Closing the gap in series scale up of high shear wet granulation process using impeller power and blade design

Powder Technology

Volumn 205, Issue 1-3, 2011, Pages 184-192

  Campbell, Gossett A ^a   Clancy, Donald J ^a   Zhang, Jinzhou X ^b   Gupta, Manish K ^a   Oh, Choon K ^a  

^a GLAXOSMITHKLINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Blade angle; Froude number; Granulation; Inflection point; Scale up; Tip speed

Indexed keywords

BLADE ANGLE; BLADE DESIGN; DRUG SUBSTANCES; END-POINT MEASUREMENT; FULL SCALE; HIGH-SHEAR WET GRANULATION; IMPELLER BLADES; INFLECTION POINTS; LINEAR RELATIONSHIPS; PHARMACEUTICAL INDUSTRY; PRODUCT PERFORMANCE; SCALE-UP; SMALL SCALE; TIP SPEED; WATER ADDITION; WET GRANULATION;

AIR; DESIGN; DRUG PRODUCTS; DRUG PRODUCTS PLANTS; FROUDE NUMBER; GRANULATION; SPEED; TURBOMACHINE BLADES;

GRANULATORS;

ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG GRANULATION; EQUIPMENT DESIGN; GEOMETRY; IMPELLER; PROCESS CONTROL; PROCESS MONITORING; SCALE UP; SHEAR RATE;

EID: 78049272182     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2010.09.009     Document Type: Article

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