Rules for the use of model organisms in antiaging pharmacology

Aging Cell

Volumn 5, Issue 1, 2006, Pages 17-22

  Jafari, Mahtab ^a   Rose, Michael R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antiaging; Drosophila; Drug discovery; Mortality; Pharmaceuticals; Pharmacology

Indexed keywords

ANTIDEPRESSANT AGENT; ANTIHISTAMINIC AGENT; DIGOXIN; SEROTONIN UPTAKE INHIBITOR;

AGING; ALLERGIC RHINITIS; ARTICLE; CAENORHABDITIS; COGNITIVE DEFECT; CONGESTIVE HEART FAILURE; DOSE RESPONSE; DROSOPHILA; DRUG DOSE REGIMEN; DRUG RESEARCH; GENE MUTATION; HUMAN; INFERTILITY; LONGEVITY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; SEDATION; SEXUAL DYSFUNCTION; SIDE EFFECT; SPECIES DIFFERENCE; TRANSGENIC ANIMAL;

AGING; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY METABOLISM; FERTILITY; GUIDELINES; HEREDITY; MODELS, ANIMAL; NERVOUS SYSTEM; PHARMACOLOGY, CLINICAL; RESEARCH DESIGN; SURVIVAL RATE;

ANIMALIA; CAENORHABDITIS;

EID: 33644801993     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2006.00195.x     Document Type: Article

References (46)

1. Braeckman BP, Houthoofd K, Vanfleteren JR (2002) Assessing metabolic activity in aging Caenorhabditis elegans: Concepts and controversies. Aging Cell 1, 82-88.
2. Buchanan FJ, Davis LJ (1984) Drug-induced infertility. Drug Intell. Clin. Pharm. 18, 122-132.
3. Carey JR, Liedo P, Orozco D, Vaupel JW (1992) Slowing of mortality-rates at older ages in large medfly cohorts. Science 258 (5081), 457-461.
4. Chippindale AK, Leroi AM, Kim SB, Rose MR (1993) Metabolic aspects of the trade-off between fecundity and longevity in Drosophila melanogaster. J. Evol. Biol. 10, 269-293.
5. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Oparil S, Wright JT, Roccella J (2003) Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42, 1206-1252.
6. Clayton AH, Pradko JF, Croft HA, Montano CB, Leadbetter RA, Bolden-Watson C, Bass KI, Donahue RM, Jamerson BD, Metz A (2002) Prevalence of sexual dysfunction among newer antidepressants. J. Clin. Psychiatry 63, 357-366.
7. Curtsinger JW, Fukui HH, Townsend DR, Vaupel JW (1992) Demography of Genotypes of Failure of the limited life-span paradign in Drosophila Melanogaster. Science 258, 461-463.
8. Djawdan M, Sugiyama TT, Schlaeger LK, Bradley TJ, Rose MR (1996) Metabolic aspects of the trade-off between fecundity and longevity in Drosophila melanogaster. Physiol. Zool. 69, 1176-1195.
9. Drapeau MD, Gass EK, Simison MD, Mueller LD, Rose MR (2000) Testing the heterogeneity theory of late-life mortality plateus by using cohorts of Drosophila melanogaster. Exp. Gerontol. 35, 71-84.
10. Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science 307, 258-262.
11. Finch CE (1990) Longevity, Senescence, and the Genome. Chicago: University of Chicago Press.
12. Fleming JE, Spicer GC, Garrison RC, Rose MR (1993) Two dimensional protein electrophoretic analysis of postponed aging in Drosophila. Genetica 91, 183-198.
13. Graves JL (1993) The costs of reproduction and dietary restriction-parallels between insects and mammals. Growth Dev. Aging 57, 233-249.
14. Greenwood M, Irwin JO (1939) Biostatistics of senility. Hum. Biol. 11, 1-23.
15. Kang HL, Benzer S, Min KT (2002) Life extension in Drosophila by feeding a drug. Proc. Natl Acad. Sci. USA 99, 838-843.
16. Khazaeli AA, Van Voorhies W, Curtsinger JW (2005) The relationship between life span and adult body size is highly strain-specific in Drosophila melanogaster. Exp. Gerontol. 40, 377-385.
17. Leroi AM, Chippindale AK, Rose MR (1994) Long-term laboratory evolution of a genetic trade-off in Drosophila melanogaster I. The role of genotype-environment interaction. Evolution 48, 1244-1257.
18. Lin YJ, Seroud L, Benzer S (1998) Extended life-span and stress resistance in the Drosophila mutant methuselah. Science 282, 943-946.
19. Lonn E, Yusuf S, Hoogwerf B, Pogue J, Yi Q, Zinman B, Bosch J, Dagenais G, Man J, Gerstein HC (2002) Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes. Diabetes Care 25, 1919-1927.
20. Marden JH, Rogina B, Montooth KL, Helfand SL (2003) Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies. Proc. Natl Acad. Sci. USA 100, 3369-3373.
21. Martinez DE (1998) Mortality patterns suggest lack of senescence in hydra. Exp. Gerontol. 33, 217-225.
22. Maynard Smith J (1959) Sex-limited inheritance of longevity in Drosophila subobscura. J. Genet. 56, 1-9.
23. Melov S, Doctrow SR, Schneider JA, Haberson J, Patel M, Coskun PE, Huffman K, Wallace DC, Malfroy B (2001) Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics. J. Neurosci. 21, 8348-8353.
24. Melov S, Ravenscroft J, Malik S, Gill MS, Walker DW, Clayton PE, Wallace DC, Malfroy B, Doctrow SR, Lithgow GJ (2000) Extension of life-span with superoxide dismutase/catalase mimetics. Science 289, 1567-1569.
25. Mueller LD, Nusbaum TJ, Rose MR (1995) The Gompertz equation as a predictive tool in demography. Exp. Gerontol. 30, 553-569.
26. Ng KH, Chong D, Wong CK, Ong HT, Lee CY, Lee BW, Shek LP (2004) Central nervous system side effects of first- and second-generation antihistamines in school children with perennial allergic rhinitis: A randomized, double-blind, placebo-controlled comparative study. Pediatrics. 113: E116-121.
27. Phelan JP, Rose MR (2005) Why dietary restriction substantially increases longevity in animal models but won't in humans. Ageing Res. Rev. 4, 339-350.
28. Pirraglia PA, Stafford RS, Singer DE (2003) Trends in prescribing of selective serotonin reuptake inhibitors and other newer antidepressant agents in adult primary care. Prim. Care Companion J. Clin. Psychiatry 5, 153-157.
29. Pletcher SD, Macdonald SJ, Margueri R, Certa U, Stearns SC, Goldstein DB, Partridge L (2002) Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr. Biol. 12, 712-723.
30. Rathore SS, Curtis JP, Wang Y, Bristow MR, Krumhols HM (2003) Association of serum digoxin concentration and outcomes in patients with heart failure. JAMA 289, 871-878.
31. Rauser CL, Mueller LD, Rose MR (2003) Aging, fertility and immortality. Exp. Gerontol. 38, 27-33.
32. Rauser CL, Mueller LD, Rose MR (2006) The evolution of late life. Ageing Research Reviews. In press.
33. Rogina B, Reenan RB, Nilsen SP, Helfand SL (2000) Extended life-span conferred by cotransporter gene mutations in Drosophila. Science 290, 2137-2140.
34. Rose MR (1984) Artificial selection on a fitness-component in Drosophila melanogaster. Evolution 38, 516-526.
35. Rose MR (1991) Evolutionary Biology of Aging. New York: Oxford University Press.
36. Rose MR, Long AD (2002) Ageing: The many-headed monster. Curr. Biol. 12, R311-R312.
37. Rose MR, Drapeau MD, Yazdi PG, Shah KH, Moise DB, Thakar RR, Rauser CL, Mueller LD (2002) Evolution of late life mortality in Drosophila melanogaster. Evolution 56, 1982-1991.
38. Rose MR, Passananti HB, Mato M (2004) Methuselah Flies: A Case Study in the Evolution of Aging. Singapore: World Scientific Publishing.
39. Rose MR, Passananti HB, Chippindale AK, Phelan JP, Matos M, Teotónio H, Mueller LD (2005) The effects of evolution are local: evidence from experimental evolution in Drosophila. Integr. Comp. Biol. 45, 486-491.
40. Rose MR, Rauser CL, Mueller LD (2005) Late life: A new frontier for physiology. Physiol. Biochem. Zool. 78, 869-878.
41. Service PM (1987) Physiological mechanism of increased stress resistance in Drosophila melanogaster selected for postponed senescence. Physiol. Zool. 60, 321-326.
42. Tatar M, Kopelman A, Epstein D, Tu M-P, Yin C-M, Garofalo RS (2001) A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292, 107-109.
43. Van Voorhies WA, Ward S (1999) Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate. Proc. Natl Acad. Sci. USA 96, 399-403.
44. Vaupel JW, Carey JR, Christensen K, Johnson TE, Yashin AI, Holm NV, Iachine IA, Kannisto V, Khazaeli AA, Liedo P, Longo VD, Zeng Y, Manton KG, Curtsinger JW (1998) Biodemographic trajectories of longevity. Science 280, 855-860.
45. Weindruch R, Walford RL (1988) The Retardation of Aging and Disease by Dietary Restriction. Springfield, Illinois: Charles C Thomas.
46. Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686-689.