Tissue type plasminogen activator facilitates NMDA-receptor-mediated retinal apoptosis through an independent fibrinolytic cascade

Investigative Ophthalmology and Visual Science

Volumn 46, Issue 4, 2005, Pages 1504-1507

  Kumada, Masako ^a   Niwa, Masayuki ^a   Hara, Akira ^a   Matsuno, Hiroyuki ^a   Mori, Hideki ^a   Ueshima, Shigeru ^b   Matsuo, Osamu ^b   Yamamoto, Tetsuya ^a   Kozawa, Osamu ^a  

^a GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ANTIPLASMIN; EXCITOTOXIN; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PLASMIN; PLASMINOGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE; AMINO ACID RECEPTOR STIMULATING AGENT; EYE PROTEIN; N METHYLASPARTIC ACID; NERVE GROWTH FACTOR; PIGMENT EPITHELIUM DERIVED FACTOR; PIGMENT EPITHELIUM-DERIVED FACTOR; PLASMINOGEN ACTIVATOR; SERINE PROTEINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; ENZYME DEGRADATION; FIBRINOLYSIS; KNOCKOUT MOUSE; MALE; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RETINA CELL; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; DRUG EFFECT; INJECTION; METABOLISM; PATHOLOGY; PHYSIOLOGY; RETINA;

ANIMALS; APOPTOSIS; EXCITATORY AMINO ACID AGONISTS; EYE PROTEINS; FIBRINOLYSIS; IN SITU NICK-END LABELING; INJECTIONS; MALE; MICE; MICE, INBRED C57BL; N-METHYLASPARTATE; NERVE GROWTH FACTORS; PLASMIN; PLASMINOGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLASMINOGEN ACTIVATORS; RECEPTORS, N-METHYL-D-ASPARTATE; RETINA; SERPINS; TISSUE PLASMINOGEN ACTIVATOR; URINARY PLASMINOGEN ACTIVATOR;

EID: 18244362345     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.04-0595     Document Type: Article

References (29)

1. Sappino AP, Madani R, Huarte J, et al. Extracellular proteolysis in the adult murine brain. J Clin Invest. 1993;92:679-685.
2. Tsirka SE, Gualandris A, Amaral DG, et al. Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator. Nature. 1995;377:340-344.
3. Wang YF, Tsirka SE, Strickland S, et al. Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat Med. 1998;4:228-231.
4. Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1988;1:623-634.
5. Meldrum B, Garthwaite J. Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol Sci. 1990;11:379-387.
6. Tsirka SE, Rogove AD, Strickland S. Neuronal cell death and tPA. Nature, 1996;384:123-124.
7. Dreyer EB, Zurakowski D, Schumer RA, et al. Elevated glutamate in the vitreous body of humans and monkeys with glaucoma. Arch Ophthalmol. 1996;114:299-305.
8. Louzada-Junior P, Dias JJ, Santos WF, et al. Glutamate release in experimental ischaemia of the retina: an approach using microdialysis. J Neurochem. 1992;59:358-363.
9. Kumada M, Niwa M, Wang X, et al. Endogenous tissue type plasminogen activator facilitates NMDA-induced retinal damage. Toxicol Appl Pharmacol. 2004;200:48-53.
10. Collen D, Lijnen HR. Basic and clinical aspects of fibrinolysis and thrombolysis. Blood. 1991;78:3114-3124.
11. Carmeliet P, Schoonjans L, Kieckens L, et al. Physiological consequences of loss of plasminogen activator gene function in mice. Nature. 1994;368:419-424.
12. Hara A, Niwa M, Iwai T, et al. Neuronal apoptosis studied by a sequential TUNEL technique: a method for tract-tracing. Brain Res Brain Res Protoc. 1999;4:140-146.
13. Daugeliene L, Niwa M, Hara A, et al. Transient ischemic injury in the rat retina caused by thrombotic occlusion-thrombolytic reperfusion. Invest Ophthalmol Vis Sci. 2000;41:2743-2747.
14. Tripathi BJ, Geanon JD, Tripathi RC. Distribution of tissue plasminogen activator in human and monkey eyes: an immunohistochemical study. Ophthalmology. 1987;94:1434-1438.
15. Tripathi RC, Tripathi BJ, Park JK. Localization of urokinase-type plasminogen activator in human eyes: an immunocytochemical study. Exp Eye Res. 1990;51:545-552.
16. Baranes D, Lopez-Garcia JC, et al. Reconstitution of the hippocampal mossy fiber and associational-commissural pathways in a novel dissociated cell culture system. Proc Natl Acad Sci USA. 1996;93: 4706-4711.
17. Gualandris A, Jones TE, Strickland S, et al. Membrane depolarization induces calcium-dependent secretion of tissue plasminogen activator. J Neurosci. 1996;16:2220-2225.
18. Parmer RJ, Mahata M, Mahata S, et al. Tissue plasminogen activator (t-PA) is targeted to the regulated secretory pathway: catecholamine amine storage vesicles as a reservoir for the rapid release of t-PA. J Biol Chem. 1997;272:1976-1982.
19. Lochner JE, Kingma M, Kuhn S, et al. Real-time imaging of the axonal transport of granules containing a tissue plasminogen activator/green fluorescent protein hybrid. Mol Biol Cell. 1998;9: 2463-2476.
20. Salles FJ, Strickland S. Localization and regulation of the tissue plasminogen activator-plasmin system in the hippocampus. J Neurosci. 2002;22:2125-2234.
21. Lam TT, Abler AS, Kwong JM, Tso MO. N-methy-D-aspartate (NMDA)-induced apoptosis in rat retina. Invest Ophthalmol Vis Sci. 1999;40:2391-2397.
22. Li Y, Schlamp CL, Nickells RW. Experimental induction of retinal ganglion cell death in adult mice. Invest Ophthalmol Vis Sci. 1999;40:1004-1008.
23. Siliprandi R, Canella R, Carmignoto G, et al. N-methyl-D-aspartate induced neurotoxicity in the adult rat retina. Vis Neurosci. 1992; 8:567-573.
24. Hahn JS, Aizenman E, Lipton SA. Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801. Proc Natl Acad Sci USA. 1988;85: 6556-6560.
25. Ferreira IL, Duarte CB, Carvalho AP. Ca2+ influx through glutamate receptor-associated channels in retina Ca2+ cells correlates with neuronal cell death. Eur J Pharmacol. 1996;302:153-162.
26. Tsirka SE, Rogove AD, Strickland S. Neuronal cell death and tPA. Nature. 1996;384:123-124.
27. Nicole O, Docagne F, Ali C, et al. The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling. Nat Med. 2001;7:59-64.
28. Gilis A, Declerck JP. Proteinase specificity and functional diversity in point mutants of plasminogen activator inhibitor 1. J Biol Chem. 1997;272:12662-12666.
29. Matys T, Strickland S. Tissue plasminogen activator and NMDA receptor cleavage. Nat Med. 2003;9:371-373.