Evaluation of intra-articular delivery of hyaluronic acid functionalized biopolymeric nanoparticles in healthy rat knees

Bio-Medical Materials and Engineering

Volumn 20, Issue 3-4, 2010, Pages 235-242

  Zille, Hervé ^a   Paquet, Joseph ^a   Henrionnet, Christel ^a   Scala Bertola, Julien ^a   Leonard, Michèle ^b   Six, Jean Luc ^b   Deschamp, Frantz ^c   Netter, Patrick ^a   Vergès, José ^d   Gillet, Pierre ^a   Grossin, Laurent ^a  

^a Biopôle de l Université de Lorraine   (France)

^b LAB DE CHIM PHYS MACROMOLECULAIRE   (France)

^c SEPAREX SA   (France)

^d BIOIBERICA SA   (Spain)

Author keywords

hyaluronate; Intra articular injection; nanoparticles

Indexed keywords

AMPHIPHILICS; BIODISTRIBUTIONS; CHONDROCYTES; CYTOKINES; DEGRADATION PRODUCTS; DRUG CARRIER; DRUG DELIVERY SYSTEM; FUNCTIONALIZED; HISTOLOGICAL OBSERVATIONS; HYALURONATE; HYALURONIC ACIDS; INFLAMMATORY RESPONSE; INTRA-ARTICULAR INJECTION; KNEE JOINT; MALE RATS; MICRO-PARTICLES; MRNA EXPRESSION LEVEL; NANO-DEVICES; NATURAL POLYSACCHARIDE; PLGA NANOPARTICLES; POLY(D , L-LACTIC ACID); POLY(D , L-LACTIC-CO-GLYCOLIC ACID); PROTEOGLYCANS; RAT MODEL;

ANIMALS; BIOCHEMISTRY; BODY FLUIDS; DEGRADATION; DISEASES; DRUG DELIVERY; ENCAPSULATION; GLUCOSE; HISTOLOGY; JOINTS (ANATOMY); LACTIC ACID; ORGANIC ACIDS; ORGANIC POLYMERS; POLYVINYL ALCOHOLS; RATS; TISSUE;

NANOPARTICLES;

ANIMALIA; RATTUS;

BIOMATERIAL; DRUG CARRIER; HYALURONIC ACID; LACTIC ACID; NANOPARTICLE; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANIMAL; ARTICLE; CHEMISTRY; DRUG EFFECT; EVALUATION; INTRAARTICULAR DRUG ADMINISTRATION; JOINT; MALE; MATERIALS TESTING; PATHOLOGY; RAT; SYNOVIUM;

ANIMALS; COATED MATERIALS, BIOCOMPATIBLE; DRUG CARRIERS; HYALURONIC ACID; INJECTIONS, INTRA-ARTICULAR; JOINTS; LACTIC ACID; MALE; MATERIALS TESTING; NANOPARTICLES; POLYGLYCOLIC ACID; RATS; SYNOVIAL MEMBRANE;

EID: 78649494661     PISSN: 09592989     EISSN: None     Source Type: Journal    
DOI: 10.3233/BME-2010-0637     Document Type: Conference Paper

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