Development of a sensitive and selective LC-MS/MS method for simultaneous determination of gemcitabine and 2,2-difluoro-2-deoxyuridine in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 22, 2009, Pages 2123-2129

  Bowen, Chester ^a   Wang, Sherry ^a   Licea Perez, Hermes ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

2,2 Difluoro 2 deoxyuridine; Dansyl chloride; Derivatization; Gemcitabine; Mass spectrometry; UPLC

Indexed keywords

2,2-DIFLUORO-2-DEOXYURIDINE; DANSYL CHLORIDE; DERIVATIZATION; GEMCITABINE; UPLC;

CHLORINE COMPOUNDS; CHROMATOGRAPHIC ANALYSIS; COLUMN CHROMATOGRAPHY; ETHERS; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; PLASMA (HUMAN); PLASMAS; SIZE SEPARATION; SPECTRUM ANALYSIS;

MASS SPECTROMETRY;

2,2 DIFLUORO 2 DEOXYURIDINE; DANSYL CHLORIDE; DRUG METABOLITE; GEMCITABINE; TETRAHYDROURIDINE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD SAMPLING; CONCENTRATION (PARAMETERS); DEAMINATION; DERIVATIZATION; DRUG DETERMINATION; DRUG STABILITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, LIQUID; DEOXYCYTIDINE; FLOXURIDINE; HUMANS; NEOPLASMS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 67649213981     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.06.002     Document Type: Article

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