Development of a novel HPLC-MS/MS method for the determination of aconitine and its application to in vitro and rat microdialysis samples

Biomedical Chromatography

Volumn 23, Issue 7, 2009, Pages 692-699

  Zhang, Quan Long ^a   Hu, Jin Hong ^a   Zhu, Quan Gang ^a   Li, Feng Qian ^a   Liu, Ji Yong ^a   Wang, Dan ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Aconitine; HPLC MS MS; Microdialysis; Recovery; Unbound tissue concentration

Indexed keywords

ACETONITRILE; AMINO ACIDS; BODY FLUIDS; DIALYSIS; ELECTROSPRAY IONIZATION; RATS;

ACONITINE; HPLC-MS-MS; IN-VITRO; ITS APPLICATIONS; LC-MS-MS; MICRO-DIALYSIS; MICRODIALYSATES; MICRODIALYSIS SAMPLES; TISSUES CONCENTRATIONS; UNBIND TISSUE CONCENTRATION;

RECOVERY;

ACONITINE; DIALYSIS FLUID; PROPAFENONE;

ACCURACY; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; DRUG STRUCTURE; ELECTROSPRAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; IONIZATION; MICRODIALYSIS; NONHUMAN; PH; RAT; TANDEM MASS SPECTROMETRY; ANIMAL; BLOOD; CALIBRATION; CHEMISTRY; METHODOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL ANALYSIS; STATISTICAL MODEL;

RATTUS;

ACONITINE; ANIMALS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DATA INTERPRETATION, STATISTICAL; DIALYSIS SOLUTIONS; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; LINEAR MODELS; MICRODIALYSIS; PROPAFENONE; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 70149109586     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1162     Document Type: Article

References (24)

1. Baron JM, Holler D, Schiffer R, Frankenberg S, Neis M, Merk HF and Jugert FK. Expression of multiple cytochrome p450 enzymes and multidrug resistance-associated transport proteins in human skin keratinocytes. Journal of Investigative Dermatology 2001; 116: 541-548.
2. Beike J, Frommherz L, Wood M, Brinkmann B and Kohler H. Determination of aconitine in body fluids by LC-MS-MS. Internation Journal of Legal Medicine 2004; 118: 289-293.
3. Bello-Ramirez AM, Nava-Ocampo AA. A QSAR analysis of toxicity of Aconitum alkaloids. Fundamentals of Clinical Pharmacology 2004; 18: 699-704.
4. Benfeldt E, Hansen SH, Volund A, Menne T and Shah VP. Bioequivalence of topical formulations in humans: evaluation by dermal microdialysis sampling and the dermatopharmacokinetic method. Journal of Investigative Dermatology 2007; 127: 170-178.
5. Cano-Cebrian MJ, Zornoza T, Polache A and Granero L. Quantitative in vivo microdialysis in pharmacokinetic studies: some reminders. Current Drug Metaboism 2005; 6: 83-90.
6. Catterall WA. Activation of the action potential Na+ ionophore by neurotoxins. An allosteric model. Journal of Biological Chemistry 1977; 252: 8669-8676.
7. Dickens P, Tai YT, But PP, Tomlinson B, Ng HK and Yan KW. Fatal accidental aconitine poisoning following ingestion of Chinese herbal medicine: a report of two cases. Forensic Science International 1994; 67: 55-58.
8. Elmquist WF and Sawchuk RJ. Application of microdialysis in pharmacokinetic studies. Pharmaceutical Research 1997; 14: 267-288.
9. Herkenne C, Alberti I, Naik A, Kalia YN, Mathy FX, Preat V and Guy RH. In vivo methods for the assessment of topical drug bioavailability. Pharmaceutical Research 2008. 25: 87-103.
10. Kaneko R, Hattori S, Furuta S, Hamajima M, Hirata Y, Watanabe K, Seno H and Ishii A. Sensitive analysis of aconitine, hypaconitine, mesaconitine and jesaconitine in human body fluids and Aconitum tubers by LC/ ESITOF-MS. Journal of Mass Spectrometry 2006; 41: 810-814.
11. Kang L, Yue S, Wang X and Fang M. The mechanism underlying the analgesic efect of the iontophoresis of aconitine on the adjuvant arthritis in rats. Chinese Journal of Physical and Medical Rehabilitation 2005; 27: 733-736.
12. Liu ZM, Niu X, Yang XZ and Niu SD. [Percutaneous absorption of aconitine and mesaconitine in extracts of Radix Aconitum kusnezoffii]. Zhong Xi Yi Jie He Xue Bao 2006; 4: 68-72.
13. Ohno Y. The experimental approach to the murder case of aconite poisoning. Journal of Toxicology: Toxin Reviews 1998; 17: 1-11.
14. Ohta H, Seto Y and Tsunoda N. Determination of Aconitum alkaloids in blood and urine samples. I. High-performance liquid chromatographic separation, solid-phase extraction and mass spectrometric confirmation. Journal of Chromatography B Biomedical Science Applications 1997; 691: 351-356.
15. Rao S and Sikdar SK. Modification of alpha subunit of RIIA sodium channels by aconitine. Pflugers Archiv 2000; 439: 349-355.
16. Shi H, Zhou C, Li Y, Wang G and Sun Y. [Anti-inflammatory effect of aconitines]. Zhongguo Zhong Yao Za Zhi 1990; 15: 174-177, 192.
17. Tazawa T, Zhao HQ, Li Y, Meselhy MR, Nakamura N, Akao T and Hattori M. A new enzyme immunoassay for aconitine and its application to quantitative determination of aconitine levels in plasma. Biology and Pharmacy Bulletin 2003; 26: 1289-1294.
18. Ungerstedt U. Microdialysis - principles and applications for studies in animals and man. Journal of Internal Medicine 1991; 230: 365-373.
19. Wada K, Nihira M, Hayakawa H, Tomita Y, Hayashida M and Ohno Y. Effects of long-term administrations of aconitine on electrocardiogram and tissue concentrations of aconitine and its metabolites in mice. Forensic Science International 2005; 148: 21-29.
20. Wang XW and Xie H. Alkaloids of Chinese Aconitum plants. Drugs of the Future 1999; 24: 877-882.
21. Wang ZH, Guo D, He Y, Hu C and Zhang J. Quantitative determination of Aconitum alkaloids in blood and urine samples by high-performance liquid chromatography. Phytochem Anal 2004; 15: 16-20.
22. Yue S, Yin C and Wang X. Effects of different pH buffer solution and corneum on the absorption of Aconitum alkaloids introduced by direct current in vitro. Chinese Journal of Physical and Medical Rehabilitation 2006; 32: 887-889.
23. Zheng H, Shi LF and Hu JH. Assessment of in vitro and in vivo recovery of sinomenine using microdialysis. Skin Research Technology 2007a; 13: 323-329.
24. Zheng H, Shi LF and Hu JH. Pharmacokinetic study of free-form sinomenine in rat skin by microdialysis coupled with liquid chromatography-electrospray mass spectrometry. Biomedical Chromatography 2007b; 21: 101-106.