Lipopolysaccharide downregulates CD91/low-density lipoprotein receptor-related protein 1 expression through SREBP-1 overexpression in human macrophages

Atherosclerosis

Volumn 227, Issue 1, 2013, Pages 79-88

  Costales, P ^a   Castellano, J ^a   Revuelta Lopez E ^a   Cal, R ^a   Aledo, R ^a   Llampayas, O ^a   Nasarre, L ^a   Juarez, C ^b   Badimon, L ^a   Llorente Cortes V ^a  

^a Institut Català de Ciències Cardiovasculars   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Aggregated LDL; Human macrophages; LDLR; Lipopolysaccharide; LRP1; SREBP 1; SREBP 2

Indexed keywords

LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MESSENGER RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; INTERNALIZATION; LIPID METABOLISM; MACROPHAGE; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN EXPRESSION; UPREGULATION;

DOWN-REGULATION; HUMANS; LIPOPOLYSACCHARIDES; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-1; MACROPHAGES; NUCLEAR PROTEINS; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

EID: 84873454315     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2012.12.021     Document Type: Article

References (48)

1. Hvidberg V., Maniecki M.B., Jacobsen C., Højrup P., Møller H.J., Moestrup S.K. Identification of the receptor scavenging hemopexin-heme complexes. Blood 2005, 106:2572-2579.
2. Pineda D., Ampurdanés C., Medina M.G., et al. Tissue plasminogen activator induces microglial inflammation via a noncatalytic molecular mechanism involving activation of mitogen-activated protein kinases and Akt signaling pathways and AnnexinA2 and Galectin-1 receptors. Glia 2012, 60:526.
3. Gaultier A., Simon G., Niessen S., et al. LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome. J Proteome Res 2010, 9:6689.
4. Gonias S.L., Gaultier A., Jo M. Regulation of the urokinase receptor (uPAR) by LDL receptor-related protein-1 (LRP1). Curr Pharm Des 2011, 17:1962.
5. Mantuano E., Inoue G., Li X., et al. The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of Schwann cells by binding to low-density lipoprotein receptor-related protein. J Neurosci 2008, 28:11571.
6. Gaultier A., Salicioni A.M., Arandjelovic S., Gonias S.L. Regulation of the composition of the extracellular matrix by low density lipoprotein receptor-related protein-1: activities based on regulation of mRNA expression. J Biol Chem 2006, 281:7332.
7. Orr A.W., Elzie C.A., Kucik D.F., Murphy-Ullrich J.E. Thrombospondin signalling through the calreticulin/LDL receptor-related protein co-complex stimulates random and directed cell migration. J Cell Sci 2003, 116:2917.
8. Emonard H., Bellon G., de Diesbach P., Mettlen M., Hornebeck W., Courtoy P.J. Regulation of matrix metalloproteinase (MMP) activity by the low-density lipoprotein receptor-related protein (LRP). A new function for an "old friend". Biochimie 2005, 87:369.
9. Boucher P., Gotthardt M., Li W.P., Anderson R.G., Herz J. LRP: role in vascular wall integrity and protection from atherosclerosis. Science 2003, 300:329.
10. Overton C.D., Yancey P.G., Major A.S., Linton M.F., Fazio S. Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse. Circ Res 2007, 100:670.
11. Libby P. Inflammation in atherosclerosis. Nature 2002, 420:868.
12. Ketelhuth D.F., Hansson G.K. Cellular immunity, low-density lipoprotein and atherosclerosis: break of tolerance in the artery wall. Thromb Haemost 2011, 106:779.
13. Libby P., Ridker P.M., Maseri A. Inflammation and atherosclerosis. Circulation 2002, 105:1135.
14. Creely S.J., McTernan P.G., Kusminski C.M., et al. Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol Metab 2007, 292:E740-E747.
15. Wiedermann C.J., Kiechl S., Dunzendorfer S., et al. Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from the Bruneck Study. J Am Coll Cardiol 1999, 34:1975.
16. Kalay N., Kutukoglu I., Ozdogru I., et al. The relationship between Chlamydophila pneumoniae IgG titer and coronary atherosclerosis. Cardiol J 2008, 15:245.
17. Sawayama Y., Hamada M., Otaguro S., et al. Chronic Helicobacter pylori infection is associated with peripherals arterial disease. J Infect Chemother 2008, 14:250.
18. Gurcel L., Abrami L., Girardin S., Tschopp J., van der Goot F.G. Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell 2006, 126:1135.
19. Im S.S., Yousef L., Blaschitz C., et al. Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a. Cell Metab 2011, 13:540.
20. Im S.S., Osborne T.F. Protection from bacterial-toxin-induced apoptosis in macrophages requires the lipogenic transcription factor sterol regulatory element binding protein 1a. Mol Cell Biol 2012, 32:2196.
21. Costales P., Aledo R., Vérnia S., et al. Selective role of sterol regulatory element binding protein isoforms in aggregated LDL-induced vascular low density lipoprotein receptor-related protein-1 expression. Atherosclerosis 2010, 213:458.
22. Lillis A.P., Greenlee M.C., Mikhailenko I., et al. Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. J Immunol 2008, 181:364.
23. Yancey P.G., Blakemore J., Ding L., et al. Macrophage LRP-1 controls plaque cellularity by regulating efferocytosis and Akt activation. Arterioscler Thromb Vasc Biol 2010, 30:787.
24. Sakr S.W., Eddy R.J., Barth H., et al. The uptake and degradation of matrix-bound lipoproteins by macrophages require an intact actin Cytoskeleton, Rho family GTPases, and myosin ATPase activity. J Biol Chem 2001, 276:37649.
25. Patel M., Morrow J., Maxfield F.R., Strickland D.K., Greenberg S., Tabas I. The cytoplasmic domain of the low density lipoprotein (LDL) receptor-related protein, but not that of the LDL receptor, triggers phagocytosis. J Biol Chem 2003, 278:44799.
26. Llorente-Cortés V., Royo T., Otero-Viñas M., Berrozpe M., Badimon L. Sterol regulatory element binding proteins downregulate LDL receptor-related protein (LRP1) expression and LRP1-mediated aggregated LDL uptake by human macrophages. Cardiovasc Res 2007, 74:526.
27. Haka A.S., Grosheva I., Chiang E., et al. Macrophages create an acidic extracellular hydrolytic compartment to digest aggregated lipoproteins. Mol Biol Cell 2009, 20:4932.
28. Llorente-Cortés V., Otero-Viñas M., Sánchez S., Rodríguez C., Badimon L. Low-density lipoprotein upregulates low-density lipoprotein receptor-related protein expression in vascular smooth muscle cells: possible involvement of sterol regulatory element binding protein-2-dependent mechanism. Circulation 2002, 106:3104.
29. Aderem A., Underhill D.M. Mechanisms of phagocytosis in macrophages. Annu Rev Immunol 1999, 17:593.
30. Gagnon E., Duclos S., Rondeau C., et al. Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages. Cell. 2002, 110:119.
31. Dignam J.D., Lebovitz R.M., Roeder R.G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 1983, 11:1475.
32. Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959, 37:911.
33. Chen X., Zhang C., Zhao M., et al. Melatonin alleviates lipopolysaccharide-induced hepatic SREBP-1c activation and lipid accumulation in mice. J Pineal Res 2011, 51:416.
34. Diomede L., Albani D., Bianchi M., Salmona M. Endotoxin regulates the maturation of sterol regulatory element binding protein-1 through the induction of cytokines. Eur Cytokine Netw 2001, 12:625.
35. Lawler J.F., Yin M., Diehl A.M., Roberts E., Chatterjee S. Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase. J Biol Chem 1998, 273:5053.
36. Gierens H., Nauck M., Roth M., et al. Interleukin-6 stimulates LDL receptor gene expression via activation of sterol-responsive and Sp1 binding elements. Arterioscler Thromb Vasc Biol 2000, 20:1777.
37. Black S.M., Schott M.E., Batdorf B.H., et al. IL-4 induces protection of vascular endothelial cells against killing by complement and melittin through lipid biosynthesis. Eur J Immunol 2010, 40:803-812.
38. Black S.M., Schott M.E., Benson B.A., Rutherford M.S., Levay-Young B.K., Dalmasso A.P. Interleukin-4 induces lipogenesis in porcine endothelial cells, which in turns is critical for induction of protection against complement-mediated injury. Transplant Proc 2008, 40:638-640.
39. Wahli W., Michalik L. PPARs at the crossroads of lipid signaling and inflammation. Trends Endocrinol Metab 2012, 23:351.
40. Gasparini C., Feldmann M. NF-κB as a target for modulating inflammatory responses. Curr Pharm Des 2012, 18:5735-5745.
41. Ye Q., Chen Y., Lei H., et al. Inflammatory stress increases unmodified LDL uptake via LDL receptor: an alternative pathway for macrophage foam-cell formation. Inflamm Res 2009, 58:809.
42. Boyanovsky B.B., Shridas P., Simons M., van der Westhuyzen D.R., Webb N.R. Syndecan-4 mediates macrophage uptake of group V secretory phospholipase A2-modified LDL. J Lipid Res 2009, 50:641.
43. Persson J., Nilsson J., Lindholm M.W. Cytokine response to lipoprotein lipid loading in human monocyte-derived macrophages. Lipids Health Dis 2006, 26:5.
44. Graham V.S., Di Maggio P., Armengol S., Lawson C., Wheeler-Jones C.P., Botham K.M. Inhibition of macrophage inflammatory cytokine secretion by chylomicron remnants is dependent on their uptake by the low density lipoprotein receptor. Biochim Biophys Acta 2011, 1811:209.
45. Shi Y., Yamauchi T., Gaultier A., Takimoto S., Campana W.M., Gonias S.L. Regulation of cytokine expression by Schwann cells in response to α2-macroglobulin binding to LRP1. J Neurosci Res 2011, 89:544.
46. Gardai S.J., Xiao Y.Q., Dickinson M., et al. By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell 2003, 115:13.
47. Keogh B., Parker A.E. Toll-like receptors as targets for immune disorders. Trends Pharmacol Sci 2011, 32:435.
48. Seneviratne A.N., Sivagurunathan B., Monaco C. Toll-like receptors and macrophage activation in atherosclerosis. Clin Chim Acta 2012, 413:3.