Experience with the Diosna mini-granulator and assessment of process scalability

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 52, Issue 3, 2001, Pages 297-303

  Bock, Thomas K ^a   Kraas, Ulrike ^b  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

Author keywords

Diosna P 1 6 Laboratory Pharma Mixer; Diosna P 10 P 100 Pharma Mixer; High shear granulator; Scalability

Indexed keywords

ARTICLE; DRUG GRANULATION; MACHINE; MATERIALS; METHODOLOGY; PARAMETER; PARTICLE SIZE; PHARMACEUTICAL ENGINEERING; PROCESS CONTROL; REPRODUCIBILITY; TABLET FORMULATION; TABLET MANUFACTURE;

PARTICLE SIZE; POWDERS; TECHNOLOGY, PHARMACEUTICAL;

EID: 0034763874     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(01)00197-7     Document Type: Article

References (7)

1. Scale-up of granulation in high shear mixers
2. Granulations
3. Studies on upscaling parameters of the Gral high shear granulation process
4. Applicability of a scale-up methodology for wet granulation processes in Collette Gral high shear mixer-granulators
5. Scaleup of a high-shear granulation process using a normalized impeller work parameter
6. Effectiveness of binders in wet granulation: A comparison using model formulations of different tabletability
7. Granulation in high speed mixers. Part 4: Effect of liquid saturation on the agglomeration