Determination of gemcitabine and its metabolite in extracellular fluid of rat brain tumor by ultra performance liquid chromatography-tandem mass spectrometry using microdialysis sampling after intralesional chemotherapy

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 919-920, Issue , 2013, Pages 10-19

  Sun, Ying ^a   Tang, Daoquan ^a   Chen, Hui ^a   Zhang, Fan ^a   Fan, Bin ^b   Zhang, Bei ^c   Fang, Shaoying ^a   Lu, Qian ^a   Wei, Yaqin ^a   Yin, Jiale ^a   Yin, Xiaoxing ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^c XUZHOU CENTRAL HOSPITAL   (China)

Author keywords

2',2' Difluoro 2' deoxyuridine; Extracellular fluid; Gemcitabine; Microdialysis; UPLC MS MS

Indexed keywords

DEOXYURIDINE; EXTRACELLULAR FLUID; GEMCITABINE; MICRO-DIALYSIS; UPLC-MS/MS;

ACETONITRILE; BRAIN; CEREBROSPINAL FLUID; CHEMOTHERAPY; DIALYSIS; ELECTROSPRAY IONIZATION; FORMIC ACID; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; RATS; TUMORS;

DRUG PRODUCTS;

5 BROMOURACIL; ACETONITRILE; DRUG METABOLITE; FORMIC ACID; GEMCITABINE;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN PERFUSION; CALIBRATION; CANCER CHEMOTHERAPY; CEREBROSPINAL FLUID; CONTROLLED STUDY; DRUG DETERMINATION; ELECTROSPRAY; EXTRACELLULAR FLUID; FLOW RATE; GLIOMA; LIMIT OF QUANTITATION; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; STRIATE CORTEX; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BRAIN CHEMISTRY; BRAIN NEOPLASMS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYCYTIDINE; DRUG STABILITY; FLOXURIDINE; GLIOMA; LIMIT OF DETECTION; LINEAR MODELS; MALE; MICRODIALYSIS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84873581099     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.12.027     Document Type: Article

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