Inhibition of p21-activated kinase 4 expression suppresses the proliferation of Hep-2 laryngeal carcinoma cells via activation of the ATM/Chk1/2/p53 pathway

International Journal of Oncology

Volumn 42, Issue 2, 2013, Pages 683-689

  Sun, Xin ^a   Liu, Bin ^a   Wang, Jin ^a   Li, Jun ^a   Ji, Wen Yue ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Cell cycle arrest; CldU and IdU double staining; Laryngeal carcinoma; P21 activated kinase 4; Survival rate

Indexed keywords

ATM PROTEIN; CASPASE 3; CASPASE 9; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CLOXURIDINE; IDOXURIDINE; MESSENGER RNA; P21 ACTIVATED KINASE 4; PROTEIN P53; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER MODEL; CANCER SIZE; CANCER SURVIVAL; CARCINOMA CELL; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LARYNX CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SURVIVAL RATE; SURVIVAL TIME;

ANIMALS; APOPTOSIS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CARCINOMA; CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LARYNGEAL NEOPLASMS; MICE; P21-ACTIVATED KINASES; PROTEIN KINASES; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84873637828     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1718     Document Type: Article

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