Optimization of operating conditions in a high-shear mixer using DEM model: Determination of optimal fill level

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 12, 2002, Pages 1550-1557

  Terashita, Keijiro ^a   Nishimura, Takehiko ^a   Natsuyama, Susumu ^b  

^a Osaka Prefecture University   (Japan)

^b POWREX Corp   (Japan)

Author keywords

Discrete element method; Fill level; Granulation; High shear mixer; Kinetic energy; Optimization

Indexed keywords

ARTICLE; CAPSULE FILLING; DISCRETE ELEMENT METHOD SIMULATION; DRUG GRANULATION; DRUG MANUFACTURE; ENERGY; KINETICS; MIXER; PHARMACEUTICAL ENGINEERING; SHEAR STRESS; SIMULATION; VALIDATION PROCESS; DRUG FORMULATION; DRUG INDUSTRY; INSTRUMENTATION; METHODOLOGY; PARTICLE SIZE; POWDER; ROTATION; TABLET; THEORETICAL MODEL;

DRUG COMPOUNDING; DRUG INDUSTRY; KINETICS; MODELS, THEORETICAL; PARTICLE SIZE; POWDERS; ROTATION; TABLETS;

EID: 1842865302     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.1550     Document Type: Article

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