A resurrected mammalian hAT transposable element and a closely related insect element are highly active in human cell culture

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 6, 2013, Pages

  Li, Xianghong ^a   Ewis, Hosam ^a   Hice, Robert H ^b   Malani, Nirav ^c   Parker, Nicole ^a   Zhou, Liqin ^a   Feschotte, Cédric ^d   Bushman, Frederic D ^c   Atkinson, Peter W ^b   Craig, Nancy L ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF TEXAS AT ARLINGTON   (United States)

Author keywords

Gene therapy; HAT element; Insertional mutagenesis; Target site selection; Transgenesis

Indexed keywords

PLASMID DNA;

ACETYLATION; ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA HAIRPIN; DNA METHYLATION; GENE FREQUENCY; GENE INSERTION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC ENGINEERING; HUMAN; HUMAN CELL; IN VITRO STUDY; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TRANSPOSON; TRIBOLIUM CASTANEUM;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; DNA TRANSPOSABLE ELEMENTS; GENE TRANSFER, HORIZONTAL; GENES, INSECT; GENETIC ENGINEERING; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; PHYLOGENY; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; TRANSPOSASES; TRIBOLIUM;

EID: 84873450062     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1121543109     Document Type: Article

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