Scale-up of a pharmaceutical granulation in fixed bowl mixer-granulators

International Journal of Pharmaceutics

Volumn 133, Issue 1-2, 1996, Pages 127-131

  Landin, M ^a   York, P ^a   Cliff, M J ^b   Rowe, R C ^b   Wigmore, A J ^c  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c Aeromatic Fielder Ltd   (United Kingdom)

Author keywords

Granulation; Mixer granulators; Scale up

Indexed keywords

LACTOSE; STARCH;

APPARATUS; ARTICLE; DRUG GRANULATION; FORCE; GEOMETRY; PREDICTION; PRIORITY JOURNAL; VELOCITY; VISCOSITY;

EID: 0029998342     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(95)04427-2     Document Type: Article

References (9)

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2. Kaminsky, G., Personal communication, 1994.
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4. McCabe, W.L., Smith, J.C. and Harriot, P., Agitation and Mixing of Liquids. In: Unit Operations of Chemical Engineering. McGraw Hill Inc., New York, 5th edition, 1993, pp. 248-281
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6. Parker, M.D., Rowe, R.C. and Upjohn, N.G., Mixer torque rheometry - a method for quantifying the consistency of wet granulations. Pharm. Tech. Int., 2(8) (1990) 50-62.
7. Rowe, R.C. and Sadeghnejad, G.R., The rheological properties of microcrystalline cellulose powder/water mixes-measurement using a mixer torque rheometer. Int. J. Pharm., 38 (1987) 227-229.
8. Schaefer, T., Equipment for wet granulation. Acta Pharm. Suec., 25 (1988) 205-228.
9. Timko, R.J., Cliff, M.J. and Rosenberg, H.A., High intensity mixer granulators. In: Kadam, K.L. (Ed.), Granulation Technology for Bioproducts. CRC Press, Boston, 1990, pp. 119-178.