Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 7, 2013, Pages 2599-2604

  Mason, Kylie D ^a,b   Lin, Ann ^a   Robb, Lorraine ^a,b,d   Josefsson, Emma C ^a,b   Henley, Katya J ^a,b   Gray, Daniel H D ^a,b   Kile, Benjamin T ^a,b   Roberts, Andrew W ^a,b,c   Strasser, Andreas ^a,b   Huang, David C S ^a,b   Waring, Paul ^b   O'Reilly, Lorraine A ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c ROYAL MELBOURNE HOSPITAL   (Australia)

^d ST VINCENT S HOSPITAL   (Australia)

Author keywords

Apoptosis; Bcl 2 family

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIBODY; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SURVIVAL; CHIMERA; CONTROLLED STUDY; EMBRYO; FETUS; GENE MUTATION; GLOMERULONEPHRITIS; HEMATOPOIETIC SYSTEM; HYPERGAMMAGLOBULINEMIA; IMMUNE COMPLEX DEPOSITION; IMMUNOLOGICAL TOLERANCE; LETHARGY; LIVER CELL; LYMPHADENOPATHY; LYMPHOCYTE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTOSIS; MOUSE; NECROTIZING ARTERITIS; NONHUMAN; PLASMA CELL; POINT MUTATION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SURVIVAL; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTE COUNT; VASCULITIS; WEIGHT REDUCTION;

ANIMALS; APOPTOSIS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CHEMOKINES; CROSSES, GENETIC; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HISTOLOGICAL TECHNIQUES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE;

EID: 84873723430     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1215097110     Document Type: Article

References (37)

1. Goodnow CC, Sprent J, Fazekas de St Groth B, Vinuesa CG (2005) Cellular and genetic mechanisms of self tolerance and autoimmunity. Nature 435(7042):590-597. (Pubitemid 40825498)
2. Strasser A (2005) The role of BH3-only proteins in the immune system. Nat Rev Immunol 5(3):189-200.
3. Strasser A, Pellegrini M (2004) T-lymphocyte death during shutdown of an immune response. Trends Immunol 25(11):610-615. (Pubitemid 39369738)
4. Strasser A, Harris AW, Huang DCS, Krammer PH, Cory S (1995) Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J 14(24):6136-6147. (Pubitemid 26007301)
5. Strasser A, Jost PJ, Nagata S (2009) The many roles of FAS receptor signaling in the immune system. Immunity 30(2):180-192.
6. Youle RJ, Strasser A (2008) The BCL-2 protein family: Opposing activities that mediate cell death. Nat Rev Mol Cell Biol 9(1):47-59.
7. Ke F, et al. (2012) BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice. Cell Death Differ 19(6):915-925.
8. Chipuk JE, Green DR (2008) How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol 18(4):157-164.
9. Willis SN, et al. (2007) Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 315(5813):856-859.
10. Lindsten T, et al. (2000) The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell 6(6):1389-1399. (Pubitemid 32045931)
11. Knudson CM, Tung KSK, Tourtellotte WG, Brown GAJ, Korsmeyer SJ (1995) Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270(5233):96-99.
12. Rathmell JC, Lindsten T, Zong W-X, Cinalli RM, Thompson CB (2002) Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat Immunol 3(10):932-939. (Pubitemid 35154006)
13. Wei MC, et al. (2001) Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death. Science 292(5517):727-730. (Pubitemid 32385543)
14. Zong WX, Lindsten T, Ross AJ, MacGregor GR, Thompson CB (2001) BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev 15(12):1481-1486. (Pubitemid 32552527)
15. Takeuchi O, et al. (2005) Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci USA 102(32):11272-11277. (Pubitemid 41153810)
16. Delgado-Vega AM, et al. (2010) Bcl-2 antagonist killer 1 (BAK1) polymorphisms influence the risk of developing autoimmune rheumatic diseases in women. Ann Rheum Dis 69(2):462-465.
17. Josefsson EC, et al. (2011) Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. J Exp Med 208(10):2017-2031.
18. Willis SN, et al. (2005) Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 19(11):1294-1305. (Pubitemid 41003019)
19. Santamaria P (2001) Effector lymphocytes in autoimmunity. Curr Opin Immunol 13(6):663-669.
20. Mathis D, Benoist C (2009) Aire. Annu Rev Immunol 27:287-312.
21. Sakaguchi S, Yamaguchi T, Nomura T, Ono M (2008) Regulatory T cells and immune tolerance. Cell 133(5):775-787. (Pubitemid 351707693)
22. Mauri C, Bosma A (2012) Immune regulatory function of B cells. Annu Rev Immunol 30:221-241.
23. Anderson MS, et al. (2002) Projection of an immunological self shadow within the thymus by the aire protein. Science 298(5597):1395-1401. (Pubitemid 35346134)
24. Vikstrom I, et al. (2010) Mcl-1 is essential for germinal center formation and B cell memory. Science 330(6007):1095-1099.
25. Zhou P, Qian L, Kozopas KM, Craig RW (1997) Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions. Blood 89(2):630-643. (Pubitemid 27051700)
26. Campbell KJ, et al. (2010) Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance. Blood 116(17):3197-3207.
27. Biswas S, et al. (2010) A role for proapoptotic Bax and Bak in T-cell differentiation and transformation. Blood 116(24):5237-5246.
28. Strasser A, Harris AW, Bath ML, Cory S (1990) Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 348(6299):331-333. (Pubitemid 120029100)
29. Strasser A, Harris AW, Cory S (1993) E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells. Oncogene 8(1):1-9. (Pubitemid 23047224)
30. Gottlieb B, et al. (2009) BAK1 gene variation and abdominal aortic aneurysms. Hum Mutat 30(7):1043-1047.
31. Strasser A, et al. (1991) Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Natl Acad Sci USA 88(19):8661-8665. (Pubitemid 21915417)
32. Bouillet P, et al. (1999) Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286(5445):1735-1738. (Pubitemid 129515880)
33. Carrington EM, et al. (2010) BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs. Proc Natl Acad Sci USA 107(24):10967-10971.
34. Tse C, et al. (2008) ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res 68(9):3421-3428.
35. Bardwell PD, et al. (2009) The Bcl-2 family antagonist ABT-737 significantly inhibits multiple animal models of autoimmunity. J Immunol 182(12):7482-7489.
36. Ogilvy S, et al. (1999) Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival. Proc Natl Acad Sci USA 96(26):14943-14948. (Pubitemid 30019744)
37. O' Reilly LA, et al. (2009) Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature 461(7264):659-663.