A proximal pair of positive charges provides the dominant ligand-binding contribution to complement-like domains from the LRP (low-density lipoprotein receptor-related protein)

Biochemical Journal

Volumn 443, Issue 1, 2012, Pages 65-73

  Gettins, Peter G W ^a   Dolmer, Klavs ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Affinity; Complement like repeat domain (CR domain); Ligand specificity; Low density lipoprotein receptor; Low density lipoprotein receptor related protein (LRP); Lysine binding; Model compound; Thermodynamics

Indexed keywords

ARGININE; ASPARTIC ACID; COMPLEMENT; HISTIDINE; LIGAND; LOW DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LYSINE; PLASMINOGEN ACTIVATOR INHIBITOR 1;

AMINO ACID SEQUENCE; ARTICLE; ELECTRICITY; ENERGY TRANSFER; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

ALANINE; AMINO ACID MOTIFS; ARGININE; ASPARTIC ACID; BINDING SITES; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; LDL-RECEPTOR RELATED PROTEINS; LYSINE; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS;

EID: 84858321170     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20111867     Document Type: Article

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