Synthesis, antichagasic in vitro evaluation, cytotoxicity assays, molecular modeling and SAR/QSAR studies of a 2-phenyl-3-(1-phenyl-1H-pyrazol-4-yl)-acrylic acid benzylidene-carbohydrazide series

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 1, 2009, Pages 295-302

  Vera DiVaio, Maria A F ^a   Freitas, Antônio C C ^a   Castro, Helena C ^a   de Albuquerque, Sérgio ^b   Cabral, Lucio M ^c   Rodrigues, Carlos R ^c   Albuquerque, Magaly G ^c   Martins, Rita C A ^d   Henriques, Maria G M O ^e   Dias, Luiza R S ^a  

^a FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^d Centro de Ensino Superior do Pará   (Brazil)

^e INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

1 Phenyl 1H pyrazol; Benzylidene carbohydrazides; Chagas disease; Trypanocidal evaluation

Indexed keywords

2 PHENYL 3 (1 PHENYL 1H PYRAZOL 4 YL)ACRYLIC ACID BENZYLIDENE CARBOHYDRAZIDE; ANTITRYPANOSOMAL AGENT; CRYSTAL VIOLET; N' BENZYLIDENE 2 PHENYL 3 (1 PHENYL 1H PYRAZOL 4 YL)CARBOHYDRAZIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOASSAY; CHAGAS DISEASE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; HYDROPHOBICITY; IC 50; IN VITRO STUDY; MOLECULAR MODEL; MOUSE; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ACTIVITY RELATION;

EID: 57749198638     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.085     Document Type: Article

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