Scale-up of high shear granulation based on the internal stress measurement

Chemical and Pharmaceutical Bulletin

Volumn 53, Issue 4, 2005, Pages 351-354

  Watano, Satoru ^a   Okamoto, Takumi ^a   Sato, Yoshinobu ^b   Osako, Yoshifumi ^c  

^a Osaka Prefecture University   (Japan)

^b ONO PHARMACEUTICAL CO   (Japan)

^c Fuji Paudal Co Ltd   (Japan)

Author keywords

Granulation; High shear mixer; Physical property; Scale up; Tip speed

Indexed keywords

EXCIPIENT; HYDROXYPROPYLCELLULOSE; LACTOSE; MICROCRYSTALLINE CELLULOSE; STARCH;

ACCELERATION; AGITATOR BLADE; ARTICLE; DRUG GRANULATION; EQUIPMENT DESIGN; LINEAR SYSTEM; PHYSICAL PARAMETERS; PROCESS OPTIMIZATION; PURIFICATION; SCALE UP; SHEAR STRENGTH; SHEAR STRESS; STRESS; TABLET COMPRESSION; TABLET DISINTEGRATION TIME; TABLET PROPERTY; VELOCITY; WET GRANULATION;

ALGORITHMS; DRUG COMPOUNDING; POWDERS; STRESS, MECHANICAL;

EID: 21144449901     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.53.351     Document Type: Article

References (11)

1. Lindberg N. O., Pharm. Acta Helv., 14, 197-204 (1977).
2. Lindberg N. O., Leander L., Reenstierna B., Drug Dev. Ind. Pharm., 8, 775-782 (1982).
3. Leuenberger H., Pharm. Acta Helv., 57, 72-82 (1982).
4. Leuenberger H., Acta Pharm. Technol., 29, 274-280 (1983).
5. Bier H. P., Leuenberger H., Sucker H., Pharm. Ind., 41, 375-380 (1979).
6. Holm P., Schaefer T., Kristensen H. G., Powder Technol., 43, 213-223 (1985).
7. Holm P., Schaefer T., Kristensen H. G., Powder Technol., 43, 225-233 (1985).
8. Watano S., Numa T., Miyanami K., Osako Y., Chem. Pharm. Bull., 48, 1154-1159 (2000).
9. Watano S., Numa T., Miyanami K., Osako Y., Powder Technol., 115, 124-130 (2001).
10. Okada K., Pharm. Tech. Jpn., 10, 31-36 (1994).
11. Watano S., Shimoda E., Osako Y., Chem. Pharm. Bull., 50, 26-30 (2002).