-
1
-
-
0025304539
-
Rheumatoid arthritis: Pathophysiology and implications for therapy
-
Harris ED Jr. Rheumatoid arthritis: pathophysiology and implications for therapy. N Engl J Med 1990; 322:1277-1289.
-
(1990)
N Engl J Med
, vol.322
, pp. 1277-1289
-
-
Harris Jr., E.D.1
-
2
-
-
0023811772
-
Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis
-
Cush JJ, Lipsky PE. Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis. Arthritis Rheum 1988; 31:1230-1238.
-
(1988)
Arthritis Rheum
, vol.31
, pp. 1230-1238
-
-
Cush, J.J.1
Lipsky, P.E.2
-
3
-
-
0033524159
-
Infliximab (chimeric anti-tumour necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: A randomized phase III trial
-
Maini RN, St Clair EW, Breedveld F, et al. Infliximab (chimeric anti-tumour necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomized phase III trial. Lancet 1999; 354:1932-1939.
-
(1999)
Lancet
, vol.354
, pp. 1932-1939
-
-
Maini, R.N.1
St Clair, E.W.2
Breedveld, F.3
-
5
-
-
0034735842
-
Infliximab and methotrexate in the treatment of rheumatoid arthritis
-
Lipsky PE, van der Heijde DM, St Clair EW, et al. Infliximab and methotrexate in the treatment of rheumatoid arthritis. N Engl J Med 2000; 343:1594-1602.
-
(2000)
N Engl J Med
, vol.343
, pp. 1594-1602
-
-
Lipsky, P.E.1
Van Der Heijde, D.M.2
St Clair, E.W.3
-
6
-
-
0037389680
-
Anakinra, a recombinant human interleukin-1 receptor antagonist (r-metHuIL-1ra), in patients with rheumatoid arthritis: A large, international, multicenter, placebo-controlled trial
-
Fleischmann RM, Schechtman J, Bennett R, et al. Anakinra, a recombinant human interleukin-1 receptor antagonist (r-metHuIL-1ra), in patients with rheumatoid arthritis: A large, international, multicenter, placebo-controlled trial. Arthritis Rheum 2003; 48:927-934.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 927-934
-
-
Fleischmann, R.M.1
Schechtman, J.2
Bennett, R.3
-
7
-
-
25444467441
-
Do we need new treatment that goes beyond tumor necrosis factor blockers for rheumatoid arthritis?
-
Voll RE, Kalden JR. Do we need new treatment that goes beyond tumor necrosis factor blockers for rheumatoid arthritis? Ann N Y Acad Sci 2005; 1051:799-810.
-
(2005)
Ann N Y Acad Sci
, vol.1051
, pp. 799-810
-
-
Voll, R.E.1
Kalden, J.R.2
-
9
-
-
0024269961
-
Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis
-
Hirano T, Matsuda T, Turner M, et al. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol 1988; 18: 1797-1801.
-
(1988)
Eur J Immunol
, vol.18
, pp. 1797-1801
-
-
Hirano, T.1
Matsuda, T.2
Turner, M.3
-
10
-
-
0023942493
-
Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritis
-
Houssiau FA, Devogelaer JP, Van Damme J, et al. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritis. Arthritis Rheum 1988; 31:784-788.
-
(1988)
Arthritis Rheum
, vol.31
, pp. 784-788
-
-
Houssiau, F.A.1
Devogelaer, J.P.2
Van Damme, J.3
-
11
-
-
0027305079
-
Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis
-
Sack U, Kinne R, Marx T, et al. Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis. Rheumatol Int 1993; 13:45-51.
-
(1993)
Rheumatol Int
, vol.13
, pp. 45-51
-
-
Sack, U.1
Kinne, R.2
Marx, T.3
-
12
-
-
0027518860
-
Serum interleukin 6 levels in rheumatoid arthritis: Correlation with clinical and laboratory indices of disease activity
-
Madhok R, Crilly A, Watson J, Capell HA. Serum interleukin 6 levels in rheumatoid arthritis: correlation with clinical and laboratory indices of disease activity. Ann Rheum Dis 1993; 52:232-234.
-
(1993)
Ann Rheum Dis
, vol.52
, pp. 232-234
-
-
Madhok, R.1
Crilly, A.2
Watson, J.3
Capell, H.A.4
-
13
-
-
0027502201
-
Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth
-
Sato K, Tsuchiya M, Saldanha J, et al. Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth. Cancer Res 1993; 53:851-856.
-
(1993)
Cancer Res
, vol.53
, pp. 851-856
-
-
Sato, K.1
Tsuchiya, M.2
Saldanha, J.3
-
14
-
-
0027978341
-
Effects of recombinant human interleukin-6 in cancer patients: A phase I-II study
-
van Gameren MM, Willemse PH, Mulder NH, et al. Effects of recombinant human interleukin-6 in cancer patients: a phase I-II study. Blood 1994; 84:1434-1441.
-
(1994)
Blood
, vol.84
, pp. 1434-1441
-
-
Van Gameren, M.M.1
Willemse, P.H.2
Mulder, N.H.3
-
15
-
-
0023887261
-
Recombinant human interleukin-6(IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes
-
Castell JV, Gomez-Lechon MJ, David M, et al. Recombinant human interleukin-6(IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes. FEBS Lett 1988; 232:347-350.
-
(1988)
FEBS Lett
, vol.232
, pp. 347-350
-
-
Castell, J.V.1
Gomez-Lechon, M.J.2
David, M.3
-
16
-
-
0024446495
-
Interleukin-6 is a potent thrombopoietic factor in vivo in mice
-
Ishibashi T, Kimura H, Shikama Y, et al. Interleukin-6 is a potent thrombopoietic factor in vivo in mice. Blood 1989; 74:1241-1244.
-
(1989)
Blood
, vol.74
, pp. 1241-1244
-
-
Ishibashi, T.1
Kimura, H.2
Shikama, Y.3
-
17
-
-
0038798085
-
Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis
-
Nakahara H, Song J, Sugimoto M, et al. Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis. Arthritis Rheum 2003; 48:1521-1529.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 1521-1529
-
-
Nakahara, H.1
Song, J.2
Sugimoto, M.3
-
18
-
-
0027136189
-
Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6
-
USA
-
Tamura T, Udagawa N, Takahashi N, et al. Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. Proc Natl Acad Sci USA 1993; 90:11924-11928.
-
(1993)
Proc Natl Acad Sci
, vol.90
, pp. 11924-11928
-
-
Tamura, T.1
Udagawa, N.2
Takahashi, N.3
-
19
-
-
18844423323
-
IL-6 promoter polymorphism in patients with rheumatoid arthritis
-
Pawlik A, Wrzesniewska J, Florczak M, et al. IL-6 promoter polymorphism in patients with rheumatoid arthritis. Scand J Rheumatol 2005; 34:109-113.
-
(2005)
Scand J Rheumatol
, vol.34
, pp. 109-113
-
-
Pawlik, A.1
Wrzesniewska, J.2
Florczak, M.3
-
20
-
-
0032536542
-
Interleukin-6 is required for the development of collagen-induced arthritis
-
Alonzi T, Fattori E, Lazzaro D, et al. Interleukin-6 is required for the development of collagen-induced arthritis. J Exp Med 1998; 187:461-468.
-
(1998)
J Exp Med
, vol.187
, pp. 461-468
-
-
Alonzi, T.1
Fattori, E.2
Lazzaro, D.3
-
21
-
-
0033503152
-
Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice
-
Sasai M, Saeki Y, Ohshima S, et al. Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice. Arthritis Rheum 1999; 42:1635-1643.
-
(1999)
Arthritis Rheum
, vol.42
, pp. 1635-1643
-
-
Sasai, M.1
Saeki, Y.2
Ohshima, S.3
-
22
-
-
4344590199
-
Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice
-
Hata H, Sakaguchi N, Yoshitomi H, et al. Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J Clin Invest 2004; 114:582-588.
-
(2004)
J Clin Invest
, vol.114
, pp. 582-588
-
-
Hata, H.1
Sakaguchi, N.2
Yoshitomi, H.3
-
23
-
-
0037037586
-
A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis
-
Atsumi T, Ishihara K, Kamimura D, et al. A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. J Exp Med 2002; 196:979-990.
-
(2002)
J Exp Med
, vol.196
, pp. 979-990
-
-
Atsumi, T.1
Ishihara, K.2
Kamimura, D.3
-
24
-
-
0032429668
-
Blockage of Interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis
-
Takagi N, Mihara M, Moriya Y, et al. Blockage of Interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Arthritis Rheum 1998; 41:2117-2121.
-
(1998)
Arthritis Rheum
, vol.41
, pp. 2117-2121
-
-
Takagi, N.1
Mihara, M.2
Moriya, Y.3
-
25
-
-
0035090840
-
Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys
-
Mihara M, Kotoh M, Nishimoto N, et al. Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys. Clin Immunol 2001; 98:319-326.
-
(2001)
Clin Immunol
, vol.98
, pp. 319-326
-
-
Mihara, M.1
Kotoh, M.2
Nishimoto, N.3
-
26
-
-
0036899812
-
Therapeutic benefit after blocking interleukin-6 activity in rheumatoid arthritis with an anti-interleukin-6 receptor monoclonal antibody
-
Choy EH, Isenberg DA, Garrood T, et al. Therapeutic benefit after blocking interleukin-6 activity in rheumatoid arthritis with an anti-interleukin-6 receptor monoclonal antibody. Arthritis Rheum 2002; 46:3143-3150.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 3143-3150
-
-
Choy, E.H.1
Isenberg, D.A.2
Garrood, T.3
-
27
-
-
0038166958
-
Toxicity, pharmacokinetics, and dose finding study of repetitive treatment with humanized anti-interleukin 6 receptor antibody, MRA, in rheumatoid arthritis: Phase I/II clinical study
-
Nishimoto N, Yoshizaki K, Maeda K, et al. Toxicity, pharmacokinetics, and dose finding study of repetitive treatment with humanized anti-interleukin 6 receptor antibody, MRA, in rheumatoid arthritis: phase I/II clinical study. J Rheumatol 2003; 30:1426-1435.
-
(2003)
J Rheumatol
, vol.30
, pp. 1426-1435
-
-
Nishimoto, N.1
Yoshizaki, K.2
Maeda, K.3
-
28
-
-
2642558925
-
Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebo-controlled trial
-
Nishimoto N, Yoshizaki K, Miyasaka N, et al. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum 2004; 50:1761-1769. This trial was the first to demonstrate the safety and efficacy of tocilizumab treatment in patients with RA.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 1761-1769
-
-
Nishimoto, N.1
Yoshizaki, K.2
Miyasaka, N.3
-
29
-
-
10044279965
-
Efficacy of IL-6 receptor antagonist MRA in rheumatoid arthritis patients with an incomplete response to methotrexate (CHARISMA)
-
Maini RN, Taylor PC, Pavelka K, et al. Efficacy of IL-6 receptor antagonist MRA in rheumatoid arthritis patients with an incomplete response to methotrexate (CHARISMA) [abstract]. Arthritis Rheum 2003; 48 (suppl):S652.
-
(2003)
Arthritis Rheum
, vol.48
, Issue.SUPPL.
-
-
Maini, R.N.1
Taylor, P.C.2
Pavelka, K.3
-
30
-
-
20144362101
-
Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis
-
Yokota S, Miyamae T, Imagawa T, et al. Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum 2005; 52:818-825. This was the first study to demonstrate the efficacy of tocilizumab for systemic onset juvenile idiopathic arthritis.
-
(2005)
Arthritis Rheum
, vol.52
, pp. 818-825
-
-
Yokota, S.1
Miyamae, T.2
Imagawa, T.3
-
31
-
-
11144358366
-
A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
-
Ito H, Takazoe M, Fukuda Y, et al. A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 2004; 126:989-996. This was the first double-blind study to demonstrate the efficacy of tocilizumab in Crohn's disease.
-
(2004)
Gastroenterology
, vol.126
, pp. 989-996
-
-
Ito, H.1
Takazoe, M.2
Fukuda, Y.3
-
32
-
-
27144488346
-
Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman's disease
-
Nishimoto N, Kanakura Y, Aozasa K, et al. Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman's disease. Blood 2005; 106:2627-2632. This study demonstrated the safety and efficacy of tocilizumab in multicentric Castleman's disease, especially the wasting component.
-
(2005)
Blood
, vol.106
, pp. 2627-2632
-
-
Nishimoto, N.1
Kanakura, Y.2
Aozasa, K.3
|