Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model

Neurobiology of Aging

Volumn 34, Issue 5, 2013, Pages 1355-1368

  Dassie, Elisa ^a   Andrews, Melissa R ^a   Bensadoun, Jean Charles ^b   Cacquevel, Matthias ^b   Schneider, Bernard L ^b   Aebischer, Patrick ^b   Wouters, Fred S ^c   Richardson, Jill C ^d   Hussain, Ishrut ^d   Howlett, David R ^d   Spillantini, Maria Grazia ^a   Fawcett, James W ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b EPFL   (Switzerland)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Adeno associated virus; Alzheimer's disease; Alzheimer's precursor protein; Memory; Neurodegeneration; Tau; Tauopathy; Viral vectors

Indexed keywords

GREEN FLUORESCENT PROTEIN; PARVOVIRUS VECTOR; TAU PROTEIN;

AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; GENE; GENE MUTATION; GENE OVEREXPRESSION; HIPPOCAMPAL CA1 REGION; IN VITRO STUDY; MALE; MAZE TEST; MEMORY DISORDER; MOLECULAR PATHOLOGY; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEURONAL LOSS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; TASK PERFORMANCE; TAU GENE; TAUOPATHY; VIRAL GENE DELIVERY SYSTEM; VIRUS MUTANT; WILD TYPE;

ADENOVIRIDAE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; TAU PROTEINS; TAUOPATHIES; TRANSFECTION;

EID: 84873442155     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.11.011     Document Type: Article

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