nuclear factor- κ B activity is required for skeletal muscle differentiation: role of interleukin-6. Molecular Biology of the Cell 2004 15 4 2013 2026 2-s2.0-1642423481 10.1091/mbc.E03-08-0585 (Pubitemid 38401847)
58. Al-Shanti N., Saini A., Faulkner S. H., Stewart C. E., Beneficial synergistic interactions of TNF- α and IL-6 in C2 skeletal myoblasts-potential cross-talk with IGF system. Growth Factors 2008 26 2 61 73 2-s2.0-42549159606 10.1080/08977190802025024 (Pubitemid 351584058)
59. Hayden M. S., Ghosh S., Signaling to NF- κ B. Genes and Development 2004 18 18 2195 2224 2-s2.0-4444376712 10.1101/gad.1228704 (Pubitemid 39209568)
60. Bonizzi G., Karin M., The two NF- κ B activation pathways and their role in innate and adaptive immunity. Trends in Immunology 2004 25 6 280 288 2-s2.0-2342464085 10.1016/j.it.2004.03.008 (Pubitemid 38610351)
61. Jackson M. J., Redox regulation of skeletal muscle. IUBMB Life 2008 60 8 497 501 2-s2.0-52049106413 10.1002/iub.72
62. Cai D., Frantz J. D., Tawa N. E. Jr., Melendez P. A., Oh B. C., Lidov H. G. W., Hasselgren P. O., Frontera W. R., Lee J., Glass D. J., Shoelson S. E., IKK β /NF- κ B activation causes severe muscle wasting in mice. Cell 2004 119 2 285 298 2-s2.0-5444262078 10.1016/j.cell.2004.09.027 (Pubitemid 39360909)
63. Ladner K. J., Caligiuri M. A., Guttridge D. C., Tumor necrosis factor-regulated biphasic activation of NF- κ b is required for cytokine-induced loss of skeletal muscle gene products. Journal of Biological Chemistry 2003 278 4 2294 2303 2-s2.0-0037462802 10.1074/jbc.M207129200 (Pubitemid 36801299)
64. Kamata H., Manabe T., Oka S. I., Kamata K., Hirata H., Hydrogen peroxide activates I κ B kinases through phosphorylation of serine residues in the activation loops. FEBS Letters 2002 519 1-3 231 237 2-s2.0-0037157177 10.1016/S0014-5793(02)02712-6 (Pubitemid 34522025)
65. Dodd S., Hain B., Judge A., Hsp70 prevents disuse muscle atrophy in senescent rats. Biogerontology 2009 10 5 605 611 2-s2.0-69249229777 10.1007/s10522-008-9203-1
66. Senf S. M., Dodd S. L., McClung J. M., Judge A. R., Hsp70 overexpression inhibits NF- κ B and Foxo3a transcriptional activities and prevents skeletal muscle atrophy. The FASEB Journal 2008 22 11 3836 3845 2-s2.0-55549101931 10.1096/fj.08-110163
67. Alonso M., Collado P. S., González-Gallego J., Melatonin inhibits the expression of the inducible isoform of nitric oxide synthase and nuclear factor kappa B activation in rat skeletal muscle. Journal of Pineal Research 2006 41 1 8 14 2-s2.0-33745574971 10.1111/j.1600-079X.2006.00323.x (Pubitemid 43980689)
68. Roberts C. K., Won D., Pruthi S., Lin S. S., Barnard R. J., Effect of a diet and exercise intervention on oxidative stress, inflammation and monocyte adhesion in diabetic men. Diabetes Research and Clinical Practice 2006 73 3 249 259 2-s2.0-33746274987 10.1016/j.diabres.2006.02.013 (Pubitemid 44107591)
69. Gielen S., Adams V., Möbius-Winkler S., Linke A., Erbs S., Yu J., Kempf W., Schubert A., Schuler G., Hambrecht R., Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. Journal of the American College of Cardiology 2003 42 5 861 868 2-s2.0-20244363895 10.1016/S0735-1097(03)00848-9 (Pubitemid 37059745)
70. Brooks S. V., Vasilaki A., Larkin L. M., McArdle A., Jackson M. J., Repeated bouts of aerobic exercise lead to reductions in skeletal muscle free radical generation and nuclear factor κ B activation. Journal of Physiology 2008 586 16 3979 3990 2-s2.0-50049091026 10.1113/jphysiol.2008.155382
71. Jimenez-Jimenez R., Cuevas M. J., Almar M., Eccentric training impairs NF- κ B activation and over-expression of inflammation-related genes induced by acute eccentric exercise in the elderly. Mechanisms of Ageing and Development 2008 129 6 313 321
72. Gomez-Cabrera M. C., Domenech E., Viña J., Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radical Biology and Medicine 2008 44 2 126 131 2-s2.0-37849021505 10.1016/j.freeradbiomed.2007. 02.001
73. Ji L. L., Modulation of skeletal muscle antioxidant defense by exercise: role of redox signaling. Free Radical Biology and Medicine 2008 44 2 142 152 2-s2.0-37849002320 10.1016/j.freeradbiomed.2007.02.031
74. Lima-Cabello E., Cuevas M. J., Garatachea N., Baldini M., Almar M., Gonzalez-Gallego J., Eccentric exercise induces nitric oxide synthase expression through nuclear factor-KB modulation in rat skeletal muscle. Journal of Applied Physiology 2010 108 3 575 583 2-s2.0-77949583896 10.1152/japplphysiol.00816. 2009
75. Harper A. E., Miller R. H., Block K. P., Branched-chain amino acid metabolism. Annual Review of Nutrition 1984 4 409 454 2-s2.0-0021197124
76. Creeth J. M., Cooper B., Donald A. S. R., Clamp J. R., Studies of the limited degradation of mucus glycoproteins. The effect of dilute hydrogen peroxide. Biochemical Journal 1983 211 2 323 332 2-s2.0-0020569744 (Pubitemid 13092523)
77. Wergedal J. E., Harper A. E., Metabolic adaptations in higher animals. 10. Glutamic dehydrogenase activity of rats consuming high protein diets. Proceedings of the Society for Experimental Biology and Medicine 1964 116 600 604
78. Felig P., Pozefsk T., Marlis E., Cahill G. F. Jr., Alanine: key role in gluconeogenesis. Science 1970 167 3920 1003 1004
79. Mallet L. E., Exton J. H., Park C. R., Control of gluconeogenesis from amino acids in the perfused rat liver. Journal of Biological Chemistry 1969 244 20 5713 5723 2-s2.0-0014691081
80. Bannai S., Christensen H. N., Vadgama J. V., Ellory J. C., Englesberg E., Guidotti G. G., Gazzola G. C., Kilberg M. S., Lajtha A., Sacktor B., Amino acid transport systems. Nature 1984 311 5984 308 2-s2.0-0021771882
81. Hundal H. S., h.s.hundal@dundee.ac.uk Taylor P. M., Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling. American Journal of Physiology 2009 296 4 E603 E613 10.1152/ajpendo.91002.2008
82. Ehrensvard G., Fischer A., Stjernholm R., Protein metabolism of tissue cells in vitro; the chemical nature of some obligate factors of tissue cell nutrition. Acta Physiologica Scandinavica 1949 18 2-3 218 230
83. Ardawi M. S. M., Newsholme E. A., Glutamine metabolism in lymphocytes of the rat. Biochemical Journal 1983 212 3 835 842 2-s2.0-0020617998 (Pubitemid 13056902)
84. Newsholme P., Curi R., Gordon S., Newsholme E. A., Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages. Biochemical Journal 1986 239 1 121 125 2-s2.0-0023029455 (Pubitemid 17178383)
85. Pithon-Curi T. C., De Melo M. P., Curi R., Glucose and glutamine utilization by rat lymphocytes, monocytes and neutrophils in culture: a comparative study. Cell Biochemistry and Function 2004 22 5 321 326 2-s2.0-4644336154 10.1002/cbf.1109 (Pubitemid 39274006)
86. Yaqoob P., Calder P. C., Glutamine requirement of proliferating T lymphocytes. Nutrition 1997 13 7-8 646 651 2-s2.0-0030745596 10.1016/S0899-9007(97)83008-0 (Pubitemid 27347166)
87. Rohde T., Maclean D. A., Pedersen B. K., Glutamine, lymphocyte proliferation and cytokine production. Scandinavian Journal of Immunology 1996 44 6 648 650 2-s2.0-0029797129 (Pubitemid 26400381)
88. Yaqoob P., Calder P. C., Cytokine production by human peripheral blood mononuclear cells: differential sensitivity to glutamine availability. Cytokine 1998 10 10 790 794 2-s2.0-0032192268 10.1006/cyto.1998.0358 (Pubitemid 28495231)
89. Hubert-Buron A., Leblond J., Jacquot A., Ducrotte P., Dechelotte P., Coeffier M., Glutamine pretreatment reduces IL-8 production in human intestinal epithelial cells by limiting IkappaBalpha ubiquitination. Journal of Nutrition 2006 136 6 1461 1465 (Pubitemid 43765345)
90. Erbil Y., Öztezcan S., Giriş M., Barbaros U., Olgaç V., Bilge H., Küçücük H., Toker G., The effect of glutamine on radiation-induced organ damage. Life Sciences 2005 78 4 376 382 2-s2.0-27744600233 10.1016/j.lfs.2005.04.068 (Pubitemid 41597546)
91. Deer C., Erbil Y., Giriş M., Yanik B. T., Tunca F., Olgaç V., Abbasolu S. D., Oztezcan S., Toker G., The effect of glutamine on pancreatic damage in TNBS-induced colitis. Digestive diseases and sciences 2006 51 10 1841 1846 2-s2.0-33846923645 10.1007/s10620-006-9189-y
92. Fillmann H., Kretzmann N. A., San-Miguel B., Llesuy S., Marroni N., González-Gallego J., Tuñón M. J., Glutamine inhibits over-expression of pro-inflammatory genes and down-regulates the nuclear factor kappaB pathway in an experimental model of colitis in the rat. Toxicology 2007 236 3 217 226 2-s2.0-34250902480 10.1016/j.tox.2007.04.012 (Pubitemid 46977112)
93. Perkins N. D., Integrating cell-signalling pathways with NF- κ B and IKK function. Nature Reviews Molecular Cell Biology 2007 8 1 49 62 2-s2.0-33845768987 10.1038/nrm2083 (Pubitemid 46012014)
94. Sharif O., Bolshakov V. N., Raines S., Newham P., Perkins N. D., Transcriptional profiling of the LPS induced NF- κ B response in macrophages. BMC Immunology 2007 8, article no. 1 2-s2.0-33846850216 10.1186/1471-2172-8-1 (Pubitemid 46210971)
95. Gilmore T. D., Introduction to NF- κ B: players, pathways, perspectives. Oncogene 2006 25 51 6680 6684 2-s2.0-33750466230 10.1038/sj.onc.1209954 (Pubitemid 44657845)
96. Li W., Moylan J. S., Chambers M. A., Smith J., Reid M. B., Interleukin-1 stimulates catabolism in C2C12 myotubes. American Journal of Physiology 2009 297 3 C706 C714 2-s2.0-70349263330 10.1152/ajpcell.00626.2008
97. Fouad D., Siendones E., Costán G., Muntané J., Role of NF- κ B activation and nitric oxide expression during PGE1 protection against D-galactosamine-induced cell death in cultured rat hepatocytes. Liver International 2004 24 3 227 236 2-s2.0-3142754211 (Pubitemid 38930862)
98. Yasukawa T., Tokunaga E., Ota H., Sugita H., Martyn J. A. J., Kaneki M., S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance. Journal of Biological Chemistry 2005 280 9 7511 7518 2-s2.0-14844300857 10.1074/jbc.M411871200 (Pubitemid 40349643)
99. Hamel F. G., Upward J. L., Siford G. L., Duckworth W. C., Inhibition of proteasome activity by selected amino acids. Metabolism 2003 52 7 810 814 2-s2.0-0043092316 10.1016/S0026-0495(03)00093-3 (Pubitemid 36949540)
100. Blomstrand E., eva.blomstrand@gih.se Eliasson J., Karlssonr H. K.R., Köhnke R., Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. Journal of Nutrition 2006 136 1 269S 273S (Pubitemid 43156522)
101. S6k phosphorylation in human skeletal muscle after resistance exercise. American Journal of Physiology 2004 287 1 E1 E7 10.1152/ajpendo.00430. 2003 (Pubitemid 38856275)
102. 2+/CaM Signaling to hVps34. Cell Metabolism 2008 7 5 456 465 2-s2.0-42649112409 10.1016/j.cmet.2008.03.002 (Pubitemid 351598024)
103. Hardin B. J., Campbell K. S., Smith J. D., Arbogast S., Smith J., Moylan J. S., Reid M. B., TNF- α acts via TNFR1 and muscle-derived oxidants to depress myofibrillar force in murine skeletal muscle. Journal of Applied Physiology 2008 104 3 694 699 2-s2.0-41549114074 10.1152/japplphysiol.00898.2007 (Pubitemid 351468797)
104. Lecarpentier Y., Physiological role of free radicals in skeletal muscles. Journal of Applied Physiology 2007 103 6 1917 1918 2-s2.0-36849035700 10.1152/japplphysiol.01047.2007 (Pubitemid 350232371)
105. Musarò A., antonio.musaro@uniroma1.it Fulle S., Fanò G., Oxidative stress and muscle homeostasis. Current Opinion in Clinical Nutrition and Metabolic Care 2010 13 3 236 242 10.1097/MCO.0b013e3283368188
106. Bonetto A., Penna F., Muscaritoli M., Minero V. G., Fanelli F. R., Baccino F. M., Costelli P., Are antioxidants useful for treating skeletal muscle atrophy? Free Radical Biology and Medicine 2009 47 7 906 916 2-s2.0-69249213367 10.1016/j.freeradbiomed.2009.07.002
107. Moylan J. S., Reid M. B., Oxidative stress, chronic disease, and muscle wasting. Muscle and Nerve 2007 35 4 411 429 2-s2.0-34047213532 10.1002/mus.20743 (Pubitemid 46542961)
108. Andrade F. H., Reid M. B., Allen D. G., Westerblad H., Effect of hydrogen peroxide and dithiothreitol on contractile function of single skeletal muscle fibres from the mouse. Journal of Physiology 1998 509 2 565 575 2-s2.0-0032103008 10.1111/j.1469-7793.1998.565bn.x (Pubitemid 28287013)
109. Shang F., fu.shang@tufts.edu Taylor A., Ubiquitin-proteasome pathway and cellular responses to oxidative stress. Free Radical Biology and Medicine 2011 51 1 5 16 10.1016/j.freeradbiomed.2011.03.031
110. Li Y. P., Schwartz R. J., Waddell I. D., Holloway B. R., Reid M. B., Skeletal muscle myocytes undergo protein loss and reactive oxygen- mediated NF- κ B activation in response to tumor necrosis factor α The FASEB Journal 1998 12 10 871 880 2-s2.0-0031802331 (Pubitemid 28294677)
111. Li Y. P., Atkins C. M., Sweatt J. D., Reid M. B., Mitochondria mediate tumor necrosis factor- α /NF- κ B signaling in skeletal muscle myotubes. Antioxidants and Redox Signaling 1999 1 1 97 104 2-s2.0-0033086243 (Pubitemid 129619766)
112. Cheng J., Turksen K., Yu Q. C., Schreiber H., Teng M., Fuchs E., Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter- driven TNF α transgenic mice. Genes and Development 1992 6 8 1444 1456 2-s2.0-0026770257
113. Wei Y., Chen K., Whaley-Connell A. T., Stump C. S., Ibdah J. A., Sowers J. R., Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species. American Journal of Physiology 2008 294 3 R673 R680 (Pubitemid 351346942)
114. Nathan C., Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling. Journal of Clinical Investigation 2003 111 6 769 778 2-s2.0-0037365968 10.1172/JCI200318174 (Pubitemid 37074948)
115. Marzani B., Balage M., Vénien A., Astruc T., Papet I., Dardevet D., Mosoni L., Antioxidant supplementation restores defective leucine stimulation of protein synthesis in skeletal muscle from old rats. Journal of Nutrition 2008 138 11 2205 2211 2-s2.0-55949123726 10.3945/jn.108.094029
116. Mosoni L., Balage M., Vazeille E., Combaret L., Morand C., Zagol-Ikapitte I., Boutaud O., Marzani B., Papet I., Dardevet D., Antioxidant supplementation had positive effects in old rat muscle, but through better oxidative status in other organs. Nutrition 2010 26 11-12 1157 1162 2-s2.0-77957803185 10.1016/j.nut.2009.09.016
117. D'Antona G., Ragni M., Cardile A., Tedesco L., Dossena M., Bruttini F., Caliaro F., Corsetti G., Bottinelli R., Carruba M. O., Valerio A., Nisoli E., Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice. Cell Metabolism 2010 12 4 362 372 2-s2.0-77957661352 10.1016/j.cmet.2010.08.016
118. Smith G. I., Atherton P., Reeds D. N., Mohammed B. S., Rankin D., Rennie M. J., Mittendorfer B., mittendb@wustl.edu Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial. American Journal of Clinical Nutrition 2011 93 2 402 412 10.3945/ajcn.110.005611