Glycyrrhizic acid and 18β-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1, CRE and NFAT activation

Phytomedicine

Volumn 20, Issue 3-4, 2013, Pages 295-302

  Kao, Tzu Chien ^a   Wu, Chi Hao ^b   Yen, Gow Chin ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

18 Glycyrrhetinic acid; Glucocorticoid receptor; Glucocorticoid resistance; Glycyrrhizic acid; Phosphoinositide 3 kinase

Indexed keywords

CYCLIC AMP; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLYCYRRHETINIC ACID; GLYCYRRHIZIC ACID; HEME OXYGENASE 1; MIFEPRISTONE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE 1; REACTIVE OXYGEN METABOLITE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONJUGATION; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE; ENZYME ACTIVATION; GLYCYRRHETINIC ACID; GLYCYRRHIZIC ACID; HELA CELLS; HUMANS; HYDROGEN PEROXIDE; MONOCYTES; NFATC TRANSCRIPTION FACTORS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOL PHOSPHATES; RECEPTORS, GLUCOCORTICOID; TRANSCRIPTION FACTOR AP-1;

GLYCYRRHIZA;

EID: 84873744315     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.10.013     Document Type: Article

References (29)

1. P.J. Barnes Mechanisms and resistance in glucocorticoid control of inflammation Journal of Steroid Biochemistry and Molecular Biology 120 2010 76 85
2. P.J. Barnes, and I.M. Adcock Glucocorticoid resistance in inflammatory diseases The Lancet 373 2009 1905 1917
3. K. De Bosscher, G. Haegeman, and D. Elewaut Targeting inflammation using selective glucocorticoid receptor modulators Current Opinion in Pharmacology 10 2010 497 504
4. A. Ghigo, F. Damilano, L. Braccini, and E. Hirsch PI3K inhibition in inflammation: toward tailored therapies for specific diseases Bioessays 32 2010 185 196
5. M. Guha, J.K. Fang, R. Monks, M.J. Birnbaum, and N.G. Avadhani Activation of Akt is essential for the propagation of mitochondrial respiratory stress signaling and activation of the transcriptional coactivator heterogeneous ribonucleoprotein A2 Molecular Biology of the Cell 21 2010 3578 3589
6. M. Guha, and N. Mackman LPS induction of gene expression in human monocytes Cellular Signalling 13 2001 85 94
7. P.T. Hawkins, K.E. Anderson, K. Davidson, and L.R. Stephens Signalling through class I PI3Ks in mammalian cells Biochemical Society Transactions 34 2006 647 662
8. K. Hazeki, S. Kinoshita, T. Matsumura, K. Nigorikawa, H. Kubo, and O. Hazeki Opposite effects of wortmannin and 2-(4-morpholinyl)-8-phenyl-1(4H)- benzopyran-4-one hydrochloride on toll-like receptor-mediated nitric oxide production: negative regulation of nuclear factor-{kappa}B by phosphoinositide 3-kinase Molecular Pharmacology 69 2006 1717 1724
9. X. Hu, P.K. Paik, J. Chen, A. Yarilina, L. Kockeritz, and T.T. Lu IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins Immunity 24 2006 563 574
10. E. Irusen, J.G. Matthews, A. Takahashi, P.J. Barnes, K.F. Chung, and I.M. Adcock p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma Journal of Allergy and Clinical Immunology 109 2002 649 657
11. M. Itoh Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation Molecular Endocrinology 16 2002 2382 2392
12. T.C. Kao, M.H. Shyu, and G.C. Yen Glycyrrhizic acid and 18beta-glycyrrhetinic acid inhibit inflammation via PI3K/Akt/GSK3beta signaling and glucocorticoid receptor activation Journal of Agricultural and Food Chemistry 58 2010 8623 8629
13. T.C. Kao, M.H. Shyu, and G.C. Yen Neuroprotective effects of glycyrrhizic acid and 18beta-glycyrrhetinic acid in PC12 cells via modulation of the PI3K/Akt pathway Journal of Agricultural and Food Chemistry 57 2009 754 761
14. M.H. Laird, S.H. Rhee, D.J. Perkins, A.E. Medvedev, W. Piao, and M.J. Fenton TLR4/MyD88/PI3K interactions regulate TLR4 signaling Journal of Leukocyte Biology 85 2009 966 977
15. D. Martin, A.I. Rojo, M. Salinas, R. Diaz, G. Gallardo, and J. Alam Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol Journal of Biological Chemistry 279 2004 8919 8929
16. J.A. Marwick, I.M. Adcock, and K.F. Chung Overcoming reduced glucocorticoid sensitivity in airway disease: molecular mechanisms and therapeutic approaches Drugs 70 2010 929 948
17. E.A. Medina, I.R. Morris, and M.T. Berton Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain Journal of Immunology 185 2010 7562 7572
18. M.R. Muller, and A. Rao NFAT, immunity and cancer: a transcription factor comes of age Nature Reviews Immunology 10 2010 645 656
19. M. Ojaniemi, V. Glumoff, K. Harju, M. Liljeroos, K. Vuori, and M. Hallman Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages European Journal of Immunology 33 2003 597 605
20. V. Oliveira-Marques, H.S. Marinho, L. Cyrne, and F. Antunes Role of hydrogen peroxide in NF-kappaB activation: from inducer to modulator Antioxidants and Redox Signalling 11 2009 2223 2243
21. A. Paine, B. Eiz-Vesper, R. Blasczyk, and S. Immenschuh Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential Biochemical Pharmacology 80 2010 1895 1903
22. M. Pan, M.M. Winslow, L. Chen, A. Kuo, D. Felsher, and G.R. Crabtree Enhanced NFATc1 nuclear occupancy causes T cell activation independent of CD28 costimulation Journal of Immunology 178 2007 4315 4321
23. K.T. Papazisis, G.D. Geromichalos, K.A. Dimitriadis, and A.H. Kortsaris Optimization of the sulforhodamine B colorimetric assay Journal of Immunological Methods 208 1997 151 158
24. B. Ploeger, T. Mensinga, A. Sips, W. Seinen, J. Meulenbelt, and J. DeJongh The pharmacokinetics of glycyrrhizic acid evaluated by physiologically based pharmacokinetic modeling Drug Metabolism Reviews 33 2001 125 147
25. N.M. Reddy, S. Vegiraju, A. Irving, B.C. Paun, I.G. Luzina, and S.P. Atamas Targeted deletion of Jun/AP-1 in alveolar epithelial cells causes progressive emphysema and worsens cigarette smoke-induced lung inflammation American Journal of Pathology 180 2012 562 574
26. F.L. Ricciardolo, F.P. Nijkamp, and G. Folkerts Nitric oxide synthase (NOS) as therapeutic target for asthma and chronic obstructive pulmonary disease Current Drug Targets 7 2006 721 735
27. W.J. van Beurden, G.A. Harff, P.N. Dekhuijzen, M.J. van den Bosch, J.P. Creemers, and F.W. Smeenk An efficient and reproducible method for measuring hydrogen peroxide in exhaled breath condensate Respiratory Medicine 96 2002 197 203
28. X. Wang, and Y. Liu Regulation of innate immune response by MAP kinase phosphatase-1 Cell Signal 19 2007 1372 1382
29. A.Y. Wen, K.M. Sakamoto, and L.S. Miller The role of the transcription factor CREB in immune function Journal of Immunology 185 2010 6413 6419