Inflammatory stress increases unmodified LDL uptake via LDL receptor: An alternative pathway for macrophage foam-cell formation

Inflammation Research

Volumn 58, Issue 11, 2009, Pages 809-818

  Ye, Qiang ^a   Chen, Yaxi ^a   Lei, Han ^a   Liu, Qing ^a   Moorhead, John F ^b   Varghese, Zac ^b   Ruan, Xiong Z ^a,b  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Atherosclerosis; Inflammation; LDL receptor; SREBP cleavage activating protein; THP 1 macrophages

Indexed keywords

CHOLESTEROL; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CHEMICAL STRESS; CONTROLLED STUDY; ELECTROPHORESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEEDBACK SYSTEM; FOAM CELL; HUMAN; HUMAN CELL; INFLAMMATION; INTRACELLULAR TRANSPORT; MACROPHAGE; MONOCYTE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; WESTERN BLOTTING;

ANIMALS; CELL LINE; FOAM CELLS; HUMANS; INFLAMMATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOPOLYSACCHARIDES; LIPOPROTEINS, LDL; MACROPHAGES; MEMBRANE PROTEINS; RECEPTORS, LDL; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; STRESS, PHYSIOLOGICAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 70349954706     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-009-0052-4     Document Type: Article

References (43)

1. MP De Winther MJ Gijbels KW Van Dijk LM Havekes MH Hofker 2000 Transgenic mouse models to study the role of the macrophage scavenger receptor class A in atherosclerosis Int J Tissue React 22 85 91 10937358
2. AC Nicholson M Febbraio J Han RL Silverstein DP Hajjar 2000 CD36 in atherosclerosis. The role of a class B macrophage scavenger receptor Ann N Y Acad Sci 902 128 131 10865832 1:CAS:528:DC%2BD3cXksFSlu7Y%3D
3. M Krieger 1992 Molecular flypaper and atherosclerosis: structure of the macrophage scavenger receptor Trends Biochem Sci 17 141 146 1585457 10.1016/0968-0004(92)90322-Z 1:CAS:528:DyaK38XkvVOlsrg%3D
4. M Krieger JM Abrams A Lux H Steller 1992 Molecular flypaper, atherosclerosis, and host defense: structure and function of the macrophage scavenger receptor Cold Spring Harb Symp Quant Biol 57 605 609 1339697 1:CAS:528:DyaK3sXmsVOnsLw%3D
5. B Liu C Xie JA Richardson SD Turley JM Dietschy 2007 Receptor-mediated and bulk-phase endocytosis cause macrophage and cholesterol accumulation in Niemann-Pick C disease J Lipid Res 48 1710 1723 17476031 10.1194/jlr.M700125- JLR200 1:CAS:528:DC%2BD2sXot1Ogt7o%3D (Pubitemid 47311988)
6. JR Smith TF Osborne JL Goldstein MS Brown 1990 Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene J Biol Chem 265 2306 2310 2298751 1:CAS:528:DyaK3cXhtFensbw%3D
7. MS Brown JL Goldstein 1986 A receptor-mediated pathway for cholesterol homeostasis Science 232 34 47 3513311 10.1126/science.3513311 1:CAS:528:DyaL28Xhs1GrtbY%3D
8. MR Briggs C Yokoyama X Wang MS Brown JL Goldstein 1993 Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence J Biol Chem 268 14490 14496 8390995 1:CAS:528: DyaK3sXkvVyhu70%3D
9. JL Goldstein MS Brown 1985 The LDL receptor and the regulation of cellular cholesterol metabolism J Cell Sci Suppl 3 131 137 3914990 1:CAS:528:DyaL28XhvVelu74%3D
10. X Wang R Sato MS Brown X Hua JL Goldstein 1994 SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis Cell 77 53 62 8156598 10.1016/0092-8674(94)90234-8 1:CAS:528:DyaK2cXis1KmsLw%3D (Pubitemid 24184687)
11. C Yokoyama X Wang MR Briggs A Admon J Wu X Hua, et al. 1993 SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene Cell 75 187 197 8402897 1:CAS:528:DyaK2cXkslajuw%3D%3D
12. X Wang MR Briggs X Hua C Yokoyama JL Goldstein MS Brown 1993 Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization J Biol Chem 268 14497 14504 8314806 1:CAS:528:DyaK3sXltFWltLw%3D
13. HB Sanchez L Yieh TF Osborne 1995 Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene J Biol Chem 270 1161 1169 7836375 10.1074/jbc.270.3.1161 1:CAS:528:DyaK2MXjtFOksbw%3D
14. X Hua C Yokoyama J Wu MR Briggs MS Brown JL Goldstein, et al. 1993 SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element Proc Natl Acad Sci USA 90 11603 11607 7903453 10.1073/pnas.90.24.11603 1:CAS:528:DyaK2cXht1Knuro%3D (Pubitemid 24008687)
15. A Nohturfft RA Bose-Boyd S Scheek JL Goldstein MS Brown 1999 Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi Proc Natl Acad Sci USA 96 11235 11240 10500160 10.1073/pnas.96.20.11235 1:CAS:528:DyaK1MXmvVCmsrY%3D (Pubitemid 29487364)
16. MS Brown JL Goldstein 1999 A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood Proc Natl Acad Sci USA 96 11041 11048 10500120 10.1073/pnas.96.20.11041 1:CAS:528:DyaK1MXmvVCntLY%3D (Pubitemid 29487324)
17. A Nohturfft MS Brown JL Goldstein 1998 Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain J Biol Chem 273 17243 17250 9642295 10.1074/jbc.273.27.17243 1:CAS:528:DyaK1cXkt12gtr4%3D (Pubitemid 28311764)
18. X Hua A Nohturfft JL Goldstein MS Brown 1996 Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein Cell 87 415 426 8898195 10.1016/S0092-8674(00)81362-8 1:CAS:528:DyaK28XmvVOktL0%3D (Pubitemid 26374316)
19. JL Goldstein RB Rawson MS Brown 2002 Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis Arch Biochem Biophys 397 139 148 11795864 10.1006/abbi.2001.2615 1:CAS:528:DC%2BD38XktlyhsA%3D%3D (Pubitemid 34852273)
20. T Yang JL Goldstein MS Brown 2000 Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum J Biol Chem 275 29881 29886 10896675 10.1074/jbc.M005439200 1:CAS:528:DC%2BD3cXmvFKjtbk%3D (Pubitemid 32043873)
21. J Sakai RB Rawson 2001 The sterol regulatory element-binding protein pathway: control of lipid homeostasis through regulated intracellular transport Curr Opin Lipidol 12 261 266 11353328 10.1097/00041433-200106000-00004 1:CAS:528:DC%2BD3MXktlKjtL0%3D (Pubitemid 32521950)
22. RL Fernando Z Varghese JF Moorhead 1993 Oxidation of low-density lipoproteins by rat mesangial cells and the interaction of oxidized low-density lipoproteins with rat mesangial cells in vitro Nephrol Dial Transplant 8 512 518 8394531 1:STN:280:DyaK3szlsVKnsw%3D%3D
23. DC Wheeler RL Fernando MP Gillett J Zaruba J Persaud D Kingstone, et al. 1991 Characterisation of the binding of low-density lipoproteins to cultured rat mesangial cells Nephrol Dial Transplant 6 701 708 1754106 1:STN:280: DyaK38%2Fptlahuw%3D%3D
24. JF Moorhead MK Chan M El-Nahas Z Varghese 1982 Lipid nephrotoxicity in chronic progressive glomerular and tubulo-interstitial disease Lancet 2 1309 1311 6128601 10.1016/S0140-6736(82)91513-6 1:CAS:528:DyaL3sXhslOiu70%3D
25. JR Diamond 1991 Analogous pathobiologic mechanisms in glomerulosclerosis and atherosclerosis Kidney Int Suppl 31 S29 S34 2046267 1:STN:280: DyaK3M3lvFyrtg%3D%3D
26. JR Diamond MJ Karnovsky 1988 Focal and segmental glomerulosclerosis: analogies to atherosclerosis Kidney Int 33 917 924 3292816 10.1038/ki.1988.87 1:CAS:528:DyaL1cXktVCmtbs%3D
27. JE Salmon MJ Roman 2008 Subclinical atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus Am J Med 121 S3 S8 18926167 10.1016/j.amjmed.2008.06.010
28. A Bongu E Chang R Ramsey-Goldman 2002 Can morbidity and mortality of SLE be improved? Best Pract Res Clin Rheumatol 16 313 332 12041956 10.1053/berh.2001.0228
29. EG Lowrie NL Lew 1990 Death risk in hemodialysis patients: the predictive value of commonly measured variables and an evaluation of death rate differences between facilities Am J Kidney Dis 15 458 482 2333868 1:STN:280:DyaK3c3ktVaitg%3D%3D
30. Y Liu J Coresh JA Eustace JC Longenecker B Jaar NE Fink, et al. 2004 Association between cholesterol level and mortality in dialysis patients: role of inflammation and malnutrition JAMA 291 451 459 14747502 10.1001/jama.291.4. 451 1:CAS:528:DC%2BD2cXos1Wjsg%3D%3D (Pubitemid 38129749)
31. XZ Ruan JF Moorhead JL Tao KL Ma DC Wheeler SH Powis, et al. 2006 Mechanisms of dysregulation of low-density lipoprotein receptor expression in vascular smooth muscle cells by inflammatory cytokines Arterioscler Thromb Vasc Biol 26 1150 1155 16543490 10.1161/01.ATV.0000217957.93135.c2 1:CAS:528:DC%2BD28XjsVersb0%3D (Pubitemid 43732126)
32. XZ Ruan Z Varghese SH Powis JF Moorhead 2001 Dysregulation of LDL receptor under the influence of inflammatory cytokines: a new pathway for foam cell formation Kidney Int 60 1716 1725 11703589 10.1046/j.1523-1755.2001.00025.x 1:CAS:528:DC%2BD3MXotlGnsbw%3D (Pubitemid 32999976)
33. XZ Ruan Z Varghese R Fernando JF Moorhead 1998 Cytokine regulation of low-density lipoprotein receptor gene transcription in human mesangial cells Nephrol Dial Transplant 13 1391 1397 9641167 10.1093/ndt/13.6.1391 1:CAS:528:DyaK1cXktFeksbk%3D (Pubitemid 28254312)
34. Y Chen XZ Ruan Q Li A Huang JF Moorhead SH Powis, et al. 2007 Inflammatory cytokines disrupt LDL-receptor feedback regulation and cause statin resistance: a comparative study in human hepatic cells and mesangial cells Am J Physiol Renal Physiol 293 F680 F687 17634396 10.1152/ajprenal.00209.2007 1:CAS:528:DC%2BD2sXhtVOqt7vJ (Pubitemid 47403337)
35. LL Gallo R Atasoy GV Vahouny CR Treadwell 1978 Enzymatic assay for cholesterol ester hydrolase activity J Lipid Res 19 913 916 712250 1:CAS:528:DyaE1cXlvFaru7k%3D
36. W Gamble M Vaughan HS Kruth J Avigan 1978 Procedure for determination of free and total cholesterol in micro- or nanogram amounts suitable for studies with cultured cells J Lipid Res 19 1068 1070 731127 1:CAS:528: DyaE1MXltFSjuw%3D%3D
37. T Mikita G Porter RM Lawn D Shiffman 2001 Oxidized low density lipoprotein exposure alters the transcriptional response of macrophages to inflammatory stimulus J Biol Chem 276 45729 45739 11577090 10.1074/jbc. M106114200 1:CAS:528:DC%2BD3MXptVynu74%3D
38. N Umetani Y Kanayama M Okamura N Negoro T Takeda 1996 Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages Biochim Biophys Acta 1303 199 206 8908154
39. L Yang JB Yang J Chen GY Yu P Zhou L Lei, et al. 2004 Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasone Cell Res 14 315 323 15353128 10.1038/sj.cr.7290231 1:CAS:528:DC%2BD2cXoslGgt7k%3D (Pubitemid 43231812)
40. HS Kruth W Huang I Ishii WY Zhang 2002 Macrophage foam cell formation with native low density lipoprotein J Biol Chem 277 34573 34580 12118008 10.1074/jbc.M205059200 1:CAS:528:DC%2BD38Xnt1Wis7g%3D (Pubitemid 35056282)
41. SA Evensen KS Galdal E Nilsen 1983 LDL-induced cytotoxicity and its inhibition by anti-oxidant treatment in cultured human endothelial cells and fibroblasts Atherosclerosis 49 23 30 6651910 10.1016/0021-9150(83)90004-7 1:CAS:528:DyaL3sXmtVOlsro%3D
42. G Sobal J Menzel H Sinzinger 2000 Why is glycated LDL more sensitive to oxidation than native LDL? A comparative study Prostaglandins Leukot Essent Fatty Acids 63 177 186 11049692 10.1054/plef.2000.0204 1:CAS:528: DC%2BD3cXotlWmtbw%3D (Pubitemid 30825045)
43. T Yang PJ Espenshade ME Wright D Yabe Y Gong R Aebersold, et al. 2002 Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER Cell 110 489 500 12202038 10.1016/S0092-8674(02)00872-3 1:CAS:528:DC%2BD38Xmslyjt70%3D (Pubitemid 35232292)