메뉴 건너뛰기




Volumn 46, Issue 2, 2013, Pages 148-156

Potential roles of activation-induced cytidine deaminase in promotion or prevention of autoimmunity in humans

Author keywords

Class switch recombination deficiency; Primary immunodeficiency; Tolerance

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE;

EID: 84873629665     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916934.2012.750299     Document Type: Article
Times cited : (34)

References (63)
  • 2
    • 34249814325 scopus 로고    scopus 로고
    • Pathophysiology of B-cell intrinsic immunoglobulin class switch recombination deficiencies
    • Durandy, A., N. Taubenheim, S. Peron, and A. Fischer. 2007. Pathophysiology of B-cell intrinsic immunoglobulin class switch recombination deficiencies. Adv. Immunol. 94: 275-306
    • (2007) Adv. Immunol. , vol.94 , pp. 275-306
    • Durandy, A.1    Taubenheim, N.2    Peron, S.3    Fischer, A.4
  • 3
    • 0027533185 scopus 로고
    • Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM
    • Korthauer, U., D. Graf, H. W. Mages, et al. 1993. Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. Nature 361: 539-541
    • (1993) Nature , vol.361 , pp. 539-541
    • Korthauer, U.1    Graf, D.2    Mages, H.W.3
  • 4
    • 0035940417 scopus 로고    scopus 로고
    • Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM
    • Ferrari, S., S. Giliani, A. Insalaco, et al. 2001. Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. Proc. Natl. Acad. Sci. USA 98: 12614-12619
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12614-12619
    • Ferrari, S.1    Giliani, S.2    Insalaco, A.3
  • 5
    • 0030702854 scopus 로고    scopus 로고
    • Clinical spectrum of X-linked hyper-IgM syndrome
    • Levy, J., T. Espanol-Boren, C. Thomas, et al. 1997. Clinical spectrum of X-linked hyper-IgM syndrome. J. Pediatr. 131: 47-54
    • (1997) J. Pediatr. , vol.131 , pp. 47-54
    • Levy, J.1    Espanol-Boren, T.2    Thomas, C.3
  • 6
    • 0345276650 scopus 로고    scopus 로고
    • The X-linked hyper-IgM syndrome: Clinical and immunologic features of 79 patients
    • Winkelstein, J. A., M. C. Marino, H. Ochs, et al. 2003. The X-linked hyper-IgM syndrome: clinical and immunologic features of 79 patients. Medicine (Baltimore) 82: 373-384
    • (2003) Medicine (Baltimore) , vol.82 , pp. 373-384
    • Winkelstein, J.A.1    Marino, M.C.2    Ochs, H.3
  • 7
    • 0034264851 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
    • Revy, P., T. Muto, Y. Levy, et al. 2000. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell 102: 565-575
    • (2000) Cell , vol.102 , pp. 565-575
    • Revy, P.1    Muto, T.2    Levy, Y.3
  • 8
    • 0037019315 scopus 로고    scopus 로고
    • AID mutates e coli suggesting a DNA deamination mechanism for antibody diversification
    • Petersen-Mahrt, S. K., R. S. Harris, and M. S. Neuberger. 2002. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 418: 99-104
    • (2002) Nature , vol.418 , pp. 99-104
    • Petersen-Mahrt, S.K.1    Harris, R.S.2    Neuberger, M.S.3
  • 9
    • 0037388165 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
    • Bransteitter, R., P. Pham, M. D. Scharff, and M. F. Goodman. 2003. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc. Natl. Acad. Sci. USA 100: 4102-4107
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4102-4107
    • Bransteitter, R.1    Pham, P.2    Scharff, M.D.3    Goodman, M.F.4
  • 10
    • 79551681406 scopus 로고    scopus 로고
    • The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates
    • Basu,U., F. L. Meng, C. Keim, et al. 2011. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell 144: 353-363
    • (2011) Cell , vol.144 , pp. 353-363
    • Basu, U.1    Meng, F.L.2    Keim, C.3
  • 11
    • 19044396637 scopus 로고    scopus 로고
    • Analysis of class switch recombination and somatic hypermutation in patients affected with autosomal dominant hyper-IgM syndrome type 2
    • Imai, K., Y. Zhu, P. Revy, et al. 2005. Analysis of class switch recombination and somatic hypermutation in patients affected with autosomal dominant hyper-IgM syndrome type 2. Clin. Immunol. 115: 277-285
    • (2005) Clin. Immunol. , vol.115 , pp. 277-285
    • Imai, K.1    Zhu, Y.2    Revy, P.3
  • 12
    • 66149087337 scopus 로고    scopus 로고
    • The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence
    • Geisberger, R., C. Rada, and M. S. Neuberger. 2009. The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence. Proc. Natl. Acad. Sci. USA 106: 6736-6741
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 6736-6741
    • Geisberger, R.1    Rada, C.2    Neuberger, M.S.3
  • 13
    • 0142092610 scopus 로고    scopus 로고
    • Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
    • Imai, K., G. Slupphaug, W. I. Lee, et al. 2003. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Nat. Immunol. 4: 1023-1028
    • (2003) Nat. Immunol. , vol.4 , pp. 1023-1028
    • Imai, K.1    Slupphaug, G.2    Lee, W.I.3
  • 14
    • 6344256944 scopus 로고    scopus 로고
    • Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation
    • Rada, C., J. M. Di Noia, and M. S. Neuberger. 2004. Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol. Cell 16: 163-171
    • (2004) Mol. Cell , vol.16 , pp. 163-171
    • Rada, C.1    Di Noia, J.M.2    Neuberger, M.S.3
  • 15
    • 36549036731 scopus 로고    scopus 로고
    • APE1-and APE2-dependent DNA breaks in immunoglobulin class switch recombination
    • Guikema, J. E., E. K. Linehan, D. Tsuchimoto, et al. 2007. APE1-and APE2-dependent DNA breaks in immunoglobulin class switch recombination. J. Exp. Med. 204: 3017-3026
    • (2007) J. Exp. Med. , vol.204 , pp. 3017-3026
    • Guikema, J.E.1    Linehan, E.K.2    Tsuchimoto, D.3
  • 16
    • 33749519393 scopus 로고    scopus 로고
    • Somatic hypermutation and class switch recombination in Msh6(2/2)Ung(2/2) double-knockout mice
    • Shen, H. M., A. Tanaka, G. Bozek, D. Nicolae, and U. Storb. 2006. Somatic hypermutation and class switch recombination in Msh6(2/2)Ung(2/2) double-knockout mice. J. Immunol. 177: 5386-5392
    • (2006) J. Immunol. , vol.177 , pp. 5386-5392
    • Shen, H.M.1    Tanaka, A.2    Bozek, G.3    Nicolae, D.4    Storb, U.5
  • 17
    • 0035807955 scopus 로고    scopus 로고
    • Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination
    • Ehrenstein, M. R., C. Rada, A. M. Jones, C. Milstein, and M. S. Neuberger. 2001. Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination. Proc. Natl. Acad. Sci. USA 98: 14553-14558
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 14553-14558
    • Ehrenstein, M.R.1    Rada, C.2    Jones, A.M.3    Milstein, C.4    Neuberger, M.S.5
  • 18
    • 0037017390 scopus 로고    scopus 로고
    • Role for Mismatch Repair Proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions
    • Schrader, C. E., J. Vardo, and J. Stavnezer. 2002. Role for Mismatch Repair Proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions. J. Exp. Med. 195: 367-373
    • (2002) J. Exp. Med. , vol.195 , pp. 367-373
    • Schrader, C.E.1    Vardo, J.2    Stavnezer, J.3
  • 19
    • 58149165112 scopus 로고    scopus 로고
    • Human PMS2 deficiency is associated with impaired immunoglobulin class switch recombination
    • Peron, S., A. Metin, P. Gardes, et al. 2008. Human PMS2 deficiency is associated with impaired immunoglobulin class switch recombination. J. Exp. Med. 205: 2465-2472
    • (2008) J. Exp. Med. , vol.205 , pp. 2465-2472
    • Peron, S.1    Metin, A.2    Gardes, P.3
  • 20
    • 84856895159 scopus 로고    scopus 로고
    • Human MSH6 deficiency is associated with impaired antibody maturation
    • Gardes, P., M. Forveille, M. A. Alyanakian, et al. 2012. Human MSH6 deficiency is associated with impaired antibody maturation. J. Immunol. 188: 2023-2029
    • (2012) J. Immunol. , vol.188 , pp. 2023-2029
    • Gardes, P.1    Forveille, M.2    Alyanakian, M.A.3
  • 21
    • 34748863465 scopus 로고    scopus 로고
    • IgH class switching and translocations use a robust non-classical endjoining pathway
    • Yan, C. T., C. Boboila, E. K. Souza, et al. 2007. IgH class switching and translocations use a robust non-classical endjoining pathway. Nature 449: 478-482
    • (2007) Nature , vol.449 , pp. 478-482
    • Yan, C.T.1    Boboila, C.2    Souza, E.K.3
  • 22
    • 0041381361 scopus 로고    scopus 로고
    • AID mutant analyses indicate requirement for class-switch-specific cofactors
    • Ta, V. T., H. Nagaoka, N. Catalan, et al. 2003. AID mutant analyses indicate requirement for class-switch-specific cofactors. Nat. Immunol. 4: 843-848
    • (2003) Nat. Immunol. , vol.4 , pp. 843-848
    • Ta, V.T.1    Nagaoka, H.2    Catalan, N.3
  • 23
    • 0141992113 scopus 로고    scopus 로고
    • C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion
    • Barreto, V., B. Reina-San-Martin, A. R. Ramiro, K. M. McBride, and M. C. Nussenzweig. 2003. C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol. Cell 12: 501-508
    • (2003) Mol. Cell , vol.12 , pp. 501-508
    • Barreto, V.1    Reina-San-Martin, B.2    Ramiro, A.R.3    McBride, K.M.4    Nussenzweig, M.C.5
  • 24
    • 79960998395 scopus 로고    scopus 로고
    • Activationinduced cytidine deaminase (AID) is required for B-cell tolerance in humans
    • Meyers, G., Y. S. Ng, J. M. Bannock, et al. 2011. Activationinduced cytidine deaminase (AID) is required for B-cell tolerance in humans. Proc. Natl. Acad. Sci. USA 108: 11554-11559
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 11554-11559
    • Meyers, G.1    Ng, Y.S.2    Bannock, J.M.3
  • 25
    • 34447288471 scopus 로고    scopus 로고
    • CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance
    • Herve, M., I. Isnardi, Y. S. Ng, et al. 2007. CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance. J. Exp. Med. 204: 1583-1593
    • (2007) J. Exp. Med. , vol.204 , pp. 1583-1593
    • Herve, M.1    Isnardi, I.2    Ng, Y.S.3
  • 26
    • 1242296822 scopus 로고    scopus 로고
    • Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut
    • Suzuki, K., B. Meek, Y. Doi, et al. 2004. Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc. Natl. Acad. Sci. USA 101: 1981-1986
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 1981-1986
    • Suzuki, K.1    Meek, B.2    Doi, Y.3
  • 27
    • 10744226125 scopus 로고    scopus 로고
    • Clinical, immunologic and genetic analysis of 29 patients with autosomal recessive hyper-IgM syndrome due to Activation-Induced Cytidine Deaminase deficiency
    • Quartier, P., J. Bustamante, O. Sanal, et al. 2004. Clinical, immunologic and genetic analysis of 29 patients with autosomal recessive hyper-IgM syndrome due to Activation-Induced Cytidine Deaminase deficiency. Clin. Immunol. 110: 22-29
    • (2004) Clin. Immunol. , vol.110 , pp. 22-29
    • Quartier, P.1    Bustamante, J.2    Sanal, O.3
  • 28
    • 0029933493 scopus 로고    scopus 로고
    • Hyper-IgM syndrome associated with rheumatoid arthritis: Report of RA in a patient with primary impaired CD40 pathway
    • Sibilia, J., A. Durandy, T. Schaeverbeke, and J. P. Fermand. 1996. Hyper-IgM syndrome associated with rheumatoid arthritis: report of RA in a patient with primary impaired CD40 pathway. Br. J. Rheumatol. 35: 282-284
    • (1996) Br. J. Rheumatol. , vol.35 , pp. 282-284
    • Sibilia, J.1    Durandy, A.2    Schaeverbeke, T.3    Fermand, J.P.4
  • 29
    • 0041689676 scopus 로고    scopus 로고
    • Predominant autoantibody production by early human B cell precursors
    • Wardemann, H., S. Yurasov, A. Schaefer, et al. 2003. Predominant autoantibody production by early human B cell precursors. Science 301: 1374-1377
    • (2003) Science , vol.301 , pp. 1374-1377
    • Wardemann, H.1    Yurasov, S.2    Schaefer, A.3
  • 30
    • 0037375554 scopus 로고    scopus 로고
    • Antigen receptor selection by editing or downregulation of V(D)J recombination
    • Nemazee, D., and K. A. Hogquist. 2003. Antigen receptor selection by editing or downregulation of V(D)J recombination. Curr. Opin. Immunol. 15: 182-189
    • (2003) Curr. Opin. Immunol. , vol.15 , pp. 182-189
    • Nemazee, D.1    Hogquist, K.A.2
  • 31
    • 80052376347 scopus 로고    scopus 로고
    • The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans
    • Menard, L., D. Saadoun, I. Isnardi, et al. 2011. The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans. J. Clin. Invest. 121: 3635-3644
    • (2011) J. Clin. Invest. , vol.121 , pp. 3635-3644
    • Menard, L.1    Saadoun, D.2    Isnardi, I.3
  • 32
    • 55349142293 scopus 로고    scopus 로고
    • IRAK-4-and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans
    • Isnardi, I., Y. S. Ng, I. Srdanovic, et al. 2008. IRAK-4-and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans. Immunity 29: 746-757
    • (2008) Immunity , vol.29 , pp. 746-757
    • Isnardi, I.1    Ng, Y.S.2    Srdanovic, I.3
  • 33
    • 84861833417 scopus 로고    scopus 로고
    • Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapy
    • Sauer, A. V., H. Morbach, I. Brigida, et al. 2012. Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapy. J. Clin. Invest. 122: 2141-2152
    • (2012) J. Clin. Invest. , vol.122 , pp. 2141-2152
    • Sauer, A.V.1    Morbach, H.2    Brigida, I.3
  • 34
    • 1342265786 scopus 로고    scopus 로고
    • T cellindependent somatic hypermutation in murine B cells with an immature phenotype
    • Mao, C., L. Jiang, M. Melo-Jorge, et al. 2004. T cellindependent somatic hypermutation in murine B cells with an immature phenotype. Immunity 20: 133-144
    • (2004) Immunity , vol.20 , pp. 133-144
    • Mao, C.1    Jiang, L.2    Melo-Jorge, M.3
  • 35
    • 34447617375 scopus 로고    scopus 로고
    • Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors
    • Han, J. H., S. Akira, K. Calame, et al. 2007. Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors. Immunity 27: 64-75
    • (2007) Immunity , vol.27 , pp. 64-75
    • Han, J.H.1    Akira, S.2    Calame, K.3
  • 36
    • 33947216515 scopus 로고    scopus 로고
    • T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells
    • Ueda, Y., D. Liao, K. Yang, A. Patel, and G. Kelsoe. 2007. T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells. J. Immunol. 178: 3593-3601
    • (2007) J. Immunol. , vol.178 , pp. 3593-3601
    • Ueda, Y.1    Liao, D.2    Yang, K.3    Patel, A.4    Kelsoe, G.5
  • 37
    • 70349260308 scopus 로고    scopus 로고
    • Activationinduced cytidine deaminase expression and activity in the absence of germinal centers: Insights into hyper-IgM syndrome
    • Kuraoka, M., D. Liao, K. Yang, et al. 2009. Activationinduced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome. J. Immunol. 183: 3237-3248
    • (2009) J. Immunol. , vol.183 , pp. 3237-3248
    • Kuraoka, M.1    Liao, D.2    Yang, K.3
  • 38
    • 79961011020 scopus 로고    scopus 로고
    • Activationinduced cytidine deaminase mediates central tolerance in B cells
    • Kuraoka, M., T. M. Holl, D. Liao, et al. 2011. Activationinduced cytidine deaminase mediates central tolerance in B cells. Proc. Natl. Acad. Sci. USA 108: 11560-11565
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 11560-11565
    • Kuraoka, M.1    Holl, T.M.2    Liao, D.3
  • 39
    • 0029076561 scopus 로고
    • CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4 T cells
    • Rathmell, J. C., M. P. Cooke, W. Y. Ho, et al. 1995. CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4 T cells. Nature 376: 181-184
    • (1995) Nature , vol.376 , pp. 181-184
    • Rathmell, J.C.1    Cooke, M.P.2    Ho, W.Y.3
  • 40
    • 0030592564 scopus 로고    scopus 로고
    • Expansion or elimination of B cells in vivo: Dual roles for CD40-and Fas (CD95)-ligands modulated by the B cell antigen receptor
    • Rathmell, J. C., S. E. Townsend, J. C. Xu, R. A. Flavell, and C. C. Goodnow. 1996. Expansion or elimination of B cells in vivo: dual roles for CD40-and Fas (CD95)-ligands modulated by the B cell antigen receptor. Cell 87: 319-329
    • (1996) Cell , vol.87 , pp. 319-329
    • Rathmell, J.C.1    Townsend, S.E.2    Xu, J.C.3    Flavell, R.A.4    Goodnow, C.C.5
  • 41
    • 0035860559 scopus 로고    scopus 로고
    • An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    • Schiemann, B., J. L. Gommerman, K. Vora, et al. 2001. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 293: 2111-2114
    • (2001) Science , vol.293 , pp. 2111-2114
    • Schiemann, B.1    Gommerman, J.L.2    Vora, K.3
  • 42
    • 0033428703 scopus 로고    scopus 로고
    • Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
    • Mackay, F., S. A. Woodcock, P. Lawton, et al. 1999. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J. Exp. Med. 190: 1697-1710
    • (1999) J. Exp. Med. , vol.190 , pp. 1697-1710
    • MacKay, F.1    Woodcock, S.A.2    Lawton, P.3
  • 44
    • 0025583751 scopus 로고
    • Pathogenic anti-DNA antibodies in SLE: Idiotypic families and genetic origins
    • Paul, E., A. Manheimer-Lory, A. Livneh, et al. 1990. Pathogenic anti-DNA antibodies in SLE: idiotypic families and genetic origins. Int. Rev. Immunol. 5: 295-313
    • (1990) Int. Rev. Immunol. , vol.5 , pp. 295-313
    • Paul, E.1    Manheimer-Lory, A.2    Livneh, A.3
  • 45
    • 0025978752 scopus 로고
    • Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus
    • van Es, J. H., F. H. Gmelig Meyling,W. R. van de Akker, et al. 1991. Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus. J. Exp. Med. 173: 461-470
    • (1991) J. Exp. Med. , vol.173 , pp. 461-470
    • Van Es, J.H.1    Gmelig Meyling, F.H.2    Van De Akker, W.R.3
  • 46
    • 0032169223 scopus 로고    scopus 로고
    • Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjogren's syndrome
    • Stott, D. I., F. Hiepe, M. Hummel, G. Steinhauser, and C. Berek. 1998. Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjogren's syndrome. J. Clin. Invest. 102: 938-946
    • (1998) J. Clin. Invest. , vol.102 , pp. 938-946
    • Stott, D.I.1    Hiepe, F.2    Hummel, M.3    Steinhauser, G.4    Berek, C.5
  • 47
    • 0035881829 scopus 로고    scopus 로고
    • Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in myasthenia gravis
    • Sims, G. P., H. Shiono, N. Willcox, and D. I. Stott. 2001. Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in myasthenia gravis. J. Immunol. 167: 1935-1944
    • (2001) J. Immunol. , vol.167 , pp. 1935-1944
    • Sims, G.P.1    Shiono, H.2    Willcox, N.3    Stott, D.I.4
  • 48
    • 21544463136 scopus 로고    scopus 로고
    • The evolution of human anti-double-stranded DNA autoantibodies
    • Wellmann, U., M. Letz, M. Herrmann, et al. 2005. The evolution of human anti-double-stranded DNA autoantibodies. Proc. Natl. Acad. Sci. USA 102: 9258-9263
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 9258-9263
    • Wellmann, U.1    Letz, M.2    Herrmann, M.3
  • 49
    • 84864968123 scopus 로고    scopus 로고
    • Activation-induced deaminase contributes to the antibodyindependent role of B cells in the development of autoimmunity
    • Jiang, C., M. L. Zhao, K. M. Waters, and M. Diaz. 2012. Activation-induced deaminase contributes to the antibodyindependent role of B cells in the development of autoimmunity. Autoimmunity 45: 440-448
    • (2012) Autoimmunity , vol.45 , pp. 440-448
    • Jiang, C.1    Zhao, M.L.2    Waters, K.M.3    Diaz, M.4
  • 50
    • 34249826624 scopus 로고    scopus 로고
    • Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice
    • Jiang, C., J. Foley, N. Clayton, et al. 2007. Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice. J. Immunol. 178: 7422-7431
    • (2007) J. Immunol. , vol.178 , pp. 7422-7431
    • Jiang, C.1    Foley, J.2    Clayton, N.3
  • 51
    • 57449111276 scopus 로고    scopus 로고
    • Activation-induced deaminase heterozygous MRL/lpr mice are delayed in the production of high-affinity pathogenic antibodies and in the development of lupus nephritis
    • Jiang, C., M. L. Zhao, and M. Diaz. 2009. Activation-induced deaminase heterozygous MRL/lpr mice are delayed in the production of high-affinity pathogenic antibodies and in the development of lupus nephritis. Immunology 126: 102-113
    • (2009) Immunology , vol.126 , pp. 102-113
    • Jiang, C.1    Zhao, M.L.2    Diaz, M.3
  • 52
    • 59049098881 scopus 로고    scopus 로고
    • Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: Concurrent upregulation of somatic hypermutation and class switch DNA recombination
    • Zan, H., J. Zhang, S. Ardeshna, et al. 2009. Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination. Autoimmunity 42: 89-103
    • (2009) Autoimmunity , vol.42 , pp. 89-103
    • Zan, H.1    Zhang, J.2    Ardeshna, S.3
  • 53
    • 51849125587 scopus 로고    scopus 로고
    • Activationinduced cytidine deaminase deficiency causes organ-specific autoimmune disease
    • Hase, K., D. Takahashi, M. Ebisawa, et al. 2008. Activationinduced cytidine deaminase deficiency causes organ-specific autoimmune disease. PLoS One 3: e3033
    • (2008) PLoS One , vol.3
    • Hase, K.1    Takahashi, D.2    Ebisawa, M.3
  • 54
    • 70149094600 scopus 로고    scopus 로고
    • AID constrains germinal center size by rendering B cells susceptible to apoptosis
    • Zaheen, A., B. Boulianne, J. Y. Parsa, et al. 2009. AID constrains germinal center size by rendering B cells susceptible to apoptosis. Blood 114: 547-554
    • (2009) Blood , vol.114 , pp. 547-554
    • Zaheen, A.1    Boulianne, B.2    Parsa, J.Y.3
  • 55
    • 10644282845 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: Implications for epigenetic reprogramming
    • Morgan, H. D., W. Dean, H. A. Coker, W. Reik, and S. K. Petersen-Mahrt. 2004. Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming. J. Biol. Chem. 279: 52353-52360
    • (2004) J. Biol. Chem. , vol.279 , pp. 52353-52360
    • Morgan, H.D.1    Dean, W.2    Coker, H.A.3    Reik, W.4    Petersen-Mahrt, S.K.5
  • 56
    • 57649196594 scopus 로고    scopus 로고
    • DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45
    • Rai, K., I. J. Huggins, S. R. James, et al. 2008. DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell 135: 1201-1212
    • (2008) Cell , vol.135 , pp. 1201-1212
    • Rai, K.1    Huggins, I.J.2    James, S.R.3
  • 57
    • 77649104794 scopus 로고    scopus 로고
    • Reprogramming towards pluripotency requires AID-dependent DNA demethylation
    • Bhutani, N., J. J. Brady, M. Damian, et al. 2010. Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature 463: 1042-1047
    • (2010) Nature , vol.463 , pp. 1042-1047
    • Bhutani, N.1    Brady, J.J.2    Damian, M.3
  • 58
    • 77249148019 scopus 로고    scopus 로고
    • Genome-wide erasure of DNA methylation in mouse primordial germcells is affected by AID deficiency
    • Popp, C.,W. Dean, S. Feng, et al. 2010. Genome-wide erasure of DNA methylation in mouse primordial germcells is affected by AID deficiency. Nature 463: 1101-1105
    • (2010) Nature , vol.463 , pp. 1101-1105
    • Popp, C.1    Dean, W.2    Feng, S.3
  • 59
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • Bennett, C. L., J. Christie, F. Ramsdell, et al. 2001. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27: 20-21
    • (2001) Nat. Genet. , vol.27 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3
  • 60
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow, M. E., E. W. Jeffery, K. A. Hjerrild, et al. 2001. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27: 68-73
    • (2001) Nat. Genet. , vol.27 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.W.2    Hjerrild, K.A.3
  • 61
    • 84555203265 scopus 로고    scopus 로고
    • Activationinduced cytidine deaminase expression in CD4 T cells is associated with a unique IL-10-producing subset that increases with age
    • Qin, H., K. Suzuki, M. Nakata, et al. 2011. Activationinduced cytidine deaminase expression in CD4 T cells is associated with a unique IL-10-producing subset that increases with age. PLoS One 6: e29141
    • (2011) PLoS One , vol.6
    • Qin, H.1    Suzuki, K.2    Nakata, M.3
  • 62
    • 0033577903 scopus 로고    scopus 로고
    • A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
    • Chan, O. T., L. G. Hannum, A. M. Haberman, M. P. Madaio, and M. J. Shlomchik. 1999. A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J. Exp. Med. 189: 1639-1648
    • (1999) J. Exp. Med. , vol.189 , pp. 1639-1648
    • Chan, O.T.1    Hannum, L.G.2    Haberman, A.M.3    Madaio, M.P.4    Shlomchik, M.J.5
  • 63
    • 77957729025 scopus 로고    scopus 로고
    • Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity
    • Guo, W., D. Smith, K. Aviszus, et al. 2010. Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity. J. Exp. Med. 207: 2225-2237
    • (2010) J. Exp. Med. , vol.207 , pp. 2225-2237
    • Guo, W.1    Smith, D.2    Aviszus, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.