Design, synthesis, characterization and anti-inflammatory evaluation of novel pyrazole amalgamated flavones

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 5, 2013, Pages 1315-1321

  Chavan, Hemant V ^a   Bandgar, Babasaheb P ^a   Adsul, Laxman K ^a   Dhakane, Valmik D ^a   Bhale, Pravin S ^a   Thakare, Vishnu N ^b   Masand, Vijay ^c  

^a SOLAPUR UNIVERSITY   (India)

^b Sinhgad Institute of Pharmaceutical Sciences   (India)

^c Vidyabharati Mahavidyalaya Camp ^*  (India)

Author keywords

Anti inflammatory activity; COSY; Flavones; HMBC; HSQC; Molecular docking; Pyrazole

Indexed keywords

1 METHYL 3 ( 2,4,6 TRIMETHOXYPHENYL) 1H PYRAZOLE; 1 METHYL 5 ( 2,4,6 TRIMETHOXYPHENYL) 1H PYRAZOLE; 4 [5 (4 BROMOPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; CARBON 13; CARRAGEENAN; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DERACOXIB; FAMPROFAZONE; FIPRONIL; FLAVONE DERIVATIVE; HYDROGEN; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; PYRACLONIL; PYRAZOLE DERIVATIVE; RAMIFENAZONE; RIMONABANT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD VESSEL PERMEABILITY; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG DESIGN; DRUG INHIBITION; DRUG SYNTHESIS; ENZYME INHIBITION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HIND PAW EDEMA; IN VITRO STUDY; IN VIVO STUDY; ISOMER; MOLECULAR DOCKING; MOUSE; NONHUMAN; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CYCLOOXYGENASE INHIBITORS; DRUG DESIGN; FLAVONES; MICE; MODELS, MOLECULAR; PYRAZOLES; RATS;

MUS; RATTUS;

EID: 84873710044     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.12.094     Document Type: Article

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