Stress measurements in high-shear granulators using calibrated "test" particles: Application to scale-up

Powder Technology

Volumn 140, Issue 3, 2004, Pages 217-227

  Tardos, Gabriel I ^a,b   Hapgood, Karen P ^a   Ipadeola, Oyabo O ^a   Michaels, James N ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Granulation; Scale up; Shear stress

Indexed keywords

BINDERS; DETERGENTS; GRANULATION; IMPELLERS; SHEAR DEFORMATION; STRESSES;

HIGH-SHEAR GRANULATION; LIQUID BINDERS;

POWDERS;

DETERGENT;

CALIBRATION; FLUID MECHANICS; GRANULATION; MEASUREMENT METHOD; MIXER; STRESS;

AGITATION; CALIBRATION; CONFERENCE PAPER; DRUG INDUSTRY; GEOMETRY; IMPELLER; PARTICLE SIZE; PELLET EXTRUSION; POWDER; ROTATION; SCALE UP; SHEAR STRESS;

EID: 2342505853     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2004.01.015     Document Type: Conference Paper

References (20)

1. Ennis B.J., Tardos G.I., Pfeffer R. A microlevel-based characterization of granulation phenomena. Powder Technology. 65:1991;257-272
2. Tardos G.I., Khan I.M., Mort P.R. Critical parameters and Limiting conditions in Binder Granulation of fine powders. Powder Technology. 94:1997;245-258
3. Staniforth J.N., Quincey S.M. Granulation monitoring in a planetary mixer using a probe vibration analysis technique. International Journal of Pharmaceutics. 32:1986;177-185
4. Ohike A., Ashihara K., Ibuki R. Granulation monitoring by fast Fourier transform technique. Chemical and Pharmaceutical Bulletin. 47:1999;1734-1739
5. Faure A., York P., Rowe R.C. Process control and scale-up of pharmaceutical wet granulation processes: a review. European Journal of Pharmaceutics. 52:2001;269-277
6. Adams M.J., Edmondson B., Caughey D.G., Yahya R. An experimental and theoretical study of the squeeze-film deformation and flow of elasto-plastic fluids. Journal of Non-Newtonian Fluid Mechanics. 51:1994;61-72
7. Lian G., Yu Y., Huang W., Adams M.J. On the squeeze flow of a powder-law fluid between rigid spheres. Journal of Non-Newtonian Fluid Mechanics. 100:2001;151-164
8. Sherwood J.D., Durban D. Squeeze flow of a Herschel-Bulkley fluid. Journal of Non-Newtonian Fluid Mechanics. 77:1998;115-121
9. Pierat P., Agrawal D.K., Caram H.S. Effect of moisture on the yield locus of granular materials: theory of shift. Powder Technology. 99:1998;220-227
10. Schwedes J. Testers for measuring flow properties of particulate solids. Powder Handling and Processing. 12(4):2000 (October/December);337-354
11. Peschl I. Principles of soil mechanics for the characterization of industrial powders. Powder Handling and Processing. 13(1):2001 (January/March);11-18
12. Khan M.I., Tardos G.I. Stability of wet Agglomerates in Granular shear flows. J. Fluid Mech. 347:1997;347-368
13. Talu I., Tardos G.I., Khan M.I. Computer simulation of wet granulation. Powder Technology. 110:2000;59-75
14. Plank R., Diehl B., Grinstead H., Zega J. Quantifying liquid coverage and powder flux in high-shear granulators. Powder Technology. 134:2003;223-234
15. Mort P.R., Capeci S.W., Holder J.W. Control of agglomerate attributes in a continuous binder-agglomeration process. Powder Technology. 117:2001;173-176
16. Landin M., York P., Cliff M.J., Rowe R.C., Wigmore A.J. Scale-up of pharmaceutical granulation in a fixed bowl mixer-granulator. International Journal of Pharmaceutics. 133:1996;127-131
17. Landin M., York P., Cliff M.J., Rowe R.C., Wigmore A.J. The effect of batch size on scale-up of a pharmaceutical granulation in a fixed bowl mixer-granulator. International Journal of Pharmaceutics. 134:1996;243-246
18. Mort P.R., Tardos G.I. Scale-up of agglomeration processes using transformations. KONA. 17:1999;64-76
19. Iveson S.M., Litster J.D., Hapgood K., Ennis B.J. Nucleation, growth and breakage phenomena in agitated wet granulation processes: a review. Powder Technology. 117:2001;3-39
20. Farber L., Tardos G.I., Michaels J.M. Use of X-ray tomography to study the porosity and morphology of granules. Powder Technology. 132:2003;57-63