Controlled release of transforming growth factor β1 from biodegradable polymer microparticles

Journal of Biomedical Materials Research

Volumn 50, Issue 3, 2000, Pages 440-451

  Lu, Lichun ^a   Stamatas, Georgios N ^a   Mikos, Antonios G ^a  

^a RICE UNIVERSITY   (United States)

Author keywords

Biodegradable microparticles; Bone regeneration; Growth factor delivery; Poly(DL lactic co glycolic acid); Poly(ethylene glycol); Polymer blends; Transforming growth factor 1

Indexed keywords

AGGLOMERATION; BIODEGRADATION; CARBOXYLIC ACIDS; ENCAPSULATION; PH EFFECTS; POLYETHYLENE GLYCOLS; POLYMER BLENDS; POLYPEPTIDES; PROTEINS; REACTION KINETICS;

MICROPARTICLES; POLYGLYCOLIC ACID; POLYLACTIC ACID; TRANSFORMING GROWTH FACTOR;

BIOMATERIALS;

BIOMATERIAL; POLYMER; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; BONE REGENERATION; CONTROLLED RELEASE FORMULATION; ENCAPSULATION; IMPLANTATION; KINETICS; PH MEASUREMENT; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN SECRETION;

NON-PROGRAMMATIC;

ANIMALS; CAPSULES; CATTLE; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; HUMANS; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; POLYMERS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034069615     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4636(20000605)50:3<440::AID-JBM19>3.0.CO;2-G     Document Type: Article

References (33)

1. Patrick CW Jr, Mikos AG, McIntire LV, editors. Frontiers in tissue engineering. New York: Pergamon; 1998.
2. Lanza RP, Langer R, Chick WL, editors. Principles of tissue engineering. Austin, TX: R. G. Lands; 1997.
3. Noda M, Camilliere JJ. In vivo stimulation of bone formation by transforming growth factor β. Endocrinology 1989;124:2991-2994.
4. Hock JM, Canalis E, Centrella M. Transforming growth factor-β stimulates bone matrix apposition and bone cell replication in cultured fetal rat calvariae. Endocrinology 1990;126: 491-426.
5. Beck LS, Deguzman L, Lee WP, Xu Y, McFatridge LA, Gillett NA, Amento EP. TGF-β1 induces bone closure of skull defects. J Bone Miner Res 1991;6:1257-1265.
6. Gombotz WR, Pankey SC, Bouchard LS, Ranchalis J, Puolakkainen P. Controlled release of TGF-β1 from a biodegradable matrix for bone regeneration. J Biomater Sci Polym Ed 1993;5: 49-63.
7. Hollinger JO, Leong K. Poly(α-hydroxy acids): carriers for bone morphogenetic proteins. Biomaterials 1996;17:187-194.
8. Anderson JM, Shive MS. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev 1997; 28:5-24.
9. Nimni ME. Polypeptide growth factors: targeted delivery systems. Biomaterials 1997;18:1201-1225.
10. Rosier RN, O'Keefe RJ, Hicks DG. The potential role of transforming growth factor beta in fracture healing. Clin Orthop Suppl 1998;355:294-300.
11. Lu L, Mikos AG. Biodegradable polymers for cell transplantation. Science Med 1999;6:6-7.
12. Cohen S, Yoshioka T, Lucarelli M, Hwang LH, Langer R. Controlled delivery systems for proteins based on poly(lactic/ glycolic acid) microspheres. Pharm Res 1991;8:713-720.
13. Cleek RL, Rege AA, Denner LA, Eskin SG, Mikos AG. Inhibition of smooth muscle cell growth in vitro by an antisense oligodeoxynucleotide released from poly(DL-lactic-co-glycolic acid) microparticles. J Biomed Mater Res 1997;35:525-530.
14. Crotts G, Park TG. Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres: release kinetics and stability issues. J Microencapsul 1998;15:699-713.
15. Cao X, Shoichet MS. Delivering neuroactive molecules from biodegradable microspheres for application in central nervous system disorders. Biomaterials 1999;20:329-339.
16. Suggs LJ, Mikos AG, Synthetic biodegradable polymers for medical applications. In: Mark JE, editor. Physical properties of polymers handbook. Woodbury, NY: American Institute of Physics; 1996. p 615-624.
17. Cleek RL, Ting KC, Eskin SG, Mikos AG. Microparticles of poly(DL-lactic-co-glycolic acid)/poly(ethylene glycol) blends for controlled drug delivery. J Control Release 1997;48:259-268.
18. Krewson CE, Dause R, Mak M, Saltzman WM. Stabilization of nerve growth factor in controlled release polymers and in tissue. J Biomater Sci Polym Ed 1996;8:103-117.
19. Lu L, Garcia CA, Mikos AG. In vitro degradation of thin poly(DL-lactic-co-glycolic acid) films. J Biomed Mater Res 1999; 46:236-244.
20. Mikos AG, Thorsen AJ, Czerwonka LA, Bao Y, Langer R, Winslow DN, Vacanti JP. Preparation and characterization of poly(L-lactic acid) foams. Polymer 1994;35:1068-1077.
21. Yan C, Resau JH, Hewetson J, West M, Rill WL, Kende M. Characterization and morphological analysis of protein-loaded poly(lactide-co-glycolide) microparticles prepared by water-in-oil-in-water emulsion technique. J Control Release 1994;32: 231-241.
22. Batycky RP, Hanes J, Langer R, Edwards DA. A theoretical model of erosion and macromolecular drug release from biodegrading microspheres. J Pharm Sci 1997;86:1464-1477.
23. Blanco D, Alonso MJ. Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: effect of the protein and polymer properties and of the co-encapsulation of surfactants. J Pharm Biopharm 1998;45:285-294.
24. Peter SJ, Lu L, Kim DJ, Stamatas GN, Miller MJ, Yaszemski MJ, Mikos AG. Effects of transforming growth factor-β1 released from biodegradable polymer microparticles on marrow stromal osteoblasts cultured on poly(propylene fumarate) scaffolds. J Biomed Mater Sci, to appear.
25. McKinney L, Hollinger JO. A bone regeneration study: transforming growth factor-β1 and its delivery. J Craniofac Surg 1996;7:36-45.
26. Puleo DA, Huh WW, Duggirala SS, DeLuca PP. In vitro cellular responses to bioerodible particles loaded with recombinant human bone morphogenetic protein-2. J Biomed Mater Res 1998; 41:104-110.
27. Kenley R, Warden L, Turek T, Jin L, Ron E, Hollinger JO. Osseous regeneration in the rat calvarium using novel delivery systems for recombinant human bone morphogenetic protein-2 (rhBMP-2). J Biomed Mater Res 1994;28:1139-1147.
28. Marden LJ, Hollinger JO, Chaudhari A, Turek T, Schaub RG, Ron E. Recombinant human bone morphogenetic protein-2 is superior to demineralized bone matrix in repairing craniotomy defects in rats. J Biomed Mater Res 1994;28:1127-1138.
29. King GN, King N, Cruchley AT, Wozney JM, Hughes FJ. Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects. J Dent Res 1997;76:1460-1470.
30. Levine JP, Bradley J, Turk AE, Ricci JL, Benedict JJ, Steiner G, Longaker MT, McCarthy JG. Bone morphogenetic protein promotes vascularization and osteoinduction in preformed hydroxyapatite in the rabbit. Ann Plast Surg 1997;39:158-168.
31. Zegzula HD, Buck DC, Brekke J, Wozney JM, Hollinger JO. Bone formation with use of rhBMP-2 (recombinant human bone morphogenetic protein-2). J Bone Joint Surg Am 1997;79: 1778-1790.
32. Rodgers JB, Vasconez HC, Wells MD, DeLuca PP, Faugere MC, Fink BF, Hamilton D. Two lyophilized polymer matrix recombinant human bone morphogenetic protein-2 carriers in rabbit calvarial defects. J Craniofac Surg 1998;9:147-153.
33. Whang K, Tsai DC, Nam EK, Aitken M, Sprague SM, Patel PK, Healy KE. Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds. J Biomed Mater Res 1998;42:491-499.