High-performance liquid chromatographic method for the determination of gemcitabine and 2′,2′-difluorodeoxyuridine in plasma and tissue culture media

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 835, Issue 1-2, 2006, Pages 136-142

  Kirstein, Mark N ^a,b   Hassan, Iman ^a,b   Guire, Dan E ^a,b   Weller, Dennis R ^a,b   Dagit, Jason W ^a   Fisher, James E ^a   Remmel, Rory P ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

dFdU; Gemcitabine; HPLC; In vitro bioreactor cell culture; UV

Indexed keywords

ACETONITRILE; ENZYME INHIBITION; METABOLISM; PATIENT TREATMENT; PHARMACOKINETICS; TISSUE;

DFDU; GEMCITABINE; IN VITRO BIOREACTOR CELL CULTURE;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

2',2' DIFLUOROURIDINE; ACETONITRILE; BLOOD EXTRACT; BUFFER; CYTIDINE DEAMINASE; DEOXYCYTIDINE; DRUG METABOLITE; GEMCITABINE; PHOSPHATE BUFFERED SALINE; SULFONIC ACID DERIVATIVE; TETRAHYDROURIDINE; TISSUE CULTURE MEDIUM; UNCLASSIFIED DRUG;

ACCURACY; ACIDIFICATION; ANALYTICAL EQUIPMENT; ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BIOREACTOR; BLOOD SAMPLING; CELL CULTURE; CENTRIFUGATION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG INFUSION; DRUG STRUCTURE; EVALUATION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; INFUSION RATE; PH; PLASMA; PRIORITY JOURNAL; SENSITIVITY AND SENSIBILITY; SPECTRAL SENSITIVITY; STANDARD; STATISTICAL ANALYSIS; ULTRAVIOLET RADIATION; VALIDATION PROCESS; VORTEX MOTION;

BIOREACTORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CULTURE MEDIA; DEOXYCYTIDINE; DRUG STABILITY; FLOXURIDINE; HUMANS; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 33646059877     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.03.023     Document Type: Article

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