Suppression of inflammatory responses during myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis is regulated by AKT3 signaling

Journal of Immunology

Volumn 190, Issue 4, 2013, Pages 1528-1539

  Tsiperson, Vladislav ^a   Gruber, Ross C ^a   Goldberg, Michael F ^a   Jordan, Ayana ^a   Weinger, Jason G ^b   Macian, Fernando ^a   Shafit Zagardo, Bridget ^a,c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c YESHIVA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 2; MESSENGER RNA; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PROTEIN AKT3; PROTEIN KINASE B; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ACUTE DISEASE; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CHIMERA; CHRONIC DISEASE; CONTROLLED STUDY; CYTOKINE RESPONSE; DEMYELINATION; DISEASE SEVERITY; GAMMA INTERFERON GENE; GENE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; INTERLEUKIN 17 GENE; INTERLEUKIN 2 GENE; MALE; MOUSE; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VENTRAL ROOT;

ACUTE DISEASE; ANIMALS; CHRONIC DISEASE; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENETIC PREDISPOSITION TO DISEASE; INFLAMMATION MEDIATORS; LUMBOSACRAL REGION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS C-AKT; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; SPINAL CORD;

EID: 84873560332     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1201387     Document Type: Article

References (34)

1. Manning, B. D., and L. C. Cantley. 2007. AKT/PKB signaling: navigating downstream. Cell 129: 1261-1274.
2. Engelman, J. A., J. Luo, and L. C. Cantley. 2006. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat. Rev. Genet. 7: 606-619.
3. Cho, H., J. L. Thorvaldsen, Q. Chu, F. Feng, and M. J. Birnbaum. 2001. Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J. Biol. Chem. 276: 38349-38352.
4. Yang, Z. Z., O. Tschopp, M. Hemmings-Mieszczak, J. Feng, D. Brodbeck, E. Perentes, and B. A. Hemmings. 2003. Protein kinase B alpha/Akt1 regulates placental development and fetal growth. J. Biol. Chem. 278: 32124-32131.
5. Chen, W. S., P. Z. Xu, K. Gottlob, M. L. Chen, K. Sokol, T. Shiyanova, I. Roninson, W. Weng, R. Suzuki, K. Tobe, et al. 2001. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 15: 2203-2208.
6. Flores, A. I., S. P. Narayanan, E. N. Morse, H. E. Shick, X. Yin, G. Kidd, R. L. Avila, D. A. Kirschner, and W. B. Macklin. 2008. Constitutively active Akt induces enhanced myelination in the CNS. J. Neurosci. 28: 7174-7183.
7. Cho, H., J. Mu, J. K. Kim, J. L. Thorvaldsen, Q. Chu, E. B. Crenshaw, III, K. H. Kaestner, M. S. Bartolomei, G. I. Shulman, and M. J. Birnbaum. 2001. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292: 1728-1731.
8. Tschopp, O., Z. Z. Yang, D. Brodbeck, B. A. Dummler, M. Hemmings-Mieszczak, T. Watanabe, T. Michaelis, J. Frahm, and B. A. Hemmings. 2005. Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis. Development 132: 2943-2954.
9. Easton, R. M., H. Cho, K. Roovers, D. W. Shineman, M. Mizrahi, M. S. Forman, V. M. Lee, M. Szabolcs, R. de Jong, T. Oltersdorf, et al. 2005. Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol. Cell. Biol. 25: 1869-1878.
10. Ahmed, N. N., H. L. Grimes, A. Bellacosa, T. O. Chan, and P. N. Tsichlis. 1997. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc. Natl. Acad. Sci. USA 94: 3627-3632.
11. Cantrell, D. 2002. Protein kinase B (Akt) regulation and function in T lymphocytes. Semin. Immunol. 14: 19-26.
12. Kane, L. P., P. G. Andres, K. C. Howland, A. K. Abbas, and A. Weiss. 2001. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFNgamma but not TH2 cytokines. Nat. Immunol. 2: 37-44.
13. Plas, D. R., S. Talapatra, A. L. Edinger, J. C. Rathmell, and C. B. Thompson. 2001. Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J. Biol. Chem. 276: 12041-12048.
14. Wieman, H. L., J. A. Wofford, and J. C. Rathmell. 2007. Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Mol. Biol. Cell 18: 1437-1446.
15. Pierau, M., S. Engelmann, D. Reinhold, T. Lapp, B. Schraven, and U. H. Bommhardt. 2009. Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation. J. Immunol. 183: 6124-6134.
16. Mao, C., E. G. Tili, M. Dose, M. C. Haks, S. E. Bear, I. Maroulakou, K. Horie, G. A. Gaitanaris, V. Fidanza, T. Ludwig, et al. 2007. Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition. J. Immunol. 178: 5443-5453.
17. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
18. Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76: 4350-4354.
19. Suh, H. S., M. Cosenza-Nashat, N. Choi, M. L. Zhao, J. F. Li, J. W. Pollard, R. L. Jirtle, H. Goldstein, and S. C. Lee. 2010. Insulin-like growth factor 2 receptor is an IFNgamma-inducible microglial protein that facilitates intracellular HIV replication: implications for HIV-induced neurocognitive disorders. Am. J. Pathol. 177: 2446-2458.
20. Stromnes, I. M., and J. M. Goverman. 2006. Active induction of experimental allergic encephalomyelitis. Nat. Protoc. 1: 1810-1819.
21. Endersby, R., X. Zhu, N. Hay, D. W. Ellison, and S. J. Baker. 2011. Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. Cancer Res. 71: 4106-4116.
22. Davidson, T. S., and E. M. Shevach. 2011. Polyclonal Treg cells modulate T effector cell trafficking. Eur. J. Immunol. 41: 2862-2870.
23. Wehrens, E. J., G. Mijnheer, C. L. Duurland, M. Klein, J. Meerding, J. van Loosdregt, W. de Jager, B. Sawitzki, P. J. Coffer, B. Vastert, et al. 2011. Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells. Blood 118: 3538-3548.
24. Xie, Q. W., R. Whisnant, and C. Nathan. 1993. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide. J. Exp. Med. 177: 1779-1784.
25. Misko, T. P., J. L. Trotter, and A. H. Cross. 1995. Mediation of inflammation by encephalitogenic cells: interferon gamma induction of nitric oxide synthase and cyclooxygenase 2. J. Neuroimmunol. 61: 195-204.
26. Tada, Y., A. Ho, T. Matsuyama, and T. W. Mak. 1997. Reduced incidence and severity of antigen-induced autoimmune diseases in mice lacking interferon regulatory factor-1. J. Exp. Med. 185: 231-238.
27. Lin, R. F., T. S. Lin, R. G. Tilton, and A. H. Cross. 1993. Nitric oxide localized to spinal cords of mice with experimental allergic encephalomyelitis: an electron paramagnetic resonance study. J. Exp. Med. 178: 643-648.
28. Galea, E., D. J. Reis, and D. L. Feinstein. 1994. Cloning and expression of inducible nitric oxide synthase from rat astrocytes. J. Neurosci. Res. 37: 406-414.
29. Chew, L. J., W. C. King, A. Kennedy, and V. Gallo. 2005. Interferon-gamma inhibits cell cycle exit in differentiating oligodendrocyte progenitor cells. Glia 52: 127-143.
30. Thakur, A. B., and N. F. Landolfi. 1999. A potent neutralizing monoclonal antibody can discriminate amongst IFNgamma from various primates with greater specificity than can the human IFNgamma receptor complex. Mol. Immunol. 36: 1107-1115.
31. Kang, Z., C. Z. Altuntas, M. F. Gulen, C. Liu, N. Giltiay, H. Qin, L. Liu, W. Qian, R. M. Ransohoff, C. Bergmann, et al. 2010. Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis. Immunity 32: 414-425.
32. Komiyama, Y., S. Nakae, T. Matsuki, A. Nambu, H. Ishigame, S. Kakuta, K. Sudo, and Y. Iwakura. 2006. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol. 177: 566-573.
33. Arnett, H. A., J. Mason, M. Marino, K. Suzuki, G. K. Matsushima, and J. P. Ting. 2001. TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat. Neurosci. 4: 1116-1122.
34. Shaw, M., P. Cohen, and D. R. Alessi. 1998. The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2. Biochem. J. 336: 241-246.