The determination of gemcitabine and 2′-deoxycytidine in human plasma and tissue by APCI tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 847, Issue 2, 2007, Pages 142-152

  Honeywell, R ^a   Laan, A C ^a   van Groeningen, C J ^a   Strocchi, E ^b   Ruiter, R ^a   Giaccone, G ^a   Peters, G J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Deoxycytidine; Difluorodeoxycytidine; Gemcitabine; HPLC; Mass spectrometry

Indexed keywords

ATMOSPHERIC PRESSURE CHEMICAL IONIZATION (APCI); DEOXYCYTIDINES; DIFLUORODEOXYURIDINES (DFDU); GEMCITABINES; HUMAN PLASMAS; LIMIT OF QUANTITATION (LOQ); MULTI REACTION MONITORING (+MRM) MODES;

LIQUID CHROMATOGRAPHY; LIVING SYSTEMS STUDIES; MASS SPECTROMETRY; PRECIPITATION (CHEMICAL); TISSUE;

PROTEINS;

15 N 3 DEOXYCYTIDINE; ACETONITRILE; DEOXYCYTIDINE; FORMIC ACID; GEMCITABINE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BLOOD ANALYSIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DESORPTION; DRUG BLOOD LEVEL; DRUG DOSE ESCALATION; ELUTION; FREEZE DRYING; HUMAN; HUMAN TISSUE; INFUSION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; PHASE 1 CLINICAL TRIAL; PRECIPITATION; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLINICAL TRIALS, PHASE I; DEOXYCYTIDINE; HUMANS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

EID: 33847255317     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.09.045     Document Type: Article

References (25)

1. Van Moorsel C.J., Peters G.J., and Pinedo H.M. Oncologist 2 (1997) 127
2. Adjei A.A. Lung Cancer 34 Suppl. 4 (2001) S103
3. Belani C.P., and Langer C. Lung Cancer 38 Suppl. 4 (2002) 13
4. Favaretto A.G. Ann. Oncol. 17 Suppl. 5 (2006) v82
5. Heinemann V. Oncology 60 (2001) 8
6. Peters G.J., van der Wilt C.L., Van Moorsel C.J., Kroep J.R., Bergman A.M., and Ackland S.P. Pharmacol. Ther. 87 (2000) 227
7. Kamat A.M., Karashima T., Davis D.W., Lashinger L., Bar-Eli M., Millikan R., Shen Y., Dinney C.P., and McConkey D.J. Mol. Cancer Ther. 3 (2004) 279
8. Giovannetti E., Mey V., Nannizzi S., Pasqualetti G., Marini L., Del Tacca M., and Danesi R. Mol. Pharmacol. 68 (2005) 110
9. Decatris M.P., Sundar S., and O'Byrne K.J. Cancer Treat. Rev. 30 (2004) 53
10. Pauwels B., Korst A.E., Lardon F., and Vermorken J.B. Oncologist 10 (2005) 34
11. Gandhi V., Plunkett W., Du M., Ayres M., and Estey E.H. J. Clin. Oncol. 20 (2002) 665
12. Tempero M., Plunkett W., Ruiz V.H., Hainsworth V.J., Hochster H., Lenzi R., and Abbruzzese J. J. Clin. Oncol. 21 (2003) 3402
13. Veerman G., Ruiz V.H., Vermorken V.J.B., Noordhuis P., Braakhuis B.J., Pinedo H.M., and Peters G.J. Cancer Chemother. Pharmacol. 38 (1996) 335
14. Anderson H., Thatcher N., Walling J., and Hansen H. Br. J. Cancer 74 (1996) 460
15. Van Moorsel C.J., Kroep J.R., Pinedo H.M., Veerman G., Voorn D.A., Postmus P.E., Vermorken J.B., van Groeningen C.J., van der Vijgh W.J., and Peters G.J. Ann. Oncol. 10 (1999) 441
16. Wang L.Z., Goh B.C., Lee H.S., Noordhuis P., and Peters G.J. Ther. Drug Monit. 25 (2003) 552
17. Freeman K.B., Anliker S., Hamilton M., Osborne D., Dhahir P.H., Nelson R., and Allerheiligen S.R. J. Chromatogr. B 665 (1995) 171
18. Keith B., Xu Y., and Grem J.L. J. Chromatogr. B 785 (2003) 65
19. Lin N.M., Zeng S., Ma S.L., Fan Y., Zhong H.J., and Fang L. Acta Pharmacol. Sin. 25 (2004) 1584
20. Sottani C., Zucchetti M., Zaffaroni M., Bettinelli M., and Minoia C. Rapid Commun. Mass Spectrom. 18 (2004) 1017
21. Xu Y., Keith B., and Grem J.L. J. Chromatogr. B 802 (2004) 263
22. Peters G.J., Laurensse E.J., Leyva A., and Pinedo H.M. Clin. Chim. Acta 158 (1986) 193
23. De Lange S.M., van der Born K., Kroep J.R., Jensen H.A., Pfeiffer P., Cleverly A., van Groeningen C.J., and Peters G.J. Eur. J. Clin. Pharmacol. 61 (2005) 843
24. Goksel T., Hatipoglu O.N., Ozturk C., Gorguner M., Kiyik M., Yilmaz U., Guzelant A., Tasbakan S., Tabakoglu E., Firat H., Tutar U., Cikrikicioglu S., Akkoclu A., Soyer S., Cakir E., Itil O., and Sanal S. Respirology 10 (2005) 456
25. Yilmaz B., Kadioglu Y.Y., and Aksoy Y. J. Chromatogr. B 791 (2003) 103