Nanoparticles for improved local retention after intra-articular injection into the knee joint

Pharmaceutical Research

Volumn 30, Issue 1, 2013, Pages 257-268

  Morgen, Michael ^a   Tung, David ^b   Boras, Britton ^c   Miller, Warren ^a   Malfait, Anne Marie ^d   Tortorella, Micky ^e  

^a Bend Research Incorporated   (United States)

^b BioMed Valley Discoveries   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d RUSH UNIVERSITY MEDICAL CENTER   (United States)

^e GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

Author keywords

Cross linked hydrogels; Increased retention; Intra articular injection; Nanoparticles

Indexed keywords

COPOLYMER; DEXTRAN; ETHYL CELLULOSE; EUDRAGIT; FLUORESCEIN ISOTHIOCYANATE; HYALURONIC ACID; NANOPARTICLE; POLY[2 METHOXY B (2 ETHYLHEXYLOXY) 1,4 PHENYLENEVINYLENE]; POLYCAPROLACTONE B CO POLYETHYLENEOXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CROSS LINKING; DRUG ADMINISTRATION ROUTE; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG RETENTION; DRUG SOLUBILITY; FEMALE; FLUORESCENCE MICROSCOPY; FLUORESCENCE MOLECULAR TOMOGRAPHY; HUMAN; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; KNEE; NANOANALYSIS; NANOFABRICATION; NANOPHARMACEUTICS; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SYNOVIAL FLUID; TOMOGRAPHY; VISCOSITY; ZETA POTENTIAL;

ANIMALS; DRUG CARRIERS; FEMALE; HUMANS; HYALURONIC ACID; HYDROGELS; INJECTIONS, INTRA-ARTICULAR; KNEE JOINT; NANOPARTICLES; OSTEOARTHRITIS; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; SYNOVIAL FLUID; VISCOSITY;

EID: 84873729849     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0870-x     Document Type: Article

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