D-chiro-inositol and pinitol extend the life span of drosophila melanogaster

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 68, Issue 3, 2013, Pages 226-234

  Hada, Binika ^a   Yoo, Mi Ra ^a   Seong, Ki Moon ^b   Jin, Young Woo ^b   Myeong, Hyeon Koon ^c   Min, Kyung Jin ^a  

^a Inha University   (South Korea)

^b Korea Hydro & Nuclear Power Co   (South Korea)

^c Solgent Co Ltd   (South Korea)

Author keywords

D chiro inosito; D. melanogaster; dFOXO; Life span; Pinitol

Indexed keywords

DROSOPHILA PROTEIN; DRUG DERIVATIVE; FORKHEAD TRANSCRIPTION FACTOR; FOXO PROTEIN, DROSOPHILA; INOSITOL; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PINITOL; S6 KINASE;

ANIMAL; ARTICLE; DROSOPHILA MELANOGASTER; DRUG EFFECT; FEMALE; FERTILITY; LOCOMOTION; LONGEVITY; MALE; METABOLISM; PHYSIOLOGICAL STRESS; PHYSIOLOGY; SIGNAL TRANSDUCTION; STARVATION;

ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; FERTILITY; FORKHEAD TRANSCRIPTION FACTORS; INOSITOL; LOCOMOTION; LONGEVITY; MALE; MAP KINASE KINASE 4; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; STARVATION; STRESS, PHYSIOLOGICAL;

MLCS; MLOWN;

EID: 84873630159     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/gls156     Document Type: Article

References (42)

1. Kirkwood TB, Austad SN. Why do we age? Nature. 2000;408:233-238.
2. Fontana L, Partridge L, Longo VD. Extending healthy life span-from yeast to humans. Science. 2010;328:321-326.
3. Lane MA, Tilmont EM, De Angelis H, et al. Short-term calorie restriction improves disease-related markers in older male rhesus monkeys (Macaca mulatta). Mech Ageing Dev. 2000;112:185-196.
4. Burger JM, Hwangbo DS, Corby-Harris V, Promislow DE. The functional costs and benefits of dietary restriction in Drosophila. Aging Cell. 2007;6:63-71.
5. Sinclair DA. Toward a unified theory of caloric restriction and longevity regulation. Mech Ageing Dev. 2005;126:987-1002.
6. Ingram DK, Zhu M, Mamczarz J, Zou S, Lane MA, Roth GS, deCabo R. Calorie restriction mimetics: An emerging research field. Aging Cell. 2006;5:97-108.
7. Anisimov VN, Semenchenko AV, Yashin AI. Insulin and longevity: Antidiabetic biguanides as geroprotectors. Biogerontology. 2003;4:297-307.
8. Dilman VM, Anisimov VN. Effect of treatment with phenformin, diphenylhydantoin or l-dopa on life span and tumour incidence in c3h/sn mice. Gerontology. 1980;26:241-246.
9. Dhahbi JM, Mote PL, Fahy GM, Spindler SR. Identification of potential caloric restriction mimetics by microarray profiling. Physiol Genom. 2005;23:343-350.
10. Onken B, Driscoll M. Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans healthspan via AMPK, LKB1, and SKN-1. PLoS One. 2010;5(1):e8758.
11. Anisimov VN, Berstein LM, Egormin PA, et al. Metformin slows down aging and extends life span of female SHR mice. Cell Cycle. 2008;7:2769-2773.
12. Yao Y, Shan F, Bian J, Chen F, Wang M, Ren G. D-chiro-inositol-enriched tartary buckwheat bran extract lowers the blood glucose level in KK-AY mice. J Agric Food Chem. 2008;56:10027-10031.
13. Larner J. D-chiro-inositol-its functional role in insulin action and its deficit in insulin resistance. Int J Exp Diabetes Res. 2002;3:47-60.
14. Davis A, Christiansen M, Horowitz JF, Klein S, Hellerstein MK, Ostlund RE, Jr. Effect of pinitol treatment on insulin action in subjects with insulin resistance. Diabetes Care. 2000;23:1000-1005.
15. Bhat KA, Shah BA, Gupta KK, Pandey A, Bani S, Taneja SC. Semi-synthetic analogs of pinitol as potential inhibitors of TNF-alpha cytokine expression in human neutrophils. Bioorg Med Chem Lett. 2009;19:1939-1943.
16. Chung HY, Kim HJ, Kim JW, Yu BP. The inflammation hypothesis of aging: Molecular modulation by calorie restriction. Ann NY Acad Sci. 2001;928:327-335.
17. G argano JW, Martin I, Bhandari P, Grotewiel MS. Rapid iterative negative geotaxis (ring): A new method for assessing age-related locomotor decline in drosophila. Exp Gerontol. 2005;40:386-395.
18. Broughton SJ, Piper MD, Ikeya T, et al. Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci USA. 2005;102:3105-3110.
19. Flatt T. Survival costs of reproduction in drosophila. Exp Gerontol. 2011;46:369-375.
20. Jafari M, Rose MR. Rules for the use of model organisms in anti-aging pharmacology. Aging Cell. 2006;5:17-22.
21. Jafari M. Drosophila melanogaster as a model system for the evaluation of anti-aging compounds. Fly (Austin). 2010;4(3):253-257.
22. Partridge L, Gems D. Mechanisms of ageing: Public or private? Nat Rev Genet. 2002;3:165-175.
23. G uarente L, Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature. 2000;408:255-262.
24. G iannakou ME, Partridge L. Role of insulin-like signalling in Drosophila lifespan. Trends Biochem Sci. 2007;32:180-188.
25. Puig O, Marr MT, Ruhf ML, Tjian R. Control of cell number by Drosophila foxo: Downstream and feedback regulation of the insulin receptor pathway. Genes Dev. 2003;17:2006-2020.
26. Junger MA, Rintelen F, Stocker H, et al. The Drosophila forkhead transcription factor foxo mediates the reduction in cell number associated with reduced insulin signaling. J Biol. 2003;2:20.
27. Tettweiler G, Miron M, Jenkins M, Sonenberg N, Lasko PF. Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Genes Dev. 2005;19: 1840-1843.
28. Villa-Cuesta E, Sage BT, Tatar M. A role for Drosophila dFoxO and dFoxO 5′UTR internal ribosomal entry sites during fasting. PLoS One. 2010;5(7):e11521 (doi:10.1371/journal. pone.0011521).
29. Wessells R, Fitzgerald E, Piazza N, et al. d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila. Aging Cell 2009;8(5):542-552.
30. Lee KS, Iijima-Ando K, Iijima K, et al. JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span. J Biol Chem. 2009;284:29454-29461.
31. Kenyon CJ. The genetics of ageing. Nature. 2010;464:504-512.
32. Erratum in: Nature. 2010;467(7315):622.
33. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 1993;366:461-464.
34. Clancy DJ, Gems D, Harshman LG, et al. Extension of life-span by loss of chico, a Drosophila insulin receptor substrate protein. Science. 2001;292:104-106.
35. Kaeberlein M. Resveratrol and rapamycin: Are they anti-aging drugs? Bioessays. 2010;32:96-99.
36. Min KJ, Yamamoto R, Buch S, Pankratz M, Tatar M. Drosophila lifespan control by dietary restriction independent of insulin-like signaling. Aging Cell. 2008;7:199-206.
37. G reer EL, Brunet A. Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell. 2009;8:113-127.
38. Dominici FP, Arostegui DG, Bartke A, Kopchick JJ, Turyn D. Compensatory alterations of insulin signal transduction in liver of growth hormone receptor knockout mice. J Endocrinol. 2000;166:579-590.
39. Bartke A, Wright JC, Mattison JA, Ingram DK, Miller RA, Roth GS. Extending the lifespan of long-lived mice. Nature. 2001;414:412.
40. Le Bourg E. The rate of living theory. Spontaneous locomotor activity, aging and longevity in Drosophila melanogaster. Exp Gerontol. 1987;22:359-369.
41. Johnson TE, Lithgow GJ, Murakami S. Hypothesis: Interventions that increase the response to stress offer the potential for effective life prolongation and increased health. J Gerontol A Biol Sci Med Sci. 1996;51:B392-B395.
42. Holzenberger M, Dupont J, Ducos B, et al. Igf-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. 2003;421: 182-187.