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Volumn 216, Issue 1, 2011, Pages 332-340

Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory

Author keywords

Alzheimer's disease; Hippocampal formation; Learned alternation; P301L; Retrohippocampal area; Tauopathy; Y maze

Indexed keywords

GREEN FLUORESCENT PROTEIN; TAU PROTEIN;

EID: 78149410465     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2010.08.013     Document Type: Article
Times cited : (15)

References (53)
  • 1
    • 0033142961 scopus 로고    scopus 로고
    • Review: tau protein pathology in Alzheimer's disease and related disorders
    • Tolnay M., Probst A. Review: tau protein pathology in Alzheimer's disease and related disorders. Neuropathol Appl Neurobiol 1999, 25:171-187.
    • (1999) Neuropathol Appl Neurobiol , vol.25 , pp. 171-187
    • Tolnay, M.1    Probst, A.2
  • 2
    • 0036819090 scopus 로고    scopus 로고
    • Frontotemporal lobar degeneration-tau as a pied piper?
    • Tolnay M., Probst A. Frontotemporal lobar degeneration-tau as a pied piper?. Neurogenetics 2002, 4:63-75.
    • (2002) Neurogenetics , vol.4 , pp. 63-75
    • Tolnay, M.1    Probst, A.2
  • 3
    • 0035757529 scopus 로고    scopus 로고
    • Beta-amyloid, neuronal death and Alzheimer's disease
    • Carter J., Lippa C.F. Beta-amyloid, neuronal death and Alzheimer's disease. Curr Mol Med 2001, 1:733-737.
    • (2001) Curr Mol Med , vol.1 , pp. 733-737
    • Carter, J.1    Lippa, C.F.2
  • 4
    • 0033613129 scopus 로고    scopus 로고
    • Cellular mechanisms of beta-amyloid production and secretion
    • Sinha S., Lieberburg I. Cellular mechanisms of beta-amyloid production and secretion. Proc Natl Acad Sci 1999, 96:11049-11053.
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 11049-11053
    • Sinha, S.1    Lieberburg, I.2
  • 6
    • 49149083015 scopus 로고    scopus 로고
    • Evidence that non-fibrillar tau causes pathology linked to neurodegeneration and behavioral impairments
    • Brunden K.R., Trojanowski J.Q., Lee V.M.Y. Evidence that non-fibrillar tau causes pathology linked to neurodegeneration and behavioral impairments. J Alzheimers Dis 2008, 14:393-399.
    • (2008) J Alzheimers Dis , vol.14 , pp. 393-399
    • Brunden, K.R.1    Trojanowski, J.Q.2    Lee, V.M.Y.3
  • 8
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991, 82:239-259.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 9
    • 0342368728 scopus 로고    scopus 로고
    • The extent of neurofibrillary pathology in perforant pathway neurons is the key determinant of dementia in the very old
    • Garcia-Sierra F., Hauw J.J., Duyckaerts C., Wischik C.M., Luna-Munoz J., Mena R. The extent of neurofibrillary pathology in perforant pathway neurons is the key determinant of dementia in the very old. Acta neuropathol 2000, 100:29-35.
    • (2000) Acta neuropathol , vol.100 , pp. 29-35
    • Garcia-Sierra, F.1    Hauw, J.J.2    Duyckaerts, C.3    Wischik, C.M.4    Luna-Munoz, J.5    Mena, R.6
  • 10
    • 0038708285 scopus 로고    scopus 로고
    • Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease
    • Giannakopoulos P., Herrmann F.R., Bussiere T., Bouras C., Kovari E., Perl D.P., et al. Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology 2003, 60:1495-1500.
    • (2003) Neurology , vol.60 , pp. 1495-1500
    • Giannakopoulos, P.1    Herrmann, F.R.2    Bussiere, T.3    Bouras, C.4    Kovari, E.5    Perl, D.P.6
  • 11
    • 0036154419 scopus 로고    scopus 로고
    • Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease
    • Mitchell T.W., Mufson E.J., Schneider J.A., Cochran E.J., Nissanov J., Han L.Y., et al. Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease. Ann Neurol 2002, 51:182-189.
    • (2002) Ann Neurol , vol.51 , pp. 182-189
    • Mitchell, T.W.1    Mufson, E.J.2    Schneider, J.A.3    Cochran, E.J.4    Nissanov, J.5    Han, L.Y.6
  • 12
    • 0034070445 scopus 로고    scopus 로고
    • Alzheimer-related tau-pathology in the perforant path target zone and in the hippocampal stratum oriens and radiatum correlates with onset and degree of dementia
    • Thal D.R., Holzer M., Rub U., Waldmann G., Gunzel S., Zedlick D., et al. Alzheimer-related tau-pathology in the perforant path target zone and in the hippocampal stratum oriens and radiatum correlates with onset and degree of dementia. Exp Neurol 2000, 163:98-110.
    • (2000) Exp Neurol , vol.163 , pp. 98-110
    • Thal, D.R.1    Holzer, M.2    Rub, U.3    Waldmann, G.4    Gunzel, S.5    Zedlick, D.6
  • 13
    • 27944491109 scopus 로고    scopus 로고
    • Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L)
    • Ramsden M., Kotilinek L., Forster C., Paulson J., McGowan E., SantaCruz K., et al. Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). J Neurosci 2005, 25:10637-10647.
    • (2005) J Neurosci , vol.25 , pp. 10637-10647
    • Ramsden, M.1    Kotilinek, L.2    Forster, C.3    Paulson, J.4    McGowan, E.5    SantaCruz, K.6
  • 14
    • 22344438508 scopus 로고    scopus 로고
    • Tau suppression in a neurodegenerative mouse model improves memory function
    • Santacruz K., Lewis J., Spires T., Paulson J., Kotilinek L., Ingelsson M., et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science 2005, 309:476-481.
    • (2005) Science , vol.309 , pp. 476-481
    • Santacruz, K.1    Lewis, J.2    Spires, T.3    Paulson, J.4    Kotilinek, L.5    Ingelsson, M.6
  • 15
    • 33646519920 scopus 로고    scopus 로고
    • Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy
    • Spires T.L., Orne J.D., SantaCruz K., Pitstick R., Carlson G.A., Ashe K.H., et al. Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy. Am J Pathol 2006, 168:1598-1607.
    • (2006) Am J Pathol , vol.168 , pp. 1598-1607
    • Spires, T.L.1    Orne, J.D.2    SantaCruz, K.3    Pitstick, R.4    Carlson, G.A.5    Ashe, K.H.6
  • 16
    • 33846466652 scopus 로고    scopus 로고
    • Plaques, tangles, and memory loss in mouse models of neurodegeneration
    • Eriksen J.L., Janus C.G. Plaques, tangles, and memory loss in mouse models of neurodegeneration. Behav Genet 2007, 37:79-100.
    • (2007) Behav Genet , vol.37 , pp. 79-100
    • Eriksen, J.L.1    Janus, C.G.2
  • 17
    • 1542784350 scopus 로고    scopus 로고
    • Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau
    • Klein R.L., Lin W.L., Dickson D.W., Lewis J., Hutton M., Duff K., et al. Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau. Am J Pathol 2004, 164:347-353.
    • (2004) Am J Pathol , vol.164 , pp. 347-353
    • Klein, R.L.1    Lin, W.L.2    Dickson, D.W.3    Lewis, J.4    Hutton, M.5    Duff, K.6
  • 18
    • 33845915434 scopus 로고    scopus 로고
    • Bilateral entorhinal cortex lesions impair acquisition of delayed spatial alternation in rats
    • Ramirez J.J., Campbell D., Poulton W., Barton C., Swails J., Geghman K., et al. Bilateral entorhinal cortex lesions impair acquisition of delayed spatial alternation in rats. Neurobiol Learn Mem 2007, 87:264-268.
    • (2007) Neurobiol Learn Mem , vol.87 , pp. 264-268
    • Ramirez, J.J.1    Campbell, D.2    Poulton, W.3    Barton, C.4    Swails, J.5    Geghman, K.6
  • 19
    • 84958342973 scopus 로고
    • Chance orders of alternative stimuli in visual discrimination experiments
    • Gellerman L.W. Chance orders of alternative stimuli in visual discrimination experiments. J Genetic Psychol 1933, 42:206-208.
    • (1933) J Genetic Psychol , vol.42 , pp. 206-208
    • Gellerman, L.W.1
  • 20
    • 0021276313 scopus 로고
    • Sparing and recovery of spatial alternation performance after entorhinal cortex lesions in rats
    • Ramirez J.J., Stein D.G. Sparing and recovery of spatial alternation performance after entorhinal cortex lesions in rats. Behav Brain Res 1984, 13:53-61.
    • (1984) Behav Brain Res , vol.13 , pp. 53-61
    • Ramirez, J.J.1    Stein, D.G.2
  • 21
    • 41549129361 scopus 로고    scopus 로고
    • Tau expression levels from various adeno-associated virus vector serotypes produce graded neurodegenerative disease states
    • Klein R.L., Dayton R.D., Tatom J.B., Diaczynsky C.G., Salvatore M.F. Tau expression levels from various adeno-associated virus vector serotypes produce graded neurodegenerative disease states. Eur J Neurosci 2008, 27:1615-1625.
    • (2008) Eur J Neurosci , vol.27 , pp. 1615-1625
    • Klein, R.L.1    Dayton, R.D.2    Tatom, J.B.3    Diaczynsky, C.G.4    Salvatore, M.F.5
  • 22
    • 32944471565 scopus 로고    scopus 로고
    • Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins
    • Klein R.L., Dayton R.D., Leidenheimer N.J., Jansen K., Golde T.E., Zweig R.M. Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins. Mol Ther 2006, 13:517-527.
    • (2006) Mol Ther , vol.13 , pp. 517-527
    • Klein, R.L.1    Dayton, R.D.2    Leidenheimer, N.J.3    Jansen, K.4    Golde, T.E.5    Zweig, R.M.6
  • 23
    • 0015168149 scopus 로고
    • Silver staining of Alzheimer's neurofibrillary changes by means of physical development
    • Gallyas F. Silver staining of Alzheimer's neurofibrillary changes by means of physical development. Acta Morphol Acad Sci Hung 1971, 19:1-8.
    • (1971) Acta Morphol Acad Sci Hung , vol.19 , pp. 1-8
    • Gallyas, F.1
  • 25
    • 78651153462 scopus 로고
    • A " direct-coloring" thiocholine method for cholinesterases
    • Karnovsky M.J., Roots L. A " direct-coloring" thiocholine method for cholinesterases. J Histochem Cytochem 1964, 12:219-221.
    • (1964) J Histochem Cytochem , vol.12 , pp. 219-221
    • Karnovsky, M.J.1    Roots, L.2
  • 26
    • 0025279165 scopus 로고
    • Axon sprouting in the rodent and Alzheimer's disease brain: a reactivation of developmental mechanisms?
    • Cotman C.W., Geddes J.W., Kahle J.S. Axon sprouting in the rodent and Alzheimer's disease brain: a reactivation of developmental mechanisms?. Prog Brain Res 1990, 83:427-434.
    • (1990) Prog Brain Res , vol.83 , pp. 427-434
    • Cotman, C.W.1    Geddes, J.W.2    Kahle, J.S.3
  • 27
    • 0031451612 scopus 로고    scopus 로고
    • Lesion-induced plasticity of central neurons sprouting of single fibres in the rat hippocampus after unilateral entorhinal cortex lesion
    • Deller T., Frotscher M. Lesion-induced plasticity of central neurons sprouting of single fibres in the rat hippocampus after unilateral entorhinal cortex lesion. Prog Neurobiol 1997, 53:687-727.
    • (1997) Prog Neurobiol , vol.53 , pp. 687-727
    • Deller, T.1    Frotscher, M.2
  • 28
    • 0024817554 scopus 로고
    • Acetylcholinesterase stain intensity patterns in the rat dentate gyrus: a quantitative description based on digital image analysis
    • King M.A., Walker D.W., Hunter B.E., Reep R.L. Acetylcholinesterase stain intensity patterns in the rat dentate gyrus: a quantitative description based on digital image analysis. Neuroscience 1989, 33:203-231.
    • (1989) Neuroscience , vol.33 , pp. 203-231
    • King, M.A.1    Walker, D.W.2    Hunter, B.E.3    Reep, R.L.4
  • 29
    • 78149414963 scopus 로고    scopus 로고
    • Pronounced microgliosis and neurodegeneration in aged rats after tau gene transfer. Neurobiol. Aging; , [Epub ahead of print].
    • Klein RL, Dayton RD, Diaczynsky CG, Wang DB. Pronounced microgliosis and neurodegeneration in aged rats after tau gene transfer. Neurobiol. Aging; 2009, [Epub ahead of print].
    • Klein, R.L.1    Dayton, R.D.2    Diaczynsky, C.G.3    Wang, D.B.4
  • 30
    • 57149105135 scopus 로고    scopus 로고
    • Towards a functional organization of the medial temporal lobe memory system: role of the parahippocampal and medial entorhinal cortical areas
    • Eichenbaum H., Lipton P.A. Towards a functional organization of the medial temporal lobe memory system: role of the parahippocampal and medial entorhinal cortical areas. Hippocampus 2008, 18:1314-1324.
    • (2008) Hippocampus , vol.18 , pp. 1314-1324
    • Eichenbaum, H.1    Lipton, P.A.2
  • 31
    • 33646153054 scopus 로고    scopus 로고
    • Cooperation between the hippocampus and the entorhinal cortex in spatial memory: a disconnection study
    • Parron C., Poucet B., Save E. Cooperation between the hippocampus and the entorhinal cortex in spatial memory: a disconnection study. Behav Brain Res 2006, 170:99-109.
    • (2006) Behav Brain Res , vol.170 , pp. 99-109
    • Parron, C.1    Poucet, B.2    Save, E.3
  • 32
    • 33646457942 scopus 로고    scopus 로고
    • Conjunctive representation of position, direction, and velocity in entorhinal cortex
    • Sargolini F., Fyhn M., Hafting T., McNaughton B.L., Witter M.P., Moser M.B., et al. Conjunctive representation of position, direction, and velocity in entorhinal cortex. Science 2006, 312:758-762.
    • (2006) Science , vol.312 , pp. 758-762
    • Sargolini, F.1    Fyhn, M.2    Hafting, T.3    McNaughton, B.L.4    Witter, M.P.5    Moser, M.B.6
  • 33
    • 12344267143 scopus 로고    scopus 로고
    • Spatial memory in the rat requires the dorsolateral band of the entorhinal cortex
    • Steffenach H.A., Witter M., Moser M.B., Moser E.I. Spatial memory in the rat requires the dorsolateral band of the entorhinal cortex. Neuron 2005, 45:301-313.
    • (2005) Neuron , vol.45 , pp. 301-313
    • Steffenach, H.A.1    Witter, M.2    Moser, M.B.3    Moser, E.I.4
  • 34
    • 0017345260 scopus 로고
    • Behavioral correlates of denervation and reinnervation of the hippocampal formation of the rat: recovery of alternation performance following unilateral entorhinal cortex lesions
    • Loesche J., Steward O. Behavioral correlates of denervation and reinnervation of the hippocampal formation of the rat: recovery of alternation performance following unilateral entorhinal cortex lesions. Brain Res Bull 1977, 2:31-39.
    • (1977) Brain Res Bull , vol.2 , pp. 31-39
    • Loesche, J.1    Steward, O.2
  • 35
    • 0017362412 scopus 로고
    • Behavioral correlates of denervation and reinnervation of the hippocampal formation of the rat: open field activity and cue utilization following bilateral entorhinal cortex lesions
    • Steward O., Loesche J., Horton W.C. Behavioral correlates of denervation and reinnervation of the hippocampal formation of the rat: open field activity and cue utilization following bilateral entorhinal cortex lesions. Brain Res Bull 1977, 2:41-48.
    • (1977) Brain Res Bull , vol.2 , pp. 41-48
    • Steward, O.1    Loesche, J.2    Horton, W.C.3
  • 36
    • 0036354282 scopus 로고    scopus 로고
    • A comparison of the effects of fimbria-fornix, hippocampal, or entorhinal cortex lesions on spatial reference and working memory in rats: short versus long postsurgical recovery period
    • Galani R., Obis S., Coutureau E., Jarrard L., Cassel J.C. A comparison of the effects of fimbria-fornix, hippocampal, or entorhinal cortex lesions on spatial reference and working memory in rats: short versus long postsurgical recovery period. Neurobiol Learn Mem 2002, 77:1-16.
    • (2002) Neurobiol Learn Mem , vol.77 , pp. 1-16
    • Galani, R.1    Obis, S.2    Coutureau, E.3    Jarrard, L.4    Cassel, J.C.5
  • 37
    • 0027257348 scopus 로고
    • On the role of the hippocampus in learning and memory in the rat
    • Jarrard L.E. On the role of the hippocampus in learning and memory in the rat. Behav Neural Biol 1993, 60:9-26.
    • (1993) Behav Neural Biol , vol.60 , pp. 9-26
    • Jarrard, L.E.1
  • 38
    • 0031898237 scopus 로고    scopus 로고
    • The effects of cytotoxic entorhinal lesions and electrolytic medial septal lesions on the acquisition and retention of a spatial working memory task
    • Marighetto A., Yee B.K., Rawlins J.N. The effects of cytotoxic entorhinal lesions and electrolytic medial septal lesions on the acquisition and retention of a spatial working memory task. Exp Brain Res 1998, 119:517-528.
    • (1998) Exp Brain Res , vol.119 , pp. 517-528
    • Marighetto, A.1    Yee, B.K.2    Rawlins, J.N.3
  • 39
    • 0032896886 scopus 로고    scopus 로고
    • The effects of NMDA-induced retrohippocampal lesions on performance of four spatial memory tasks known to be sensitive to hippocampal damage in the rat
    • Pouzet B., Welzl H., Gubler M.K., Broersen L., Veenman C.L., Feldon J., et al. The effects of NMDA-induced retrohippocampal lesions on performance of four spatial memory tasks known to be sensitive to hippocampal damage in the rat. Eur J Neurosci 1999, 11:123-140.
    • (1999) Eur J Neurosci , vol.11 , pp. 123-140
    • Pouzet, B.1    Welzl, H.2    Gubler, M.K.3    Broersen, L.4    Veenman, C.L.5    Feldon, J.6
  • 40
    • 4444352849 scopus 로고    scopus 로고
    • Effects of neonatal excitotoxic lesions of the entorhinal cortex on cognitive functions in the adult rat
    • Schmadel S., Schwabe K., Koch M. Effects of neonatal excitotoxic lesions of the entorhinal cortex on cognitive functions in the adult rat. Neuroscience 2004, 128:365-374.
    • (2004) Neuroscience , vol.128 , pp. 365-374
    • Schmadel, S.1    Schwabe, K.2    Koch, M.3
  • 41
    • 0034426011 scopus 로고    scopus 로고
    • Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
    • Lewis J., McGowan E., Rockwood J., Melrose H., Nacharaju P., Van Slegtenhorst M., et al. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet 2000, 25:402-405.
    • (2000) Nat Genet , vol.25 , pp. 402-405
    • Lewis, J.1    McGowan, E.2    Rockwood, J.3    Melrose, H.4    Nacharaju, P.5    Van Slegtenhorst, M.6
  • 42
    • 2442587216 scopus 로고    scopus 로고
    • Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain
    • Arendash G.W., Lewis J., Leighty R.E., McGowan E., Cracchiolo J.R., Hutton M., et al. Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain. Brain Res 2004, 1012:29-41.
    • (2004) Brain Res , vol.1012 , pp. 29-41
    • Arendash, G.W.1    Lewis, J.2    Leighty, R.E.3    McGowan, E.4    Cracchiolo, J.R.5    Hutton, M.6
  • 43
    • 34447323183 scopus 로고    scopus 로고
    • Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation
    • Murakami T., Paitel E., Kawarabayashi T., Ikeda M., Chishti M.A., Janus C., et al. Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation. Am J Pathol 2006, 169:1365-1375.
    • (2006) Am J Pathol , vol.169 , pp. 1365-1375
    • Murakami, T.1    Paitel, E.2    Kawarabayashi, T.3    Ikeda, M.4    Chishti, M.A.5    Janus, C.6
  • 44
    • 33745699023 scopus 로고    scopus 로고
    • Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice
    • Pennanen L., Wolfer D.P., Nitsch R.M., Gotz J. Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice. Genes Brain Behav 2006, 5:369-379.
    • (2006) Genes Brain Behav , vol.5 , pp. 369-379
    • Pennanen, L.1    Wolfer, D.P.2    Nitsch, R.M.3    Gotz, J.4
  • 45
    • 0036373861 scopus 로고    scopus 로고
    • The role of axonal sprouting in functional reorganization after CNS injury: lessons from the hippocampal formation
    • Ramirez J.J. The role of axonal sprouting in functional reorganization after CNS injury: lessons from the hippocampal formation. Restor Neurol Neurosci 2001, 19:237-262.
    • (2001) Restor Neurol Neurosci , vol.19 , pp. 237-262
    • Ramirez, J.J.1
  • 48
    • 77952883062 scopus 로고    scopus 로고
    • Rate of entorhinal and hippocampal atrophy in incipient and mild AD: relation to memory function
    • Stoub T.R., Rogalski E.J., Leurgans S., Bennett D.A., deToledo-Morrell L. Rate of entorhinal and hippocampal atrophy in incipient and mild AD: relation to memory function. Neurobiol Aging 2010, 31:1089-1098.
    • (2010) Neurobiol Aging , vol.31 , pp. 1089-1098
    • Stoub, T.R.1    Rogalski, E.J.2    Leurgans, S.3    Bennett, D.A.4    deToledo-Morrell, L.5
  • 49
    • 41349086384 scopus 로고    scopus 로고
    • Characterizing the memory changes in persons with mild cognitive impairment
    • Belleville S., Sylvain-Roy S., de Boysson C., Menard M.C. Characterizing the memory changes in persons with mild cognitive impairment. Prog Brain Res 2008, 169:365-375.
    • (2008) Prog Brain Res , vol.169 , pp. 365-375
    • Belleville, S.1    Sylvain-Roy, S.2    de Boysson, C.3    Menard, M.C.4
  • 50
    • 17744362737 scopus 로고    scopus 로고
    • Working memory and learning in early Alzheimer's disease
    • Germano C., Kinsella G.J. Working memory and learning in early Alzheimer's disease. Neuropsychol Rev 2005, 15:1-10.
    • (2005) Neuropsychol Rev , vol.15 , pp. 1-10
    • Germano, C.1    Kinsella, G.J.2
  • 51
    • 0021145680 scopus 로고
    • Alzheimer's disease: cell-specific pathology isolates the hippocampal formation
    • Hyman B.T., Van Hoesen G.W., Damasio A.R., Barnes C.L. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science 1984, 225:1168-1170.
    • (1984) Science , vol.225 , pp. 1168-1170
    • Hyman, B.T.1    Van Hoesen, G.W.2    Damasio, A.R.3    Barnes, C.L.4
  • 52
    • 0022535539 scopus 로고
    • Perforant pathway changes and the memory impairment of Alzheimer's disease
    • Hymn B.T., Van Hoesen G.W., Kromer L.J., Damasio A.R. Perforant pathway changes and the memory impairment of Alzheimer's disease. Ann Neurol 1986, 20:472-481.
    • (1986) Ann Neurol , vol.20 , pp. 472-481
    • Hymn, B.T.1    Van Hoesen, G.W.2    Kromer, L.J.3    Damasio, A.R.4
  • 53
    • 0026547876 scopus 로고
    • Ultrastructural and immunohistochemical study of degenerate neurite-bearing ghost tangles
    • Ikeda K., Haga C., Oyanagi S., Iritani S., Kosaka K. Ultrastructural and immunohistochemical study of degenerate neurite-bearing ghost tangles. J Neurol 1992, 239:191-194.
    • (1992) J Neurol , vol.239 , pp. 191-194
    • Ikeda, K.1    Haga, C.2    Oyanagi, S.3    Iritani, S.4    Kosaka, K.5


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